Citations 2
Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage
Collaborators, GBD 2021 Global Subarachnoid Hemorrhage Risk Factors, Rautalin, Ilari, Stark, Benjamin, Johnson, Catherine O., Kaprio, Jaakko , Korja, Miikka, Krishnamurthi, Rita , Nair, Balakrishnan , Vergouwen, Mervyn D. I. , Abdelkader, Atef , Abdullahi, Auwal , Abualruz, Hasan , Abukhadijah, Hana J , Adamu, Lawan Hassan, Adegboye, Oyelola A. , Adzigbli, Leticia Akua, Agyemang‐Duah, Williams , Ahinkorah, Bright Opoku, Ahmad, Aqeel , Ahmad, Danish , Ahmadzade, Amir Mahmoud , Akkaif, Mohammed Ahmed , Ali, Mohammed Usman, Alif, Sheikh Mohammad , Alimohamadi, Yousef, Alsabri, Mohammed , Altaf, Awais , Alvis‐Guzmán, Nelson , Alwafi, Hassan , Al‐Wardat, Mohammad , Alyahya, Mohammad S. , Amin, Tarek Tawfik , Amindarolzarbi, Alireza , Amusa, Ganiyu , Angappan, Dhanalakshmi , Anuoluwa, Boluwatife Stephen, Anwar, Saleha, Anyasodor, Anayochukwu Edward , Apostol, Geminn Louis Carace, Areda, Demelash, Artamonov, Anton A, Artanti, Kurnia Dwi , Ashemo, Mubarek Yesse , Athar, Mohammad , Aujayeb, Avinash , Awotidebe, Adedapo Wasiu , Azadnajafabad, Sina , Aziz, Shahkaar , Bagheri, Nasser , Taqanaki, Pegah Bahrami , Bahramian, Saeed , Bai, Ruhai , Baig, Atif Amin , Baltatu, Ovidiu Constantin , Bam, Kiran, Barker‐Collo, Suzanne , Bärnighausen, Till , Bastan, Mohammad‐Mahdi , Basu, Sanjay , Bell, Shelly L, Benseñor, Isabela M , Berhie, Alemshet Yirga , Bhagavathula, Akshaya Srikanth , Bhaskar, Sonu , Bhat, Ajay Nagesh, Bhat, Vivek , Birhan, Mekuriaw Mesfin , Borhany, Hamed, Breitner, Susanne , Bulamu, Norma B. , Butt, Zahid A , Cabral, Lucas Scotta , Santos, Florentino Luciano Caetano dos , Cámera, Luis Alberto , Capodici, Angelo , Chadwick, Joshua , Chakraborty, Promit Ananyo , Chanie, Gashaw Sisay , Chattu, Vijay Kumar , Chi, Gerald, Chichagi, Fatemeh , Columbus, Alyssa , Criqui, Michael H, Ohadi, Mohammad Amin Dabbagh , Dadras, Omid , Dalli, Lachlan L. , Debopadhaya, Shayom , Dervišević, Emina , Devanbu, Vinoth Gnana Chellaiyan, Dewan, Syed Masudur Rahman , Dhane, Amol S. , Chi, Thanh, Phuong, Thao Huynh, Dohare, Sushil , Докова, Клара , Dowou, Robert Kokou , Dsouza, Haneil Larson , Dutta, Siddhartha , Dziedzic, Arkadiusz , E’mar, Abdel Rahman, Edvardsson, David , Efendi, Ferry, Nahas, Nevine El , Elgendy, Islam Y. , Eltaha, Chadi, Emeto, Theophilus I. , Fakhradiyev, Ildar , Faris, Pawan , Fauk, Nelsensius Klau , Fazylov, Timur, Fekadu, Ginenus , Fetensa, Getahun, Fischer, Florian, Foschi, Matteo , Fridayani, Ni Kadek Yuni, Gaipov, Abduzhappar , Gajjar, Avi A. , Ganesan, Balasankar , Gebregergis, Miglas Welay, Gebremeskel, Teferi Gebru , Getie, Molla , Ghadirian, Fataneh , Ghasemzadeh, Afsaneh , Gholamalizadeh, Maryam , Gil, Artyom , Goleij, Pouya , Goulart, Alessandra C. , Goulart, Bárbara Niegia Garcia de , Guan, Shi‐Yang , Gupta, Sapna , Habibzadeh, Farrokh , Hadi, Najah R, Hankey, Graeme J. , Harlianto, Netanja I. , Hasani, Hamidreza, Hasnain, Md Saquib , Haubold, Johannes , Havmoeller, Rasmus, Hay, Simon I , Hbid, Youssef , Heidari, Golnaz , Hiraike, Yuta, Hoan, Nguyen Quoc , Hosseinzadeh, Mehdi , Hwang, Bing‐Fang , Ibitoye, Segun Emmanuel , Ikiroma, Adalia , Isola, Gaetano , Iwagami, Masao , Jacob, Louis, Jain, Akhil, Jakovljević, Mihajlo , Jatau, Abubakar Ibrahim , Jawaid, Talha, Jayapal, Sathish Kumar , Jonas, Jost B, Joseph, Nitin , Jürisson, Mikk , Kadashetti, Vidya, Kalani, Rizwan, Kamireddy, Arun , Kandel, Himal , Behnagh, Arman Karimi , Kashoo, Faizan , Kayode, Gbenga A , Kazemi, Foad , Khader, Yousef , Khaing, Inn Kynn , Khan, Fayaz Ahmad , Khan, Mohammad Jobair , Kashani, Hamid Reza Khayat , Khosla, Atulya Aman , Kim, Kwanghyun , Kim, Yun Jin , Korzh, Oleksii , Krishan, Kewal , Krishna, Varun, Krishnamoorthy, Vijay , Kuddus, Mohammed , Kulimbet, Mukhtar , Lahariya, Chandrakant, Lai, Daphne Teck Ching , Lai, Hanpeng , Laksono, Tri, Lallukka, Tea , Latifinaibin, Kaveh, Le, Nhi Huu Hanh, Le, Thao T. , Lee, Munjae , Lee, Yo Han , Lenzi, Jacopo , Leonardi, Matilde, Li, Ming‐Chieh , Li, Xiaopan , Lim, Stephen S , Lin, Jialing , Saute, Ricardo Lutzky , Malik, Ahmad Azam , Marateb, Hamid Reza , Maroufi, Seyed Farzad , Maugeri, Andrea , McPhail, Steven , Mehndiratta, Man Mohan, Mestrovic, Tomislav, Mettananda, Chamila Dinushi Kukulege , Miazgowski, Tomasz , Minervini, Giuseppe , Mithra, Prasanna , Mohamed, Abdalla Z. , Mohammad, Ameen Mosa , Mohammed, Shafiu , Moni, Mohammad Ali , Moradi, Yousef, Moraga, Paula , Morawska, Lídia , Munjal, Kavita , Murray, Christopher J L , Nagarajan, Ahamarshan Jayaraman , Naik, Ganesh R. , Najdaghi, Soroush , Davani, Delaram Narimani , DELETE-ME, Nawsherwan, Nazri-Panjaki, Athare , Negoi, Ruxandra Irina , Nematollahi, Soroush , Nguyen, Hau Thi Hien, Nguyen, Hau Thi Hien, Nguyen, Phat Tuan , Nguyễn, Văn Thành , Niazi, Robina Khan, Nikoobar, Ali , Sá, Antonio Tolentino Nogueira de , Nomura, Shuhei , Nzoputam, Chimezie Igwegbe , Oancea, Bogdan , Ojo-Akosile, Tolulope R, Oliveira, Gláucia Maria Moraes de , Olorukooba, Abdulhakeem Abayomi , Osuagwu, Uchechukwu Levi , Ouyahia, Amel, A, Mahesh Padukudru P, Panagiotakos, Demosthenes B. , Parikh, Romil R., Park, Seoyeon , Pedersini, Paolo , Peprah, Emmanuel , Perico, Norberto, Petermann-Rocha, Fanny Emily, Plotnikov, Evgenii , Полибин, Р. 