Mayo Clinic - AuthorCitation

MOLECULAR CLASSIFICATION OF PRIMARY MEDIASTINAL LARGE B CELL LYMPHOMA USING FORMALIN‐FIXED, PARAFFIN‐EMBEDDED TISSUE SPECIMENS – AN LLMPP PROJECT

Rosenwald, Andreas , Ott, German , Ramsower, Colleen , Braziel, Rita M., Weisenburger, Dennis D. , Chan, John, Cook, James R. , Fu, Kai , Greiner, Timothy C. , Smeland, Erlend B., Glinsmann‐Gibson, Betty, Gascoyne, Randy D. , Staudt, Louis M. , Mottok, Anja , Wright, George W. , Campo, Elı́as , Delabie, Jan , Song, Joo Y. , Chan, J.W., Holte, Harald , Jaffe, Elaine S. , Connors, Joseph M. , Scott, David W. , Steidl, Christian , Rimsza, Lisa M.

Hematological Oncology | June 7, 2017 | Volume: 35 | Issue: S2 | Pages: 59-60

What to do when you question cardiac troponin values

Mair, Johannes , Huber, Kurt , Möckel, Martin , Thygesen, Kristian , Jaffe, Allan S. , Lindahl, Bertil , Giannitsis, Evangelos , Plebani, Mario , Jaffe, Allan S. , Huber, Kurt , Mockel, Martin

European Heart Journal: Acute Cardiovascular Care | May 9, 2017 | Volume: 7 | Issue: 6 | Pages: 577-586

10.1177/2048872617708973 | PMID 28485179

High-sensitivity cardiac troponin assays enable cardiac troponin measurement with a high degree of analytical sensitivity and a low level of analytical imprecision at the low measuring range. One of the most important advantages of these new assays is that they allow novel, more rapid approaches for ruling in or ruling out acute myocardial infarctions. The increase in the early diagnostic sensitivity of high-sensitivity cardiac troponin assays comes at the cost of a reduced acute myocardial infarction specificity of the biomarker, because more patients with other causes of acute or chronic myocardial injury without overt myocardial ischaemia are detected than with previous cardiac troponin assays. Increased troponin concentrations that do not fit with the clinical presentation are seen in the daily routine, mainly as a result of a variety of pathologies, and if tested in the same sample, even discrepancies between high-sensitivity cardiac troponin I and troponin T test results may sometimes be found as well. In addition, analytically false-positive test results occasionally may occur since no assay is perfect. In this review, we summarise the biochemical, pathophysiological and analytical background of the work-up for such a clinical setting.

