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Ghetti, Bernardino

https://orcid.org/0000-0002-1842-8019

Mayo Clinic

Indiana University Indianapolis

Citations 75

P3‐009: PSEN1 M233V MUTATION CAUSES VERY EARLY ONSET ALZHEIMER DISEASE: THE IMPORTANCE OF NEUROPATHOLOGIC ARCHIVAL TISSUE
Ilangovan, Saroja, Reyes, Marc G., Oblak, Adrian L. , Epperson, Francine, Murrell, Jill R. , Ghetti, Bernardino , Dickson, Dennis W.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2014.05.1096 Get It

Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease
Benzinger, Tammie L.S. , Blazey, Tyler , Xiong, Chengjie , Raichle, Marcus E. , Ances, Beau M. , Bateman, Randall J. , Cairns, Nigel J., Fagan, Anne M. , Goate, Alison , Marcus, Daniel S. , Aisen, Paul, Christensen, Jon, Ercole, Lindsay, Hornbeck, Russ C. , Farrar, Angela, Aldea, Patricia, Jasielec, Mateusz S., Owen, Christopher J. , Xie, Xianyun, Mayeux, Richard , Klunk, William E. , Mathis, Chester A. , Ringman, John M. , Thompson, Paul M. , Saykin, Andrew J. , Johnson, Keith A. , Salloway, Stephen , Correia, Stephen , Schofield, Peter R. , Masters, Colin L. , Villemagne, Victor L. , Martins, Ralph N. , Ourselin, Sébastien , Rossor, Martin N. , Fox, Nick C. , Cash, David M. , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Morris, John C. , Jack, Clifford R. , Koeppe, Robert A. , Su, Yi , Xiong, Chengjie , Snyder, Abraham Z. , Brickman, Adam M. , McDade, Eric , Ghetti, Bernardino , Sperling, Reisa Anne , Rowe, Christopher Cleon , Holtzman, David M. , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Ances, Beau M , Fox, Nick C , Morris, John C , Cash, David M , Goate, Alison M

Proceedings of the National Academy of Sciences | November 5, 2013 | Volume: 110 | Issue: 47 | Pages: No page available

10.1073/pnas.1317918110 Get It

Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering of these biomarkers prior to dementia remains untested. In a cohort with Alzheimer’s disease mutations, we performed an integrated whole-brain analysis of three major imaging techniques: amyloid PET, [ 18 F]fluro-deoxyglucose PET, and structural MRI. We found that most gray-matter structures with amyloid plaques later have hypometabolism followed by atrophy. Critically, however, not all regions lose metabolic function, and not all regions atrophy, even when there is significant amyloid deposition. These regional disparities have important implications for clinical trials of disease-modifying therapies.
P3–008: Genome‐wide analysis of genetic variants associated with depressive symptoms in older adults
Mackin, Scott, Aisen, Paul, Petersen, Ronald, Weiner, Michael W. , Farlow, Martin R. , Gao, Sujuan , Nho, Kwangsik T. , Swaminathan, Shanker , Kim, Sungeun , Risacher, Shannon L. , Ramanan, Vijay K. , Shen, Li , McDonald, Brenna C. , Ghetti, Bernardino , Saykin, Andrew J. , Green, Robert C.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_14 | Pages: No page available

10.1016/j.jalz.2013.05.1077 Get It