Citations 100
IC‐P‐099: Elevated PiB precedes dementia in autosomal dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort
Raichle, Marcus E. , Marcus, Daniel C. , Ringman, John M. , Salloway, Stephen , Correia, Steve, Johnson, Keith A. , Villemagne, Victor L. , Mayeux, Richard , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Moulder, Krista L., Benzinger, Tammie L.S. , Blazey, Tyler , Koeppe, Robert A. , Jack, Clifford R. , Su, Yi , Snyder, Abraham Z. , Thompson, Paul M. , Ghetti, Bernardino , Saykin, Andrew J. , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Martins, Ralph N. , Mathis, Chester A. , Klunk, William E. , Weiner, Michael D. , Bateman, Randall J. , Goate, Alison , Morris, John C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_2 | Pages: No page available
O2‐06‐05: A voxel‐based morphometry study of volumetric MRI in familial Alzheimer's disease
Cash, David, Ryan, Natalie S. , Kinnunen, Kirsi M. , Yeatman, Tom, Malone, Ian B. , Raichle, Marc, Marcus, Daniel S., Ringman, John M. , Thompson, Paul , Salloway, Steven, Correia, Stephen , Villemagne, Victor L. , Mayeux, Richard , Fagan, Anne M. , Cairns, Nigel J., Buckles, Virginia, Moulder, Krista L., Ridgway, Gerard R. , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Saykin, Andrew J. , Salloway, Steve , Johnson, Keith J. , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Martins, Ralph N. , Brickman, Adam M. , Weiner, Michael W. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available
P4‐153: Elevated PiB precedes dementia in autosomal‐dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort
Raichle, Marc, Su, Yi , Marcus, Daniel S. , Ringman, John M. , Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Moulder, Krista L., Villemagne, Victor L. , Benzinger, Tammie L.S. , Blazey, Tyler , Koeppe, Robert A. , Jack, Clifford R. , Snyder, Abraham Z. , Johnson, Keith J. , Sperling, Reisa Anne , Thompson, Paul M. , Ghetti, Bernardino , Saykin, Andrew J. , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Martins, Ralph N. , Mathis, Chester A. , Klunk, William E. , Bateman, Randall J. , Goate, Alison , Morris, John C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_19 | Pages: No page available
O2‐06‐02: FDG metabolism in the DIAN study of autosomal dominant Alzheimer's disease
Marcus, Daniel S. , Raichle, Marc, Correia, Stephen , Weiner, Michael W. , Fagan, Anne M. , Buckles, Virginia, Moulder, Krista L., Mayeux, Richard , Cairns, Nigel J. , Ringman, John M. , Salloway, Stephen , Johnson, Keith A. , Becker, John Alex , Koeppe, Robert A. , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Ghetti, Bernardino , Masters, Colin L. , Mathis, Chester A. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Martins, Ralph N. , Morris, John C. , Sperling, Reisa Anne
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available
IC‐P‐020: A voxel‐based morphometry study of volumetric MRI in familial Alzheimer's disease
Ryan, Natalie S. , Yeatman, Tom, Malone, Ian B. , Raichle, Marc, Marcus, Daniel S. , Ringman, John M. , Salloway, Stephen , Correia, Stephen , Johnson, Keith A. , Villemagne, Victor L. , Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Moulder, Krista L., Cash, David M. , Ridgway, Gerard R. , Kinnunen, Kirsi M. , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Martins, Ralph N. , Brickman, Adam M. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_1 | Pages: No page available
IC‐P‐032: Cross‐sectional cerebral volumetric differences and associations with estimated time to age‐at‐onset in familial Alzheimer's disease: Findings from the DIAN study
Leung, Kelvin K., Cardoso, Manuel, Malone, Ian B. , Yeatman, Tom, Nicholas, Jennifer M. , Raichle, Marcus E. , Marcus, Daniel, Ringman, John M. , Salloway, Stephen , Correia, Stephen , Sperling, Reisa, Villemagne, Victor L. , Mayeux, Richard , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Kinnunen, Kirsi M. , Cash, David M. , Liang, Yuying , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Ghetti, Bernardino , Johnson, Keith J. , Schofield, Peter R. , Rowe, Christopher Cleon , Masters, Colin L. , Brickman, Adam M. , Martins, Ralph N. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_1 | Pages: No page available