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A., Wubie, Yihun Miskir, Xiao, Hong , Xu, Xiaoyue , Yano, Yuichiro , Yarahmadi, Amir , Ye, Pengpeng, Yon, Dong Keon , Zanghì, Aurora , Zare, Iman, Zastrozhin, Michael, Zhang, Zhi-Jiang , Zhang, Zhiqiang , Zhang, Zhiqiang, Zhao, Hanqing , Zhou, Shang Cheng, Zhumagaliuly, Abzal , Zia, Hafsa, Roth, Gregory A., Topór‐Mądry, Roman , Oliveira, Arão Belitardo , Rahim, Fakher , Saddik, Basema , Waheed, Yasir , Liu, Xuefeng , Zhang, Yunquan , Ozair, Ahmad , Buendía, Jefferson Antonio , Korja, Miikka , Baig, Atif Amin , Shanawaz, Mohd , Elgendy, Islam Y , Hankey, Graeme J , Alif, Sheikh M , Rezaei, Negar , Bhagavathula, Akshaya Srikanth , Van den Eynde, Jef , Ozair, Ahmad , Collaborators, GBD 2021 Global Subarachnoid Hemorrhage Risk Factors, Rautalin, Ilari Matias , Volovici, Victor , Ranta, Annemarei , Rinkel, Gabriël J.E. , Abate, Yohannes Habtegiorgis, Abbastabar, Hedayat , Abd-Allah, Foad , Abdi, Parsa , Abdollahi, Arash , Abiodun, Olugbenga Olusola , Aboagye, Richard Gyan , Abouzid, Mohamed , Abtahi, Dariush , Abu‐Rumeileh, Samir , Abualhasan, Ahmed , Abu‐Zaid, Ahmed , Addo, Isaac Yeboah , Adedoyin, Rufus Adesoji , Adra, Saryia , Ahinkorah, Bright Opoku , Ahmed, Ali , Ahmed, Haroon , Ahmed, Syed Anees , Aji, Budi , Al‐Ajlouni, Yazan A. , Al‐Aly, Ziyad , ALBashtawy, Mohammed , Aljunid, Syed Mohamed , Alomari, Mahmoud A. , Alrawashdeh, Ahmad , Alsabri, Mohammed A., Salman, Rustam Al‐Shahi , Al‐Tammemi, Ala’a B. , Al‐Worafi, Yaser Mohammed , Aly, Hany Z. , Alzoubi, Karem Hasan , Amani, Reza, Anderlini, Deanna , Anil, Abhishek , Arabloo, Jalal , Ärnlöv, Johan , Arumugam, Ashokan , Aryan, Zahra , Jafarabadi, Mohammad Asghari , Ashraf, Tahira , Athari, Seyyed Shamsadin , Azzam, Ahmed Y , Babu, Giridhara R. , Bako, Abdulaziz Tijjani , Banach, Maciej , Bandyopadhyay, Soham , Banik, Biswajit , Bardhan, Mainak , Barqawi, Hiba Jawdat , Barua, Lingkan , Beyene, Kebede Abera , Bhat, Vivek, Bhatti, Gurjit Kaur , Bhatti, Jasvinder Singh , Bijani, Ali , Bikbov, Boris , Birhanu, Mulugeta Molla , Bitra, Veera Raghavulu , Boloor, Archith , Brenner, Hermann , Bugiardini, Raffaele , Călina, Daniela Cornelia , Campos, Luciana Aparecida , Campos‐Nonato, Ismael , Carvalho, Félix , Castañeda-Orjuela, Carlos A , Catapano, Alberico Luigi , Cegolon, Luca , Chakraborty, Chiranjib , Chakraborty, Sandip , Chandika, Rama Mohan , Chaudhary, Anis Ahmad , Chi, Gerald , Ching, Patrick R , Chopra, Hitesh , Choudhari, Sonali Gajanan , Chowdhury, E. , Chu, Dinh‐Toi , Chung, Sheng‐Chia , Silva, Alanna Gomes da , Dai, Xiaochen , Dalal, Koustuv , D’Amico, Emanuele , Dashti, Mohsen , Davletov, Kairat , Cruz-Góngora, Vanessa Vianey De la , Delgado‐Enciso, Iván , Devanbu, Vinoth Gnana Chellaiyan, Dibas, Mahmoud , Doheim, Mohamed Fahmy , Dongarwar, Deepa , D’Oria, Mario , Doshi, Ojas Prakashbhai , Doshi, Rajkumar , Efendi, Defi , Efendi, Ferry , Elhadi, Muhammed , Eltahir, Mohd. Elmagzoub , Fabin, Natalia , Fagbamigbe, Adeniyi Francis , Fahim, Ayesha , Fares, Jawad , Ferreira, Nuno Bravo , Gandhi, Aravind P. , Garg, Ravindra Kumar , Gebrehiwot, Mesfin , Ghadimi, Delaram J. , Ghahramani, Sulmaz , Ghazy, Ramy Mohamed , Ghozy, Sherief , Gilani, Jaleed Ahmed , Gnedovskaya, Elena V. , Hadei, Mostafa , Hamidi, Samer , Hanifi, Nasrin , Haro, Josep María , Hasan, Faizul , Tabatabaei, Mahgol Sadat Hassan Zadeh , Heidari, Mohammad , Hemmati, Mehdi , Holla, Ramesh , Hostiuc, Sorin , Huang, Junjie , Huynh, Hong-Han , Ikeda, Nayu , Ilaghi, Mehran , Ilesanmi, Olayinka Stephen , Ilić, Irena , Ilić, Milena , Islam, Md. Rabiul , Ismail, Nahlah Elkudssiah , Iso, Hiroyasu , Jafarzadeh, Abdollah , Jairoun, Ammar Abdulrahman , Kalani, Rizwan, Kamal, Vineet Kumar , Kanchan, Tanuj , Karami, Jafar , Karaye, Ibraheem M. , Karimi, Yeganeh , Kesse‐Guyot, Emmanuelle , Khan, Fayaz, Khatatbeh, Haitham , Khatatbeh, Moawiah Mohammad , Kheirallah, Khalid Ahmed , Khidri, Feriha Fatima , Khormali, Moein , Kısa, Adnan , Kısa, Sezer , Kivimäki, Mika , Kolahi, Ali‐Asghar , Kompani, Farzad , Kostev, Karel , Kothari, Nikhil , Kunutsor, Setor K. , Kurniasari, Maria Dyah , Kusuma, Dian Palupi , Kytö, Ville , Vecchia, Carlo La , Lahariya, Chandrakant , Latief, Kamaluddin , Lee, Seung Won , Lee, Wei‐Chen , Leonardi, Matilde, Liu, Xuefeng , Lohner, Valerie , Lorenzovici, László , Lotufo, Paulo A. , Lucchetti, Giancarlo , Lusk, Jay B. , Amin, Hawraz Ibrahim M. , Malhotra, Armaan Kush , Malhotra, Kashish , Malta, Déborah Carvalho , Mansournia, Mohammad Alì , Mantovani, LG , Manu, Emmanuel, Marino, Mirko , Martínez, Ramón , Martini, Santi , Martorell, Miquel , Marzo, Roy Rillera , Mathangasinghe, Yasith , Mathews, Elezebeth , Mehmood, Asim , Mehrabani-Zeinabad, Kamran , Menezes, Ritesh G. , Meo, Sultan A , Meretoja, Atte , Meštrović, Tomislav , Sá, Ana Carolina Micheletti Gomide Nogueira de , Minh, Le Huu Nhat , Mirică, Andreea , Мirrakhimov, Erkin М , Mirza‐Aghazadeh‐Attari, Mohammad , Mishra, Ajay Kumar , Mohamed, Ahmed Ismail , Mohammadi, Soheil , Mohammadian-Hafshejani, Abdollah , Mokdad, Ali H. , Molinaro, Sabrina , Momani, Shaher , Ghalibaf, AmirAli Moodi , Moradi, Maryam , Msherghi, Ahmed A.A. , Ansari, Noureddin Nakhostin , Nargus, Shumaila , Natto, Zuhair S. , Nauman, Javaid , DELETE-ME, Nawsherwan, Nayak, Vinod C , Newton, Charles R. , Nigatu, Yeshambel T. , Noubiap, Jean Jacques , Nugen, Fred , Oduro, Michael Safo , Okati‐Aliabad, Hassan , Okeke, Sylvester Reuben , Okekunle, Akinkunmi Paul , Olagunju, Andrew T , Olaiya, Muideen Tunbosun , Olufadewa, Isaac Iyinoluwa , Ornello, Raffaele , Ortiz‐Prado, Esteban , Ouyahia, Amel , Owolabi, Mayowa , Padrón‐Monedero, Alicia , Padubidri, Jagadish Rao , Panos, Leonidas D , Pantazopoulos, Ioannis N. , Parikh, Romil R., Patel, Jay , Patel, Urvish , Patoulias, Dimitrios , Pereira, Gavin F , Perianayagam, Arokiasamy , Perna, Simone , Petermann‐Rocha, Fanny , Philip, Anil K. , Пирадов, М. А. , Pradhan, Jalandhar , Puvvula, Jagadeesh , Qasim, Nameer Hashim , Raggi, Alberto , Rahimi‐Movaghar, Vafa , Rahman, Muhammad Aziz , Rahmani, Amir Masoud , Sanati, Ali Rajabpour , Ramasamy, Shakthi Kumaran , Ramazanu, Sheena , Rathish, Devarajan , Rawaf, Salman , Redwan, Elrashdy M , Remuzzi, Giuseppe , Romoli, Michele, Romozzi, Marina , Ross, Allen Guy , Rout, Himanshu Sekhar , Roy, Priyanka , Saad, Aly M A , Saadatian, Zahra , Sabour, Siamak , Sacco, Simona , Sadeghi, Erfan , Saeed, Usman, Sharif‐Askari, Fatemeh Saheb , Sahebkar, Amirhossein , Sajib, Md Refat Uz Zaman , Saleh, Mohamed A. , Samodra, Yoseph Leonardo , MİLİCEVİC, Milena Santric, Saravanan, Aswini , Sarkar, Tanmay, Sarode, Sachin Chakradhar , Sartorius, Benn , Satpathy, Maheswar , Schneider, Ione Jayce Ceola , Schuermans, Art , Selvaraj, Siddharthan , Senthilkumaran, Subramanian , Sepanlou, Sadaf Ghajarieh , Shahwan, Moyad Jamal , Shamim, Muhammad Aaqib , Shamsi, Anas , Shannawaz, Mohammed , Rad, Javad Sharifi, Sharma, Vishal , Shittu, Aminu , Shiue, Ivy , Shlobin, Nathan A. , Siddig, Emmanuel Edwar , Spartalis, Michael , Stanaway, Jeffrey D , Starodubova, Antonina Vladimirovna , Szarpak, Łukasz , Tabatabaeizadeh, Seyed‐Amir , Tabatabaeizadeh, Seyed-Amir, Talaat, Iman Mamdouh , Temsah, Mohamad‐Hani , Thakur, Ramna , Thirunavukkarasu, Sathish, Tiwari, Krishna, Truyen, Thien Tan Tri Tai , Tsai, Daniel Hsiang‐Te , Ullah, Atta , Unnikrishnan, Bhaskaran , Unsworth, Carolyn Anne, Usman, Jibrin Sammani , Valizadeh, Rohollah , Varghese, Joe , Vasankari, Tommi Juhani , Venketasubramanian, Narayanaswamy , Vervoort, Dominique , Villafañe, Jorge Hugo , Vinayak, Manish , Wafa, Hatem A , Walde, Mandaras Tariku, Willeit, Peter , Wolfe, Charles D.A. , Wolfe, Charles D. A., Yamagishi, Kazumasa , Yaribeygi, Habib , Yaya, Sanni , Ye, Pengpeng, Yonemoto, Naohiro , Yu, Chuanhua , Zastrozhin, Michael, Zhang, Chen , Zhang, Zhiqiang, Zielińska, Magdalena , Zyoud, Samer H. , Roth, Gregory A. , Feigin, Valery L. , Kulimbet, Mukhtar , Rahim, Fakher
JAMA Neurology | May 23, 2025 | Volume: 82 | Issue: 8 | Pages: 765
Importance Nontraumatic subarachnoid hemorrhage (SAH) represents the third most common stroke type with unique etiologies, risk factors, diagnostics, and treatments. Nevertheless, epidemiological studies often cluster SAH with other stroke types leaving its distinct burden estimates obscure. Objective To estimate the worldwide burden of SAH. Design, Setting, and Participants Based on the repeated cross-sectional Global Burden of Disease (GBD) 2021 study, the global burden of SAH in 1990 to 2021 was estimated. Moreover, the SAH burden was compared with other diseases, and its associations with 14 individual risk factors were investigated with available data in the GBD 2021 study. The GBD study included the burden