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Jacobson, Sandra A.

https://orcid.org/0000-0001-6839-6900

Mayo Clinic

University of Arizona

Citations 25

Unified Staging System for Lewy Body Disorders: Clinicopathologic Correlations (S27.001)
Beach, Thomas G. , Zhang, Nan , Shill, Holly A. , Driver‐Dunckley, Erika , Caviness, John N., Mehta, Shyamal H. , Sue, Lucia I., Belden, Christine M. , Powell, Jessica, Jacobson, Sandra A. , Zamrini, Edward , Davis, Kathryn, Hentz, Joseph G. , Adler, Charles H. , Sabbagh, Marwan Noel , Serrano, Geidy E. , Shprecher, David , Dugger, Brittany N.

Neurology | December 7, 2023 | Volume: 90 | Issue: 15_supplement | Pages: No page available

10.1212/wnl.90.15_supplement.s27.001 Get It

Prevalence Of Lewy-Type Synucleinopathy In The Submandibular Gland Of Subjects With Neuropathologically-Confirmed Dementia With Lewy Bodies. (S38.007)
Beach, Thomas G. , Adler, Charles, Shill, Holly A. , Sue, Lucia I., Jacobson, Sandra A. , Serrano, Geidy E. , Dugger, Brittany N. , Sabbagh, Marwan Noel

Neurology | December 7, 2023 | Volume: 82 | Issue: 10_supplement | Pages: No page available

10.1212/wnl.82.10_supplement.s38.007 Get It

Low Diagnostic Accuracy of a Clinical Diagnosis of Early Parkinson’s Disease: Findings of the Arizona Parkinson’s Disease Consortium (S37.001)
Beach, Thomas G. , Hentz, Joseph G. , Shill, Holly A. , Caviness, John N., Driver‐Dunckley, Erika , Sabbagh, Marwan, Sue, Lucia I., Jacobson, Sandra A. , Belden, Christine M. , Adler, Charles H. , Dugger, Brittany N.

Neurology | December 7, 2023 | Volume: 82 | Issue: 10_supplement | Pages: No page available

10.1212/wnl.82.10_supplement.s37.001 Get It

Clinical Features Predict Lewy Body Pathology and Differentiate between Different Pathologies: A Clinical-Pathologic Prospective Study (P6.231)
Savica, Rodolfo , Beach, Thomas G. , Joseph, Hent, Sue, Lucia I., Shill, Holly A. , Driver‐Dunckley, Erika , Caviness, John N., Jacobson, Sandra A. , Mehta, Shyamal H. , Belden, Christine M. , Adler, Charles, Serrano, Geidy E. , Dugger, Brittany N. , Davis, Kathryn A. , Sabbagh, Marwan Noel

Neurology | December 7, 2023 | Volume: 86 | Issue: 16_supplement | Pages: No page available

10.1212/wnl.86.16_supplement.p6.231 Get It

Risk of Developing Dementia in Essential Tremor (S53.004)
Shill, Holly A. , Hentz, Joe, Belden, Christine M. , Powell, Jessica, Jacobson, Sandra A. , Caviness, John N., Beach, Thomas G. , Adler, Charles, Sabbagh, Marwan Noel

Neurology | December 7, 2023 | Volume: 80 | Issue: 7_supplement | Pages: No page available

10.1212/wnl.80.7_supplement.s53.004 Get It

Neuropathological Correlates of Visual Hallucinations in Parkinsonism (S03.006)
Morshed, Trisha, Jacobson, Sandra A. , Beach, Thomas G. , Shill, Holly A. , Caviness, John N., Belden, Christine M. , Sue, Lucia I., Davis, Kathryn, Adler, Charles H. , Sabbagh, Marwan Noel , Hu, Chengcheng

Neurology | December 7, 2023 | Volume: 80 | Issue: 7_supplement | Pages: No page available

10.1212/wnl.80.7_supplement.s03.006 Get It

Unified Staging System for Lewy Body Disorders: Clinicopathologic Correlations and Comparison to Braak Staging
Adler, Charles H. , Beach, Thomas G. , Shill, Holly A. , Driver‐Dunckley, Erika , Caviness, John N., Mehta, Shyamal H. , Sue, Lucia I., Belden, Christine M. , Powell, Jessica, Jacobson, Sandra A. , Zamrini, Edward , Shprecher, David , Davis, Kathryn, Dugger, Brittany N. , Hentz, Joseph G. , Driver-Dunckley, Erika, Adler, C H , Shprecher, David , Dugger, Brittany N , Zhang, Nan , Sabbagh, Marwan Noel , Serrano, Geidy E.

Journal of Neuropathology & Experimental Neurology | September 10, 2019 | Volume: 78 | Issue: 10 | Pages: 891-899

10.1093/jnen/nlz080 Get It

Abstract This study was designed to correlate clinical findings with the extent of pathologic a-synuclein (aSyn) in the brain using the Unified Staging System for Lewy Body disorders (USSLB). Data from 280 cases from the Arizona Study of Aging and Neurodegenerative Disorders are presented. Each case had a complete USSLB staging and at least 1 full research clinical assessment, including subspecialty neurologist-administered movement and cognitive evaluation. Of the 280, 25.7% were cognitively normal, 8.6% had mild cognitive impairment, and 65.7% had dementia. All cases could be categorized into 1 of 5 USSLB stages (8.6% stage I—olfactory bulb only; 15.4% IIa—brainstem predominant; 13.6% IIb—limbic predominant; 31.8% III—brainstem and limbic; and 30.7% IV—neocortical) yet using the Braak staging system 70 cases (25.3%) could not be classified. Those with USSLB stages III and IV died at a younger age. Multiple measures of motor parkinsonism, cognitive impairment, hyposmia, and probable RBD were significantly correlated with increasing USSLB stage. We conclude that the USSLB is the most comprehensive staging system for all Lewy body disorders and allows for categorization and ranking of all brains with significant correlations to many motor and nonmotor clinical signs and symptoms.