Using Biomarkers to Guide Heart Failure Therapy

Jaffe, Allan S. , Jaffe, Allan S. , Januzzi, James Louis

Clinical Chemistry | April 28, 2017 | Volume: 63 | Issue: 5 | Pages: 954-957

10.1373/clinchem.2016.266106 | PMID 28280051

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

McConnell, Michael J. , Moran, John V. , Abyzov, Alexej , Akbarian, Schahram , Bae, Taejeong , Cortés‐Ciriano, Isidro , Erwin, Jennifer A. , Fasching, Liana , Flasch, Diane A. , Freed, Donald , Ganz, Javier , Jaffe, Andrew E. , Kwon, Min‐Seok , Lodato, Michael A. , Mills, Ryan E. , Paquola, Apuã C.M. , Rodin, Rachel E. , Rosenbluh, Chaggai , Šestan, Nenad , Sherman, Maxwell A. , Shin, Joo Heon , Song, Saera , Straub, Richard E. , Thorpe, Jeremy , Weinberger, Daniel R. , Urban, Alexander E. , Zhou, Bo , Lehner, Thomas , Senthil, Geetha , Chess, Andrew , Courchesne, Eric , Gleeson, Joseph G. , Kidd, Jeffrey M. , Park, Peter J., Pevsner, Jonathan , Vaccarino, Flora M. , Network, Brain Somatic Mosaicism, Bekiranov, Stefan , Bohrson, Craig L. , Burbulis, Ian , Chronister, William D., Coppola, Gianfilippo , Daily, Kenneth , D’Gama, Alissa M. , Emery, Sarah B., Frisbie, Trenton J., Gao, Tianliuyun , Gulyás-Kovács, Attila, Haakenson, Mark F., Keil, Jason M. , Lam, Mandy M. , Mathern, Gary W. , Omberg, Larsson , Peters, Mette A. , Pochareddy, Sirisha , Pramparo, Tiziano , Sanavia, Tiziana , Wang, Meiyan , Wierman, Margaret E. , Wolpert, Matthew J., Woodworth, Mollie B. , Zhao, Xuefang , Zhou, Weichen , Kwan, Kenneth Y , Lodato, Michael A , Mills, Ryan E , Paquola, Apua C M , Rodin, Rachel E , Rosenbluh, Chaggai , Sestan, Nenad , Shin, Joo Heon , Song, Saera , Straub, Richard E , Urban, Alexander E , Zhou, Bo , Gage, Fred H , Lehner, Thomas , Senthil, Geetha , Chess, Andrew , Courchesne, Eric , Kidd, Jeffrey M , Pevsner, Jonathan , Vaccarino, Flora M , McConnell, Michael J. , Walsh, Christopher A. , Gleeson, Joseph G. , Network, Brain Somatic Mosaicism, Barton, Alison R. , Kopera, Huira C. , Lee, Eunjung A , Marquès‐Bonet, Tomàs , Moldovan, John B. , Oetjens, Matthew T. , Ratan, Aakrosh , Shi, Lei , Škarica, Mario , Wang, Jia , Wang, Yifan , Abyzov, Alexej , Bae, Taejeong , Akbarian, Schahram

Science | April 27, 2017 | Volume: 356 | Issue: 6336 | Pages: No page available

10.1126/science.aal1641 | PMID 28450582

Single-cell diversity in the brain The cells that make up an organism may all start from one genome, but somatic mutations mean that somewhere along the line of development, an organism's individual cellular genomes diverge. McConnell et al. review the implications and causes of single-cell genomic diversity for brain function. Somatic mutations caused by mobile genetic elements or errors in DNA repair may underlie certain neuropsychiatric disorders. Science , this issue p. eaal1641

Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery

Biccard, Bruce , Sigamani, Alben , Chan, Matthew T.V. , Srinathan, Sadeesh, Abraham, Valsa , Pearse, Rupert M. , Wang, C. Y., Kurz, Andrea , Szczeklik, Wojciech , Berwanger, Otávio , Villar, Juan Carlos , Málaga, Germán , Garg, Amit X. , Chow, Clara K , Ackland, Gareth L. , Duceppe, Emmanuelle , Spence, Jessica , Tandon, Vikas , Sapsford, Robert J., Polanczyk, Carísi Anne , Tiboni, Maria , Alonso‐Coello, Pablo , Faruqui, Atiya R. , Heels‐Ansdell, Diane , Whitlock, Richard , LeManach, Yannick, Roshanov, Pavel S , McGillion, Michael , Kavsak, Peter A. , McQueen, Matthew, Thabane, Lehana , Rodseth, Reitze , Buse, Giovanna Lurati , Bhandari, Mohit , Garutti, Ignacia, Jacka, Michael J. , Schünemann, Holger J. , Cortés, Olga , Coriat, Pierre, Dvirnik, Nazari , Botto, Fernando , Pettit, Shirley , Jaffe, Allan S. , Sultan, Pervez , Devereaux, P.J. , Xavier, Denis , Walsh, Michael , Sessler, Daniel I. , Patel, Ameen , Borges, Flávia K. , Belley‐Côté, Emilie P. , Williams, Colin, Lamy, Andre L. , Garutti, Ignacio , Jaffe, Allan S. , Guyatt, Gordon , Schünemann, Holger J , Thabane, Lehana , Whitlock, Richard , Alonso-Coello, Pablo

JAMA | April 25, 2017 | Volume: 317 | Issue: 16 | Pages: 1642

10.1001/jama.2017.4360 | PMID 28444280

In Reply

Apple, Fred S. , Sandoval, Yader , Jaffe, Allan S. , Jaffe, Allan S.

