Citations 2
Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Deeb, G. Michael , Grube, Eberhard, Windecker, Stephan , Gada, Hemal, Mumtaz, Mubashir , Heiser, John, Merhi, William , Kleiman, Neal S. , Chetcuti, Stanley, Gleason, Thomas G. , Lee, Joon Sup, Cheng, Wen , Makkar, Raj , George, Barry, Kodali, Susheel , Yakubov, Steven J. , Lange, Rüdiger , Piazza, Nicolò , Oh, Jae K. , Li, Shuzhen , Reardon, Michael J. , Investigators, SURTAVI Trial, Gitter, Christopher B., Roberts, Dana, Bae, Richard , Sorajja, Paul , Sun, Benjamin , Askew, Judah, Eales, Frazier, Goessl, Mario, Kshettry, Vibhu R., Pedersen, Wesley R., Poulose, Anil, Roohani, Pezhman, Farivar, Robert Saeid, Shronts, Richard, Tarrel, R, Young, Mark , Butkus, Eddy, Pendleton, Kristin, Fry, Robert D., Heine, Carl, Roe, Kristin La, Weig, Laura, Agarwal, Himanshu , Langdon, Thomas, Satpathy, Ruby, Batter, John, Bremer, Karen, Indukuri, Unajyothi, Baas, Marijke, Oomes-Sistermans, Corry, Smits, Manola, Coenen, Carien, Driesen, Inge, Lauryssen, Lia, Poorter, Margreet, Schaap, Jeroen , Bentala, Mohamed, Heijer, Peter den, Remmers, Michel, Story, Marie, Erven, Paul M.M. van, Verbiest, H, Vos, Jeroen, Bennett, Michelle , Dunaj, Wendy, Seaton, Deborah, Waller, Deborah A., Khandheria, Bijoy K. , Bajwa, Tanvir , O’Hair, Daniel, Gheith, Ayman, Marriott, Elizabeth , Qhavi, Ajaz, Saxena, Varun Kumar, Shhadeh, Akram, Yeomans, Christine, Bessette, Lynn, Byrne, Jessica, Kieckhefer, Heather, Munoz, Marleny, Russo, Elizabeth, Morgan, Michael M., Byrne, Timothy , Caskey, Michael, Amabile, Orazio , Brady, Kevin P., Chung, Steven, Dacanay, Kelly, Fang, Hao , Franz, Douglas , Kelly, Claire , Loli, Akil , Payne, Jeremy, Wang, Norman C. , Lott, Jessi, Pool-Owens, C. Angele, Porter, Charlotte M., Hennan, Jeffrey A., Garrett, H. Edward , Paulus, Basil, Craig, J. Cymerman, Samaha, Joseph, Wolf, Bradley A., Wright, Lance, Zoghbi, Gilbert J., Willcott, Leslie, Roberts, Brad, Hebeler, Robert F., Stoler, Robert , Graybeal, Dion, Grayburn, Paul , Henry, Carl Ferdinand Howard, Mir, Osman , Vallabhan, Ravi C. , Fanous, Matthew , Kaufman, Jenifer, Chang, James D. , Manning, Warren J. , Riley, Marilyn F., Khabbaz, Kamal R. , Popma, Jeffrey J. , Caplan, Louis R. , Chui, Shing Fung, Guibone, Kim, Kumar, S. Sendil , Lioutas, Vasileios‐Arsenios , Nathan, Senthil , Searls, D. Eric, Fisher, Susan G. , Guirgues, Lindsay, Henderson, Sue, Loving, Laura Ashley, McWalters, Nicole, Patterson, Kelly, Burkart, Jesse, Carcedo, Bryan, Stacey, Russell, Bladergroen, Mark, Edmonson, Supakunya, Epps, Stacey, Katz, Marc , Sangha, Amandeep, Aucoin, Jennifer, Roberts, Monique, Aubin, Jaime, Hotard, Callie, Tassin, Michelle, Fail, Peter , Feinberg, Edgar, Netherland, Donald, Abben, Richard, Allam, Mohamad, Bates, Michael , Dearman, Richard, Gervais, Donald, Haight, Edward, Metes, Michael, Naquin, Jeanette, Tedesco, Victor, Thibodeaux, Lisa, Thompson, Karen , Aberle, Sally, Amaro, Dana, Rose, Geoffrey, Schérer, M. , Rinaldi, Michael , Skipper, Eric, Bridges, Charles R., Downey, William, Iyengar, Phaniraj, Martin, Jerry L., Ryan, Liam , Stiegel, Robert M., Story, John S., Alsabaawi, Khaled, Gheorghiu, Mitch, Singh, Chetana, Yashar, Jason, Siegel, Robert J. , Cheng, Wen, Altman, Karen, Jilaihawi, Hasan , Khouw, Stephanie, Salseth, Tracey, Stegic, Jasminka, Trento, Alfredo , Lazarte, Rosa, Sohn, Jeanie, Khalique, Omar , Castellon, Marco Gonzalez, Contreras, Jose Gutierrez, Kitago, Tomoko , Lekic, Tim, Naka, Yoshifumi , Smith, Craig R. , Abreu, Leana, Clement, Emerson, Sabir, Sajjad, Aji, Janah, Bowen, Frank W., Kaddissi, Georges, Mirsen, Thomas, Muntazar, Muhammad, Ogbara, Jeffrey, Rosenbloom, Michael , Schell, W, Then, Ryna , Carl, Heidi, Kreydi, Ghassan, Wolak, Heather, Sandidge, Gregory, Ali, Omar, Asfaw, Zewditu E., Kafi, Ali, Schreiber, Theodore , Andaya, Lourdes, Baciewicz, Frank A., Bassett, Joseph, Choksi, Nishit, Kassas, Safwan, Munir, Ahmad, Kothmeier, Franziska, Stroh, Annemarie, Goppel, Gertrud, Hettich, I, Opitz, A, Ruge, Hendrik , Badiu, Cătălin Constantin , Brenner, Susanne C. , Ehlmidi, Yacine, Herold, Ulf, Kreuzpointner, Robert Josef, Mazzitelli, Domenico, Vincze, Dóra, Camuglia, Krista, Cowhig, Dahlia, Newbold, Stephanie P. , Pierce, Cynthia, Wootton, Samantha, Vemulapalli, Sreekanth , Babi, Ali, Banks, Adam, Gaca, Jeffrey G., Glower, Donald D. , Halim, Sharif, Hendry, Robert, Hernández, Christian , Kiefer, Todd L., Marrotte, Eric J. , Maldonado, Andres Pineda, Wyck, David Van , Vavalle, John P. , Vora, Amit N. , Zeylikman, Yuriy, Amber, Kara, Barnitt, Anne, Lamm, Janet E., Mandelstam, Lara, Schroeder, Ryan W. , Sumner, Roxanne, Nair, Deepu, De, Ajanta, Gaudiani, Vincent A., Joye, James