Citations 10
Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study
Kinnunen, Kirsi M. , Cash, David M. , Poole, Teresa, Frost, Chris , Benzinger, Tammie L.S. , Ahsan, R. Laila, Leung, Kelvin K., Cardoso, M. Jorge , Modat, Marc , Malone, Ian B. , Morris, John C. , Bateman, Randall J. , Marcus, Daniel S. , Goate, Alison , Salloway, Stephen , Correia, Stephen , Chhatwal, Jasmeer P. , Mayeux, Richard , Martins, Ralph N. , Farlow, Martin R. , Saykin, Andrew J. , Jack, Clifford R. , Schofield, Peter R. , Weiner, Michael W. , Ringman, John M. , Thompson, Paul M. , Masters, Colin L. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C. , (DIAN), Dominantly Inherited Alzheimer Network, Sperling, Reisa Anne , Brickman, Adam M. , Ghetti, Bernardino , McDade, Eric , Rowe, Christopher Cleon , (DIAN), Dominantly Inherited Alzheimer Network, Jack, Clifford R , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Fox, Nick C , Morris, John C , Cash, David M , Goate, Alison M
Alzheimer's & Dementia | July 22, 2017 | Volume: 14 | Issue: 1 | Pages: 43-53
Abstract Introduction Identifying at what point atrophy rates first change in Alzheimer's disease is important for informing design of presymptomatic trials. Methods Serial T1‐weighted magnetic resonance imaging scans of 94 participants (28 noncarriers, 66 carriers) from the Dominantly Inherited Alzheimer Network were used to measure brain, ventricular, and hippocampal atrophy rates. For each structure, nonlinear mixed‐effects models estimated the change‐points when atrophy rates deviate from normal and the rates of change before and after this point. Results Atrophy increased after the change‐point, which occurred 1–1.5 years (assuming a single step change in atrophy rate) or 3–8 years (assuming gradual acceleration of atrophy) before expected symptom onset. At expected symptom onset, estimated atrophy rates were at least 3.6 times than those before the change‐point. Discussion Atrophy rates are pathologically increased up to seven years before “expected onset”. During this period, atrophy rates may be useful for inclusion and tracking of disease progression.
Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2
Jack, Clifford R. , Barnes, Josephine , Bernstein, Matt A. , Borowski, Bret, Brewer, James, Clegg, Shona , Dale, Anders M. , Carmichael, Owen , Ching, Christopher R. K. , DeCarli, Charles , Desikan, Rahul S. , Fennema‐Notestine, Christine , Fjell, Anders M. , Fox, Nick C. , Gunter, Jeff, Holland, Dominic , Hua, Xue , Kantarci, Kejal , Krueger, Gunnar, Leung, Kelvin K., Mackin, Scott, Maillard, Pauline , Malone, Ian B. , Mattsson, Niklas , McEvoy, Linda K. , Modat, Marc , Mueller, Susanne G. , Nosheny, Rachel L. , Ourselin, Sébastien , Schuff, Norbert, Senjem, Matthew L. , Simonson, Alix, Thompson, Paul M. , Rettmann, Dan , Vemuri, Prashanthi , Walhovd, Kristine B. , Zhao, Yansong , Zuk, Samantha M., Weiner, Michael W. , DeCarli, Charles , Borowski, Bret J, Zuk, Samantha, Fletcher, Evan M. , Gutman, Boris A , Insel, Philip S. , Killiany, Ronald , Bernstein, Matt A , Jack, Clifford R , Vemuri, Prashanthi , Dale, Anders M , Thompson, Paul M , Senjem, Matthew L , Ching, Christopher R K , Kantarci, Kejal , Fox, Nick C , Maillard, Pauline
Alzheimer's & Dementia | July 17, 2015 | Volume: 11 | Issue: 7 | Pages: 740-756
AbstractIntroductionAlzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders.MethodsWe review the contributions of the MRI core from present and past cycles of ADNI (ADNI‐1, ‐Grand Opportunity and ‐2). We also review plans for the future‐ADNI‐3.ResultsContributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials.DiscussionOver the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.
IC‐P‐106: LONGITUDINAL RATES OF ATROPHY IN FAMILIAL ALZHEIMER'S DISEASE
Leung, Kelvin K., Ahsan, Laila, Nicholas, Jennifer M. , Malone, Ian B. , Sperling, Reisa R., Villemagne, Victor L. , Weiner, Michael W. , Marcus, Daniel C. , Cash, David M. , Kinnunen, Kirsi M. , Cardoso, M. Jorge , Modat, Marc , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Sperling, Reisa, Bateman, Randall J. , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_6 | Pages: No page available
IC‐P‐150: Comparison of accelerated and nonaccelerated MRI in ADNI: Effects on measures of brain and ventricular volumes and rates of atrophy
Leung, Kelvin K., Nielsen, Casper , Clegg, Shona , Malone, Ian B. , Nicholas, Jennifer M. , Cash, David M. , Ourselin, Sébastien , Thompson, Paul M. , Jack, Clifford R. , Weiner, Michael W. , Fox, Nick C.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_2 | Pages: No page available
P1–269: Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene‐dependent?
