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McDade, Eric

https://orcid.org/0000-0002-6764-3866

Mayo Clinic

Washington University in St. Louis

Citations 129

Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing
Chhatwal, Jasmeer P. , Johnson, Keith A. , Hedden, Trey , Jaimes, Sehily Y., Benzinger, Tammie L.S. , Jack, Clifford R. , Ringman, John M. , Marcus, Daniel S. , Farlow, Martin R. , Danek, Adrian , Xiong, Chengjie , Yakushev, Igor , Laske, Christoph , Masters, Colin L. , Schofield, Peter R. , Salloway, Stephen , Martins, Ralph N. , Cairns, Nigel J. , Buckles, Virginia, Morris, John C. , Bateman, Randall J. , Network, for the Dominantly Inherited Alzheimer, Westover, M. Brandon , Jack, Clifford R , Schofield, Peter R , Bateman, Randall J , Masters, Colin L , Xiong, Chengjie , Benzinger, Tammie L S , Schultz, Aaron P. , Ances, Beau M. , Ghetti, Bernardino , Koeppe, Robert A. , Galasko, Douglas , Xiong, Chengjie , Kinnunen, Kirsi M. , McDade, Eric , Sperling, Reisa Anne , Network, for the Dominantly Inherited Alzheimer, Morris, John C , Westover, M Brandon

Brain | February 15, 2018 | Volume: 141 | Issue: 5 | Pages: 1486-1500

10.1093/brain/awy053 Get It

[O1–02–03]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: FINDINGS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK
Dincer, Aylin , Christensen, Jon, Cairns, Nigel J., Fagan, Anne M. , Marcus, Daniel S. , Hornbeck, Russ C. , Paumier, Katrina L. , Raichle, Marcus E. , Gordon, Brian A. , Blazey, Tyler , Su, Yi , Hari‐Raj, Amrita , Flores, Shaney , McDade, Eric , Wang, Guoqiao , Xiong, Chengjie , Hassenstab, Jason , Jack, Clifford R. , Koeppe, Robert A. , Ances, Beau M. , Holtzman, David M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2017.07.041 Get It

[F3–01–01]: OPPORTUNITIES AND CHALLENGES FOR IMPLEMENTING ALZHEIMERS BIOMARKERS IN RESEARCH STUDIES
Jagust, William J. , Blennow, Kaj , Jack, Clifford R. , McDade, Eric

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_18 | Pages: No page available

10.1016/j.jalz.2017.07.262 Get It

[IC‐P‐166]: UTILITY OF PERFUSION PET MODELS AS MEASURE OF NEURODEGENERATION IN AN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE POPULATION: REPORT FROM THE DIAN STUDY
Su, Yi , Jasielec, Mateusz S., Vlassenko, Andrei G. , Hornbeck, Russ C. , Cash, Lisa, Raichle, Marcus E. , Buckles, Virginia, Cairns, Nigel J. , Fagan, Anne M. , Klunk, Bill E., Marcus, Daniel S. , Mayeux, Richard , Paumier, Katrina L. , Ringman, John M. , Xiong, Chengjie , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Ances, Beau M. , Brickman, Adam M. , Cruchaga, Carlos , Goate, Alison , Jack, Clifford R. , Klunk, Bill E., Koeppe, Robert A. , McDade, Eric , Saykin, Andrew J. , Thompson, Paul M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_2 | Pages: No page available

10.1016/j.jalz.2017.06.2541 Get It

[IC‐P‐054]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: RESULTS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK
Hari‐Raj, Amrita , Dincer, Aylin , Christensen, Jon, Wang, Guoqiao , Cairns, Nigel J. , Fagan, Anne M. , Marcus, Daniel S., Hornbeck, Russ C. , Paumier, Katrina L. , Raichle, Marcus E. , Gordon, Brian A. , Blazey, Tyler , Su, Yi , Flores, Shaney , McDade, Eric , Xiong, Chengjie , Hassenstab, Jason , Jack, Clifford R. , Koeppe, Robert A. , Ances, Beau M. , Holtzman, David M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2017.06.2327 Get It

[IC‐P‐057]: CLINICAL RISK RELATED TO CEREBRAL MICROHEMORRHAGES IN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE: LONGITUDINAL RESULTS FROM THE DIAN STUDY
Ringman, John M. , Salloway, Stephen , Su, Yi , Hornbeck, Russ C. , Raichle, Marcus E. , Marcus, Daniel S. , Cairns, Nigel J. , Xiong, Chengjie , Buckles, Virginia, Paumier, Katrina L. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Kantarci, Kejal , Jack, Clifford R. , McDade, Eric , Clifford, David J , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Mills, Susan , Ances, Beau M. , Cruchaga, Carlos , Goate, Alison , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2017.06.2330 Get It