D., Brown, Lidia, Hessler, Christine, Rammohan, Chad, Vial, Conrad, Charles, Elizabeth S. , DeQuesada, Angela, Kaner, Maria, Mathewson, Sonya, Pitts, Kristy, Wheeler, Lauren , Wilson, Ashley, Davidson, Estella, Frohwein, Stephen, Lerakis, Stamatios , Sullivan, Angela, Babaliaros, Vasilis , Guyton, Robert A. , Thourani, Vinod H. , Anderson, Aaron, Belagaje, Samir , Benameur, Karima , Devireddy, Chandan , Harrison, A , Hudson, Kristen, Lieppe, William, Macheers, Steven, Mavromatis, Kreton , Sanders, Keith A., Sarin, Eric L., Winkel, Daniel, Duininck, Liesbeth W., Gussinklo, Titia, Jadoenath-Oedai, Shashikala, Ruiter, Arno, Berg, Nico van den, Velden-Macauley, Liz E.N. van der, Huis, Maaike van, Verelst, S., Geleijnse, Marcel L. , Vletter, Wim B., Bekker, Margaretha, Bekkers, Joseph A., Biesheuvel, Karla, Birim, Özcan, Raap, Goris Bol, Daemen, Joost , Jaegere, Peter Paul de, Wijngaarden, Rob de Lind van, Khajeh, Ladbon, Kik, Charles, Oei, Frans B S , Scheele, Maaike, Woestijne, Pieter C. van de , Geuns, Robert‐Jan van , Leeuwen, Wouter J. van, Henderson, Amy, Straight, Faye, Tischler, Marc E., Dauerman, Harold L. , Ittleman, Frank, Schmoker, Joseph, Abernethy, Abraham, Alkhalil, Imran, Azarbal, Amir , Chava, Sreedivya, Commichau, Christopher, Denkmann, Jan, DeStephan, Christine M., Ehle, Gregory, Falduto, Catherine, Gorman, Mark , Kadavath, Sabeeda , Leavitt, Bruce J., Mack, Allison, Malasana, Gangadhar, Moossavi, Shahab, Phuong, Newton , Rambod, Mehdi, Sharma, Ashwini , Terrien, Edward F., Worgan, Barbara, Zeglin-Sawczuk, Magdalena, Burgess, Brian , Killbride, Susan, Temple, Amy, Burnside, Joyce, Good, Christopher, Agarwal, Shikhar , Casale, Alfred S., Skelding, Kimberly A., Carter, Russell, Cummings, Christopher L. , Grana, Vicente, Haegerl, Carl, Harjai, Kishore J. , Singh, Deepak , Stahl, Russell F., Stella, Joseph, Stewart, Birute, Wood, Kim, Alexander, Donna, Barton, S. G., Logtens, Elaine, Marsh, Anna-Marie , McAdam, John, Kovac, Jan , Spyt, Tomasz, Garimella, Soumitra, Szostek, J., Zlocha, Viktor, Kirkland, Lavonda, Reid, Lori L., Reilly, Susan, Menderhall, Melody, Martin, William, Park, Steven , Smith, J. Michael, Gersch, Karen, Hiratzka, Loren F. , Kachoris, John, Okum, Eric , Cardozo, Maria , Cyr, G., Duvall, W. Lane , Flynn, Aidan , Krupowies, Nancy, Parker, Matthew , Hagberg, Robert, McKay, Raymond G. , Azemi, Talhat, Brown, Robert S., Fusco, Daniel, Hosley, Catherine, Kiernan, Francis J., Margey, Ronan, Preissler, Paul, Sadiq, Immad R., Silverman, Isaac, Taboada, Susan, Underhill, David J, Lopez, Becky, Mullin, Stephanie, Quesada, Christine, Lawrence, Tracy , Naqvi, Tasneem Z. , Matthews, Ray , Starnes, Vaughn A., Clavijo, Leonardo , Cunningham, Mark J. , Kim‐Tenser, May , Sanossian, Nerses , Shavelle, David M. , DelMotte, Danielle, Henry, Samantha, Moltrassie, JoAnne, Cooper, Raymond, Lee, James T. , Parikh, Sachin , Zweig, Brian, O’Neill, William, Paone, Gaetano , Borgi, Jamil, Brewer, Robert J., Eng, Marvin H. , Miller, D. Claire , Mitsias, Panayiotis , Morgan, Jeffrey A. , Nemeh, Hassan, Muñoz, Javier Alcaide, Fernandez, Maria Medina, Chinchilla, Fernando Carrasco, Bailón, Isabel Rodríguez, Garcı́a, José Marı́a Hernández, Such, Miguel, Alonso‐Briales, Juan H., Cosme, Carlos de la Cruz , Domínguez-Franco, Antonio J., López, Maria J. Mataró, Melero, José M., Muñoz-Garcia, Antonio-Jesus, Espín, Gemma Sánchez, Maese, Jose Manuel Fernández, Suarez, Esther Villa, Hera, Jesús M. de la, Cortina, Juan Carlos Llosa, Tassa, Cesar Morís de la, Fernández, Pablo Avanzas, Fernández, Lorena Benavente, Calleja, S. , Valle, Raquel Del, Pérez, Carlos Morales, Silva, Jacobo , Bluntschli, Eva, Keller, Dorothée, Maritz, Sandra, Ruest, Rafael, Schönenberger, Christa, Trovato, Moreno, Brugger, Nicolas , Göber, Volkhard, Kurmann, Reto , Reineke, Sylvia, Zürcher, Fabian, Carrel, Thierry , Balasubramaniam, Rupashani, Bellwald, Sebastian, Broeg, Anne, Bühlmann, Monika , Büllesfeld, Lutz, Chaloulos-Lakovidis, Panagiotis, Englberger, Lars, Gloekler, Steffen , Goldlin, Martina Beatrice, Huber, Christoph , Khattab, Ahmed A., Kurmann, Rebekka , Liesirova, Kai , Maamari, Basel , Mattle, Heinrich P. , Meinel, Thomas R. , Panos, Leonidas D , Schönhoff, Florian, Sleszak, Agnieszka, Vaisnora, Lukas , Martial, Rascha von, Wenaweser, Peter, Zuk, Katarzyna, Musso, Iris, Allen, Meredith, Gonzales, Michael , Horton, Ken, Doty, John R., Caine, W. , Clayson, Stephen E., Harkness, James, Hoesch, Robert, Huan, Mengjing, Jones, K., Miner, Edward, Reid, B.B., Sunderman, Elizabeth, Citro, Kathleen, Fisher, Michele, Willhide, Judi, Corretti, Mary C., Conte, John V., Mandal, Kaushik , Resar, Jon R. , Chacko, Matthews, Hasan, Rani K. , Heil, Barbara, Marsh, Elizabeth, Price, Joel , Sciortino, Chris, Tolentino, Jennie, Bui, Anh, Lee, Ming Sum, Watanabe, Colin, Aharonian, Vicken, Moore, Naing, Ajani, Zahra , Mansukhani, Prakash, Sangha, Navdeep , Yun, Kwok L., Hylander, Susanne, Corbascio, Matthias , Hillebrant, Carl-Gustaf, Feldt, Kari , Kostulas, Konstantinos, Settergren, Magnus , Yamasaki, Keita, Anderson, Michelle A. , Bloomfield, Charlotte E., Burton-Wood, Natalie, Harland, Charlotte, Somers, Kathryn, Ware, Tracey L., Deakin, Sarah, Geldard, Susan, Schlosshan, Dominik , Blackman, Daniel J. , Kaul, Pankaj , Evans, Betsy, Javangula, Kalyana, Limaye, Sameer S., Malkin, Christopher J. , Wanklyn, Peter, Farhi, Anita, Manapat, Arika, Maranan, Leandro, Mihelis, Effe, Ng, Amelia, Ricketts, Melissa L., Kronzon, Itzhak, Perk, Gila, Brinster, Derek R., Kliger, Chad , Azhar, Salman , Bonomo, Roger, Dharva, Rubin, Fontana, Gregory P., Mandel, Steven, Mehla, Priti , Patel, Nirav , Plestis, Konstadinos A. , Fox, Stephanie A. , Mardell, Stephen, Novick, Teresa, Sandie, Kelsey, Jonge, Wes de, McLeod, Claudia, Mroz, Luke, Weigand, Andrea, Kiaii, Bob, Teefy, Patrick, Debicki, Derek , Diamantouros, Pantelis , Mandzia, Jennifer , McKenzie, Francine, Valdis, Matthew , Young, Bryan D. , Klein, W, Sawicki, Kristina, Bakhos, Mamdouh, Leya, Ferdinand, Biller, José , Lewis, Bruce, Morales‐Vidal, Sarkis, Schneck, Michael, Tuchek, J. Michael, Biddle, Amanda, Ernst, Dereen, Haubenschild, Julie, Howe-Clayton, Desirae, Johnson, Ramona , Mundt, Pamela, Reiter, Jacqulyn, Kutzke, Kim, Maalouf, Joseph F., Sinak, Lawrence J., Pochettino, Alberto , Sandhu, Gurpreet S. , Alkhouli, Mohamad , Best, Patricia J.M. , Bresnahan, John F., Eleid, Mackram F. , Fulgham, Jimmy R., Greason, Kevin L. , Gulati, Rajiv , Holmes, David R. , Mathew, Verghese, Meissner, Irene, Radford, Jonathan, Reeder, Guy S., Sarraf, Mohammad , Suri, Rakesh M. , Swenson, Courtney, Williams, Lindsy N., Jiang, Zuyi, Lapierre, Serge, Phan, Thi Mong Ngoc, Buithieu, Jean, Varennes, Benoît de , Piazza, Nicolo, Lachapelle, Kevin , Liam, Durcan, Martucci, Giuseppe , Blömer, Han, Herder, Wiebren, Geest, Els Van der, Wal, Metske van der, Izaksson, Rob, Kootstra, Hetty, Pultrum, Maarten, Walinga, Tamara, Boonstra, Piet W. , Boven, Adrianus J. van, Amrane, Hafid, Hofma, Sjoerd H., Schuiling, Wouter J. , Terluin, Hanny, Timmerman, Margje, Weerdt, Arno Peter van der, Vossenberg, Tessel , Barnes, Caroline , Griffin, Sandra, Marcus, Rachel , Wang, Zuyue, Widell, Jared, Bafi, Ammar S., Waksman, Ron , Choi, Joseph , Corso, Paul J., Laureno, Robert, Lin, Mark, Lowery, Robert G. , Malla, Prerna , Pichard, Augusto D., Satler, Lowell F. , Shults, Christian, Decklever, Cecily, Evans, Danika, Tuttle, Kendra, Marcus, Richard H., Chawla, Atul, Hockmuth, David, Jacoby, Michael, Jenson, Bart, McAllister, David W., Prabhakar, Ganga, Verhofste, Marnix, Morin, Colette, Potvin, Lucie, Jean, Nathalie St., Garceau, Patrick, Asgar, Anita , Cartier, Raymond , Bonan, Raoul, Dominquez, Manuel, Dorval, Jean‐François , Ibrahim, Réda , Lavoie, Marc-André, Benner, Autumn, Brunetti, Deborah, Ciprich, Christine, Lobur, Elena, Lonergan, Noele, McGlew, Suellyn, Oplinger, Jeanne, Oster, Tracy, Polise, Lucille, Purpura, Jenelle, Sentman, Susan, Zile, Catherine Van, Arogundade, Olasunkanmi, Gillan, Linda, Koulogiannis, Konstantinos , Brown, John , Kipperman, Robert, Blitz, Lawrence R., Cohen, Barry M., Généreux, Philippe , Magovern, Christopher J., Rosenberg, Richard, Safirstein, Jordan, Turner, Joanne , Xydas, Steve, Jones, Teresa, Montgomery, Susan, Kovach, Todd, Navas, Jorge A. , Lin, Lang, Rovin, Joshua D. , Arora, Ajay , Ofenloch, John C., Schneider, Jean-Raphael, Spriggs, Douglas, Stone, Lisa Cacari , Turner, Nancy J. , Basnet, Sandeep , Bhat, Arjun, Fusilero, Michael, Muthiki, Sowmya, Muthyala, Samatha, Vrestil, Nicole Saint, Sharma, Madhav , Singh, Julie , Chaudhry, Farooq A. , Sengupta, Partho P. , Sharma, Samin K. , Tang, Gilbert H.L. , Anyanwu, Anelechi, Bronster, David J., Dangas, George , Kini, Annapoorna , Stelzer, Paul, Stewart, Allan, Swain, Julie A., Annunziato, Samantha, Delliliune, Diane, Garzon, Ruby, Seeratan, Vidya, Rosman, David A., Suma, Valentin, Trost, Biana, Hartman, Alan, Katz, Stanley, Rutkin, Bruce, Boutis, Loukas, Carey, Ruthanne, DeAngelis, Teresa, DeOrchis, Vincent, Esposito, Rick, Jauhar, Rajiv , Kaplan, Barry B., Laighold, Saaron, Meraj, Perwaiz , Palazzo, Robert E., Parihar, Raminder, Podwall, David, Yu, Pey‐Jen , Abu, Miriam, Bavbekova, Saniye, Bowden, Morgan, Clark, Emily, Gaudio, Stephanie, Houanche, Pascale, Kalish, Chloe, Kapitman, Anna, Lee, Hanah, Oviedo, F. Franch, Pushkar, Illya, Robin, Tonya, Shaheen, Devin, Sin, Danielle, Taylor, Zachary , Tovar, Joseph, Daele, Jessie