estimates of nontraumatic SAH among all ages in 204 countries and territories between 1990 and 2021. Exposures SAH and 14 modifiable risk factors. Main Outcomes and Measures Absolute numbers and age-standardized rates with 95% uncertainty intervals (UIs) of SAH incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) as well as risk factor–specific population attributable fractions (PAFs). Results In 2021, the global age-standardized SAH incidence was 8.3 (95% UI, 7.3-9.5), prevalence was 92.2 (95% UI, 84.1-100.6), mortality was 4.2 (95% UI, 3.7-4.8), and DALY rate was 125.2 (95% UI, 110.5-142.6) per 100 000 people. The highest burden estimates were found in Latin America, the Caribbean, Oceania, and high-income Asia Pacific. Although the absolute number of SAH cases increased, especially in regions with a low sociodemographic index, all age-standardized burden rates decreased between 1990 and 2021: the incidence by 28.8% (95% UI, 25.7%-31.6%), prevalence by 16.1% (95% UI, 14.8%-17.7%), mortality by 56.1% (95% UI, 40.7%-64.3%), and DALY rate by 54.6% (95% UI, 42.8%-61.9%). Of 300 diseases, SAH ranked as the 36th most common cause of death and 59th most common cause of DALY in the world. Of all worldwide SAH-related DALYs, 71.6% (95% UI, 63.8%-78.6%) were associated with the 14 modeled risk factors of which high systolic blood pressure (population attributable fraction [PAF] = 51.6%; 95% UI, 38.0%-62.6%) and smoking (PAF = 14.4%; 95% UI, 12.4%-16.5%) had the highest attribution. Conclusions and Relevance Although the global age-standardized burden rates of SAH more than halved over the last 3 decades, SAH remained one of the most common cardiovascular and neurological causes of death and disabilities in the world, with increasing absolute case numbers. These findings suggest evidence for the potential health benefits of proactive public health planning and resource allocation toward the prevention of SAH.
Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Deeb, G. Michael , Grube, Eberhard, Windecker, Stephan , Gada, Hemal, Mumtaz, Mubashir , Heiser, John, Merhi, William , Kleiman, Neal S. , Chetcuti, Stanley, Gleason, Thomas G. , Lee, Joon Sup, Cheng, Wen , Makkar, Raj , George, Barry, Kodali, Susheel , Yakubov, Steven J. , Lange, Rüdiger , Piazza, Nicolò , Oh, Jae K. , Li, Shuzhen , Reardon, Michael J. , Investigators, SURTAVI Trial, Gitter, Christopher B., Roberts, Dana, Bae, Richard , Sorajja, Paul , Sun, Benjamin , Askew, Judah, Eales, Frazier, Goessl, Mario, Kshettry, Vibhu R., Pedersen, Wesley R., Poulose, Anil, Roohani, Pezhman, Farivar, Robert Saeid, Shronts, Richard, Tarrel, R, Young, Mark , Butkus, Eddy, Pendleton, Kristin, Fry, Robert D., Heine, Carl, Roe, Kristin La, Weig, Laura, Agarwal, Himanshu , Langdon, Thomas, Satpathy, Ruby, Batter, John, Bremer, Karen, Indukuri, Unajyothi, Baas, Marijke, Oomes-Sistermans, Corry, Smits, Manola, Coenen, Carien, Driesen, Inge, Lauryssen, Lia, Poorter, Margreet, Schaap, Jeroen , Bentala, Mohamed, Heijer, Peter den, Remmers, Michel, Story, Marie, Erven, Paul M.M. van, Verbiest, H, Vos, Jeroen, Bennett, Michelle , Dunaj, Wendy, Seaton, Deborah, Waller, Deborah A., Khandheria, Bijoy K. , Bajwa, Tanvir , O’Hair, Daniel, Gheith, Ayman, Marriott, Elizabeth , Qhavi, Ajaz, Saxena, Varun Kumar, Shhadeh, Akram, Yeomans, Christine, Bessette, Lynn, Byrne, Jessica, Kieckhefer, Heather, Munoz, Marleny, Russo, Elizabeth, Morgan, Michael M., Byrne, Timothy , Caskey, Michael, Amabile, Orazio , Brady, Kevin P., Chung, Steven, Dacanay, Kelly, Fang, Hao , Franz, Douglas , Kelly, Claire , Loli, Akil , Payne, Jeremy, Wang, Norman C. , Lott, Jessi, Pool-Owens, C. Angele, Porter, Charlotte M., Hennan, Jeffrey A., Garrett, H. Edward , Paulus, Basil, Craig, J. Cymerman, Samaha, Joseph, Wolf, Bradley A., Wright, Lance, Zoghbi, Gilbert J., Willcott, Leslie, Roberts, Brad, Hebeler, Robert F., Stoler, Robert , Graybeal, Dion, Grayburn, Paul , Henry, Carl Ferdinand Howard, Mir, Osman , Vallabhan, Ravi C. , Fanous, Matthew , Kaufman, Jenifer, Chang, James D. , Manning, Warren J. , Riley, Marilyn F., Khabbaz, Kamal R. , Popma, Jeffrey J. , Caplan, Louis R. , Chui, Shing Fung, Guibone, Kim, Kumar, S. Sendil , Lioutas, Vasileios‐Arsenios , Nathan, Senthil , Searls, D. Eric, Fisher, Susan G. , Guirgues, Lindsay, Henderson, Sue, Loving, Laura Ashley, McWalters, Nicole, Patterson, Kelly, Burkart, Jesse, Carcedo, Bryan, Stacey, Russell, Bladergroen, Mark, Edmonson, Supakunya, Epps, Stacey, Katz, Marc , Sangha, Amandeep, Aucoin, Jennifer, Roberts, Monique, Aubin, Jaime, Hotard, Callie, Tassin, Michelle, Fail, Peter , Feinberg, Edgar, Netherland, Donald, Abben, Richard, Allam, Mohamad, Bates, Michael , Dearman, Richard, Gervais, Donald, Haight, Edward, Metes, Michael, Naquin, Jeanette, Tedesco, Victor, Thibodeaux, Lisa, Thompson, Karen , Aberle, Sally, Amaro, Dana, Rose, Geoffrey, Schérer, M. , Rinaldi, Michael , Skipper, Eric, Bridges, Charles R., Downey, William, Iyengar, Phaniraj, Martin, Jerry L., Ryan, Liam , Stiegel, Robert M., Story, John S., Alsabaawi, Khaled, Gheorghiu, Mitch, Singh, Chetana, Yashar, Jason, Siegel, Robert J. , Cheng, Wen, Altman, Karen, Jilaihawi, Hasan , Khouw, Stephanie, Salseth, Tracey, Stegic, Jasminka, Trento, Alfredo , Lazarte, Rosa, Sohn, Jeanie, Khalique, Omar , Castellon, Marco Gonzalez, Contreras, Jose Gutierrez, Kitago, Tomoko , Lekic, Tim, Naka, Yoshifumi , Smith, Craig R. , Abreu, Leana, Clement, Emerson, Sabir, Sajjad, Aji, Janah, Bowen, Frank W., Kaddissi, Georges, Mirsen, Thomas, Muntazar, Muhammad, Ogbara, Jeffrey, Rosenbloom, Michael , Schell, W, Then, Ryna , Carl, Heidi, Kreydi, Ghassan, Wolak, Heather, Sandidge, Gregory, Ali, Omar, Asfaw, Zewditu E., Kafi, Ali, Schreiber, Theodore , Andaya, Lourdes, Baciewicz, Frank A., Bassett, Joseph, Choksi, Nishit, Kassas, Safwan, Munir, Ahmad, Kothmeier, Franziska, Stroh, Annemarie, Goppel, Gertrud, Hettich, I, Opitz, A, Ruge, Hendrik , Badiu, Cătălin Constantin , Brenner, Susanne C. , Ehlmidi, Yacine, Herold, Ulf, Kreuzpointner, Robert Josef, Mazzitelli, Domenico, Vincze, Dóra, Camuglia, Krista, Cowhig, Dahlia, Newbold, Stephanie P. , Pierce, Cynthia, Wootton, Samantha, Vemulapalli, Sreekanth , Babi, Ali, Banks, Adam, Gaca, Jeffrey G., Glower, Donald D. , Halim, Sharif, Hendry, Robert, Hernández, Christian , Kiefer, Todd L., Marrotte, Eric J. , Maldonado, Andres Pineda, Wyck, David Van , Vavalle, John P. , Vora, Amit N. , Zeylikman, Yuriy, Amber, Kara, Barnitt, Anne, Lamm, Janet E., Mandelstam, Lara, Schroeder, Ryan W. , Sumner, Roxanne, Nair, Deepu, De, Ajanta, Gaudiani, Vincent A., Joye, James D., Brown, Lidia, Hessler, Christine, Rammohan, Chad, Vial, Conrad, Charles, Elizabeth S. , DeQuesada, Angela, Kaner, Maria, Mathewson, Sonya, Pitts, Kristy, Wheeler, Lauren , Wilson, Ashley, Davidson, Estella, Frohwein, Stephen, Lerakis, Stamatios , Sullivan, Angela, Babaliaros, Vasilis , Guyton, Robert A. , Thourani, Vinod H. , Anderson, Aaron, Belagaje, Samir , Benameur, Karima , Devireddy, Chandan , Harrison, A , Hudson, Kristen, Lieppe, William, Macheers, Steven, Mavromatis, Kreton , Sanders, Keith A., Sarin, Eric L., Winkel, Daniel, Duininck, Liesbeth W., Gussinklo, Titia, Jadoenath-Oedai, Shashikala, Ruiter, Arno, Berg, Nico van den, Velden-Macauley, Liz E.N. van der, Huis, Maaike van, Verelst, S., Geleijnse, Marcel L. , Vletter, Wim B., Bekker, Margaretha, Bekkers, Joseph A., Biesheuvel, Karla, Birim, Özcan, Raap, Goris Bol, Daemen, Joost , Jaegere, Peter Paul de, Wijngaarden, Rob de Lind van, Khajeh, Ladbon, Kik, Charles, Oei, Frans B S , Scheele, Maaike, Woestijne, Pieter C. van de , Geuns, Robert‐Jan van , Leeuwen, Wouter J. van, Henderson, Amy, Straight, Faye, Tischler, Marc E., Dauerman, Harold L. , Ittleman, Frank, Schmoker, Joseph, Abernethy, Abraham, Alkhalil, Imran, Azarbal, Amir , Chava, Sreedivya, Commichau, Christopher, Denkmann, Jan, DeStephan, Christine M., Ehle, Gregory, Falduto, Catherine, Gorman, Mark , Kadavath, Sabeeda , Leavitt, Bruce J., Mack, Allison, Malasana, Gangadhar, Moossavi, Shahab, Phuong, Newton , Rambod, Mehdi, Sharma, Ashwini , Terrien, Edward F., Worgan, Barbara, Zeglin-Sawczuk, Magdalena, Burgess, Brian , Killbride, Susan, Temple, Amy, Burnside, Joyce, Good, Christopher, Agarwal, Shikhar , Casale, Alfred S., Skelding, Kimberly A., Carter, Russell, Cummings, Christopher L. , Grana, Vicente, Haegerl, Carl, Harjai, Kishore J. , Singh, Deepak , Stahl, Russell F., Stella, Joseph, Stewart, Birute, Wood, Kim, Alexander, Donna, Barton, S. G., Logtens, Elaine, Marsh, Anna-Marie , McAdam, John, Kovac, Jan , Spyt, Tomasz, Garimella, Soumitra, Szostek, J., Zlocha, Viktor, Kirkland, Lavonda, Reid, Lori L., Reilly, Susan, Menderhall, Melody, Martin, William, Park, Steven , Smith, J. Michael, Gersch, Karen, Hiratzka, Loren F. , Kachoris, John, Okum, Eric , Cardozo, Maria , Cyr, G., Duvall, W. Lane , Flynn, Aidan , Krupowies, Nancy, Parker, Matthew , Hagberg, Robert, McKay, Raymond G. , Azemi, Talhat, Brown, Robert S., Fusco, Daniel, Hosley, Catherine, Kiernan, Francis J., Margey, Ronan, Preissler, Paul, Sadiq, Immad R., Silverman, Isaac, Taboada, Susan, Underhill, David J, Lopez, Becky, Mullin, Stephanie, Quesada, Christine, Lawrence, Tracy , Naqvi, Tasneem Z. , Matthews, Ray , Starnes, Vaughn A., Clavijo, Leonardo , Cunningham, Mark