Citations 4
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Jones, Barbara , Soni, Nilam J. , Sullivan, Liam R, Musher, Daniel M., Erstad, Brian L. , Pickens, Chiagozie I. , Metlay, Joshua P. , Cao, Bin , Gendlina, Inessa , Hojat, Leila S , Laguio‐Vila, Maryrose , Liang, Stephen Y., Waterer, Grant , Paine, Marilynn, Wilson, Kevin R. , Jones, Barbara E , Ramirez, Julio A , Oren, Eyal , Soni, Nilam J , Sullivan, Liam R , Restrepo, Marcos I , Musher, Daniel M , Erstad, Brian L , Pickens, Chiagozie , Vaughn, Valerie M , Helgeson, Scott A , Crothers, Kristina , Metlay, Joshua P , Bissell Turpin, Brittany D , Cao, Bin , Chalmers, James D , Dela Cruz, Charles S , Hojat, Leila S , Laguio-Vila, Maryrose , Liang, Stephen Y , Waterer, Grant W , Wilson, Kevin , Ramírez, Julio A. , Oren, Eyal , Sullivan, Liam R, Vaughn, Valerie M. , Helgeson, Scott A. , Crothers, Kristina , Bissell, Brittany D. , Chalmers, James D. , Liang, Stephen Y. , Hawkins, Conall
American Journal of Respiratory and Critical Care Medicine | July 18, 2025 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract Background: Understanding of the diagnosis and treatment of adults with community-acquired pneumonia (CAP) has evolved thanks to new evidence, experience, and emerging technologies. This document updates evidence-based clinical practice guidelines on four key questions for the diagnosis and management of adult patients with CAP. Methods: A multidisciplinary panel integrated systematic reviews of comparative evidence with other relevant research and clinical experience, then applied Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology to produce recommendations using the Evidence to Decision Framework. Results: The panel formulated clinical recommendations that address questions related to CAP, including lung ultrasound for diagnosis, empiric antibacterial therapy if a test for a respiratory virus is positive, antibiotic duration, and the use of systemic corticosteroids. Conclusions: The panel formulated and provided the rationale for recommendations on selected diagnostic and treatment strategies for adult patients with CAP.
Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study
Balte, Pallavi , Sun, Yifei , Allen, Nori, Arynchyn, Alexander , Bowler, Russell P. , Elkind, Mitchell S, Garcia‐Bedoya, Olga , Garudadri, Suresh , Hansel, Nadia N. , Hermann, E.A. , Hoffman, Eric A. , Kaplan, Robert C. , Laine, Andrew F. , Lynch, David A. , Matsushita, Kunihiro , McKleroy, William , Naik, Sneha N. , O'Driscoll, O., Rusk, A.M., Salvatore, Mary , Smith, Benjamin M. , Sotres‐Alvarez, Daniela , Umans, Jason G. , Washko, George R. , Woodruff, Prescott G. , Ortega, Victor E. , Oelsner, Elizabeth C. , Balte, Pallavi P , Bowler, Russell P , San Jose Estepar, Raul , Hoffman, Eric A , Humphries, Stephen M , Krishnan, Jerry A , Podolanczuk, Anna J , Rusk, Annie, Wenzel, Sally E , Oelsner, Elizabeth C , Kim, John S. , Allen, Nori, Angelini, Elsa D. , Barr, R. Graham , Blaha, Michael Joseph , Carr, J. Jeffrey , Cole, Shelley A. , Couper, David , Demmer, Ryan T. , Doyle, Margaret F. , Estépar, Raúl San Jośe , Humphries, Stephen M. , Hunninghake, Gary M. , Lee, Joyce , Make, Barry J. , Min, Yuan‐I , O’Connor, George T. , Oren, Eyal , Podolanczuk, Anna J. , Post, Wendy S. , Pottinger, Tess D. , Regan, Elizabeth Anne , Schwartz, David A. , Vasan, Ramachandran S. , Wenzel, Sally E. , Xanthakis, Vanessa
American Journal of Respiratory and Critical Care Medicine | April 16, 2025 | Volume: 211 | Issue: 7 | Pages: 1196-1210
Abstract Rationale Increased risk of coronavirus disease (COVID-19) hospitalization and death has been reported among patients with clinical lung disease. Objectives To test the association of objective measures of prepandemic lung function and structure with COVID-19 outcomes in U.S. adults. Methods Prepandemic obstruction (FEV1/FVC < 0.70) and restriction (FEV1/FVC ⩾ 0.7, FVC < 80%) were defined based on the most recent spirometry exam conducted in 11 prospective U.S. general population–based cohorts. Severe obstruction was classified by FEV1 < 50%. Percentage emphysema, percentage high-attenuation areas, and interstitial lung abnormalities were defined on computed tomography in a subset. Incident COVID-19 was ascertained via questionnaires, serosurvey, and medical records from 2020 to 2023 and classified as severe (hospitalized or fatal) or nonsevere. Cause-specific hazard models were adjusted for sociodemographics, anthropometry, smoking, comorbidities, and COVID-19 vaccination status. Measurements and Main Results Among 29,323 participants (mean age, 67 yr), there were 748 severe incident COVID-19 cases over median follow-up of 17.3 months from March 1, 2020. Greater hazards of severe COVID-19 were associated with severe obstruction (vs. normal; adjusted hazard ratio [aHR], 2.11; 95% confidence interval [CI], 1.02–1.27), restriction (vs. normal; aHR, 1.40; 95% CI, 1.12–1.76), and percentage emphysema (highest vs. lowest quartile; aHR, 1.64; 95% CI, 1.03–2.61), but not greater high-attenuation areas or interstitial lung abnormalities. COVID-19 vaccination provided greater absolute risk reduction in these groups. Results were similar in participants without smoking, obesity, or clinical cardiopulmonary disease. Conclusions Prepandemic severe spirometric obstruction, spirometric restriction, and greater percentage emphysema lung on computed tomography were associated with risk of severe COVID-19. These findings support enhanced COVID-19 risk mitigation for individuals with impaired lung health and warrant further mechanistic studies on interactions of lung function, structure, and vulnerability to acute respiratory illnesses.
