Back to Authors

Jones, David T.

https://orcid.org/0000-0002-4807-9833

Mayo Clinic

Mayo Clinic

Citations 339

P3‐411: ANALYSIS OF IOFLUPANE‐SPECT FINDINGS USING DATQUANT IN PATIENTS WITH IDIOPATHIC REM SLEEP BEHAVIOR DISORDER
Maltais, Daniela D., Miyagawa, Toji , Przybelski, Scott A. , Jordan, Lennon, Lesnick, Timothy G. , Louis, E. St., Silber, Michael H. , Graff‐Radford, Jonathan , Savica, Rodolfo , Drubach, Daniel A., Knopman, David S. , Petersen, Ronald C. , Fields, Julie A. , Forsberg, Leah K. , Allen, Laura A., Lowe, Val J. , Min, Hoon-Ki Paul , Jones, David T. , Knopman, David S. , Machulda, Mary M. , Nedelská, Zuzana , Boeve, Bradley F. , Kantarci, Kejal

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_21 | Pages: No page available

10.1016/j.jalz.2019.06.3445 Get It

P3‐364: RATES OF LOBAR ATROPHY IN ASYMPTOMATIC MAPT MUTATION CARRIERS
Chen, Qin , Tosakulwong, Nirubol , Lesnick, Timothy G. , Brushaber, Danielle , Dheel, Christina, Fields, Julie A. , Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Rademakers, Rosa , Syrjanen, Jeremy A. , Boxer, Adam L. , Rosen, Howard J. , Boeve, Bradley F. , Senjem, Matthew L. , Jack, Clifford R. , Jones, David T. , Knopman, David S. , Kremers, Walter K. , Lapid, Maria I. , Wszołek, Zbigniew K. , Kantarci, Kejal

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_21 | Pages: No page available

10.1016/j.jalz.2019.06.3397 Get It

P2‐329: TRACKING WHITE MATTER DEGENERATION IN ASYMPTOMATIC AND SYMPTOMATIC MAPT MUTATION CARRIERS WITH DTI
Tosakulwong, Nirubol , Lesnick, Timothy G. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley , Fields, Julie A. , Foroud, Tatiana M., Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , Manoochehri, Masood , McGinnis, Scott, Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M. , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Toga, Arthur W. , Trojanowski, John Q. , Weıntraub, Sandra , Boxer, Adam L. , Rosen, Howard J. , Chen, Qin , Boeve, Bradley F. , Schwarz, Christopher G. , Reid, Robert I. , Brannelly, Patrick , Fong, Jamie , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jack, Clifford R. , Jones, David T. , Jones, Lynne, Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Wong, Bonnie , Wszołek, Zbigniew K. , Kantarci, Kejal

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_14 | Pages: No page available

10.1016/j.jalz.2019.06.2736 Get It

P2‐314: THE MULTIDOMAIN IMPAIRMENT RATING (MIR) SCALE: INITIAL RELIABILITY DATA ON A MULTIDIMENSIONAL SCALE DESIGNED FOR FTLD SPECTRUM DISORDERS
Forsberg, Leah K. , Boxer, Adam L. , Rosen, Howard J. , Kornak, John , Heuer, Hilary W. , Fields, Julie A. , Brushaber, Danielle , Sturm, Virginia E. , Staffaroni, Adam M. , Ljubenkov, Peter A. , Denver, Reilly, Ong, Elise, Bordelon, Yvette , Coppola, Giovanni, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley, Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff-Radford, N. R., Huey, Edward D. , Karydas, Anna M., Kaufer, Daniel , Kraft, Ruth, Kramer, Joel H. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , McGinnis, Scott M., Mendez, Mario F. , Onyike, Chiadi U. , Pantelyat, Alex, Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Rogalskı, Emily , Shaw, Leslie M. , Sutherland, M. Anne, Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Trojanowski, John Q. , Weıntraub, Sandra , Boeve, Bradley F. , Machulda, Mary M. , Appleby, Brian S. , Brannelly, Patrick , Coppola, Giovanni, Domoto‐Reilly, Kimiko , Fong, Jamie , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jones, David T. , Kantarci, Kejal , Kerwin, Diana , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Sutherland, Marg, Tartaglia, Maria Carmela , Toga, Arthur W. , Wong, Bonnie , Wszołek, Zbigniew K.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_14 | Pages: No page available

10.1016/j.jalz.2019.06.2721 Get It

P2‐225: ALTERED CSF DYNAMICS INFLUENCE DISCREPANCIES BETWEEN CSF AND PET BIOMARKERS OF AMYLOID
Gunter, Jeffrey L. , Townley, Ryan , Wiste, Heather J. , Graff‐Radford, Neill R. , Graff‐Radford, Jonathan , Senjem, Matthew L. , Jack, Clifford R. , Jones, David T.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_13 | Pages: No page available

10.1016/j.jalz.2019.06.2632 Get It

P2‐226: SUBJECT FACTORS RELATED TO CSF DYNAMICS CONFOUND MEASUREMENT OF CSF BIOMARKERS IN ADNI
Townley, Ryan , Gunter, Jeffrey L. , Graff‐Radford, Jonathan , Wiste, Heather J. , Senjem, Matthew L. , Jack, Clifford R. , Jones, David T.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_13 | Pages: No page available