Van, Vidal, Samantha, Yung, Lau Yan, Jilaihawi, Hasanian, Fara, Michael , Ischida, Koto, Loulmet, Didier F., Siller, K, Staniloae, Cezar , Torres, José, Zhang, Cen , Hartlev, Christie, Huffman, Andrew, Kellum, Annie, Liptrot, Roderick, Ryan, James , Lilly, Scott , Rushing, Gregory , Grose, Noah, Lee, Vivien , Mazzaferri, Ernest L. , Mutgi, Smil, O’Neil, Susan, Perchuk, Alex, Sai‐Sudhakar, Chittoor, Slivka, Andrew , Hanes, Stacie, Banowetz, Michael, Dautenhahn, David, Mehl, Brad, Bodenhamer, Robert Mark, Ghani, Mohammad , Raikar, Goya V., Tahirkheli, Naeem , Wasemiller, Wayne, Amoroso, Elisa M , Holt, Shelley, Tucker, Claire , Martin, Randolph P., Kauten, James, Rajagopal, Vivek , Awad, Eric, Brown, W. Morris, Gott, J. Richard, Karmpaliotis, Dimitrios, Meduri, Christopher, Polsani, Venkateshwar , Rinehart, Sarah, Seiden, Lawrence, Serbanescu, Andrei, Butler, Kim D. , Elsessor, Kayla, Fehr, Brittany, Hancock, Anthony, Hollister, Regina, MacFarlane, Dawn, Rodgers, Courtney, Todd, Anita, Eubanks, Veronica, Spangler, Jessica, Wirt, Katie, Wonders, Brook, Bachinsky, William , Maini, Brijeshwar , Mumtaz, Mubashir, Aneja, Parul, Loran, David B., Shah, Jagdish, Gebhardt, Linda L., Jones, U. V., Lauterborn, Marjo, John, Henriette , Parthier, Sonja, Schaprian, Katja, Twelker, K., Nickenig, Georg, Welz, Armin, Bode, Felix J. , Fuchs, Ângela, Mellert, F, Petzold, Gabor C. , Sedaghat, Alex, Sinning, Jan‐Malte, Werner, Nikos , Bang, Helle, Brodersen, Bente Birgitte, Christensen, Pernille Roed, Eriksen, Elsebet, Groth, Susanne , Larsen, Mie Christa Jensen, Johansen, Mette Ellegaard, Lilleør, Thomas Nikolaj Bang, Larsen, Lisette Lund, Preis, Anne-Cathrine, Rieck-Broberg, Jeanette, Ihlemann, Nikolaj , Noerager, Betina, Steinbrüchel, Daniel A., Arendrup, Henrik, Franzen, Olaf, Hansen, Klaus, Højgaard, Joan , Holme, Susanne, Kjøeller, Morten, Lund, J. O., Perko, Mario J. , Sander, Kåre, Smerup, Morten , Thiis, Jens J., Thyregod, Hans Gustav Hørsted , Monnin, Kathryn, Popelas, Lori, Slyman, Martha, Grewal, Kanny, Matros, Todd, Watson, Daniel, Arshi, Arash, Blossom, Geoffrey B., Chapekis, Anthony T., Duff, Steven B., Hicks, William, Holland, Stephanie , Kander, Nathan H., Lyons, Jefferson M., Mejilla, Jennifer, Reese, Brenda, Sanchez, Carlos E. , Vora, Nirav , Erwin, Sheila, Hall, Jamie , Hayes, Natalie, Miller, Margie, Main, Michael L., Allen, Keith B. , Aggarwal, Sanjeev, Borkon, Michael, Boutwell, Christine, Davis, James R. , Grantham, Aaron, Magalski, Anthony, Olds, Karin, Buchanan, Tiffany, Daniel, Misty, Estrada, Katrina, Hollen, Matthew, Lazarsfeld-Jensen, Ann , Kennen, Jada, Bechis, Mary, Rubenson, David, Teirstein, Paul, Ahmad, Daniel, Atri, Prashant , Azarbal, Farnaz, Brewster, Scot, Brown, Christopher , Foley, T. Raymond , Groves, Elliott M. , Kalafut, Mary, Levisman, Jeffrey, Mellinger, Douglas, Odunukan, Olufunso W. , Ong, Daniel, Oyama, Jared, Panguluri, Praveen, Raney, Aidan A., Rao, Suraj, Schultz, Jason, Sharma, Alok , Stinis, Curtiss, Thompson, C. Bradley , Wadia, Subeer , Walsh, Joseph, White, Jeremy , Purrington, Elizabeth, Zulick, Chelle, Murillo, Jaime , Mahoney, Paul, Newton, Joseph, Rich, Jeffrey, Bagameri, Gabor, Dimeling, George, Jordan, Grace, Mistry, Neville F., Philpott, Jonathan M. , Sirak, John, Sourbeer, Sarah, Talreja, Deepak, Zweifler, Richard M., Helm, Elizabeth, Postema, Karen, Over, Elizabeth Van, Chilton, Dale, Mitchell, Lou, Berkompas, Duane , Fanning, Justin, Khan, Muhib , Sang, Stephane Leung Wai , Omran, Kaskar, Patzelt, Lawrence H., Thoits, Timothy , Vijayappa, Madhu, Kasle, Margie, Trautman, Leigh, Dash, Rajiv, Fischbein, Michael P. , Fearon, William F. , George, Paul V., Speight, Martina K., Tai, Waimai Amy, Albersen, Inke, Bras, Rebecca Gornelda, Feirabend, Conny, Helwig-Vernooij, Johanna Catharina, Kranen, Gerda, Oostveen, Manfred, Rost, Ilona, Deutekom, Inge van, Weelden, Atie van, Heijmen, Robin, Bosschaert, Mike Arnoud Ramon, Kroon, Thomas L. de, Hilkens, P.H.E. , Mast, Eliza G., Rensing, B. J. W. M., Schonewille, W.J., Akker, Alberta Nelina van den, Haag, Elizabeth, Jennings, Joan, Krug, Patricia, Santiago, Lyn, Seth, Sonika , Dimsuyu, Nellia, Mihalatos, Dennis, Petrossian, George , Robinson, N. Bryce , Bercow, Neil, Berke, Andrew E. , Deutsch, Ezra, Stevens, Perry, Brown, Sue, Jardim, Victor Dos Santos, Radford, Nicole, Sookhoo, Venessa, Kyereme, Kojo, Punzalan, Rachel, Sculeany, Bogdan, Brecker, Stephen , Jahangiri, Marjan , Alassa, Aiman, Chandrasekaran, Venkatachalam, Clarke, Brian , Dowling, Cameron , Moynihan, Barry, Roy, David, Sarsam, Mazin A.I., Bess, Renee, Henkel, Megan, Cohen, Gerald M., Davis, Thomas, Aboukasm, Amer, LaLonde, Thomas , Yamasaki, Hiroshi , Burkert, Marylynn, Kingma, Barbara, Wheatley, Jessica, Segar, Douglas