J. , Kim‐Tenser, May , Sanossian, Nerses , Shavelle, David M. , DelMotte, Danielle, Henry, Samantha, Moltrassie, JoAnne, Cooper, Raymond, Lee, James T. , Parikh, Sachin , Zweig, Brian, O’Neill, William, Paone, Gaetano , Borgi, Jamil, Brewer, Robert J., Eng, Marvin H. , Miller, D. Claire , Mitsias, Panayiotis , Morgan, Jeffrey A. , Nemeh, Hassan, Muñoz, Javier Alcaide, Fernandez, Maria Medina, Chinchilla, Fernando Carrasco, Bailón, Isabel Rodríguez, Garcı́a, José Marı́a Hernández, Such, Miguel, Alonso‐Briales, Juan H., Cosme, Carlos de la Cruz , Domínguez-Franco, Antonio J., López, Maria J. Mataró, Melero, José M., Muñoz-Garcia, Antonio-Jesus, Espín, Gemma Sánchez, Maese, Jose Manuel Fernández, Suarez, Esther Villa, Hera, Jesús M. de la, Cortina, Juan Carlos Llosa, Tassa, Cesar Morís de la, Fernández, Pablo Avanzas, Fernández, Lorena Benavente, Calleja, S. , Valle, Raquel Del, Pérez, Carlos Morales, Silva, Jacobo , Bluntschli, Eva, Keller, Dorothée, Maritz, Sandra, Ruest, Rafael, Schönenberger, Christa, Trovato, Moreno, Brugger, Nicolas , Göber, Volkhard, Kurmann, Reto , Reineke, Sylvia, Zürcher, Fabian, Carrel, Thierry , Balasubramaniam, Rupashani, Bellwald, Sebastian, Broeg, Anne, Bühlmann, Monika , Büllesfeld, Lutz, Chaloulos-Lakovidis, Panagiotis, Englberger, Lars, Gloekler, Steffen , Goldlin, Martina Beatrice, Huber, Christoph , Khattab, Ahmed A., Kurmann, Rebekka , Liesirova, Kai , Maamari, Basel , Mattle, Heinrich P. , Meinel, Thomas R. , Panos, Leonidas D , Schönhoff, Florian, Sleszak, Agnieszka, Vaisnora, Lukas , Martial, Rascha von, Wenaweser, Peter, Zuk, Katarzyna, Musso, Iris, Allen, Meredith, Gonzales, Michael , Horton, Ken, Doty, John R., Caine, W. , Clayson, Stephen E., Harkness, James, Hoesch, Robert, Huan, Mengjing, Jones, K., Miner, Edward, Reid, B.B., Sunderman, Elizabeth, Citro, Kathleen, Fisher, Michele, Willhide, Judi, Corretti, Mary C., Conte, John V., Mandal, Kaushik , Resar, Jon R. , Chacko, Matthews, Hasan, Rani K. , Heil, Barbara, Marsh, Elizabeth, Price, Joel , Sciortino, Chris, Tolentino, Jennie, Bui, Anh, Lee, Ming Sum, Watanabe, Colin, Aharonian, Vicken, Moore, Naing, Ajani, Zahra , Mansukhani, Prakash, Sangha, Navdeep , Yun, Kwok L., Hylander, Susanne, Corbascio, Matthias , Hillebrant, Carl-Gustaf, Feldt, Kari , Kostulas, Konstantinos, Settergren, Magnus , Yamasaki, Keita, Anderson, Michelle A. , Bloomfield, Charlotte E., Burton-Wood, Natalie, Harland, Charlotte, Somers, Kathryn, Ware, Tracey L., Deakin, Sarah, Geldard, Susan, Schlosshan, Dominik , Blackman, Daniel J. , Kaul, Pankaj , Evans, Betsy, Javangula, Kalyana, Limaye, Sameer S., Malkin, Christopher J. , Wanklyn, Peter, Farhi, Anita, Manapat, Arika, Maranan, Leandro, Mihelis, Effe, Ng, Amelia, Ricketts, Melissa L., Kronzon, Itzhak, Perk, Gila, Brinster, Derek R., Kliger, Chad , Azhar, Salman , Bonomo, Roger, Dharva, Rubin, Fontana, Gregory P., Mandel, Steven, Mehla, Priti , Patel, Nirav , Plestis, Konstadinos A. , Fox, Stephanie A. , Mardell, Stephen, Novick, Teresa, Sandie, Kelsey, Jonge, Wes de, McLeod, Claudia, Mroz, Luke, Weigand, Andrea, Kiaii, Bob, Teefy, Patrick, Debicki, Derek , Diamantouros, Pantelis , Mandzia, Jennifer , McKenzie, Francine, Valdis, Matthew , Young, Bryan D. , Klein, W, Sawicki, Kristina, Bakhos, Mamdouh, Leya, Ferdinand, Biller, José , Lewis, Bruce, Morales‐Vidal, Sarkis, Schneck, Michael, Tuchek, J. Michael, Biddle, Amanda, Ernst, Dereen, Haubenschild, Julie, Howe-Clayton, Desirae, Johnson, Ramona , Mundt, Pamela, Reiter, Jacqulyn, Kutzke, Kim, Maalouf, Joseph F., Sinak, Lawrence J., Pochettino, Alberto , Sandhu, Gurpreet S. , Alkhouli, Mohamad , Best, Patricia J.M. , Bresnahan, John F., Eleid, Mackram F. , Fulgham, Jimmy R., Greason, Kevin L. , Gulati, Rajiv , Holmes, David R. , Mathew, Verghese, Meissner, Irene, Radford, Jonathan, Reeder, Guy S., Sarraf, Mohammad , Suri, Rakesh M. , Swenson, Courtney, Williams, Lindsy N., Jiang, Zuyi, Lapierre, Serge, Phan, Thi Mong Ngoc, Buithieu, Jean, Varennes, Benoît de , Piazza, Nicolo, Lachapelle, Kevin , Liam, Durcan, Martucci, Giuseppe , Blömer, Han, Herder, Wiebren, Geest, Els Van der, Wal, Metske van der, Izaksson, Rob, Kootstra, Hetty, Pultrum, Maarten, Walinga, Tamara, Boonstra, Piet W. , Boven, Adrianus J. van, Amrane, Hafid, Hofma, Sjoerd H., Schuiling, Wouter J. , Terluin, Hanny, Timmerman, Margje, Weerdt, Arno Peter van der, Vossenberg, Tessel , Barnes, Caroline , Griffin, Sandra, Marcus, Rachel , Wang, Zuyue, Widell, Jared, Bafi, Ammar S., Waksman, Ron , Choi, Joseph , Corso, Paul J., Laureno, Robert, Lin, Mark, Lowery, Robert G. , Malla, Prerna , Pichard, Augusto D., Satler, Lowell