Salloway, Stephen
https://orcid.org/0000-0002-2631-0942
Mayo Clinic
Dementia Fund, EQT Life Sciences Amsterdam the Netherlands
Citations 115
O4–03–03: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from the Dominantly Inherited Alzheimer Network
Chhatwal, Jasmeer P. , Johnson, Keith A. , Sullivan, Caroline, Salloway, Stephen , Ringman, John M. , Marcus, Daniel S. , Correia, Stephen , Rowe, Christopher C., Mayeux, Richard , Xiong, Chengjie , Buckles, Virginia, Schultz, Aaron P. , Benzinger, Tammie L.S. , Jack, Clifford R. , Ances, Beau M. , Koeppe, Robert A. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Fox, Nick C. , Brickman, Adam M. , McDade, Eric , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Sperling, Reisa Anne
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_17 | Pages: No page available
IC‐P‐082: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from DIAN
Chhatwal, Jasmeer P. , Johnson, Keith A. , Sullivan, Caroline, Salloway, Stephen , Ringman, John M. , Marcus, Daniel S. , Correia, Stephen , Rowe, Christopher C., Mayeux, Richard , Xiong, Chengjie , Buckles, Virginia, Schultz, Aaron P. , Benzinger, Tammie L.S. , Jack, Clifford R. , Ances, Beau M. , Koeppe, Robert A. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Fox, Nick C. , Brickman, Adam M. , McDade, Eric , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Sperling, Reisa Anne
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_2 | Pages: No page available
P3–134: Dissociating volume and intensity differences in familial Alzheimer's disease
Ryan, Natalie S. , Raichle, Marc, Marcus, Daniel, Ringman, John M. , Salloway, Stephen , Sperling, Reisa, Mayeux, Richard , Fagan, Anne M. , Buckles, Virginia, Moulder, Krista L., Cash, David M. , Ridgway, Gerard R. , Modat, Marc , Kinnunen, Kirsi M. , Cardoso, M. Jorge , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Ghetti, Bernardino , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Weiner, Michael W. , Bateman, Randall J. , Goate, Alison , Morris, John M. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_15 | Pages: No page available
IC‐P‐103: Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease
Preboske, Gregory M., Ringman, John M. , Raichle, Marc, Hornbeck, Russ C. , Salloway, Stephen , Correia, Stephen , Weiner, Michael W. , Mayeux, Richard , Cairns, Nigel J. , Marcus, Daniel C. , Fagan, Anne M. , Xiong, Chengjie , Buckles, Virginia, Moulder, Krista L., Blazey, Tyler , Jack, Clifford R. , Kantarci, Kejal , Brickman, Adam M. , Saykin, Andrew J. , McDade, Eric , Rossor, Martin N. , Fox, Nick C. , Thompson, Paul M. , Rowe, Christopher Cleon , Ghetti, Bernardino , Sperling, Reisa Anne , Schofield, Peter R. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Benzinger, Tammie L.S.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_2 | Pages: No page available
P1–269: Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene‐dependent?
Ryan, Natalie S. , Finnegan, Sarah , Cardoso, Manuel, Leung, Kelvin K., Marcus, Daniel, Raichle, Marcus E. , Ringman, John M. , Salloway, Stephen , Sperling, Reisa, Mayeux, Richard , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Kinnunen, Kirsi M. , Cash, David M. , Bastos‐Leite, António J. , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Ghetti, Bernardino , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Weiner, Michael W. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_6 | Pages: No page available
IC‐P‐078: Dissociating volume and intensity differences in familial Alzheimer's disease
Ryan, Natalie S. , Cardoso, Manuel, Raichle, Marc, Marcus, Daniel, Ringman, John M. , Salloway, Stephen , Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Buckles, Virginia, Moulder, Krista L., Cash, David M. , Ridgway, Gerard R. , Modat, Marc , Kinnunen, Kirsi M. , Cardoso, Manuel, Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Ghetti, Bernardino , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_1 | Pages: No page available
O1–03–05: Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease
Preboske, Gregory M., Ringman, John M. , Raichle, Marc, Hornbeck, Russ C. , Salloway, Stephen , Correia, Stephen , Mayeux, Richard , Sperling, Reisa, Cairns, Nigel J. , Marcus, Daniel, Fagan, Anne M. , Xiong, Chengjie , Buckles, Virginia, Moulder, Krista L., Blazey, Tyler , Jack, Clifford R. , Kantarci, Kejal , Brickman, Adam M. , Saykin, Andrew J. , McDade, Eric , Rossor, Martin N. , Fox, Nick C. , Thompson, Paul M. , Rowe, Christopher Cleon , Weiner, Michael W. , Ghetti, Bernardino , Schofield, Peter R. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Benzinger, Tammie L.S.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_3 | Pages: No page available
IC‐O1–02: Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene‐dependent?