S., Heimansohn, David, Hermiller, James, Ball, Michael, Elsner, Gregory, Hanan, Scott A., Moainie, Sina L. , Nukes, Theodore, Reibold, Patrick, Robison, Robert, Salerno, Christopher T. , Sampson, Andrew, Walts, Peter A., Wandel, Emily, Li, Mary , Sarker, Sulagna, Ahmed, Shaheeda, Radhakrishnan, Sam, Arbel, Yaron , Christakis, George T., Cohen, Gideon, Czarnecki, Andrew , Hopyan, Julia, Komatsu, Ikki , McCraig, Kathleen, Shuvy, Menashe, Toma, Jonathan, Vincenzo, Basile, Wheeler, Cindi, Wolff, Rafael , Beck, Pamela J., Cabral, Donna J., DaCosta, Christine, Hudson, Laura, Pastie, Michelle, Abrahams, Nicole, Altamar, Ingrid, Buitrago, Mike, Cassman, Gabrielle, Leibovici, Zvi, Nelson, Ana, Recchia, Kelly, Robbins, Gillian, Studor, Kelly, Bethea, Brian, Beyer, Erik, Evans, Sharron, Goodis, Caleene, Mueller‐Kronast, Nils , Pantoja, Claudia, Wells, Channing, Youngblood, Colten, Snelus, Patricia, Gopal, Deepika, Jackson, Kristie, Brown, David L. , Ryan, William H. , Gopal, Ambarish, Harrington, Katherine, Mack, Michael J. , Nosnik, Pedro, Potluri, Srinivasa , Smith, Robert L. , Szerlip, Molly, Blaylock, Candice, Brinegar, Patricia, Canter, Laura, Green, LaShawna, Green, Lisa , Hazen, Pamela, Jacobs, Amber, Khan, Saba , Ludwig, Sheryl, Mata, Mary, Moore, Tammara, Underwood, Carol , Little, Stephen H. , Nagueh, Sherif F. , Albright, Kimberly, Barker, Colin M. , Bledsoe, Donald, Chiu, David, Gray, Tiffany , Imperial-Aubin, Delmar, Lin, Chun C., Moye, Stacy, Ramchandani, Mahesh, Ramlawi, Basel , Reul, Ross M. , Reyes, Manuel, Scheinin, Scott , Volpi, John , Ballmoos, Moritz Wyler von, Blackburn, Beth, Hart, Chari Y. T., Whitacker, Pearl, Lau, Jeffrey, Spies, Christian , Badawi, Ramy A., Graner, Sarah, Nakamura, Dean, Plank, Benjamin, Salem, Rony, Seto, Todd B. , Valenta, Douglas, Cruz, Amber, Gallagher, Lauren T. , Schuck, Laura, Weeks, Andre, Fishman, Lise, Schwarz, Teresa, Bavaria, Joseph E. , Anwaruddin, Saif , Giri, Jay , Khella, Sami, Li, Robert, McGarvery, Michael, Price, R A, Szeto, Wilson Y. , Sun, Yang , Wu, Libo , Tsang, Wendy , Thavendiranathan, Dinesh, Feindel, Chris, Casaubon, Leanne K. , Cusimano, Robert J. , Campo, Martín del , Osten, Mark , Höwisch-Pengel, Rita, Lechner, Gabriele, Steiger, Barbara, Allgeier, Martin, Jander, Nikolaus , Büttner, Heinz Joachim, Comberg, Thomas, Diab, Nawras , Gick, Michael, Günkel, Ludwig, Pingpoh, Clarence , Rothe, H. Jürgen, Thoma, Martin , Winker, Thomas, Häger, Christine , Sänger, Ulrike, Stader, Michael, Biaggi, Patric , Gruner, Christiane, Binder, Ronald K. , Corti, Roberto , Holy, Erik W. , Grünenfelder, Jürg , Maier, Willibald, Nietlispach, Fabian, Atkinson, Rachel , Davis, Angela , Hall, Suzanne, Mangene, Samantha, Mazzurco, Stacey, Hoit, Brian D. , Musarra, Raymond, Markowitz, Alan , Asi, Khaled, Attizzani, Guilherme F. , Chuang, Dennis Y. , Elgudin, Yakov , Le, Scott T., Serkin, Zakhar, Shams, Tanzila, Sila, Cathy, Simon, Daniel I. , Bezerra, Hiram G. , Greening, Kyle, Karson, Jodi, Page, Susie, Shawgo, Tilitha, Freeman, Jon C., Mulhern, Kevin, Nath, Jayant , Tadros, Peter, Zorn, George L., Hockstad, Eric, Lechtenberg, Colleen, Muehlebach, Gregory, Rippee, Michael , Rosterman, Lee , Sundararajan, Jayashree, Wang, Yunxia , Wiley, Mark, Atapattu, Suresh, Kall, Christian Marin y, Lowery, Maureen H., Marchena, Eduardo de , Salerno, Tomás A. , Carillo, Roger, Ferreira, Alexandre , Williams, Donald, Bhatt, Shradha, Migda, Erin M., Oakley, Jessica, Warshal, Wendy, Wilcock, Sandra, Booher, Anna M., LaBounty, Troy , Boyle, Mary Jo, Geml, Rachel, Grossman, Paul , Guerin, Danielle, Hodges, Kelley, Lammers, Deborah, Menees, Daniel, Patel, Himanshu J. , Prager, Richard L. , Romano, Matthew, Stamper, Angela, Wang, Michael, Ziarkiewicz, Melanie, Charlebois, Cheryl, Chilton, Colleen, Labinaz, Marino , Lam, Khanh, Masters, Roy G., Steffenhagen, Nikolai, Enlow-Germovsek, Melissa, Konopka, Kristin, McGargle, Rachel, Travis, Melissa, Anderson, Kathy, Crock, Fred, Edelman, Kathy, Katz, William E. , Aghaebrahim, Amin Nima, Al-Bayai, Alhamza, Bonaccorsi, Christina, Gulati, Deepak , Henry, Lisa, Kenmuir, Cynthia L. , Klein, Bradley G., Kliner, Dustin , Limaye, Kaustubh , Nanduri, Sunanda, Navid, Forozan, Patel, Pratit , Rocha, Marcelo Borges , Schindler, John , Shoirah, Hazem , Tadi, Prasanna , Tememe, Danoushka, Totoraitis, Ruta, Walker, Greg , Ziayee, Habibullah, Caufield, Lori, Yeager, Carol, Forbes, Jennifer , Schwart, Karl Q., Knight, Peter A. , Ling, Frederick, Benesch, Curtis, Bogachan, Sahin, Hicks, George L., Kelly, Adam G. , Narins, Craig R. , Stuver, Thomas, Adams, Kathy, Blair-Anton, Lynn, Haynes, Mary Lou, Watts, Carol, Baker, Michael , Mendes, Lisa A., Kaiser, Clayton