F. , Shults, Christian, Decklever, Cecily, Evans, Danika, Tuttle, Kendra, Marcus, Richard H., Chawla, Atul, Hockmuth, David, Jacoby, Michael, Jenson, Bart, McAllister, David W., Prabhakar, Ganga, Verhofste, Marnix, Morin, Colette, Potvin, Lucie, Jean, Nathalie St., Garceau, Patrick, Asgar, Anita , Cartier, Raymond , Bonan, Raoul, Dominquez, Manuel, Dorval, Jean‐François , Ibrahim, Réda , Lavoie, Marc-André, Benner, Autumn, Brunetti, Deborah, Ciprich, Christine, Lobur, Elena, Lonergan, Noele, McGlew, Suellyn, Oplinger, Jeanne, Oster, Tracy, Polise, Lucille, Purpura, Jenelle, Sentman, Susan, Zile, Catherine Van, Arogundade, Olasunkanmi, Gillan, Linda, Koulogiannis, Konstantinos , Brown, John , Kipperman, Robert, Blitz, Lawrence R., Cohen, Barry M., Généreux, Philippe , Magovern, Christopher J., Rosenberg, Richard, Safirstein, Jordan, Turner, Joanne , Xydas, Steve, Jones, Teresa, Montgomery, Susan, Kovach, Todd, Navas, Jorge A. , Lin, Lang, Rovin, Joshua D. , Arora, Ajay , Ofenloch, John C., Schneider, Jean-Raphael, Spriggs, Douglas, Stone, Lisa Cacari , Turner, Nancy J. , Basnet, Sandeep , Bhat, Arjun, Fusilero, Michael, Muthiki, Sowmya, Muthyala, Samatha, Vrestil, Nicole Saint, Sharma, Madhav , Singh, Julie , Chaudhry, Farooq A. , Sengupta, Partho P. , Sharma, Samin K. , Tang, Gilbert H.L. , Anyanwu, Anelechi, Bronster, David J., Dangas, George , Kini, Annapoorna , Stelzer, Paul, Stewart, Allan, Swain, Julie A., Annunziato, Samantha, Delliliune, Diane, Garzon, Ruby, Seeratan, Vidya, Rosman, David A., Suma, Valentin, Trost, Biana, Hartman, Alan, Katz, Stanley, Rutkin, Bruce, Boutis, Loukas, Carey, Ruthanne, DeAngelis, Teresa, DeOrchis, Vincent, Esposito, Rick, Jauhar, Rajiv , Kaplan, Barry B., Laighold, Saaron, Meraj, Perwaiz , Palazzo, Robert E., Parihar, Raminder, Podwall, David, Yu, Pey‐Jen , Abu, Miriam, Bavbekova, Saniye, Bowden, Morgan, Clark, Emily, Gaudio, Stephanie, Houanche, Pascale, Kalish, Chloe, Kapitman, Anna, Lee, Hanah, Oviedo, F. Franch, Pushkar, Illya, Robin, Tonya, Shaheen, Devin, Sin, Danielle, Taylor, Zachary , Tovar, Joseph, Daele, Jessie Van, Vidal, Samantha, Yung, Lau Yan, Jilaihawi, Hasanian, Fara, Michael , Ischida, Koto, Loulmet, Didier F., Siller, K, Staniloae, Cezar , Torres, José, Zhang, Cen , Hartlev, Christie, Huffman, Andrew, Kellum, Annie, Liptrot, Roderick, Ryan, James , Lilly, Scott , Rushing, Gregory , Grose, Noah, Lee, Vivien , Mazzaferri, Ernest L. , Mutgi, Smil, O’Neil, Susan, Perchuk, Alex, Sai‐Sudhakar, Chittoor, Slivka, Andrew , Hanes, Stacie, Banowetz, Michael, Dautenhahn, David, Mehl, Brad, Bodenhamer, Robert Mark, Ghani, Mohammad , Raikar, Goya V., Tahirkheli, Naeem , Wasemiller, Wayne, Amoroso, Elisa M , Holt, Shelley, Tucker, Claire , Martin, Randolph P., Kauten, James, Rajagopal, Vivek , Awad, Eric, Brown, W. Morris, Gott, J. Richard, Karmpaliotis, Dimitrios, Meduri, Christopher, Polsani, Venkateshwar , Rinehart, Sarah, Seiden, Lawrence, Serbanescu, Andrei, Butler, Kim D. , Elsessor, Kayla, Fehr, Brittany, Hancock, Anthony, Hollister, Regina, MacFarlane, Dawn, Rodgers, Courtney, Todd, Anita, Eubanks, Veronica, Spangler, Jessica, Wirt, Katie, Wonders, Brook, Bachinsky, William , Maini, Brijeshwar , Mumtaz, Mubashir, Aneja, Parul, Loran, David B., Shah, Jagdish, Gebhardt, Linda L., Jones, U. V., Lauterborn, Marjo, John, Henriette , Parthier, Sonja, Schaprian, Katja, Twelker, K., Nickenig, Georg, Welz, Armin, Bode, Felix J. , Fuchs, Ângela, Mellert, F, Petzold, Gabor C. , Sedaghat, Alex, Sinning, Jan‐Malte, Werner, Nikos , Bang, Helle, Brodersen, Bente Birgitte, Christensen, Pernille Roed, Eriksen, Elsebet, Groth, Susanne , Larsen, Mie Christa Jensen, Johansen, Mette Ellegaard, Lilleør, Thomas Nikolaj Bang, Larsen, Lisette Lund, Preis, Anne-Cathrine, Rieck-Broberg, Jeanette, Ihlemann, Nikolaj , Noerager, Betina, Steinbrüchel, Daniel A., Arendrup, Henrik, Franzen, Olaf, Hansen, Klaus, Højgaard, Joan , Holme, Susanne, Kjøeller, Morten, Lund, J. O., Perko, Mario J. , Sander, Kåre, Smerup, Morten , Thiis, Jens J., Thyregod, Hans Gustav Hørsted , Monnin, Kathryn, Popelas, Lori, Slyman, Martha, Grewal, Kanny, Matros, Todd, Watson, Daniel, Arshi, Arash, Blossom, Geoffrey B., Chapekis, Anthony T., Duff, Steven B., Hicks, William, Holland, Stephanie , Kander, Nathan H., Lyons, Jefferson M., Mejilla, Jennifer, Reese, Brenda, Sanchez, Carlos E. , Vora, Nirav , Erwin, Sheila, Hall, Jamie , Hayes, Natalie, Miller, Margie, Main, Michael L., Allen, Keith B. , Aggarwal, Sanjeev, Borkon, Michael, Boutwell, Christine, Davis, James R. , Grantham, Aaron, Magalski, Anthony, Olds, Karin, Buchanan, Tiffany, Daniel, Misty, Estrada, Katrina, Hollen, Matthew, Lazarsfeld-Jensen, Ann , Kennen, Jada, Bechis, Mary, Rubenson, David, Teirstein, Paul, Ahmad, Daniel, Atri, Prashant , Azarbal, Farnaz, Brewster, Scot, Brown, Christopher , Foley, T. Raymond , Groves, Elliott M. , Kalafut, Mary, Levisman, Jeffrey, Mellinger, Douglas, Odunukan, Olufunso W. , Ong, Daniel, Oyama, Jared, Panguluri, Praveen, Raney, Aidan A., Rao, Suraj, Schultz, Jason, Sharma, Alok , Stinis, Curtiss, Thompson, C. Bradley , Wadia, Subeer , Walsh, Joseph, White, Jeremy , Purrington, Elizabeth, Zulick, Chelle, Murillo, Jaime , Mahoney, Paul, Newton, Joseph, Rich, Jeffrey, Bagameri, Gabor, Dimeling, George, Jordan, Grace, Mistry, Neville F., Philpott, Jonathan M. , Sirak, John, Sourbeer, Sarah, Talreja, Deepak, Zweifler, Richard M., Helm, Elizabeth, Postema, Karen, Over, Elizabeth Van, Chilton, Dale, Mitchell, Lou, Berkompas, Duane , Fanning, Justin, Khan, Muhib , Sang, Stephane Leung Wai , Omran, Kaskar, Patzelt, Lawrence H., Thoits, Timothy , Vijayappa, Madhu, Kasle, Margie, Trautman, Leigh, Dash, Rajiv, Fischbein, Michael P. , Fearon, William F. , George, Paul V., Speight, Martina K., Tai, Waimai Amy, Albersen, Inke, Bras, Rebecca Gornelda, Feirabend, Conny, Helwig-Vernooij, Johanna Catharina, Kranen, Gerda, Oostveen, Manfred, Rost, Ilona, Deutekom, Inge van, Weelden, Atie van, Heijmen, Robin, Bosschaert, Mike Arnoud Ramon, Kroon, Thomas L. de, Hilkens, P.H.E. , Mast, Eliza G., Rensing, B. J. W. M., Schonewille, W.J., Akker, Alberta Nelina van den, Haag, Elizabeth, Jennings, Joan, Krug, Patricia, Santiago, Lyn, Seth, Sonika , Dimsuyu, Nellia, Mihalatos, Dennis, Petrossian, George , Robinson, N. 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JAMA Cardiology | August 24, 2022 | Volume: 7 | Issue: 10 | Pages: 1000
Importance In patients with severe aortic valve stenosis at intermediate surgical risk, transcatheter aortic valve replacement (TAVR) with a self-expanding supra-annular valve was noninferior to surgery for all-cause mortality or disabling stroke at 2 years. Comparisons of longer-term clinical and hemodynamic outcomes in these patients are limited. Objective To report prespecified secondary 5-year outcomes from the Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI) randomized clinical trial. Design, Setting, and Participants SURTAVI is a prospective randomized, unblinded clinical trial. Randomization was stratified by investigational site and need for revascularization determined by the local heart teams. Patients with severe aortic valve stenosis deemed to be at intermediate risk of 30-day surgical mortality were enrolled at 87 centers from June 19, 2012, to June 30, 2016, in Europe and North America. Analysis took place between August and October 2021. Intervention Patients were randomized to TAVR with a self-expanding, supra-annular transcatheter or a surgical bioprosthesis. Main Outcomes and Measures The prespecified secondary end points of death or disabling stroke and other adverse events and hemodynamic findings at 5 years. An independent clinical event committee adjudicated all serious adverse events and an independent echocardiographic core laboratory evaluated all echocardiograms at 5 years. Results A total of 1660 individuals underwent an attempted TAVR (n = 864) or surgical (n = 796) procedure. The mean (SD) age was 79.8 (6.2) years, 724 (43.6%) were female, and the mean (SD) Society of Thoracic Surgery Predicted Risk of Mortality score was 4.5% (1.6%). At 5 years, the rates of death or disabling stroke were similar (TAVR, 31.3% vs surgery, 30.8%; hazard ratio, 1.02 [95% CI, 0.85-1.22]; P = .85). Transprosthetic gradients remained lower (mean [SD], 8.6 [5.5] mm Hg vs 11.2 [6.0] mm Hg; P < .001) and aortic valve areas were higher (mean [SD], 2.2 [0.7] cm 2 vs 1.8 [0.6] cm 2 ; P < .001) with TAVR vs surgery. More patients had moderate/severe paravalvular leak with TAVR than surgery (11 [3.0%] vs 2 [0.7%]; risk difference, 2.37% [95% CI, 0.17%- 4.85%]; P = .05). New pacemaker implantation rates were higher for TAVR than surgery at 5 years (289 [39.1%] vs 94 [15.1%]; hazard ratio, 3.30 [95% CI, 2.61-4.17]; log-rank P < .001), as were valve reintervention rates (27 [3.5%] vs 11 [1.9%]; hazard ratio, 2.21 [95% CI, 1.10-4.45]; log-rank P = .02), although between 2 and 5 years only 6 patients who underwent TAVR and 7 who underwent surgery required a reintervention. Conclusions and Relevance Among intermediate-risk patients with symptomatic severe aortic stenosis, major clinical outcomes at 5 years were similar for TAVR and surgery. TAVR was associated with superior hemodynamic valve performance but also with more paravalvular leak and valve reinterventions.