Ryan, Natalie S. , Bastos‐Leite, António J. , Finnegan, Sarah , Cardoso, Manuel, Leung, Kelvin K., Marcus, Daniel, Raichle, Marcus E. , Ringman, John M. , Salloway, Stephen , Sperling, Reisa, Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Kinnunen, Kirsi M. , Cash, David M. , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Ghetti, Bernardino , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_1 | Pages: No page available
The pattern of atrophy in familial Alzheimer disease
Cash, David M. , Ridgway, Gerard R. , Ryan, Natalie S. , Kinnunen, Kirsi M. , Yeatman, Thomas, Malone, Ian B. , Benzinger, Tammie L.S. , Thompson, Paul M. , Saykin, Andrew J. , Masters, Colin L. , Ringman, John M. , Salloway, Stephen , Schofield, Peter R. , Cairns, Nigel J., Marcus, Daniel S. , Bateman, Randall J. , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C. , Liang, Yuying , Jack, Clifford R. , Ghetti, Bernardino , Sperling, Reisa Anne , Xiong, Chengjie , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Fox, Nick C , Morris, John C , Cash, David M
Neurology | September 19, 2013 | Volume: 81 | Issue: 16 | Pages: 1425-1433
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity
Jahanshad, Neda , Rajagopalan, Priya , Hua, Xue , Hibar, Derrek P., Nir, Talia M. , Toga, Arthur W. , Jack, Clifford R., Saykin, Andrew J. , Weiner, Michael W. , Medland, Sarah E. , Montgomery, Grant W. , Hansell, Narelle K. , McMahon, Katie L. , Zubicaray, Greig I. de , Martin, Nicholas G. , Wright, Margaret J. , Thompson, Paul M. , Initiative, the Alzheimer’s Disease Neuroimaging, Aisen, Paul, Petersen, Ronald, Jagust, William J. , Trojanowski, John Q. , Toga, Arthur W., Green, Robert C., Liu, Enchi , Green, Robert C., Montine, Tom, Gamst, Anthony, Thomas, Ronald G. , Donohue, Michael, Walter, Sarah , Gessert, Devon, Sather, Tamie, Harvey, Danielle, Donohue, Michael, Kornak, John , Jack, Clifford R., Felmlee, Joel P. , Schuff, Norbert, Alexander, Gene, DeCarli, Charles , Bandy, Dan, Foster, Norm, Reiman, Eric M. , Mathis, Chet, Cairns, Nigel J. , Taylor‐Reinwald, Lisa, Trojanowki, John Q., Shaw, Les, Korecka, Magdalena , Toga, Arthur W., Crawford, Karen , Neu, Scott, Khachaturian, Zaven S., Frank, R.T., Molchan, Susan, Quinn, Joseph, Lind, Betty, Dolen, Sara, Schneider, Lon S. , Pawluczyk, Sonia, Spann, Bryan M., Brewer, James, Vanderswag, Helen, Heidebrink, Judith L. , Johnson, Kris , Doody, Rachelle S., Chowdhury, Munir , Bell, Karen L. , Carroll, Maria , Leon, Sue, Mintun, Mark A., Schneider, Stacy, Marson, Daniel , Griffith, Randall, Clark, David, Grossman, Hillel, Mitsis, Effie, Romirowsky, Aliza, deToledo‐Morrell, Leyla, Duara, Ranjan , Varon, Daniel, Roberts, Peggy, Albert, Marilyn, Onyike, Chiadi, Kielb, Stephanie , Glodzik, Lidia , Santi, Susan De , Doraiswamy, P. Murali , Petrella, Jeffrey R. , Coleman, Robert E. , Arnold, Steven E. , Karlawish, Jason H., Smith, Charles D., Jicha, Gregory A. , Hardy, Peter , Lopez, Oscar L., Oakley, MaryAnn, Simpson, Donna M., Goldstein, Bonnie S., Martin, Kim, Makino, Kelly M., Ismail, M. Saleem , Brand, Connie, Mulnard, Ruth A., Thai, Gaby , Mc-Adams-Ortiz, Catherine, Mathews, Dana, Quiceno, Mary , King, Richard, Martin-Cook, Kristen, Devous, Michael D. , Cellar, Janet S., Anderson, Heather S., Swerdlow, Russell H. , Apostolova, Liana , Lu, Po H. , Bartzokis, George, Graff‐Radford, Neill R. , Parfitt, Francine, Farlow, Martin R. , Hake, Ann Marie , Matthews, Brandy R., Herring, Scott, Dyck, Christopher H. van , Carson, Richard E. , MacAvoy, Martha G., Chertkow, Howard , Bergman, Howard , Hosein, Chris, Caldwell, Curtis, Hsiung, Ging‐Yuek Robin , Feldman, Howard J., Mudge, Benita, Assaly, Michele, Kertesz, Andrew, Rogers, John, Trost, Dick, Bernick, Charles , Munic, Donna, Mesulam, Marek-Marsel, Lipowski, Kristina, Wu, Chuang‐Kuo, Johnson, Nancy E., Sadowsky, Carl, Villena, Teresa, Johnson, Kathleen, Reynolds, Brigid, Marshall, Gad A. , Frey, Meghan , Yesavage, Jerome A. , Taylor, Joy L. , Lane, Barton , Rosen, Allyson , Tinklenberg, Jared, Sabbagh, Marwan, Belden, Christine M. , Jacobson, Sandra A. , Kowall, Neil W. , Budson, Andrew E. , Johnson, Patricia Lynn, Wolday, Saba, Bwayo, Salome K., Lerner, Alan J. , Hudson, Leon, Ogrocki, Paula, Fletcher, Evan, Olichney, John , Kittur, Smita, Borrie, Michael, Lee, T.