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Shin, Alexander Y

0000-0001-9658-8192

Mayo Clinic

Mayo Clinic

Citations 86

Exploring the Utility of Carpal Tunnel Biopsy in Amyloidosis: A Current Perspective
Sullivan, Mikaela H. , Brilla, Maria Alejandra Rodríguez , Shin, Alexander Y. , Rodriguez Brilla, Maria Alejandra , Shin, Alexander Y , Klein, Christopher J.

HAND | November 26, 2024 | Volume: 21 | Issue: 2 | Pages: 211-217

10.1177/15589447241298981 Get It

Recent literature has emphasized the role of hand surgeons in screening patients with carpal tunnel syndrome (CTS) for amyloidosis by performing a carpal tunnel synovial biopsy during open carpal tunnel release (CTR). This has led to misconceptions about the diagnostic utility of synovial biopsy and the clinical evaluation of suspected amyloidosis. Controversy over carpal tunnel biopsy is exacerbated by minimally invasive advances in CTR procedures. This current perspective aims to determine the role of carpal tunnel synovial biopsy in amyloidosis and provide an update for hand surgeons regarding the nuances of amyloidosis. We conclude that carpal tunnel synovial biopsy should not be performed without CTS symptoms but only in patients meeting criteria for open CTR such as in those with severe symptoms which have failed nonoperative treatment and minimally invasive procedures are contraindicated. A screening approach for amyloidosis is proposed in patients presenting with CTS symptoms. Despite advances in the understanding, treatment, and diagnosis of amyloidosis, there remains a need for accurate, specific, and sensitive diagnostic tests.
Treatment Options for Coronal Plane Fractures of the Lunate in Kienböck Disease
Dittman, Lauren E. , Munaretto, Nicholas , Lenartowicz, Karina A. , Shin, Alexander Y. , Moran, Steven L. , Kakar, Sanjeev , Tagliero, Lauren E , Lenartowicz, Karina, Shin, Alexander Y , Bishop, Allen, Kakar, Sanjeev , Munaretto, Nicholas , Bishop, Allen T.

HAND | November 26, 2024 | Volume: 21 | Issue: 1 | Pages: 151-158

10.1177/15589447241298722 Get It

Background: The treatment for Kienböck disease varies widely based on the status of the lunate. To date, there is no consensus regarding the optimal treatment for patients with coronal plane fractures of the lunate, or Lichtman Stage IIIC. Therefore, the purpose of this study was to assess whether coronal plane fractures of the lunate in Kienböck disease healed after surgical intervention, and to determine the outcomes after surgical fixation of the lunate compared with treatment with salvage procedures. Methods: A retrospective review of 36 patients with Lichtman IIIC Kienböck disease was conducted. Patients were classified into lunate reconstruction (vascularized bone graft [VBG] or non-VBG) or salvage procedures (proximal row carpectomy [PRC] or limited fusion). Preoperative and postoperative visual analog scale (VAS) pain, range of motion, grip strength, and Mayo Wrist Score (MWS) were analyzed. Radiographs and computed tomographic scans were reviewed for Lichtman stage, fracture location, union, modified carpal height ratio, Stahl index, and radioscaphoid angle. Results: Thirteen patients underwent lunate reconstruction, 13 underwent limited fusion, and 10 underwent PRC. The overall union rate was 45% after lunate reconstruction, with average time to union of 7 months. There were no differences in union rates between VBG and non-VBG. All 3 groups experienced improvement in their postoperative grip strength and MWS. There were no statistically significant differences in preoperative to postoperative changes in clinical outcome measures between the 3 cohorts; however, when we compared lunate reconstruction with all patients who underwent salvage procedures (limited carpal fusion and PRC), we noted the latter had improved functional outcomes ( P = .019). Four patients (31%) in the reconstruction cohort and 2 patients (8%) in the limited carpal fusion group required reoperation at latest follow-up. Conclusions: Union rate of coronal plane fractures in Kienböck disease remains variable. While the proportion of patients requiring reoperation was higher in the reconstruction group, all groups of patients experienced improvement in their clinical outcomes, without a significant difference between cohorts.
Preoperative Evaluation for Free Functional Muscle Transfer in Upper Extremity Amyoplasia
Sullivan, Mikaela H. , Vilkki, Simo K. , Venkatramani, Hari , Shin, Alexander Y. , Pulos, Nicholas , Shin, Alexander Y , Pulos, Nicholas , Sabapathy, Shanmuganathan Raja