A., Robbins, Mark, Zhao, David , Ahmad, Rashid, Crenshaw, Marshall, Fredi, Joseph L., Hermann, Lisa, Hoff, Steven J. , Levack, Melissa M., Mittal, Shilpi , O’Duffy, Anne E, Petracek, Michael R., Baer, Judy, Liang, Grace , Nguyen, Son , Nguyen, Patricia K. , Burdon, Thomas A., Giacomini, John C., Yong, Celina M. , Buchbinder, Maurice , Fann, James I. , Kilgore, Shannon M., Mitchell, R. Scott, McDaniel, Sharon S., Pack, Angelina, White, Wendi, Young, Travis S. , Burgess, Pam, Pu, Min , Upadhya, Bharathi , Applegate, Robert J., Kon, Neal D., Arnan, Martinson, Baghshomali, Sanam, Bishop, L. R., Bradbury, Edward, Gandhi, Sanjay , Kincaid, Edward H., Lefkowitz, David , Lisle, Benjamin, Batteria, Melissa, Rerisi, Elizabeth, Stepinowski, Kimberly, Senicola, Tanya, Goncalves, John, Schubach, Scott , Schwartz, Richard, Antaky, Karin, Christiansen, C, Marzo, Kevin , Michel, Kathleen, Varghese, Princy , Wirkowski, Elizieta, Lévesque, Linda E. , Cleman, Michael , Forrest, John K. , Hashim, Sabet, Mangi, Abeel A. , Amin, Hardick, Darr, Umer, Dewar, Michael, Faheem, Osman, Geirsson, Arnar , Kaleel, Abdel Salam, Kaple, Ryan , Lansky, Alexandra, Grory, Brian Mac, Pfau, Steven , Schindler, Joseph , Yuh, David D., Serruys, Patrick W , Limaye, Kaustubh , Windecker, Stephan , Reardon, Michael J , Bode, Felix J , Mieghem, Nicolas M. Van , Søndergaard, Lars , Olsen, Peter Skov , Crestanello, Juan A. , George, Isaac , Serruys, Patrick W. , Williams, Mathew , Adams, David , Investigators, SURTAVI Trial, Meyer, Karen, Roberts, Dana, Sorajja, Paul , Flavin, Thomas, Gössl, Mario , Mooney, Michael R , Pendleton, Kristin, Fry, Robert, Heine, Carl, Tran, Tin, Bremer, Karen, Pieter, Jan, Verbiest, Henk, Waller, Deborah, Ahmed, Arshad , Allaqaband, Suhail Q. , Werner, Paul , Bessette, Lynn, Klein, Jason, Brady, Kevin, Chung, Steven, Franz, Douglas, Pershad, Ashish , Porter, Charlotte, Craig, John, Elijovich, Lucas , Wolf, Bradley, Wright, Lance, Roberts, Brad, Henry, Carl, Laham, Roger J. , Burke, David, Chui, Angus Shing Fung , Liu, David M. , Nathan, Senthil, Pinto, Duane S. , Searls, D. Eric, Fisher, Susan, Lim, D. Scott , Ng, Ken, Bates, Michael, Grey, William, Rose, Geoffrey, Scherer, Markus, Martin, Jerry, Cheng, Wen, Kar, Saibal , Mody, Cyrus, Ramzy, Danny , Sohn, Jeanie, Hahn, Rebecca T , Contreras, Jose Gutierrez, Kummer, Benjamin R. , Miller, Eliza C. , Nazif, Tamim , Qureshi, Abid, Rostanski, Sara , Willey, Joshua , Yaghi, Shadi , Rosenbloom, Michael, Schell, Wendy, Huang, Hong , Ali, Omar, Henry, Scott, Bleiziffer, Sabine , Hengstenberg, Christian , Brenner, Susanne, Kasel, Albert Markus , Kreuzpointner, Robert , Poppert, Holger , Seifert, Christian, Voß, Bernhard , Cowhig, Dahlia, Newbold, Stephanie, Velazquez, Eric J. , Harrison, J. Kevin, Hughes, George Chad , Ali, Yasmin, Gokhale, Sankalp , Hendry, Robert, Hernandez, Christian, Klein, Michael, Kolls, Brad J. , Maldonado, Andres M. Pineda, Price, Andrew James , Sherwood, Matthew W. , Swisher, Christa B. , Wang, Andrew , Lamm, Janet, Schroeder, Ryan, De, Ajanta, Charles, Elizabeth, Wheeler, Lauren, Merlino, John , Greene, James, Harrison, Amy, Leshnower, Bradley G. , Miller, Jeffrey S. , Nahab, Fadi B , Stewart, James, Kappetein, A. Pieter , Bekkers, Jos A. , Jaegere, Peter Paul de, Koudstaal, Peter J. , Henderson, Amy, Schneider, David J. , Tischler, Marc, Ittleman, Frank P., Coyle, David, Ehle, Gregory L., El-Haddad, Mohamed, Falduto, Catherine, Gorman, Mark, Seecheran, Naveen Anand , Burgess, Brian, Cummings, Christopher, Holland, Neil, Long, Doug, Barton, Sally, Mariscalco, Giovanni , Reid, Lori, Reilly, Susan, Seshiah, Puvi , Azemi, Talhat, Brown, Robert, Hammond, Jonathan , Underhill, David J., Escobar, Jose, Solanki, Ashish, Cooper, Raymond, Wang, Dee Dee , Greenbaum, Adam B. , Guerrero, Mayra , Cosme, Carlos De La Cruz, Muñoz-García, Antonio J. , Torres, Marta, Hera, Jesús M. de la , Tassa, Cesar Morís de la, Fernández, Pablo Avanzas, Fernández, Lorena Benavente, Valle, Raquel Del, Arnold, Marcel , Beyeler, Morin , Capek, Lukas, Corpataux, Noé , Göldlin, Martina B., Lanz, Jonas , Praz, Fabien , Spirito, Alessandro , Stortecky, Stefan , Allen, Meredith, Gonzales, Michael, Whisenant, Brian K. , Citro, Kathleen, Fisher, Michele, Shah, Ashish S. , Bui, Anh, Watanabe, Colin, Pfeffer, Thomas A , Bäck, Magnus , Rück, Andreas , Palma, Rodney De , Anderson, Michelle, Limaye, Sameer, Farhi, Anita, Ricketts, Melissa, Mandel, Steven, Chu, Michael , Bagur, Rodrigo , Gofton, Teneille , McKenzie, F. Neil, Mirsattari, Seyed M. , Young, Bryan, Dajani, Khaled Z. , Darki, Amir , Schwartz, Jeffrey, Howe-Clayton, Desirae L., Bruce, Charles J. , Freeman, William D. , Nkomo, Vuyisile T. , Pislaru, Sorin