O2‐06‐01: Disrupted functional connectivity in autosomal dominant Alzheimer's disease: Preliminary findings from the DIAN study
Chhatwal, Jasmeer P. , Johnson, Keith A. , Salloway, Stephen , Ringman, John M. , Marcus, Daniel S. , Correia, Stephen , Rowe, Christopher C., Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Xiong, Chengjie , Moulder, Krista L., Buckles, Virginia, Schultz, Aaron P. , Benzinger, Tammie L.S. , Jack, Clifford R. , Koeppe, Robert A. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Fox, Nick C. , Brickman, Adam M. , Mathis, Chester A. , Goate, Alison , Masters, Colin L. , Ghetti, Bernardino , Martins, Ralph N. , Bateman, Randall J. , Morris, John C. , Sperling, Reisa Anne
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available
P1‐015: Brain and hippocampal rates of atrophy in familial Alzheimer's disease mutation carriers: Preliminary findings from the DIAN study
Leung, Kelvin K., Cardoso, Manuel, Malone, Ian B. , Raichle, Marc, Marcus, Daniel, Ringman, John M. , Salloway, Stephen , Correia, Stephen , Sperling, Reisa, Villemagne, Victor L. , Mayeux, Richard , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Kinnunen, Kirsi M. , Cash, David M. , Liang, Yuying , Cardoso, Manuel, Modat, Marc , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Ghetti, Bernardino , Johnson, Keith J. , Schofield, Peter R. , Rowe, Christopher Cleon , Masters, Colin L. , Brickman, Adam M. , Martins, Ralph N. , Bateman, Randall J. , Goate, Alison , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_3 | Pages: No page available
IC‐P‐098: The role of APOE‐ɛ4 genotype in early mild cognitive impairment (EMCI): Preliminary results from ADNI‐2
Kim, Sungeun , Ngo, Kwangsik, Petersen, Ronald C. , Aisen, Paul , Jagust, William J. , Weiner, Michael W. , Risacher, Shannon L. , Shen, Li , Foroud, Tatiana , Jack, Clifford R. , Koeppe, Robert A. , Saykin, Andrew J.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_2 | Pages: No page available
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
Ho, April J., Stein, Jason L. , Hua, Xue , Lee, Suh , Hibar, Derrek P., Leow, Alex , Dinov, Ivo D. , Toga, Arthur W. , Saykin, Andrew J. , Shen, Li , Pankratz, Nathan , Huentelman, Matthew J. , Craig, David W. , Gerber, Jill D., Allen, April N., Corneveaux, Jason J., Stephan, Dietrich A. , DeCarli, Charles , Dechairo, Bryan, Jack, Clifford R. , Weiner, Michael W. , Raji, Cyrus A. , Becker, James T. , Carmichael, Owen , Thompson, Paul M. , Initiative, the Alzheimer's Disease Neuroimaging, Thal, Leon J., Petersen, Ronald C., Jagust, William J. , Trojanowki, John Q., Toga, Arthur W., Gamst, Anthony, Potter, William Z., Montine, Tom, Anders, Dale, Felmlee, Joel P. , Schuff, Norbert, Alexander, Gene E. , Bandy, Dan, Foster, Norm, Reiman, Eric M. , Shaw, Les, Korecka, Magdalena , Toga, Arthur W., Crawford, Karen , Neu, Scott, Kornak, John , Kachaturian, Zaven, Frank, Richard , Molchan, Susan, Vorobik, Remi, Schneider, Lon S. , Pawluczyk, Sonia, Spann, Bryan , Fleisher, Adam , Vanderswag, Helen, Heidebrink, Judith L. , Johnson, Kris , Doody, Rachelle S., Villanueva‐Meyer, Javier , Chowdhury, Munir , Bell, Karen L. , Mintun, Mark A., Schneider, Stacy, Marson, Daniel , Griffith, Randall, Badger, Beverly, Grossman, Hillel, deToledo‐Morrell, Leyla, Bach, Julie , Duara, Ranjan , Isaacson, Richard , Strauman, Silvia, Albert, Marilyn S. , Pedroso, Julia, Toroney, Jaimie, Santi, Susan M De, Doraiswamy, P. Murali , Petrella, Jeffrey R. , Aiello, Marilyn, Clark, Christopher M. , Pham, Cassie, Nuñez, Jessica, Smith, Charles D., Given, Curtis A., Hardy, Peter , DeKosky, Steven T. , Oakley, MaryAnn, Simpson, Donna M., Ismail, M. Saleem , McCallum, Colleen, Cramer, Steven C. , Mulnard, Ruth A., Mc-Adams-Ortiz, Catherine, Martin-Cook, Kristen, Devous, Michael