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Boxerman, Jerrold L

0000-0002-0594-1542

Mayo Clinic

Rhode Island Hospital and Alpert Medical School of Brown University, Department of Diagnostic Imaging, Providence, Rhode Island, United States.

Citations 3

The QIBA Profile for Dynamic Susceptibility Contrast MRI Quantitative Imaging Biomarkers for Assessing Gliomas
Shiroishi, Mark S. , Erickson, Bradley J. , Hu, Leland , Barboriak, Daniel P. , Becerra, Lino , Bell, Laura C. , Boss, Michael A. , Boxerman, Jerrold L. , Cen, Steven , Cimino, Lisa , Fan, Zhaoyang , Kirsch, John E. , Ameli, N. O. , Nazemi, Sina , Quarles, C. Chad , Rosen, Mark A. , Rodríguez, Luis Salvador, Zahlmann, Gudrun , Obuchowski, Nancy A. , Wu, Ona , Hu, Leland S., Chakhoyan, Ararat , Graaf, Wolter de, Dhakal, Kiran , Erickson, Bradley J., Kadbi, Mo , Quarles, Christopher Chad, Rodríguez, Luis G. , Rosen, Mark, Hu, Leland S , Keenan, Kathryn E , Kirsch, John E , Ameli, Nima , Nazemi, Sina , Quarles, C Chad , Rosen, Mark A , Rodriguez, Luis , Schmainda, Kathleen M , Zahlmann, Gudrun , Zhou, Yuxiang , Obuchowski, Nancy , Wu, Ona , Boxerman, Jerrold L , Boss, Michael A , Erickson, Bradley J , Barboriak, Daniel P , Bell, Laura C , Keenan, Kathryn E. , Zhou, Yuxiang , Hu, Leland S., Conte, Gian Marco , Ellingson, Benjamin M. , Emblem, Kyrre E , Erickson, Bradley J., Quarles, Christopher Chad

Radiology | December 10, 2024 | Volume: 313 | Issue: 3 | Pages: No page available

10.1148/radiol.232555 Get It

The Quantitative Imaging Biomarkers Alliance Profile for dynamic susceptibility contrast (DSC) MRI and its longitudinal claims for the precision of a DSC MRI–derived quantitative imaging biomarker to assess the relative cerebral blood volume changes in gliomas are summarized.
Consensus recommendations for a dynamic susceptibility contrast MRI protocol for use in high-grade gliomas
Boxerman, Jerrold L. , Quarles, C. Chad , Hu, Leland , Gerstner, Elizabeth R. , Smits, Marion , Barboriak, Daniel P. , Huang, Raymond, Wick, Wolfgang , Weller, Michael , Kalpathy–Cramer, Jayashree , Shankar, Lalitha , Jacobs, Paula , Chung, Caroline , Bent, Martin J. van den , Chang, Susan M. , Yung, Wai Kuen, Wen, Patrick Y. , Rosen, Bruce R. , Arons, David F., Kingston, Ann E, Sandak, David, Wallace, M. Z., Musella, Al , Haynes, Chas, Weller, Michael , van den Bent, Martin J , Boxerman, Jerrold L , Wick, Wolfgang , Smits, Marion , Barboriak, Daniel P , Erickson, Bradley J. , Kaufmann, Timothy J. , Galanis, Evanthia , Chang, Susan Marina , Yung, W K Al, Cloughesy, Timothy F. , Wen, Patrick Yung , Gilbert, Mark R. , Ellingson, Benjamin M. , Schmainda, Kathleen M

Neuro-Oncology | June 3, 2020 | Volume: 22 | Issue: 9 | Pages: 1262-1275

10.1093/neuonc/noaa141 Get It

Abstract Despite the widespread clinical use of dynamic susceptibility contrast (DSC) MRI, DSC-MRI methodology has not been standardized, hindering its utilization for response assessment in multicenter trials. Recently, the DSC-MRI Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition issued an updated consensus DSC-MRI protocol compatible with the standardized brain tumor imaging protocol (BTIP) for high-grade gliomas that is increasingly used in the clinical setting and is the default MRI protocol for the National Clinical Trials Network. After reviewing the basis for controversy over DSC-MRI protocols, this paper provides evidence-based best practices for clinical DSC-MRI as determined by the Committee, including pulse sequence (gradient echo vs spin echo), BTIP-compliant contrast agent dosing (preload and bolus), flip angle (FA), echo time (TE), and post-processing leakage correction. In summary, full-dose preload, full-dose bolus dosing using intermediate (60°) FA and field strength-dependent TE (40–50 ms at 1.5 T, 20–35 ms at 3 T) provides overall best accuracy and precision for cerebral blood volume estimates. When single-dose contrast agent usage is desired, no-preload, full-dose bolus dosing using low FA (30°) and field strength-dependent TE provides excellent performance, with reduced contrast agent usage and elimination of potential systematic errors introduced by variations in preload dose and incubation time.