Citations 4
Evidence-based guidelines for the pharmacological treatment of migraine, summary version
Ornello, Raffaele , Caponnetto, Valeria , Ahmed, Fayyaz , Al‐Khazali, Haidar M. , Ashina, Sait , Baraldi, Carlo , Bellotti, Alessia, Cevoli, Sabina , Cheng, Shuli, Chiarugi, Alberto , Christensen, Rune Häckert , Chu, Min Kyung , Crema, Santiago , Stefano, Vincenzo Di , Ekizoğlu, Esme , Fallacara, Adriana , Favoni, Valentina , Garces, Kimberly, Granato, Antonio, Granella, Franco, Ha, Woo‐Seok , Hirata, Koichi , Hoffmann, Jan , Hüssler, Eva-Maria, Hussein, Mona , Jenkins, Bronwyn , Labastida‐Ramírez, Alejandro , Laporta, Anna, Levin, Morris , Lupica, Antonino , Mampreso, Edoardo, Martinelli, Daniele , Orologio, Ilaria, Panneerchelvam, Lavindren Luke, Quattrocchi, Silvia, Romanenko, V.I. , Romozzi, Marina , Russo, Antonio , Sances, Grazia , Sarchielli, Paola , Silvestro, Marcello , Tassorelli, Cristina , Tessitore, Alessandro , Christensen, Rune H. , Ambrosini, Anna , Ashina, Sait , Baraldi, Carlo , Bellotti, Alessia , Casillo, Francesco , Cevoli, Sabina , Chiang, Chia-Chun , Chu, Min Kyung , Coppola, Gianluca , Corbelli, Ilenia , De Icco, Roberto , de Tommaso, Marina , Di Stefano, Vincenzo , Diener, Hans-Christoph , Ekizoglu, Esme , Fallacara, Adriana , Favoni, Valentina , Ha, Woo-Seok , Hassan, Amr , Hoffmann, Jan , Hussein, Mona , Iannone, Luigi Francesco , Martinelli, Daniele , Monteith, Teshamae S , Pan, Li-Ling Hope , Rozen, Todd D. , Souza, Marcio Nattan P , Pozo-Rosich, Patricia , Rainero, Innocenzo , Romanenko, Volodymyr , Romozzi, Marina , Russo, Antonio , Sances, Grazia , Schwedt, Todd J , Swerts, Diego Belandrino , Tassorelli, Cristina , Togha, Mansoureh , Vaghi, Gloria , Wang, Shuu-Jiun , Ashina, Messoud , Sacco, Simona , Ornello, Raffaele , Al-Khazali, Haidar M , Ahmed, Fayyaz , Brighina, Filippo , Calabresi, Paolo , Casillo, Francesco , Chiang, Chia‐Chun , Coppola, Gianluca , Lorenzo, Cherubino Di , Diener, Hans‐Christoph , Geppetti, Pierangelo , Goicochea, María Teresa , Guérzoni, Simona , Hassan, Amr , Huessler, Eva‐Maria , Monteith, Teshamae , Özge, Aynur , Peres, Mário Fernando Prieto , Pozo‐Rosich, Patricia , Prudenzano, Maria Pia , Quattrocchi, Silvia, Rainero, Innocenzo , Romozzi, Marina , Schwedt, Todd J. , Tessitore, Alessandro , Wang, Shuu‐Jiun , Ashina, Messoud , Sacco, Simona
Cephalalgia | April 25, 2025 | Volume: 45 | Issue: 4 | Pages: No page available
We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the GRADE approach for assessing the quality of evidence. The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.