[O1–02–04]: CLINICAL RISK RELATED TO CEREBRAL MICROHEMORRHAGES IN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE: LONGITUDINAL RESULTS FROM THE DIAN STUDY
Ringman, John M. , Salloway, Stephen , Clifford, David B. , Su, Yi , Hornbeck, Russ C. , Raichle, Marcus E. , Marcus, Daniel S. , Cairns, Nigel J. , Buckles, Virginia, Paumier, Katrina L. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Kantarci, Kejal , Jack, Clifford R. , McDade, Eric , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Mills, Susan , Ances, Beau M. , Xiong, Chengjie , Cruchaga, Carlos , Goate, Alison , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2017.07.042 Get It

[P2–372]: UTILITY OF PERFUSION PET MODELS AS MEASURES OF NEURODEGENERATION IN AN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE POPULATION: REPORT FROM THE DIAN STUDY
Jasielec, Mateusz S., Vlassenko, Andrei G. , Hornbeck, Russ C. , Cash, Lisa, Raichle, Marcus E. , Buckles, Virginia, Cairns, Nigel J. , Fagan, Anne M. , Klunk, Bill E., Marcus, Daniel S., Mayeux, Richard , Paumier, Katrina L. , Ringman, John M. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Su, Yi , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Ances, Beau M. , Brickman, Adam M. , Cruchaga, Carlos , Goate, Alison , Jack, Clifford R. , Klunk, Bill E., Koeppe, Robert A. , McDade, Eric , Saykin, Andrew J. , Thompson, Paul M. , Xiong, Chengjie , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_15 | Pages: No page available

10.1016/j.jalz.2017.06.1027 Get It

[O1–02–05]: GENOTYPIC VARIANCE MAY EXPLAIN THE BALANCE OF EARLY CORTICAL VERSUS STRIATAL AMYLOID DEPOSITION IN AUTOSOMAL DOMINANT AD
Graff‐Radford, Neill R., Salloway, Stephen , Buckles, Virginia, Johnson, Keith, Chhatwal, Jasmeer P. , Hanseeuw, Bernard , McDade, Eric , Schultz, Aaron P. , Martins, Ralph N. , Schofield, Peter R. , Masters, Colin L. , Graff‐Radford, Neill R. , Danek, Adrian , Xiong, Chengjie , Goate, Alison , Benzinger, Tammie L.S. , Morris, John C. , Bateman, Randall J. , Sperling, Reisa Anne

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2017.07.043 Get It

Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study
Kinnunen, Kirsi M. , Cash, David M. , Poole, Teresa, Frost, Chris , Benzinger, Tammie L.S. , Ahsan, R. Laila, Leung, Kelvin K., Cardoso, M. Jorge , Modat, Marc , Malone, Ian B. , Morris, John C. , Bateman, Randall J. , Marcus, Daniel S. , Goate, Alison , Salloway, Stephen , Correia, Stephen , Chhatwal, Jasmeer P. , Mayeux, Richard , Martins, Ralph N. , Farlow, Martin R. , Saykin, Andrew J. , Jack, Clifford R. , Schofield, Peter R. , Weiner, Michael W. , Ringman, John M. , Thompson, Paul M. , Masters, Colin L. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C. , (DIAN), Dominantly Inherited Alzheimer Network, Sperling, Reisa Anne , Brickman, Adam M. , Ghetti, Bernardino , McDade, Eric , Rowe, Christopher Cleon , (DIAN), Dominantly Inherited Alzheimer Network, Jack, Clifford R , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Fox, Nick C , Morris, John C , Cash, David M , Goate, Alison M

Alzheimer's & Dementia | July 22, 2017 | Volume: 14 | Issue: 1 | Pages: 43-53

10.1016/j.jalz.2017.06.2268 Get It

Abstract Introduction Identifying at what point atrophy rates first change in Alzheimer's disease is important for informing design of presymptomatic trials. Methods Serial T1‐weighted magnetic resonance imaging scans of 94 participants (28 noncarriers, 66 carriers) from the Dominantly Inherited Alzheimer Network were used to measure brain, ventricular, and hippocampal atrophy rates. For each structure, nonlinear mixed‐effects models estimated the change‐points when atrophy rates deviate from normal and the rates of change before and after this point. Results Atrophy increased after the change‐point, which occurred 1–1.5 years (assuming a single step change in atrophy rate) or 3–8 years (assuming gradual acceleration of atrophy) before expected symptom onset. At expected symptom onset, estimated atrophy rates were at least 3.6 times than those before the change‐point. Discussion Atrophy rates are pathologically increased up to seven years before “expected onset”. During this period, atrophy rates may be useful for inclusion and tracking of disease progression.