JBJS Case Connector | August 1, 2024 | Volume: 14 | Issue: 3 | Pages: No page available

10.2106/jbjs.cc.24.00038 Get It

Case: A multicenter series of 3 patients with amyoplasia of the upper extremity were indicated for gracilis free functional muscle transfer (FFMT) to restore elbow flexion and found to have an absent gracilis. A final case is discussed detailing standardized evaluation with ultrasound to confirm gracilis before surgical intervention. Conclusion: In amyoplasia, the gracilis muscle may be absent or have fatty infiltration, making this donor muscle inadequate. Preoperative ultrasound to determine the presence of the gracilis is noninvasive and recommended in patients with amyoplasia of the upper extremity being considered for FFMT.
Evaluation of the cutaneous blood supply and vascular territories of the wrist
Alder, Kareme D. , Kattil, Punnose , Lachman, Nirusha , Shin, Alexander Y. , Shin, Alexander Y , Kattil, Punnose K , Meaike, Joshua J. , Pulos, Nicholas

Orthoplastic Surgery | May 30, 2024 | Volume: 16 | Issue: C | Pages: 20-30

10.1016/j.orthop.2024.05.002 Get It

ABSTRACT Purpose: To determine and evaluate the distal forearm and wrist's cutaneous blood supply and vascular territories. Methods: Four cadaveric upper extremities were injected with a radiopaque, lead-based contrast agent through the brachial artery. After the lead-based contrast agent set, the cadaveric limbs underwent computed tomographic (CT) scanning to assess the perforators to the cutaneous skin of the distal forearm and wrist. High-resolution axial CT and three-dimensional reconstructions were generated to highlight perforating vessels stemming from their parent arteries. Subsequently, anatomic microdissections were performed to identify and trace the perforating vessels identified on CT. Results: CT analysis and anatomic microdissection demonstrated that the dorsal surface of the distal forearm and wrist are supplied by numerous perforators stemming predominantly from the anterior interosseous artery with some anastomotic contribution from the posterior interosseous, radial, and ulnar arteries. Perforators from the radial and ulnar arteries supply the volar surface. There are large anastomotic networks formed between the perforating vessels. Conclusions: The distal forearm and wrist have a robust anastomotic blood supply that has contributions from the anterior interosseous, posterior interosseous, radial, and ulnar arteries. Clinical relevance: The extensive perforator-derived blood supply to the skin likely accounts for the excellent soft tissue healing potential of the wrist following surgery utilizing multiple incisions. Highlights Distal radius fractures may require multiple incisions for anatomic reduction and fixation.Multiple incisions about the wrist are thought to predispose to wound complications and/or skin breakdown.The distal forearm and wrist have a robust anastomotic blood supply from the anterior interosseous, posterior interosseous, radial, and ulnar arteries.Multiple incisions do not necessarily predispose to wound complications given robust anastamosis.
Evaluating the Ability of Brachial Plexus-Injured Patients to Control an Externally Powered (Myoelectric) Hand Prosthesis
Lee, Ellen Y. , NELSON, A. WENDELL , Sampson, Brandon P. , Smither, F. Clay , Pulos, Nicholas , Bishop, Allen T. , Spinner, Robert J. , Shin, Alexander Y. , Shin, Alexander Y , Bishop, Allen T , Pulos, Nicholas

Journal of Bone and Joint Surgery | May 10, 2024 | Volume: 106 | Issue: 24 | Pages: 2375-2382

