Mayo Clinic - AuthorCitation

Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers

Gordon, Brian A. , Blazey, Tyler , Christensen, Jon, Dincer, Aylin , Flores, Shaney , Keefe, Sarah , Wang, Guoqiao , Hassenstab, Jason , Aschenbrenner, Andrew J. , Hornbeck, Russ C. , Jack, Clifford R. , Berman, Sarah , Brosch, Jared R. , Gauthier, Serge , Dyck, Christopher H. van , Mintun, Mark A., Klein, Gregory , Cairns, Nigel J., Marcus, Daniel S. , Raichle, Marcus E. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Jack, Clifford R , Gordon, Brian A , Bateman, Randall J , Chen, Charles D , Benzinger, Tammie L S , Hassenstab, Jason , Morris, John C , Aschenbrenner, Andrew J , Chen, Charles , Su, Yi , McDade, Eric , Li, Yan , Ances, Beau M. , Galasko, Douglas , Lah, James J. , Masellis, Mario , Ristic, Smiljana, Xiong, Chengjie , Holtzman, David M. , Berman, Sarah

Brain | January 29, 2019 | Volume: 142 | Issue: 4 | Pages: 1063-1076

10.1093/brain/awz019

O3‐13‐03: THE RELATIONSHIP BETWEEN TAU PET AND OTHER AD BIOMARKERS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE

Christensen, Jon, Dincer, Aylin , Keefe, Sarah , Wang, Guoqiao , Raichle, Marcus E. , Koeppe, Bob, Network, Dominantly Inherited Alzheimer's, Gordon, Brian A. , Blazey, Tyler , Flores, Shaney , McDade, Eric , Jack, Clifford R. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer's

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_19 | Pages: No page available

10.1016/j.jalz.2018.06.2845

IC‐P‐204: THE RELATIONSHIP BETWEEN TAU PET AND OTHER AD BIOMARKERS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE

Christensen, Jon, Dincer, Aylin , Keefe, Sarah , Wang, Guoqiao , Raichle, Marcus E. , Koeppe, Bob, Network, Dominantly Inherited Alzheimer's, Gordon, Brian A. , Blazey, Tyler , Flores, Shaney , McDade, Eric , Jack, Clifford R. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer's

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2018.06.2271

[O1–02–03]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: FINDINGS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK

Dincer, Aylin , Christensen, Jon, Cairns, Nigel J., Fagan, Anne M. , Marcus, Daniel S. , Hornbeck, Russ C. , Paumier, Katrina L. , Raichle, Marcus E. , Gordon, Brian A. , Blazey, Tyler , Su, Yi , Hari‐Raj, Amrita , Flores, Shaney , McDade, Eric , Wang, Guoqiao , Xiong, Chengjie , Hassenstab, Jason , Jack, Clifford R. , Koeppe, Robert A. , Ances, Beau M. , Holtzman, David M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2017.07.041

[IC‐P‐054]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: RESULTS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK

Hari‐Raj, Amrita , Dincer, Aylin , Christensen, Jon, Wang, Guoqiao , Cairns, Nigel J. , Fagan, Anne M. , Marcus, Daniel S., Hornbeck, Russ C. , Paumier, Katrina L. , Raichle, Marcus E. , Gordon, Brian A. , Blazey, Tyler , Su, Yi , Flores, Shaney , McDade, Eric , Xiong, Chengjie , Hassenstab, Jason , Jack, Clifford R. , Koeppe, Robert A. , Ances, Beau M. , Holtzman, David M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2017.06.2327

Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease

Benzinger, Tammie L.S. , Blazey, Tyler , Xiong, Chengjie , Raichle, Marcus E. , Ances, Beau M. , Bateman, Randall J. , Cairns, Nigel J., Fagan, Anne M. , Goate, Alison , Marcus, Daniel S. , Aisen, Paul, Christensen, Jon, Ercole, Lindsay, Hornbeck, Russ C. , Farrar, Angela, Aldea, Patricia, Jasielec, Mateusz S., Owen, Christopher J. , Xie, Xianyun, Mayeux, Richard , Klunk, William E. , Mathis, Chester A. , Ringman, John M. , Thompson, Paul M. , Saykin, Andrew J. , Johnson, Keith A. , Salloway, Stephen , Correia, Stephen , Schofield, Peter R. , Masters, Colin L. , Villemagne, Victor L. , Martins, Ralph N. , Ourselin, Sébastien , Rossor, Martin N. , Fox, Nick C. , Cash, David M. , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Morris, John C. , Jack, Clifford R. , Koeppe, Robert A. , Su, Yi , Xiong, Chengjie , Snyder, Abraham Z. , Brickman, Adam M. , McDade, Eric , Ghetti, Bernardino , Sperling, Reisa Anne , Rowe, Christopher Cleon , Holtzman, David M. , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Ances, Beau M , Fox, Nick C , Morris, John C , Cash, David M , Goate, Alison M

Proceedings of the National Academy of Sciences | November 5, 2013 | Volume: 110 | Issue: 47 | Pages: No page available

10.1073/pnas.1317918110

Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering of these biomarkers prior to dementia remains untested. In a cohort with Alzheimer’s disease mutations, we performed an integrated whole-brain analysis of three major imaging techniques: amyloid PET, [ 18 F]fluro-deoxyglucose PET, and structural MRI. We found that most gray-matter structures with amyloid plaques later have hypometabolism followed by atrophy. Critically, however, not all regions lose metabolic function, and not all regions atrophy, even when there is significant amyloid deposition. These regional disparities have important implications for clinical trials of disease-modifying therapies.