Ryan, Natalie S. , Finnegan, Sarah , Cardoso, Manuel, Leung, Kelvin K., Marcus, Daniel, Raichle, Marcus E. , Ringman, John M. , Salloway, Stephen , Sperling, Reisa, Mayeux, Richard , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Kinnunen, Kirsi M. , Cash, David M. , Bastos‐Leite, António J. , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Ghetti, Bernardino , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Weiner, Michael W. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_6 | Pages: No page available
IC‐O1–02: Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene‐dependent?
Ryan, Natalie S. , Bastos‐Leite, António J. , Finnegan, Sarah , Cardoso, Manuel, Leung, Kelvin K., Marcus, Daniel, Raichle, Marcus E. , Ringman, John M. , Salloway, Stephen , Sperling, Reisa, Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Kinnunen, Kirsi M. , Cash, David M. , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Ghetti, Bernardino , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_1 | Pages: No page available
IC‐P‐138: Brain and hippocampal rates of atrophy in familial Alzheimer's disease mutation carriers: Preliminary findings from the DIAN study
Kinnunen, Kirsi M. , Leung, Kelvin K., Cardoso, Manuel, Malone, Ian B. , Raichle, Marcus E. , Marcus, Daniel C. , Ringman, John M. , Salloway, Stephen , Correia, Stephen , Johnson, Keith A. , Villemagne, Victor L. , Mayeux, Richard , Weiner, Michael W. , Moulder, Krista L., Cash, David M. , Liang, Yuying , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Ghetti, Bernardino , Sperling, Reisa Anne , Schofield, Peter R. , Rowe, Christopher Cleon , Masters, Colin L. , Brickman, Adam M. , Martins, Ralph N. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_2 | Pages: No page available
P2‐226: Cross‐sectional cerebral volumetric differences and associations with estimated time to age‐at‐onset in familial Alzheimer's disease: Findings from the DIAN study
Kinnunen, Kirsi M. , Liang, Yuying , Leung, Kelvin K., Malone, Ian B. , Yeatman, Tom, Nicholas, Jennifer M. , Koeppe, Robert, Raichle, Marc, Marcus, Daniel, Ringman, John M. , Salloway, Stephen , Correia, Stephen , Sperling, Reisa, Villemagne, Victor L. , Mayeux, Richard , Buckles, Virginia, Moulder, Krista L., Cash, David M. , Cardoso, M. Jorge , Modat, Marc , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Ghetti, Bernardino , Johnson, Keith J. , Schofield, Peter R. , Rowe, Christopher Cleon , Masters, Colin L. , Brickman, Adam M. , Martins, Ralph N. , Weiner, Michael W. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Fox, Nick C. , Ourselin, Sébastien
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_9 | Pages: No page available
IC‐P‐032: Cross‐sectional cerebral volumetric differences and associations with estimated time to age‐at‐onset in familial Alzheimer's disease: Findings from the DIAN study
Leung, Kelvin K., Cardoso, Manuel, Malone, Ian B. , Yeatman, Tom, Nicholas, Jennifer M. , Raichle, Marcus E. , Marcus, Daniel, Ringman, John M. , Salloway, Stephen , Correia, Stephen , Sperling, Reisa, Villemagne, Victor L. , Mayeux, Richard , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Kinnunen, Kirsi M. , Cash, David M. , Liang, Yuying , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Ghetti, Bernardino , Johnson, Keith J. , Schofield, Peter R. , Rowe, Christopher Cleon , Masters, Colin L. , Brickman, Adam M. , Martins, Ralph N. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_1 | Pages: No page available
P1‐015: Brain and hippocampal rates of atrophy in familial Alzheimer's disease mutation carriers: Preliminary findings from the DIAN study
Leung, Kelvin K., Cardoso, Manuel, Malone, Ian B. , Raichle, Marc, Marcus, Daniel, Ringman, John M. , Salloway, Stephen , Correia, Stephen , Sperling, Reisa, Villemagne, Victor L. , Mayeux, Richard , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Kinnunen, Kirsi M. , Cash, David M. , Liang, Yuying , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Ghetti, Bernardino , Johnson, Keith J. , Schofield, Peter R. , Rowe, Christopher Cleon , Masters, Colin L. , Brickman, Adam M. , Martins, Ralph N. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_3 | Pages: No page available