Citations 5
Different Rates of Lobar Atrophy Between Symptomatic and Asymptomatic MAPT Mutation Carriers (S9.002)
Lesnick, Timothy G. , Przybelski, Scott A. , Tosakulwong, Nirubol , Brushaber, Danielle , Fields, Julie A. , Forsberg, Leah K. , Gavrilova, Ralitza H. , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Syrjanen, Jeremy A. , Boxer, Adam L. , Rosen, Howard J. , Boeve, Bradley F. , Chen, Qin , Senjem, Matthew L. , Jones, David T. , Knopman, David S. , Kremers, Walter K. , Wszołek, Zbigniew K. , Kantarci, Kejal
Neurology | December 7, 2023 | Volume: 92 | Issue: 15_supplement | Pages: No page available
Primary thymic mucosa-associated lymphoid tissue lymphoma complicated with renal amyloidosis
Du, Yongjing, Singh, Prince , Wang, Wei , Prince, Singh, Chen, Qin , Zhang, Ping , Li, Guisen , Wang, Li
Medicine | March 28, 2020 | Volume: 99 | Issue: 13 | Pages: e19462
Abstract Introduction: Primary mucosa-associated lymphoid tissue (MALT) lymphomas originating in thymus is rare. And, there have been few reports of patients with MALT coexisting with amyloidosis. As far as we know, this was the first case report on MALT lymphoma associated with renal amyloidosis. Patient concerns: A 57-year-old man presented with nephrotic syndrome. Further workup revealed IgM-Lambda type monoclonal gammopathy. Bone marrow biopsy showed 8% clonal plasma cells. Renal biopsy confirmed the diagnosis of Lambda light chain AL amyloidosis. positron emission tomography/computed tomography showed thymic lesions which upon biopsy were diagnosed as MALT lymphoma of the thymus. Diagnosis: Primary thymic MALT lymphoma complicated with renal amyloidosis. Interventions: The patient underwent surgical resection of the thymus mass and 2 courses of chemotherapy. Outcomes: Follow-up data showed that the patient survived 18 months after surgical excision and chemotherapy. Conclusion: The case highlights the importance of screening for malignancy in patients with renal amyloidosis.
β-Amyloid PET and neuropathology in dementia with Lewy bodies
Kantarci, Kejal , Lowe, Val J. , Przybelski, Scott A. , Lesnick, Timothy G. , Senjem, Matthew L. , Gunter, Jeffrey L. , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Ferman, Tanis J. , Parisi, Joseph E., Petersen, Ronald C. , Murray, Melissa E. , Senjem, Matthew L , Kantarci, Kejal , Murray, Melissa E , Ferman, Tanis J , Chen, Qin , Schwarz, Christopher G. , Jack, Clifford R. , Jones, David T. , Knopman, David S. , Dickson, Dennis W. , Boeve, Bradley F.
Neurology | December 20, 2019 | Volume: 94 | Issue: 3 | Pages: No page available
P2‐329: TRACKING WHITE MATTER DEGENERATION IN ASYMPTOMATIC AND SYMPTOMATIC MAPT MUTATION CARRIERS WITH DTI
Tosakulwong, Nirubol , Lesnick, Timothy G. , Bove, Jessica, Brushaber, Danielle , Coppola, Giovanni , Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley , Fields, Julie A. , Foroud, Tatiana M., Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Haley, Dana , Heuer, Hilary W. , Huey, Edward D. , Jones, Lynne C. , Karydas, Anna M., Kornak, John , Kramer, Joel H. , Lucente, Diane , Lungu, Codrin , Mackenzie, Ian R. , Manoochehri, Masood , McGinnis, Scott, Pearlman, Rodney , Petrucelli, Leonard , Potter, Madeline, Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M. , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Toga, Arthur W. , Trojanowski, John Q. , Weıntraub, Sandra , Boxer, Adam L. , Rosen, Howard J. , Chen, Qin , Boeve, Bradley F. , Schwarz, Christopher G. , Reid, Robert I. , Brannelly, Patrick , Fong, Jamie , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Jack, Clifford R. , Jones, David T. , Jones, Lynne, Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Lapid, Maria I. , Miller, Bruce L. , Wong, Bonnie , Wszołek, Zbigniew K. , Kantarci, Kejal
Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_14 | Pages: No page available
Rates of lobar atrophy in asymptomatic MAPT mutation carriers
Senjem, Matthew L. , Tosakulwong, Nirubol , Lesnick, Timothy G. , Brushaber, Danielle , Dheel, Christina, Fields, Julie A. , Forsberg, Leah K. , Gavrilova, Ralitza H. , Gearhart, Debra, Graff‐Radford, Jonathan, Graff‐Radford, Neill R., Jack, Clifford R. , Kremers, Walter K. , Rademakers, Rosa , Syrjanen, Jeremy A. , Boxer, Adam L. , Rosen, Howie, Kantarci, Kejal , Senjem, Matthew, Jack, Clifford R , Senjem, Matthew L , Kantarci, Kejal , Kremers, Walter K , Chen, Qin , Boeve, Bradley F. , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Jones, David T. , Knopman, David S. , Lapid, Maria I. , Wszołek, Zbigniew K.
Alzheimer's & Dementia: Translational Research & Clinical Interventions | July 30, 2019 | Volume: 5 | Issue: 1 | Pages: 338-346
Abstract Introduction The aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule‐associated protein tau ( MAPT ) mutation carriers. Methods MAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from asymptomatic to symptomatic) and noncarriers (n = 13) underwent structural magnetic resonance imaging and were followed annually with a median of 9.2 years. Longitudinal changes in lobar atrophy were analyzed using the tensor‐based morphometry with symmetric normalization algorithm. Results The rate of temporal lobe atrophy in asymptomatic MAPT mutation carriers was faster than that in noncarriers. Although the greatest rate of atrophy was observed in the temporal lobe in converters, they also had increased atrophy rates in the frontal and parietal lobes compared to noncarriers. Discussion Accelerated decline in temporal lobe volume occurs in asymptomatic MAPT mutation carriers followed by the frontal and parietal lobe in those who have become symptomatic. The findings have implications for monitoring the progression of neurodegeneration during clinical trials in asymptomatic MAPT mutation carriers.