D. , Cellar, Janet S., Anderson, Heather S., Laubinger, Mary M., Bartzokis, George, Lu, Po H. , Fletcher, Rita, Parfitt, Francine, Farlow, Martin R. , Herring, Scott, Hake, Ann Marie , Dyck, Christopher H. van , MacAvoy, Martha G., Bifano, Laurel A., Chertkow, Howard, Bergman, Howard , Hosein, Chris, Graham, Simon J. , Caldwell, Curtis, Assaly, Michele, Hsiung, Ging‐Yuek Robin , Kertesz, Andrew , Trost, Dick, Bernick, Charles , Johnson, Nancy , Sadowsky, Carl, Villena, Teresa, Mesner, Scott, Aisen, Paul, Johnson, Kathleen, Behan, Kelly E., Johnson, Keith A. , Rosen, Allyson , Tinklenberg, Jared, Ashford, Wes, Connor, Donald J., Obradov, Sanja, Jayam‐Trouth, Annapurni , Wang, Paul J. , Auchus, Alexander P. , Huang, Juebin , DeCarli, Charles , Kittur, Smita, Mirje, Seema, Borrie, Michael, Lee, T‐Y, Asthana, Sanjay , Carlsson, Cynthia M., Highum, Diane, Preda, Adrian , Tariot, Pierre N. , Hendin, Barry , Kataki, Maria , Zimmerman, Earl A. , Celmins, Dzintra, Brown, Alice D., Gandy, Sam, Marenberg, Marjorie E., Rovner, Barry W. , Blank, Karen, Anderson, Karen, Santulli, Robert B. , Paré, Nadia, Williamson, Jeff D. , Raj, Balebail Ashok, Giordano, Amy T., Ott, Brian R. , Wu, Chuang‐Kuo, Cohen, Ronald A. , Wilks, Kerri, Lee, Ting‐Yim , Foroud, Tatiana , Potkin, Steven G. , López, Oscar L. , Initiative, the Alzheimer's Disease Neuroimaging, Toga, Arthur W., Beckett, Laurel , Green, Robert C. , Bernstein, Matt A. , Fox, Nick C. , Koeppe, Robert A. , Foster, Norm, Chen, Kewei , Lee, Virginia M.‐Y. , Toga, Arthur W., Harvey, Danielle , Snyder, Peter J. , Kaye, Jeffrey , Quinn, Joseph F. , Lord, Joanne L. , Stern, Yaakov , Honig, Lawrence S. , Morris, John C. , Tang, Cheuk Ying , Stern, Jessica A. , Shah, Raj C. , Duara, Ranjan , Rusinek, Henry , Leon, Mony J. de , Porsteinsson, Anton P. , Diaz‐Arrastia, Ramon , Levey, Allan I. , Lah, James J. , Burns, Jeffrey M. , Silverman, Daniel H.S. , Johnson, Heather K. , Black, Sandra E. , Feldman, Howard , ROGERS, John H. , Gitelman, Darren R. , Mesulam, Marsel M. , Sperling, Reisa Anne , Rentz, Dorene M. , Sabbagh, Marwan Noel , Killiany, Ronald , Norbash, Alexander , Obisesan, Thomas O. , Friedland, Robert P. , Fletcher, Evan M. , Johnson, Sterling C. , Nguyen, Dana R. , Scharre, Douglas W. , Beversdorf, David Q. , Gandy, Sam , Pearlson, Godfrey D. , Sink, Kaycee M. , Potter, Huntington , Jack, Clifford R , Saykin, Andrew J , Shen, Li , Preda, Adrian , Toga, Arthur W , Stein, Jason L , Thompson, Paul M , Hsiung, Gink-Yuek , Pankratz, Nathan
Proceedings of the National Academy of Sciences | April 19, 2010 | Volume: 107 | Issue: 18 | Pages: 8404-8409
A recently identified variant within the fat mass and obesity-associated ( FTO ) gene is carried by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, in adults and an ~1 cm greater waist circumference. With >1 billion overweight and 300 million obese persons worldwide, it is crucial to understand the implications of carrying this very common allele for the health of our aging population. FTO is highly expressed in the brain and elevated body mass index (BMI) is associated with brain atrophy, but it is unknown how the obesity-associated risk allele affects human brain structure. We therefore generated 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative. We found a pattern of systematic brain volume deficits in carriers of the obesity-associated risk allele versus noncarriers. Relative to structure volumes in the mean template, FTO risk allele carriers versus noncarriers had an average brain volume difference of ~8% in the frontal lobes and 12% in the occipital lobes—these regions also showed significant volume deficits in subjects with higher BMI. These brain differences were not attributable to differences in cholesterol levels, hypertension, or the volume of white matter hyperintensities; which were not detectably higher in FTO risk allele carriers versus noncarriers. These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.