10.1016/j.jalz.2019.06.2633 Get It

P1‐367: COMPARISON OF IOFLUPANE‐SPECT FINDINGS USING DATQUANT IN PATIENTS WITH ALZHEIMER'S DISEASE DEMENTIA AND DEMENTIA WITH LEWY BODIES
Miyagawa, Toji , Przybelski, Scott A. , Maltais, Daniela D., Jordan, Lennon, Lesnick, Timothy G. , Graff‐Radford, Jonathan , Savica, Rodolfo , Drubach, Daniel A., Petersen, Ronald C. , Fields, Julie A. , Forsberg, Leah K. , Allen, Laura A., Parisi, Joseph E., Lowe, Val J. , Min, Hoon-Ki Paul , Jones, David T. , Knopman, David S. , Machulda, Mary M. , Nedelská, Zuzana , Murray, Melissa E. , Dickson, Dennis W. , Boeve, Bradley F. , Kantarci, Kejal

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_7 | Pages: No page available

10.1016/j.jalz.2019.06.922 Get It

P1‐349: ADVANCING CLINICAL AND BIOMARKER RESEARCH IN AD: THE LEAD STUDY
Apostolova, Liana G. , Collins, Jessica A. , Aisen, Paul, Borowski, Bret, Eloyan, Ani , Fagan, Anne M. , Gatsonis, Constantine , Kramer, Joel H. , Graff‐Radford, Neill R. , Masdeu, Joseph C. , Mendez, Mario F. , Onyike, Chiadi U. , Rogalskı, Emily , Salloway, Stephen , Dickerson, Brad C., Iaccarino, Leonardo , Foroud, Tatiana , Jack, Clifford R. , Koeppe, Robert A. , Saykin, Andrew J. , Toga, Arthur W. , Vemuri, Prashanthi , Day, Gregory S. , Honig, Lawrence S. , Jones, David T. , Masdeu, Joseph C , Wolk, David A. , Wingo, Thomas S , Rabinovici, Gil D. , Carrillo, María C.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_7 | Pages: No page available

10.1016/j.jalz.2019.06.904 Get It

The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes
Jack, Clifford R. , Wiste, Heather J. , Botha, Hugo , Weigand, Stephen D. , Therneau, Terry M. , Graff‐Radford, Jonathan , Ferman, Tanis J. , Boeve, Bradley F. , Kantarci, Kejal , Lowe, Val J. , Vemuri, Prashanthi , Fields, Julie A. , Senjem, Matthew L. , Gunter, Jeffrey L. , Petersen, Ronald C. , Jack, Clifford R , Boeve, Brad , Vemuri, Prashanthi , Senjem, Matthew L , Kantarci, Kejal , Botha, Hugo , Ferman, Tanis J , Knopman, David S. , Jones, David T. , Mielke, Michelle M. , Machulda, Mary M. , Schwarz, Christopher G.

Brain | August 28, 2019 | Volume: 142 | Issue: 10 | Pages: 3230-3242

10.1093/brain/awz268 Get It

See Gordon and Tijms (doi:10.1093/brain/awz278) for a scientific commentary on this article. Jack et al. examine relationships between the bivariate distribution of β-amyloid and tau on PET and established neurocognitive clinical syndromes. Amyloidosis appears to be required for high levels of 3R/4R tau deposition. Whereas abnormal amyloid PET is compatible with normal cognition, highly abnormal tau PET is not.
Rates of lobar atrophy in asymptomatic MAPT mutation carriers
Senjem, Matthew L. , Tosakulwong, Nirubol , Lesnick, Timothy G. , Brushaber, Danielle , Dheel, Christina, Fields, Julie A. , Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Graff‐Radford, Jonathan, Graff‐Radford, Neill R., Jack, Clifford R. , Kremers, Walter K. , Rademakers, Rosa , Syrjanen, Jeremy A. , Boxer, Adam L. , Rosen, Howie, Kantarci, Kejal , Senjem, Matthew, Jack, Clifford R , Senjem, Matthew L , Kantarci, Kejal , Kremers, Walter K , Chen, Qin , Boeve, Bradley F. , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Jones, David T. , Knopman, David S. , Lapid, Maria I. , Wszołek, Zbigniew K.

Alzheimer's & Dementia: Translational Research & Clinical Interventions | July 30, 2019 | Volume: 5 | Issue: 1 | Pages: 338-346

10.1016/j.trci.2019.05.010 Get It

Abstract Introduction The aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule‐associated protein tau ( MAPT ) mutation carriers. Methods MAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from asymptomatic to symptomatic) and noncarriers (n = 13) underwent structural magnetic resonance imaging and were followed annually with a median of 9.2 years. Longitudinal changes in lobar atrophy were analyzed using the tensor‐based morphometry with symmetric normalization algorithm. Results The rate of temporal lobe atrophy in asymptomatic MAPT mutation carriers was faster than that in noncarriers. Although the greatest rate of atrophy was observed in the temporal lobe in converters, they also had increased atrophy rates in the frontal and parietal lobes compared to noncarriers. Discussion Accelerated decline in temporal lobe volume occurs in asymptomatic MAPT mutation carriers followed by the frontal and parietal lobe in those who have become symptomatic. The findings have implications for monitoring the progression of neurodegeneration during clinical trials in asymptomatic MAPT mutation carriers.