Clinical Chemistry | April 20, 2017 | Volume: 63 | Issue: 6 | Pages: 1167-1170

10.1373/clinchem.2017.273250 | PMID 28428359

Effect of Repeat Measurements of High-Sensitivity Cardiac Troponin on the Same Sample Using the European Society of Cardiology 0-Hour/1-Hour or 2-Hour Algorithms for Early Rule-Out and Rule-In for Myocardial Infarction

Kavsak, Peter A. , Clark, Lorna , Jaffe, Allan S. , Jaffe, Allan S.

Clinical Chemistry | April 20, 2017 | Volume: 63 | Issue: 6 | Pages: 1163-1165

10.1373/clinchem.2017.272914 | PMID 28428358

Total Analytic Error for Low Cardiac Troponin Concentrations (≤10 ng/L) by Use of a High-Sensitivity Cardiac Troponin Assay

Kavsak, Peter A. , Jaffe, Allan S. , Greene, Dina N. , Christenson, Robert H. , Apple, Fred S. , Wu, Alan H.B. , Jaffe, Allan S. , Greene, Dina

Clinical Chemistry | March 21, 2017 | Volume: 63 | Issue: 5 | Pages: 1043-1045

10.1373/clinchem.2017.271361 | PMID 28325814

Interim cardiac safety analysis of NCCTG N9831 Intergroup adjuvant trastuzumab trial

Perez, Edith A. , Davidson, Nancy E. , Martino, Silvana, Dakhil, Shaker R. , Rodeheffer, R.J., Jaffe, Allan S. , Suman, Vera J. , Kaufman, Peter A. , Ingle, James N. , Gersh, Bernard J. , Hillman, David W. , Jaffe, Allan S.

Journal of Clinical Oncology | February 23, 2017 | Volume: 23 | Issue: 16_suppl | Pages: 556-556

10.1200/jco.2005.23.16_suppl.556

International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease

Fajgenbaum, David C. , Bagg, Adam , Frank, Dale , Wu, David , Srkalović, Gordan , Simpson, David , Liu, Amy , Menke, David M. , Lechowicz, Mary Jo , Wong, Raymond , Pierson, Sheila K. , Paessler, Michele, Rossi, Jean‐François, Ide, Makoto , Ruth, Jason R., Croglio, M.P. , Suarez, Alexander , Chadburn, Amy , Colleoni, Gisele W. B. , Jayanthan, Raj , Nabel, Christopher S. , Kelleher, Dermot, Voorhees, Peter M. , Yoshizaki, Kazuyuki , Oksenhendler, Éric , Elenitoba‐Johnson, Kojo S.J. , Lim, Megan S. , Menke, David, Wong, Raymond S M , Uldrick, Thomas S. , Chandrakasan, Shanmuganathan , Rossi, Jean‐François , Krymskaya, Vera P. , Nasta, Sunita , Casper, Corey , Dispenzieri, Angela , Fosså, Alexander , Kurzrock, Razelle , Doǧan, Ahmet , Rhee, Frits van , Jaffe, Elaine S. , Fajgenbaum, David C , Ide, Makoto , Lim, Megan S

Blood | January 13, 2017 | Volume: 129 | Issue: 12 | Pages: 1646-1657

10.1182/blood-2016-10-746933 | PMID 28087540

Key Points An international panel established the first ever diagnostic criteria for iMCD based on review of 244 clinical cases and 88 tissue samples. The criteria require multicentric lymphadenopathy with defined histopathology, ≥2 clinical/laboratory changes, and exclusion of iMCD mimics.

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