Evidence-based guidelines for the pharmacological treatment of migraine
Ornello, Raffaele , Caponnetto, Valeria , Ahmed, Fayyaz , Al‐Khazali, Haidar M. , Ashina, Sait , Baraldi, Carlo , Bellotti, Alessia, Cevoli, Sabina , Cheng, Shuli, Chiarugi, Alberto , Christensen, Rune Häckert , Chu, Min Kyung , Crema, Santiago , Stefano, Vincenzo Di , Ekizoğlu, Esme , Fallacara, Adriana , Favoni, Valentina , Garces, Kimberly, Granato, Antonio, Granella, Franco, Ha, Woo‐Seok , Hirata, Koichi , Hoffmann, Jan , Hüssler, Eva-Maria, Hussein, Mona , Jenkins, Bronwyn , Labastida‐Ramírez, Alejandro , Laporta, Anna, Levin, Morris , Lupica, Antonino , Mampreso, Edoardo, Martinelli, Daniele , Orologio, Ilaria, Panneerchelvam, Lavindren Luke, Quattrocchi, Silvia, Romanenko, V.I. , Romozzi, Marina , Russo, Antonio , Sances, Grazia , Sarchielli, Paola , Silvestro, Marcello , Tassorelli, Cristina , Tessitore, Alessandro , Christensen, Rune H. , Ashina, Sait , Baraldi, Carlo , Bellotti, Alessia , Casillo, Francesco , Chiang, Chia-Chun , Chu, Min Kyung , Coppola, Gianluca , Corbelli, Ilenia , De Icco, Roberto , de Tommaso, Marina , Di Stefano, Vincenzo , Diener, Hans-Christoph , Favoni, Valentina , Ha, Woo-Seok , Hoffmann, Jan , Hussein, Mona , Iannone, Luigi Francesco , Martinelli, Daniele , Monteith, Teshamae S , Pan, Li-Ling Hope , Rozen, Todd D. , Souza, Marcio Nattan P , Pozo-Rosich, Patricia , Rainero, Innocenzo , Romozzi, Marina , Russo, Antonio , Schwedt, Todd J , Swerts, Diego Belandrino , Tassorelli, Cristina , Togha, Mansoureh , Vaghi, Gloria , Wang, Shuu-Jiun , Ornello, Raffaele , Al-Khazali, Haidar M , Ahmed, Fayyaz , Ambrosini, Anna , Brighina, Filippo , Calabresi, Paolo , Casillo, Francesco , Chiang, Chia‐Chun , Coppola, Gianluca , Lorenzo, Cherubino Di , Diener, Hans‐Christoph , Geppetti, Pierangelo , Goicochea, María Teresa , Guérzoni, Simona , Hassan, Amr , Huessler, Eva‐Maria , Monteith, Teshamae , Özge, Aynur , Peres, Mário Fernando Prieto , Pozo‐Rosich, Patricia , Prudenzano, Maria Pia , Quattrocchi, Silvia, Rainero, Innocenzo , Romozzi, Marina , Schwedt, Todd J. , Tessitore, Alessandro , Wang, Shuu‐Jiun , Ashina, Messoud , Sacco, Simona
Cephalalgia | April 25, 2025 | Volume: 45 | Issue: 4 | Pages: No page available
We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by the Italian Society for the Study of Headache and the International Headache Society, aim to offer clear, actionable recommendations to healthcare professionals. They incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. The guidelines follow the Grading of Recommendations, Assessment, Development and Evaluation approach for assessing the quality of evidence. The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Guen, Yann Le , Luo, Guo , Damotte, Vincent , Jansen, Iris E. , Nicolas, Aude , Rojas, Itziar de, Bellenguez, Céline , Lian, Michelle Mulan , Parveen, Kayenat, Morizono, Takashi, Park, Hyeonseul, Grenier‐Boley, Benjamin , Naito, Tatsuhiko , Talyansky, Seth D., Yogeshwar, Selina , Sempere, Vicente Peris, Satake, Wataru , Álvarez, Victoria , Arosio, Beatrice , Boland, Anne , Daniele, Antonio , Darling, D.H., Dichgans, Martin , Dufouil, Carole , Düzel, Emrah , García‐Ribas, Guillermo, García‐Alberca, José María , García-González, Pablo, Giedraitis, Vilmantas , Graff, Caroline , Grünblatt, Edna , Hausner, Lucrezia , Jung, Yoo Jin , Deckert, Jürgen, Kern, Silke , Kuulasmaa, Teemu , Lee, Kun Ho , Lin, Ling , Masullo, Carlo , Mehrabian, Shima , Mendonça, Alexandre de , Boada, Merçé , Mir, Pablo , Moreno, Fermín , Nicolas, Gaël , Niida, Shumpei , Nordestgaard, Børge G. , Papenberg, Goran, Papma, Janne