V. , Alkhouli, Mohamad , Maor, Elad , Panaich, Sidakpal , Peterson, Angela, Raphael, Claire E. , Sanon, Saurabh , Scharf, Eugene , Lapierre, Serge, Piazza, Nicolo, Rooij, Frank van, Barnes, Caroline, Griffin, Sandra, Goldstein, Steven A. , Marcus, Rachel, Widell, Jared K., Lowery, Robert, Klein, Marc, Jacoby, Michael, Purpura, Jenelle, Cohen, Barry, English, Karen, Généreux, Philippe , Slater, James N. , Turner, Joanne, Montgomery, Susan, Barry, Michael J. , Navas, Jorge, Patel, Vijay S , Arora, Ajay K., Stone, Lisa, Turner, Nancy, Singh, Julie, Chan, Grace, DeOrchis, Vincent S., Esposito, Rick, Han, Michael David , Kaplan, Barry, Palazzo, Robert, Wright, Paul, Houanche, Pascale, Morales, Vanessa, Taylor, Zachary, Sarić, Muhamed , Galloway, Aubrey C. , Attubato, Michael , Grossi, Eugene A. , Jones, Danielle, Orsinelli, David A. , Ryan, James Michael, Ryan, Thomas A. , Kılıç, Ahmet , O'Neil, Susan, Cheatham, John P. , Mehl, Brad, Ghani, Mohammad, Randolph, John F. , Williams, John Paul , Tucker, Claire, Dean, David A. , Gott, John, Russell, Christopher, Vannan, Mani A. , Butler, Kim, Spangler, Jessica, Maini, Brijeshwar , Mumtaz, Mubashir, Aneja, Parul, Shah, Jagdish, Gebhardt, Linda, Jones, Ursula, John, Henriette, Fuchs, Angela, Sedaghat, Alexander , Vasa‐Nicotera, Mariuca , Groth, Susanne, Kristensen, Line, Rosenberg, Tine , Møller, Jacob Eifer , Andersen, Henrik, Bieliauskas, Gintautas , Carranza, Christian Lildal , Backer, Ole De , Hansen, Klaus, Lund, Jens, Richards, David A. , Hicks, William, Hayes, Natalie, King, Dana, Chhatriwalla, Adnan K , Cohen, David Jonathan , Jensen, Ann, Bechis, Mary Z., Hu, Stephen, Tyner, Jeffrey W. , BREWSTER, SCOT A., Hanna, Nicholas, Patel, Aalok P. , Thompson, Caleb, Walsh, Joseph, Cohen, Daniel, Jordan, Grace, Helm, Elizabeth, Rai, Vivek, Liang, David H. , Miller, D. Craig , Yeung, Alan C. , Rost, Ilona, Heijmen, Robin H. , Ten Berg, Jurrien , Bosschaert, Mike A.R., Berke, Andrew, Reynolds, Rebecca M. , Sharma, Rakesh , Stuart, Amanda, Chandrasekaran, Venkatachalam, Herbert, Natalie, Batra, Sanjay, Cullis, Paul, Martin, James G. , Burkert, Mary Lynn, Wheatley, Jessica, Ball, Michael, Robison, Robert, Fremes, Stephen E. , Elbaz‐Greener, Gabby , Feld, Yair , Wijeysundera, Harindra C. , Beck, Pamela, Nelson, Ana, Malek, Ali R. , Pan, Hao , Ramos, Angelica, Brinkman, William T. , Gopal, Ambarish, Szerlip, Molly , Jacobs, Amber, Ludwig, Sheryl, Underwood, Carol, Faza, Nadeen Nader , Atkins, Marvin D. , Bledsoe, Don, Chiu, David, Goel, Sachin S. , Gray, Tiffany, Lin, Chun, White, Shannon, Wong, Richmond, Lau, Jeffrey, Nakamura, Dean, Gallagher, Lauren, Siki, Mary A. , Herrmann, Howard C. , Desai, Nimesh D. , Messé, Steven R. , Price, Raymond, Quinn, Colin, Vallabhajosyula, Prashanth , Wu, Libo, Horlick, Eric , Silver, Frank, Beyersdorf, Friedhelm , Neumann, Franz‐Josef , Siepe, Matthias , Thoma, Martin, Hager, Christine, Stader, Michael, Stämpfli, Simon F. , Falk, Volkmar , Maisano, Francesco , Holubec, Tomáš , Wegener, Susanne , Atkinson, Rachel, Costa, Marco , García, Carlos , Jadhav, Vikram, Le, Scott, Miller, Benjamin F. , Deo, Salil V. , Anderson, Jennifer , Page, Susie, Freeman, Jon, Alfonso, Carlos, Panos, Anthony L. , Romano, José G. , Adelman, Eric E. , Kim, Karen C. , McDermott, Margaret, Pace, Robert, Ramchandren, Sindhu , Wang, Michael, Zahuranec, Darin B. , Ruel, Marc , Glover, Chris, Cavalcante, João L. , Sultan, Ibrahim , Campbell, David, Giurgiutiu, Dan‐Victor , Gulati, Deepak, Hawkes, Christine, Henry, Lisa, Jadhav, Ashutosh P. , Klein, Bradley, Rangaraju, Srikant , Rocha, Marcelo, Streib, Christopher , Walker, Greg, Ball, Stephen, Goel, Kashish , Ahmad, Rashid, Hermann, Lisa, Hoff, Steven, Kirshner, Howard S. , Baer, Judy, Liang, Grace, Heidenreich, Paul A. , McDaniel, Sharon, Young, Travis, Burgess, Pam, Pu, Min, Bishop, Laura, Gandhi, Sanjay, Lefkowitz, David, Rerisi, Elizabeth , Christiansen, Colleen, Misra, Ajay, Varghese, Princy, Levesque, Linda, Sugeng, Lissa , Dewar, Michael, Greer, David M. , Grory, Brian Mac, Thompson, Craig, Youn, Teddy, Yun, James J
JAMA Cardiology | August 24, 2022 | Volume: 7 | Issue: 10 | Pages: 1000