10.2106/jbjs.23.00938 Get It

Background: Restoration of hand function after traumatic brachial plexus injury (BPI) remains a formidable challenge. Traditional methods such as nerve or free muscle transfers yield suboptimal results. Advancements in myoelectric prostheses, characterized by novel signal acquisition and improved material technology, show promise in restoring functional grasp. This study evaluated the ability of adults with a BPI injury to control an externally powered prosthetic hand using nonintuitive signals, simulating the restoration of grasp with a myoelectric prosthesis. It also assessed the effectiveness of a comprehensive multidisciplinary evaluation in guiding treatment decisions. Methods: A multidisciplinary brachial plexus team assessed adults with compromised hand function due to BPI. The feasibility of amputation coupled with fitting of a myoelectric prosthesis for grasp reconstruction was evaluated. Participants' ability to control a virtual or model prosthetic hand using surface electromyography (EMG) as well as with contralateral shoulder motion-activated linear transducer signals was tested. The patient’s input and injury type, along with the information from the prosthetic evaluation, were used to determine the reconstructive plan. The study also reviewed the number of participants opting for amputation and a myoelectric prosthetic hand for grasp restoration, and a follow-up survey was conducted to assess the impact of the initial evaluation on decision-making. Results: Of 58 subjects evaluated, 47 (81%) had pan-plexus BPI and 42 (72%) received their initial assessment within 1 year post-injury. Forty-seven patients (81%) could control the virtual or model prosthetic hand using nonintuitive surface EMG signals, and all 58 could control it with contralateral uniscapular motion via a linear transducer and harness. Thirty patients (52%) chose and pursued amputation, and 20 (34%) actively used a myoelectric prosthesis for grasp. The initial evaluation was informative and beneficial for the majority of the patients, especially in demonstrating the functionality of the myoelectric prosthesis. Conclusions: The study indicates that adults with traumatic BPI can effectively operate a virtual or model myoelectric prosthesis using nonintuitive control signals. The simulation and multidisciplinary evaluation influenced informed treatment choices, with a high percentage of patients continuing to use the myoelectric prostheses post-amputation, highlighting its long-term acceptance and viability. Level of Evidence: Therapeutic Level IV . See Instructions for Authors for a complete description of levels of evidence.
Design and Development of a Powered Myoelectric Elbow Orthosis for Neuromuscular Injuries
Vignola, Claudio, Bhat, Sandesh G. , Hollander, Kevin W., Kane, Paul H., Miller, Emily J. , Martin, W. Brandon , Shin, Alexander Y. , Sugar, Thomas G. , Kane, Paul, Miller, Emily , Kaufman, Kenton R , Shin, Alexander Y , Bhat, Sandesh G , Kaufman, Kenton R.

Military Medicine | April 3, 2024 | Volume: 189 | Issue: Supplement_3 | Pages: 585-591

10.1093/milmed/usae196 Get It

ABSTRACT Introduction Recovering from neuromuscular injuries or conditions can be a challenging journey that involves complex surgeries and extensive physical rehabilitation. During this process, individuals often rely on orthotic devices to support and enable movement of the affected limb. However, users have criticized current commercially available powered orthotic devices for their bulky and heavy design. To address these limitations, we developed a novel powered myoelectric elbow orthosis. Materials and Methods The orthosis incorporates 3 mechanisms: a solenoid brake, a Bowden cable-powered constant torque elbow mechanism, and an extension limiter. The device controller and battery are in a backpack to reduce the weight on the affected arm. We performed extensive calculations and testing to ensure that the orthosis could withstand at least 15 Nm of elbow torque. We developed a custom software effectively control the orthosis, enhancing its usability and functionality. A certified orthotist fitted a subject who had undergone a gracilis free functioning muscle transfer surgery with the device. We studied the subject under Mayo clinic IRB no. 20-006849 and obtained objective measurements to assess the orthosis’s impact on upper extremity functionality during daily activities. Results The results are promising since the orthosis significantly improved elbow flexion range of motion by 40° and reduced compensatory movements at the shoulder (humerothoracic joint) by 50°. Additionally, the subject was able to perform tasks which were not possible before, such as carrying a basket with weights, highlighting the enhanced functionality provided by the orthosis. Conclusion In brief, by addressing the limitations of existing devices, this novel powered myoelectric elbow orthosis offers individuals with neuromuscular injuries/conditions improved quality of life. Further research will expand the patient population and control mechanisms.
The failed adult traumatic brachial plexus reconstruction
Lee, Ellen Y. , Spinner, Robert J. , Shin, Alexander Y. , Shin, Alexander Y , Pulos, Nicholas , Bishop, Allen T.