M., Pástor, Pau , Peters, Oliver , Popp, Julius , Molina‐Porcel, Laura , Puerta, Raquel , 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David , Todd, Stephen, Macías‐García, Daniel , Carrillo, F, Vargas, Liliana , Marín, M, Alonso, María Dolores, Gómez-Garre, P, Cañabate, Pilar , Escuela, R, Vigo-Ortega, R, Jesús, Silvia , Vacca, Alessandro , Roveta, Fausto , Boecker, Henning , Perneczky, Robert , Anastasiou, Costas Anastasios , Malik, Rainer , Parveen, Kayenat, Mihova, Kalina Yonkova , Weber, Heike , Kochen, Silvia , Saenz, Aldo, Kohler, Matias, Novack, Gisela Vanina , Tagliavini, Fabrizio , Nielsen, Sune Fallgaard, Fenoglio, Chiara , Biessels, Geert Jan , Love, Seth , Broeckhoven, Christine Van , Rubinsztein, David Chaim , Teipel, Stefan Johannes , Deramecourt, Vincent , Martínez-Larrad, María Teresa, Ghanbari, Mohsen , Mather, Karen A. , Ikram, M. 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Pérez, Periñán, María Teresa , Rodrigo, S, Valero, S, Vigo-Ortega, R, Vivancos, L. , Shadrin, Alexey A, Bahrami, Shahram , Rongve, Arvid, Athanasiu, Lavinia, Selnes, Per , Bergh, Sverre , Aarsland, Dag, Andreassen, Ole A., Tzourio, Christophe , Brice, Alexis , Ritchie, Karen , Sims, Rebecca, Gerrish, Amy, Williams, Amy, Meggy, Alun, Nash, William, Castillo-Morales, Atahualpa , Hoffmann, Per, Turton, James , Lord, Jenny , Vardy, Emma , Fisher, Elizabeth , Warren, Jason D. , Schott, Jonathan M., Rossor, Martin, Guerreiro, Rita , Al-Chalabi, Ammar, Bass, Nick, Abraham, Richard, Heun, Reinhard , Todd, Stephen, Proitsi, Petra, Hodges, Angela , Becker, Tim , Lawlor, Brian, McQuillin, Andrew, Hardy, John, Brayne, Carol, Deloukas, Panagiotis, Ben‐Shlomo, Yoav , Hooper, Nigel M. , Pickering‐Brown, Stuart , Warner, Nick, Bayer, Anthony, Singleton, Andrew , Rujescu, Dan, Giegling, Ina, Heuser, Isabella , Drichel, Dmitriy , Nöthen, Markus M. , Riemenschneider, Matthias, Gu, Wei , Scherer, Martin, Moebus, Susanne, Morris, John C. , Owen, Michael J. , Escott-Price, Valentina, Chew, Elaine Guo Yan , Chung, Sun Ju , Chao, Yinxia , Ahmad‐Annuar, Azlina , Chen, Yongping , Jiang, Lulu , Lim, Jia Lun , Liu, Chun‐Feng , Mao, Chengjie , Mok, Vincent , Pei, Zhong , Shang, Huifang , Tan, Ai Huey , Xu, Renshi , Zhang, Bao Rong, Koh, Woon‐Puay , Lim, Shen‐Yang , Khor, Chiea Chuen , Liu, Jianjun
Proceedings of the National Academy of Sciences | August 29, 2023 | Volume: 120 | Issue: 36 | Pages: No page available
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1 *04 subtypes best accounted for the association, strongest with HLA-DRB1 *04:04 and HLA-DRB1 *04:07, and intermediary with HLA-DRB1 *04:01 and HLA-DRB1 *04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1 *04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1 *04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues.
A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers
Zhang, Ming , Ferrari, Raffaele, Tartaglia, Maria Carmela , Keith, Julia , Surace, Ezequiel , Wolf, Uri, Sato, Christine , Grinberg, Mark, Liang, Yan , Xi, Zhengrui, Dupont, Kyle, McGoldrick, Philip, Weichert, Anna , McKeever, Paul M. , Schneider, Raphaël , McCorkindale, Michael D, Manzoni, Claudia , Rademakers, Rosa , Graff, Caroline , Parisi, Joseph E., Petersen, Ronald C., Miller, Bruce L. , Rooij, Jeroen van , Pijnenburg, Yolande A.L. , Zee, Julie van der, Broeckhoven, Christine Van , Ber, Isabelle Le , Deerlin, Vivianna Van, Suh, EunRan , Rohrer, Jonathan D. , Mead, Simon , Öijerstedt, Linn , Pickering‐Brown, Stuart , Rollinson, Sara, Rossi, Giacomina , Tagliavini, Fabrizio , Brooks, William S. , Dobson‐Stone, Carol , Halliday, Glenda M. , Hodges, John