-Y., Bartha, Robert , Asthana, Sanjay , Carlsson, Cynthia M., Preda, Adrian , Tariot, Pierre N. , Fleisher, Adam , Reeder, Stephanie, Bates, Vernice, Capote, Horacio, Rainka, Michelle, Kataki, Maria , Zimmerman, Earl A. , Celmins, Dzintra, Brown, Alice D., Blank, Karen, Anderson, Karen, Santulli, Robert B. , Schwartz, Eben S., Williamson, Jeff D. , Garg, Pradeep , Watkins, Franklin, Ott, Brian R. , Querfurth, Henry, Tremont, Geoffrey , Salloway, Stephen , Malloy, Paul, Correia, Stephen , Rosen, Howard J., Mintzer, Jacobo , Longmire, Crystal Flynn, Spicer, Kenneth, Rachinsky, Irina, Kertesz, Andrew, Drost, Dick, Lee, Ting‐Yim , Jack, Clifford R., Green, Robert C. , Initiative, the Alzheimer’s Disease Neuroimaging, Jack, Clifford R. , Toga, Arthur W., Beckett, Laurel , Green, Robert C., Morris, John C. , Green, Robert C., Donohue, Michael, Sather, Tamie, Donohue, Michael, Jack, Clifford R., Dale, Anders M. , Bernstein, Matt A. , Fox, Nick C. , Koeppe, Robert A. , Chen, Kewei , Mathis, Chet, Lee, Virginia M.‐Y. , Toga, Arthur W., Foroud, Tatiana , Potkin, Steven G. , Shen, Li , Snyder, Peter J. , Kaye, Jeffrey , Lord, Joanne L. , Villanueva-Meyer, Javier E. , Stern, Yaakov , Honig, Lawrence S. , Ances, Beau M. , Grossman, Hillel, Shah, Raj C. , Duara, Ranjan , Varón, Daniel , Rusinek, Henry , Leon, Mony J. de , Karlawish, Jason , Wolk, David A. , Porsteinsson, Anton P. , Womack, Kyle , Diaz‐Arrastia, Ramon , Weiner, Myron , Levey, Allan I. , Lah, James J. , Burns, Jeffrey M. , Silverman, Daniel H.S. , Johnson, Heather M. , Black, Sandra E. , Stefanovic, Bojana , Kertesz, Andrew, Kerwin, Diana , Martínez, Walter Fabián , Turner, Raymond Scott , Sperling, Reisa Anne , Johnson, Keith A. , Killiany, Ronald , Norbash, Alexander , Obisesan, Thomas O. , Carmichael, Owen , Johnson, Sterling C. , Nguyen, Dana R. , Reeder, Stephanie, Scharre, Douglas W. , Pearlson, Godfrey D. , Sink, Kaycee M. , Miller, Bruce L. , Finger, Elizabeth C. , Kertesz, Andrew, de Zubicaray, Greig I , Hansell, Narelle K , Saykin, Andrew J , Preda, Adrian , Martin, Nicholas G , Toga, Arthur W , Wright, Margaret J , Thompson, Paul M , Medland, Sarah E , Hsiung, Gink-Yuek , Jicha, Gregory A
Proceedings of the National Academy of Sciences | March 5, 2013 | Volume: 110 | Issue: 12 | Pages: 4768-4773
Aberrant connectivity is implicated in many neurological and psychiatric disorders, including Alzheimer’s disease and schizophrenia. However, other than a few disease-associated candidate genes, we know little about the degree to which genetics play a role in the brain networks; we know even less about specific genes that influence brain connections. Twin and family-based studies can generate estimates of overall genetic influences on a trait, but genome-wide association scans (GWASs) can screen the genome for specific variants influencing the brain or risk for disease. To identify the heritability of various brain connections, we scanned healthy young adult twins with high-field, high-angular resolution diffusion MRI. We adapted GWASs to screen the brain’s connectivity pattern, allowing us to discover genetic variants that affect the human brain’s wiring. The association of connectivity with the SPON1 variant at rs2618516 on chromosome 11 (11p15.2) reached connectome-wide, genome-wide significance after stringent statistical corrections were enforced, and it was replicated in an independent subsample. rs2618516 was shown to affect brain structure in an elderly population with varying degrees of dementia. Older people who carried the connectivity variant had significantly milder clinical dementia scores and lower risk of Alzheimer’s disease. As a posthoc analysis, we conducted GWASs on several organizational and topological network measures derived from the matrices to discover variants in and around genes associated with autism ( MACROD2 ), development ( NEDD4 ), and mental retardation ( UBE2A ) significantly associated with connectivity. Connectome-wide, genome-wide screening offers substantial promise to discover genes affecting brain connectivity and risk for brain diseases.