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017
Fitzmaurice, Christina , Abate, Degu , Abbasi, Naghmeh , Abbastabar, Hedayat , Abdelalim, Ahmed , Abdoli, Amir , Abdulle, Abdishakur S. 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JAMA Oncology | September 27, 2019 | Volume: 5 | Issue: 12 | Pages: 1749
The State of US Health, 1990-2016
Collaborators, The US Burden of Disease, Mokdad, Ali H. , Ballestros, Katherine, Echko, Michelle, Glenn, Scott , Olsen, Helen Elizabeth , Mullany, Erin C, Lee, Alex , Khan, Abdur Rahman , Ahmadi, Alireza , Ferrari, Alize J , Kasaeian, Amir , Werdecker, Andrea , Carter, Austin , Zipkin, Ben, Sartorius, Benn , Serdar, Berrin , Sykes, Bryan L. , Troeger, Chris, Fitzmaurice, Christina , Rehm, Colin D. , Santomauro, Damian , Kim, Daniel , Colombara, Danny V. , Schwebel, David C. , Tsoi, Derrick, Nichols, Emma , Oren, Eyal , Charlson, Fiona , Patton, George , Roth, Gregory A. , Kyu, Hmwe Hmwe , Erskine, Holly E , Huang, Hsiang , Martopullo, Ira , Nachega, Jean B. , Sanabria, Juan , Tabb, Karen M. , Krohn, Kristopher J, Cornaby, Leslie, Moses, Mark , Farvid, Maryam S. , Griswold, Max , Criqui, Michael H, Bell, Michelle L. , Nguyen, Minh , Wallin, Mitch, Mirarefin, Mojde, Younis, Mustafa Z , Fullman, Nancy , Liu, Patrick , Briant, Paul Svitil, Gona, Philimon , Havmöller, Rasmus, Kimokoti, Ruth W , Hay, Simon I , Yadgir, Simon , Biryukov, Stan, Vollset, Stein Emil, Alam, Shazia , Frank, Tahvi , Farid, Talha, Miller, Ted R. , Vos, Theo , Bärnighausen, Till , Gebrehiwot, Tsegaye, Yano, Yuichiro , Al‐Aly, Ziyad , Mehari, Alem , Handal, Alexis J. , Kandel, Amit , Anderson, Benjamin O. , Biroscak, Brian J. , Dorsey, E. Ray, Ding, Eric L. , Park, Eun‐Kee , Wagner, Gregory R. , Chen, Honglei , Sunshine, Jacob E. , Khubchandani, Jagdish , Leasher, Janet L , Leung, Janni , Unützer, Jürgen , Cahill, Leah E. , Cooper, Leslie T. , Bräuer, Michael , Breitborde, Nicholas J. K. , Topór-Mądry, Roman , Soneji, Samir , Stranges, Saverio , James, Spencer L , Amrock, Stephen M. , Jayaraman, Sudha , Skirbekk, Vegard , Kinfu, Yohannes , Bhutta, Zulfiqar A , Murray, Christopher J L , Topór‐Mądry, Roman , Bell, Max , Cooper, Leslie T , Collaborators, The US Burden of Disease, Kolte, Dhaval , Nsoesie, Elaine Okanyene , Hosgood, H. Dean, Whiteford, Harvey , Singh, Jasvinder A. , Abbas, Kaja , Ong, Sok King , Degenhardt, Louisa J , Qorbani, Mostafa , Leung, Ricky , Bazargan‐Hejazi, Shahrzad , Vollset, Stein Emil, Mozaffarian, Dariush , Hu, Guoqing , Salomon, Joshua A. , Horino, Masako , Hotez, Peter Jay , Patel, Tejas Kamleshbhai , Akinyemiju, Tomi , Jonas, Jost B , Oren, Eyal
JAMA | April 10, 2018 | Volume: 319 | Issue: 14 | Pages: 1444