R. , Piguet, Olivier , Binetti, Giuliano , Benussi, Luisa , Ghidoni, Roberta , Sorbi, Sandro , Bruni, Amalia C. , Galimberti, Daniela , Rainero, Innocenzo , Rubino, Elisa , Lleó, Alberto, Ruiz, Agustı́n , Hernández, Isabel, Pástor, Pau , Díez-Fairén, Mónica , Borroni, Barbara , Pasquier, Florence , Deramecourt, Vincent , Lebouvier, Thibaud , Perneczky, Robert , Diehl‐Schmid, Janine , Huey, Edward D. , Mayeux, Richard , Nalls, Michael A., Hernandez, Dena G., Singleton, Andrew B., Momeni, Parastoo, Zeng, Zhen , Hardy, John , Zinman, Lorne , Nalls, Michael A., Ramasamy, Adaikalavan , Hodges, John R. , Bartley, Lauren, Hernández, Isabel, Boada, Merçé , Padovani, Alessandro , Cairns, Nigel J. , Serpente, María , Scarpini, Elio, Blesa, Rafael , ouml, Maria Landqvist Wald, Nilsson, Karin , Mackenzie, Ian R. , Hsiung, Ging‐Yuek Robin , Attems, Johannes , Pietrini, Pietro , Baborie, Atik, Jaros, Evelyn, Tierney, Michael C, Razquín, Cristina , Ortega‐Cubero, Sara , Alonso, Elena, Alexopoulos, Panagiotis , Kurz, Alexander , Pinessi, Lorenzo , Rogaeva, Ekaterina, Giaccone, Giorgio , Rowe, James B. , Uphill, James, Collinge, John, Danek, Adrian , Deerlin, Vivianna M Van, Grossman, Murray, Trojanowski, John Q. , Leber, Isabelle, Hannequin, Didier , Golfier, Véronique, Vercelletto, Martine, Brice, Alexis , Nacmias, Benedetta, Bagnoli, Silvia , Hjermind, Lena E. , Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Gasparoni, Gilles, Pichler, Sabrina, Fox, Nick C. , Warren, Jason D. , Spillantini, Maria Grazia , Rizzu, Patrizia , Heutink, Peter , Snowden, Julie S. , Richardson, Anna , Maletta, Raffaele , Frangipane, Francesca, Bernardi, Livia , Conidi, Maria Elena, Smirne, Nicoletta , Rademakers, Rosa, Baker, Matt , Petersen, Ronald , Knopman, David, Josephs, Keith A. , Miller, Bruce L., Karydas, Anna M., Rosen, Howard J., Scheltens, Philip , Logroscino, Giancarlo , Capozzo, Rosa , Novelli, Valeria , Franceschi, M. , Postiglione, Alfredo, Milan, Graziella , Sorrentino, Paolo, Kristiansen, Mark, Chiang, Huei-Hsin, Rollin, Adeline, Deramecourt, Vincent, Kapogiannis, Dimitrios , Waldö, Maria Landqvist , Halliday, Glenda , Logroscino, Giancarlo , Rowe, James B , Hsiung, Gink-Yuek , Miller, Bruce L , Hardy, John , Scheltens, Philip , Rohrer, Jonathan D , Fox, Nick C , Padovani, Alessandro , Ruiz, Agustín , Pastor, Pau , Boada, Merce , Tartaglia, Maria Carmela , Pasquier, Florence , Brooks, William , McGoldrick, Philip , McCorkindale, Michael , Dickson, Dennis W. , Boeve, Bradley F. , Seeley, William W. , Swieten, John C. van , Zee, Julie van der , Deerlin, Vivianna M. Van , Nacmias, Benedetta , Scarpini, Elio , Clarimón, Jordi , Lleó, Alberto , Grafman, Jordan Henry , Robertson, Janice , Rogaeva, Ekaterina A. , Kwok, John B. , Schofield, Peter R. , Thompson, Elizabeth A. , Cruchaga, Carlos , Forloni, Gianluigi , Albani, Diego , Fenoglio, Chiara , Nilsson, Christer, Mann, David , Morris, Christopher M. , Griffiths, Timothy David , McKeith, Ian G. , Thomas, Alan , Wassermann, Eric M. , Tierney, Michael C, George‐Hyslop, Peter St , Schlachetzki, Johannes C. M. , Cappa, Stefano F. , Piaceri, Irene , Nielsen, Jørgen Erik , Riemenschneider, Markus J. , Gu, Wei , Rossor, Martin N. , Morris, Huw R. , Gerhard, Alexander , Cupidi, Chiara , Anfossi, Maria , Gallo, Maura , Dopper, Elise G.P. , Seelaar, Harro , Puca, Annibale Alessandro , Franceschi, Massimo, Chiang, Huei‐Hsin, Ferrucci, Luigi , Brice, Alexis , Rainero, Innocenzo , Galimberti, Daniela , Pijnenburg, Yolande A L , Lebouvier, Thibaud , Graff, Caroline , Borroni, Barbara
Brain | August 31, 2018 | Volume: 141 | Issue: 10 | Pages: 2895-2907