Citations 94
IC‐P‐099: Elevated PiB precedes dementia in autosomal dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort
Raichle, Marcus E. , Marcus, Daniel C. , Ringman, John M. , Salloway, Stephen , Correia, Steve, Johnson, Keith A. , Villemagne, Victor L. , Mayeux, Richard , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Moulder, Krista L., Benzinger, Tammie L.S. , Blazey, Tyler , Koeppe, Robert A. , Jack, Clifford R. , Su, Yi , Snyder, Abraham Z. , Thompson, Paul M. , Ghetti, Bernardino , Saykin, Andrew J. , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Martins, Ralph N. , Mathis, Chester A. , Klunk, William E. , Weiner, Michael D. , Bateman, Randall J. , Goate, Alison , Morris, John C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_2 | Pages: No page available
P4‐154: Progressive white matter abnormalities in autosomal‐dominant Alzheimer's disease: Results of the DIAN study
Koeppe, Robert, Raichle, Marc, Marcus, Daniel, Ringman, John M. , Thompson, Paul , Su, Yi , Salloway, Stephen , Johnson, Keith A. , Correia, Steve, Schofield, Peter , Moulder, Krista L., Buckles, Virginia, Mayeux, Richard , Villemagne, Victor L. , John, Morris, Benzinger, Tammie L.S. , Blazey, Tyler , Jack, Clifford R. , Ances, Beau M. , Snyder, Abraham Z. , Ghetti, Bernardino , Saykin, Andrew J. , Sperling, Reisa Anne , Fox, Nick C. , Rowe, Christopher Cleon , Bateman, Randall J. , Mathis, Chester A. , McDade, Eric , Weiner, Michael W. , Goate, Alison , Masters, Colin L.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_19 | Pages: No page available
O2‐06‐05: A voxel‐based morphometry study of volumetric MRI in familial Alzheimer's disease
Cash, David, Ryan, Natalie S. , Kinnunen, Kirsi M. , Yeatman, Tom, Malone, Ian B. , Raichle, Marc, Marcus, Daniel S., Ringman, John M. , Thompson, Paul , Salloway, Steven, Correia, Stephen , Villemagne, Victor L. , Mayeux, Richard , Fagan, Anne M. , Cairns, Nigel J., Buckles, Virginia, Moulder, Krista L., Ridgway, Gerard R. , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Saykin, Andrew J. , Salloway, Steve , Johnson, Keith J. , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Martins, Ralph N. , Brickman, Adam M. , Weiner, Michael W. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available
P4‐153: Elevated PiB precedes dementia in autosomal‐dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort
Raichle, Marc, Su, Yi , Marcus, Daniel S. , Ringman, John M. , Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Moulder, Krista L., Villemagne, Victor L. , Benzinger, Tammie L.S. , Blazey, Tyler , Koeppe, Robert A. , Jack, Clifford R. , Snyder, Abraham Z. , Johnson, Keith J. , Sperling, Reisa Anne , Thompson, Paul M. , Ghetti, Bernardino , Saykin, Andrew J. , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Martins, Ralph N. , Mathis, Chester A. , Klunk, William E. , Bateman, Randall J. , Goate, Alison , Morris, John C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_19 | Pages: No page available
O2‐06‐02: FDG metabolism in the DIAN study of autosomal dominant Alzheimer's disease
Marcus, Daniel S. , Raichle, Marc, Correia, Stephen , Weiner, Michael W. , Fagan, Anne M. , Buckles, Virginia, Moulder, Krista L., Mayeux, Richard , Cairns, Nigel J. , Ringman, John M. , Salloway, Stephen , Johnson, Keith A. , Becker, John Alex , Koeppe, Robert A. , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Ghetti, Bernardino , Masters, Colin L. , Mathis, Chester A. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Martins, Ralph N. , Morris, John C. , Sperling, Reisa Anne
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available
IC‐P‐020: A voxel‐based morphometry study of volumetric MRI in familial Alzheimer's disease