Journal of Hand Surgery (European Volume) | February 19, 2024 | Volume: 49 | Issue: 11 | Pages: 1298-1312

10.1177/17531934241231170 Get It

Traumatic adult brachial plexus injuries typically cause immediate loss of upper limb function. Timely multidisciplinary treatment in specialized centres often results in a useful helper arm. Both the patient and the surgical team can benefit from an open discussion to set realistic expectations. Surgical reconstruction is customized for each patient, considering their injury factors and functional objectives. Optimizing pain control, adherence to procedure indications and using meticulous surgical techniques help minimize the risk of failing to meet the patient’s goals. The need for potential alternative treatment(s) if the desired result is not achieved should be detailed before the initial reconstruction. This review discusses late treatment options, including tendon transfers, joint fusions, free functioning muscle transfers and prosthetics, for managing the failed primary reconstruction of the traumatic adult brachial plexus.
Global trends and outcomes of nerve transfers for treatment of adult brachial plexus injuries
Crowe, Christopher S. , Spinner, Robert J. , Shin, Alexander Y. , Shin, Alexander Y

Journal of Hand Surgery (European Volume) | February 19, 2024 | Volume: 49 | Issue: 9 | Pages: 1147-1156

10.1177/17531934241232062 Get It

The presentation, management and outcomes of brachial plexus injuries are likely to be subject to regional differences across the globe. A comprehensive literature search was performed to identify relevant articles related to spinal accessory to suprascapular, intercostal to musculocutaneous, and ulnar and/or median nerve fascicle to biceps and/or brachialis motor branch nerve transfers for treatment of brachial plexus injuries. A total of 6007 individual brachial plexus injuries were described with a mean follow-up of 38 months. The specific indication for accessory to suprascapular and intercostal to musculocutaneous transfers were considerably different among regions (e.g. upper plexus vs. pan-plexal), while uniform for fascicular transfer for elbow flexion (e.g. upper plexus +/− C7). Similarly, functional recovery was highly variable for accessory to suprascapular and intercostal to musculocutaneous transfers, while British Medical Research Council grade ≥3 strength after fascicular transfer for elbow flexion was frequently obtained. Overall, differences in outcomes seem to be inherent to the specific transfer being utilized. Level of evidence: III
Complications of operatively treated distal radial fractures
Townsley, Sarah, Shin, Alexander Y. , Townsley, Sarah H. , Shin, Alexander Y , Pulos, Nicholas

Journal of Hand Surgery (European Volume) | February 5, 2024 | Volume: 49 | Issue: 2 | Pages: 215-225

10.1177/17531934231192836 Get It

Distal radial fractures represent the most common fractures of the upper extremity. Operative treatment is performed for approximately one-third of distal radial fractures in the adult population. Complications following operative treatment of distal radial fractures vary depending on the treatment modality and can be stratified into preoperative and postoperative complications. Complications can occur in the near, intermediate and long term. The most common complications seen are tendon irritation and rupture, chronic regional pain syndrome (CRPS), carpal tunnel syndrome, ulnar or radial neuropathy, compartment syndrome, malunion, inadequate fixation or loss of fixation, symptomatic hardware, post-traumatic arthritis, stiffness and infection. Careful planning, treatment and patient selection can help to mitigate these complications. Level of evidence: V
Osteolysis After Augmented Scapholunate Ligament Reconstruction
Lee, Ellen Y. , Shin, Alexander Y. , Shin, Alexander Y

JBJS Case Connector | December 4, 2023 | Volume: 13 | Issue: 4 | Pages: No page available

10.2106/jbjs.cc.23.00285 Get It

Case: Augmented scapholunate ligament reconstruction using polyether ether ketone anchors and ultra-high molecular weight polyethylene synthetic tape has the theoretical advantage of improved stability, avoidance of K-wire fixation, and the potential for earlier mobilization. We present 3 cases of scaphoid and lunate osteolysis/fragmentation, operative and histologic findings at reoperation, and the sequelae of this technique. Conclusion: If planning to use suture anchors and synthetic tapes in small carpal bones, we recommend advising patients about the risk of osteolysis and monitoring closely patients who complain of pain with motion after surgery.