Importance In patients with severe aortic valve stenosis at intermediate surgical risk, transcatheter aortic valve replacement (TAVR) with a self-expanding supra-annular valve was noninferior to surgery for all-cause mortality or disabling stroke at 2 years. Comparisons of longer-term clinical and hemodynamic outcomes in these patients are limited. Objective To report prespecified secondary 5-year outcomes from the Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI) randomized clinical trial. Design, Setting, and Participants SURTAVI is a prospective randomized, unblinded clinical trial. Randomization was stratified by investigational site and need for revascularization determined by the local heart teams. Patients with severe aortic valve stenosis deemed to be at intermediate risk of 30-day surgical mortality were enrolled at 87 centers from June 19, 2012, to June 30, 2016, in Europe and North America. Analysis took place between August and October 2021. Intervention Patients were randomized to TAVR with a self-expanding, supra-annular transcatheter or a surgical bioprosthesis. Main Outcomes and Measures The prespecified secondary end points of death or disabling stroke and other adverse events and hemodynamic findings at 5 years. An independent clinical event committee adjudicated all serious adverse events and an independent echocardiographic core laboratory evaluated all echocardiograms at 5 years. Results A total of 1660 individuals underwent an attempted TAVR (n = 864) or surgical (n = 796) procedure. The mean (SD) age was 79.8 (6.2) years, 724 (43.6%) were female, and the mean (SD) Society of Thoracic Surgery Predicted Risk of Mortality score was 4.5% (1.6%). At 5 years, the rates of death or disabling stroke were similar (TAVR, 31.3% vs surgery, 30.8%; hazard ratio, 1.02 [95% CI, 0.85-1.22]; P = .85). Transprosthetic gradients remained lower (mean [SD], 8.6 [5.5] mm Hg vs 11.2 [6.0] mm Hg; P < .001) and aortic valve areas were higher (mean [SD], 2.2 [0.7] cm 2 vs 1.8 [0.6] cm 2 ; P < .001) with TAVR vs surgery. More patients had moderate/severe paravalvular leak with TAVR than surgery (11 [3.0%] vs 2 [0.7%]; risk difference, 2.37% [95% CI, 0.17%- 4.85%]; P = .05). New pacemaker implantation rates were higher for TAVR than surgery at 5 years (289 [39.1%] vs 94 [15.1%]; hazard ratio, 3.30 [95% CI, 2.61-4.17]; log-rank P < .001), as were valve reintervention rates (27 [3.5%] vs 11 [1.9%]; hazard ratio, 2.21 [95% CI, 1.10-4.45]; log-rank P = .02), although between 2 and 5 years only 6 patients who underwent TAVR and 7 who underwent surgery required a reintervention. Conclusions and Relevance Among intermediate-risk patients with symptomatic severe aortic stenosis, major clinical outcomes at 5 years were similar for TAVR and surgery. TAVR was associated with superior hemodynamic valve performance but also with more paravalvular leak and valve reinterventions.
Abstract 2222: Long-term Outcomes of Acute Coronary Syndrome Patients with Chronic Renal Insufficiency treated with Bivalirudin vs Heparin plus a Glycoprotein IIb/IIIa Inhibitor: One Year Results from the Randomized ACUITY Trial
Kirtane, Ajay J. , Dangas, George , Ohman, E. Magnus, Pocock, Stuart, Bertrand, Michel E., Hamon, Martial, Manoukian, Steven V., Hoekstra, James W., Pollack, Charles V. , Desmet, Walter , Feit, Frederick, Stella, Joseph, Stuckey, Thomas , Stone, Gregg W. , Mehran, Roxana , Gersh, Bernard J. , Cequier, Angel R. , Cohen, David Jonathan , Lansky, Alexandra J.
Circulation | July 3, 2021 | Volume: 116 | Issue: suppl_16 | Pages: No page available
10.1161/circ.116.suppl_16.ii_483-b
Background: In the ACUITY Trial, patients (pts) with chronic renal insufficiency (CRI) had significantly higher rates of ischemic events and major bleeding compared to pts without CRI at 30 days. Bivalirudin (Biv) monotherapy provided similar protection from ischemic events but with significantly less bleeding compared to heparin + a GPIIb/IIIa inhibitor (Hep+GPI). The impact of a Biv alone strategy on one year mortality is unknown. Methods: Pts with moderate and high risk acute coronary syndromes (ACS) were randomized to Hep + GPI, Biv + GPI, or Biv monotherapy. CRI was defined as baseline creatinine clearance (CrCl) <60 mL/min. We evaluated the impact of CRI and antithrombotic strategy on composite ischemia (death, MI, or revascularization) and mortality at one year. Results: Of the pts enrolled, 12,933 had baseline CrCl data: 2468 (19.1%) pts had CrCl ≥60 mL/min and 10,465 (80.9%) pts had CrCl <60 mL/min. Rates of major bleeding at 30 days in pts with CRI were significantly lower with Biv alone vs Hep+GPI (6.2% vs 9.8%, p<0.01). Pts with CRI had higher mortality at one year compared to those without CRI (8.7% vs 3.0%, p<0.001). There was no difference in composite ischemia for pts who received Biv monotherapy vs Hep + GPI (23.0% vs 21.4%, p=0.10). One year mortality by antithrombin strategy is shown in the Figure . Conclusions: CRI in pts with ACS is associated with higher rates of one year mortality. In these high risk pts, Biv monotherapy improved early clinical outcomes compared to Hep + GPI by reducing major bleeding, and resulted in similar rates of one year mortality. Cumulative Mortality at One Year, Patients with CRI