Ryan, Natalie S. , Yeatman, Tom, Malone, Ian B. , Raichle, Marc, Marcus, Daniel S. , Ringman, John M. , Salloway, Stephen , Correia, Stephen , Johnson, Keith A. , Villemagne, Victor L. , Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Moulder, Krista L., Cash, David M. , Ridgway, Gerard R. , Kinnunen, Kirsi M. , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Martins, Ralph N. , Brickman, Adam M. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_1 | Pages: No page available
O2‐06‐01: Disrupted functional connectivity in autosomal dominant Alzheimer's disease: Preliminary findings from the DIAN study
Chhatwal, Jasmeer P. , Johnson, Keith A. , Salloway, Stephen , Ringman, John M. , Marcus, Daniel S. , Correia, Stephen , Rowe, Christopher C., Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Xiong, Chengjie , Moulder, Krista L., Buckles, Virginia, Schultz, Aaron P. , Benzinger, Tammie L.S. , Jack, Clifford R. , Koeppe, Robert A. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Fox, Nick C. , Brickman, Adam M. , Mathis, Chester A. , Goate, Alison , Masters, Colin L. , Ghetti, Bernardino , Martins, Ralph N. , Bateman, Randall J. , Morris, John C. , Sperling, Reisa Anne
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available
Predicting missing biomarker data in a longitudinal study of Alzheimer disease
Lo, Raymond Y. , Jagust, William J. , Aisen, Paul , Gamst, Anthony, Soares, Holly , Montine, Tom, Thomas, Ronald G. , Walter, Sarah , Felmlee, Joel P. , Schuff, Norbert, Alexander, Gene, DeCarli, Charles , Bandy, Dan, Korecka, Magdalena , Crawford, Karen , Neu, Scott, Kornak, John , Buckholtz, Neil, Dolen, Sara, Schneider, Lon S. , Pawluczyk, Sonia, Spann, Bryan M., Brewer, James, Vanderswag, Helen, Heidebrink, Judith L. , Petersen, Ronald , Johnson, Kris , Doody, Rachelle S., Villanueva‐Meyer, Javier , Chowdhury, Munir , Bell, Karen L. , Mintun, Mark A., Schneider, Stacy, Marson, Daniel , Griffith, Randall, Grossman, Hillel, Marzloff, George, Toledo-Morrell, Leylade, Duara, Ranjan , Varón, Daniel , Roberts, Peggy, Albert, Marilyn S. , Pedroso, Julia, Toroney, Jaimie, Santi, Susan M De, Doraiswamy, P. Murali , Petrella, Jeffrey R. , Aiello, Marilyn, Clark, Christopher M. , Pham, Cassie, Nuñez, Jessica, Smith, Charles D., Given, Curtis A., Hardy, Peter , Oakley, MaryAnn, Simpson, Donna M., Ismail, M. Saleem , Brand, Connie, Richard, Jennifer, Mulnard, Ruth A., Thai, Gaby , Mc-Adams-Ortiz, Catherine, Martin-Cook, Kristen, Devous, Michael D. , Cellar, Janet S., Anderson, Heather S., Laubinger, Mary M., Bartzokis, George, Lu, Po H. , MBBCH, Neill R Graff-Radford, Parfitt, Francine, Farlow, Martin R. , Herring, Scott, Hake, Ann Marie , Dyck, Christopher H. van , MacAvoy, Martha G., Benincasa, Amanda L., Chertkow, Howard, Bergman, Howard , Hosein, Chris, Graham, Simon J. , Caldwell, Curtis, Hsiung, Ging‐Yuek Robin , Assaly, Michele, Kertesz, Andrew, Rogers, John, Trost, Dick, Bernick, Charles , Munic, Donna, Wu, Chuang‐Kuo, Johnson, Nancy , Mesulam, Marsel, Sadowsky, Carl, Villena, Teresa, Turner, Scott, Johnson, Kathleen, Behan, Kelly E., Johnson, Keith A. , Rosen, Allyson , Tinklenberg, Jared, Ashford, Wes, Sabbagh, Marwan N. , Connor, Donald J., Jacobson, Sandra A. , Jayam‐Trouth, Annapurni , Lerner, Alan J. , Hudson, Leon, Ogrocki, Paula, Fletcher, Evan, Kittur, Smita, Mirje, Seema, Borrie, Michael, Lee, T‐Y, Bartha, Dr Rob, Asthana, Sanjay , Carlsson, Cynthia M., Potkin, Steven, Preda, Adrian , Tariot, Pierre N. , Fleisher, Adam , Reeder, Stephanie, Bates, Vernice, Capote, Horacio, Rainka, Michelle, Hendin, Barry , Kataki, Maria , Zimmerman, Earl A. , Celmins, Dzintra, Brown, Alice D., Marenberg, Marjorie E., Rovner, Barry W. , Anderson, Karen, Santulli, Robert B. , Englert, Jessica, Williamson, Jeff D. , Watkins, Franklin, Ott, Brian R. , Cohen, Ronald, Salloway, Stephen , Malloy, Paul, Correia, Stephen , Rosen, Howard J. , Mintzer, Jacobo , Jack, Clifford R. , Toga, Arthur W. , Beckett, Laurel , Green, Robert C. , Donohue, Michael , Dale, Anders M. , Bernstein, Matt A. , Fox, Nick C. , Thompson, Paul M. , Chen, Kewei , Morris, John C. , Lee, Virginia M.