Citations 4
Development and implementation of an electronic Clinical Dementia Rating and Financial Capacity Instrument‐Short Form
Howell, Taylor, Gummadi, Shilpa, Bui, Chau, Santhakumar, Jessica , Knight, Kristen, Roberson, Erik D. , Marson, Daniel , Chambless, Carol, Gersteneker, Adam, Martin, Roy C. , Kennedy, Richard , Morris, John C. , Moulder, Krista L., Mayo, Connie, Carroll, Maria , Li, Yan , Petersen, Ronald C. , Nosheny, Rachel L. , Mackin, Scott, Weiner, Michael W. , Stricker, Nikki H. , Roberson, Erik , Kennedy, Richard E , Morris, John C , Zhang, Yue
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | July 24, 2022 | Volume: 14 | Issue: 1 | Pages: No page available
AbstractIntroductionTo address the need for remote assessments of cognitive decline and dementia, we developed and administered electronic versions of the Clinical Dementia Rating (CDR®) and the Financial Capacity Instrument‐Short Form (FCI‐SF) (F‐CAP®), called the eCDR and eFCI, respectively.MethodsThe CDR and FCI‐SF were adapted for remote, unsupervised, online use based on item response analysis of the standard instruments. Participants completed the eCDR and eFCI first in clinic, and then at home within 2 weeks.ResultsOf the 243 enrolled participants, 179 (73%) cognitively unimpaired (CU), 50 (21%) with mild cognitive impairment (MCI) or dementia, and 14 (6%) with an unknown diagnosis, 84% and 85% of them successfully completed the eCDR and eFCI, respectively, at home.DiscussionThese results show initial feasibility in developing and administering online instruments to remotely assess and monitor cognitive decline along the CU to MCI/very mild dementia continuum. Validation is an important next step.
Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2
Jack, Clifford R. , Barnes, Josephine , Bernstein, Matt A. , Borowski, Bret, Brewer, James, Clegg, Shona , Dale, Anders M. , Carmichael, Owen , Ching, Christopher R. K. , DeCarli, Charles , Desikan, Rahul S. , Fennema‐Notestine, Christine , Fjell, Anders M. , Fox, Nick C. , Gunter, Jeff, Holland, Dominic , Hua, Xue , Kantarci, Kejal , Krueger, Gunnar, Leung, Kelvin K., Mackin, Scott, Maillard, Pauline , Malone, Ian B. , Mattsson, Niklas , McEvoy, Linda K. , Modat, Marc , Mueller, Susanne G. , Nosheny, Rachel L. , Ourselin, Sébastien , Schuff, Norbert, Senjem, Matthew L. , Simonson, Alix, Thompson, Paul M. , Rettmann, Dan , Vemuri, Prashanthi , Walhovd, Kristine B. , Zhao, Yansong , Zuk, Samantha M., Weiner, Michael W. , DeCarli, Charles , Borowski, Bret J, Zuk, Samantha, Fletcher, Evan M. , Gutman, Boris A , Insel, Philip S. , Killiany, Ronald , Bernstein, Matt A , Jack, Clifford R , Vemuri, Prashanthi , Dale, Anders M , Thompson, Paul M , Senjem, Matthew L , Ching, Christopher R K , Kantarci, Kejal , Fox, Nick C , Maillard, Pauline
Alzheimer's & Dementia | July 17, 2015 | Volume: 11 | Issue: 7 | Pages: 740-756
AbstractIntroductionAlzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders.MethodsWe review the contributions of the MRI core from present and past cycles of ADNI (ADNI‐1, ‐Grand Opportunity and ‐2). We also review plans for the future‐ADNI‐3.ResultsContributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials.DiscussionOver the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.
P4‐137: THE TRANSITIONAL ASSOCIATION BETWEEN BETA‐AMYLOID PATHOLOGY AND REGIONAL BRAIN ATROPHY
Mackin, Scott, Aisen, Paul , Shaw, Leslie, Trojanowski, John Q. , Weiner, Michael W. , Insel, Philip S. , Mattsson, Niklas , Donohue, Michael , Jack, Clifford R.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_23 | Pages: No page available
P3–008: Genome‐wide analysis of genetic variants associated with depressive symptoms in older adults
Mackin, Scott, Aisen, Paul, Petersen, Ronald, Weiner, Michael W. , Farlow, Martin R. , Gao, Sujuan , Nho, Kwangsik T. , Swaminathan, Shanker , Kim, Sungeun , Risacher, Shannon L. , Ramanan, Vijay K. , Shen, Li , McDonald, Brenna C. , Ghetti, Bernardino , Saykin, Andrew J. , Green, Robert C.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_14 | Pages: No page available