Citations 2
The assessment and management of patients with type 2 myocardial infarction: an international Delphi study
Taggart, Caelan , Ferry, Amy V. , Chapman, Andrew , Schulberg, Stacey D. , Bularga, Anda , Wereski, Ryan, Boeddinghaus, Jasper, Kimenai, Dorien M , Lowry, Matthew T.H. , Daniels, Lori B. , French, J. , Gaggin, Hanna K. , Huynh, T. , Jacquin, Laurent , Jaffe, A S, Jernberg, Tomas , Koronowski, Ran, McCarthy, Cian P. , McCord, James , Mickley, Hans , Mueller, Christian , Newby, L. Kristin , Parsonage, William , Smith, Stephen W., Sandoval, Yader, Smilowitz, Nathaniel R. , Thygesen, Kristian , Mills, Nicholas L. , Boeddinghaus, Jasper , Cullen, Louise , Jernberg, Tomas , Mamas, Mamas , Mueller, Christian , Raphael, Claire , White, Harvey Douglas , Lindahl, Bertil , Thygesen, Kristian , Mills, Nicholas L , Daniels, Lori B , Boeddinghaus, Jasper , Chew, Derek P. , Cullen, Louise , Devereaux, P.J. , Mamas, Mamas A. , Morrow, David A. , Raphael, Claire E. , Smer, Aiman Miloud , Sandoval, Yader , Eggers, Kai M. , Lindahl, Bertil
European Heart Journal - Quality of Care and Clinical Outcomes | September 2, 2025 | Volume: 11 | Issue: 8 | Pages: 1421-1430
Abstract Aims Type 2 myocardial infarction due to myocardial oxygen supply–demand imbalance is associated with poor outcomes. There are no guidelines to inform care for these patients. The consensus on the assessment and management of type 2 myocardial infarction is gained. Methods and results An international e-Delphi study including experts in type 2 myocardial infarction identified through systematic review was conducted. Participants were asked to describe their approach to (i) definition and diagnosis, (ii) risk stratification, (iii) assessment of coronary artery disease and cardiac function, (iv) specialty management, (v) treatment and secondary prevention, and (vi) communication and rehabilitation. Statements generated in round one were circulated, with consensus defined a priori as ≥70% agreement on a 5-point Likert scale. Where no consensus was reached, statements were amended and recirculated for a final round. The response rate was 56% (38/68), 54% (37/68), and 72% (49/68) in the first, second, and third rounds, respectively. Following the first round, 67 unique statements were generated across six domains. Overall, consensus was achieved on 64% (43/67) of statements. Consensus was achieved for 42% (5/12) of statements on the diagnosis of type 2 myocardial infarction, 75% (3/4) on risk stratification, 50% (9/18) on the assessment of coronary artery disease and cardiac function, 60% (6/10), on specialty management, 100% (9/9) on treatment and secondary prevention, and 79% (11/15) on communication and rehabilitation. Conclusion Consensus was obtained across a number of domains for the assessment and management of patients with type 2 myocardial infarction. However, there was limited agreement amongst experts on the diagnostic criteria, which may benefit from refinement.
High-sensitivity point-of-care measurement of cardiac troponin
Cullen, Louise , Mair, Johannes , Hammarsten, Ola , Boeddinghaus, Jasper , Daniels, Lori B. , Huber, Kurt , Giannitsis, Evangelos , Jaffe, Allan S. , Kimenai, Dorien M , Möckel, Martin , Mueller, Christian, Thielmann, Matthias , Thygesen, Kristian , Mills, Nicholas L. , Boeddinghaus, Jasper , Daniels, Lori B , Giannitsis, Evangelos , Kimenai, Dorien M , Lindahl, Bertil , Mockel, Martin , Thielmann, Matthias , Thygesen, Kristian , Mills, Nicholas L , Cullen, Louise , Stengaard, Carsten , Jaffe, Allan S. , Krychtiuk, Konstantin A , Lindahl, Bertil
European Heart Journal | June 4, 2025 | Volume: 47 | Issue: 12 | Pages: 1392-1402
Abstract New technologies enabling access to high-sensitivity cardiac troponin (hs-cTn) assays at the point of care (POC) are available for routine use. POC technology can accelerate cardiac troponin testing within the hospital setting and support testing in other healthcare environments. Pre-analytical and analytical issues unique to POC testing are discussed. The opportunities and the evidence needed to support the routine use of hs-cTn POC assays in clinical care are outlined. Based on recent developments, the potential impact of hs-cTn at the POC in multiple clinical settings is described, and a roadmap of the steps required for successful implementation is provided.