‐Y. , Harvey, Danielle , Saykin, Andrew J. , Foroud, Tatiana , Potkin, Steven G. , Shen, Li , Kaye, Jeffrey , Quinn, Joseph F. , Lord, Joanne L. , Stern, Yaakov , Honig, Lawrence S. , Clark, David , Tang, Cheuk Ying , Shah, Raj C. , Duara, Ranjan , Rusinek, Henry , Leon, Mony J. de , López, Oscar L. , Diaz‐Arrastia, Ramon , Levey, Allan I. , Lah, James J. , Burns, Jeffrey M. , Silverman, Daniel H.S. , Johnson, Heather K. , Black, Sandra E. , Feldman, Howard , Martínez, Walter Fabián , Sperling, Reisa Anne , Rentz, Dorene M. , Killiany, Ronald , Norbash, Alexander , Nair, Anil K. , Obisesan, Thomas O. , Wang, Paul C. , Carmichael, Owen , Johnson, Sterling C. , Nguyen, Dana R. , Reeder, Stephanie, Scharre, Douglas W. , Gandy, Sam , Pearlson, Godfrey D. , Sink, Kaycee M. , Miller, Bruce L. , Preda, Adrian , Hsiung, Gink-Yuek
Neurology | April 5, 2012 | Volume: 78 | Issue: 18 | Pages: 1376-1382
Testing the Right Target and Right Drug at the Right Stage
Jack, Clifford R. , Aisen, Paul, Sperling, Reisa Anne , Jack, Clifford R
Science Translational Medicine | December 2, 2011 | Volume: 3 | Issue: 111 | Pages: No page available
Drugs aimed at the initial stages of the Alzheimer’s disease pathology should be tested a decade before the onset of dementia.
Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease
Jack, Clifford R. , Barkhof, Frederik , Bernstein, Matt A. , Cantillon, Marc, Cole, Patricia E., DeCarli, Charles , Dubois, Bruno , Duchesne, Simon , Fox, Nick C. , Frisoni, Giovanni B. , Hampel, Harald , Hill, David , Johnson, Keith A. , Scheltens, Philip , Schwarz, Adam J. , Suhy, Joyce, Thompson, Paul M. , Weiner, Michael W. , Foster, Norman L. , Frisoni, Giovanni B. , Mangin, Jean‐François , Sperling, Reisa Anne , DeCarli, Charles , Bernstein, Matt A , Jack, Clifford R , Thompson, Paul M , Barkhof, Frederik , Scheltens, Philip , Fox, Nick C
Alzheimer's & Dementia | July 25, 2011 | Volume: 7 | Issue: 4 | Pages: 474
BackgroundThe promise of Alzheimer's disease biomarkers has led to their incorporation in new diagnostic criteria and in therapeutic trials; however, significant barriers exist to widespread use. Chief among these is the lack of internationally accepted standards for quantitative metrics. Hippocampal volumetry is the most widely studied quantitative magnetic resonance imaging measure in Alzheimer's disease and thus represents the most rational target for an initial effort at standardization.Methods and ResultsThe authors of this position paper propose a path toward this goal. The steps include the following: (1) Establish and empower an oversight board to manage and assess the effort, (2) adopt the standardized definition of anatomic hippocampal boundaries on magnetic resonance imaging arising from the European Alzheimer's Disease Centers–Alzheimer's Disease Neuroimaging Initiative hippocampal harmonization effort as a reference standard, (3) establish a scientifically appropriate, publicly available reference standard data set based on manual delineation of the hippocampus in an appropriate sample of subjects (Alzheimer's Disease Neuroimaging Initiative), and (4) define minimum technical and prognostic performance metrics for validation of new measurement techniques using the reference standard data set as a benchmark.ConclusionsAlthough manual delineation of the hippocampus is the best available reference standard, practical application of hippocampal volumetry will require automated methods. Our intent was to establish a mechanism for credentialing automated software applications to achieve internationally recognized accuracy and prognostic performance standards that lead to the systematic evaluation and then widespread acceptance and use of hippocampal volumetry. The standardization and assay validation process outlined for hippocampal volumetry was envisioned as a template that could be applied to other imaging biomarkers.