Citations 7
Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis (P1.349)
Schwarz, Carolyn, Grover, Stephanie A. , Noguera, Austin, Mar, Soe , Mednick, Lauren , Banwell, Brenda , Alper, Gülay, Lotze, Timothy , Tillema, Jan‐Mendelt , Gorman, Mark , Ness, Jayne , Schreiner, Teri , Yeh, E. Ann , Schwarz, Carolyn, Powell, Victoria E. , Mah, Jean Kit-Wah , Graves, Jennifer , Rensel, Mary R. , Waldman, Amy , Schreiner, Teri , Waubant, Emmanuelle L.
Neurology | December 7, 2023 | Volume: 88 | Issue: 16_supplement | Pages: No page available
Impaired Cognition without Behavioral Problems in Pediatric Clinically Isolated Syndrome (CIS) (P02.113)
Serafin, Dana, Julián, Laura , Ackerson, Joseph, Braaten, Ellen B. , Brown, Tanya M. , Preston, Thomas J. , Zaccariello, Michael J. , Belman, Anita , Gorman, Mark , Kaufman, Emma , Ness, Jayne , Yeh, E. Ann , Krupp, Lauren , Charvet, Leigh , Benedict, Ralph H. B. , O’Donnell, Ellen , Parrish, Joy , Chitnis, Tanuja , Kaufman, Emma, Patterson, Marc C. , Rodriguez, Moses , Waubant, Emmanuelle L. , Weinstock‐Guttman, Bianca
Neurology | December 7, 2023 | Volume: 80 | Issue: 7_supplement | Pages: No page available
Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis
Mowry, Ellen M. , Krupp, Lauren , Yeh, E. Ann , Kuntz, Nancy L. , Ness, Jayne , Belman, Anita , Milazzo, Maria , Gorman, Mark , Rodriguez, Moses , Waubant, Emmanuelle L. , Krupp, Lauren , Chitnis, Tanuja , Weinstock‐Guttman, Bianca , James, Judith A. , Rodriguez, Moses
Multiple Sclerosis Journal | December 11, 2012 | Volume: 19 | Issue: 7 | Pages: 891-895
Background: As remote infections with common herpes viruses are associated with modulation of the risk of multiple sclerosis (MS), we hypothesized that antibody concentrations against these viruses may further modify risk. As many common viruses are first encountered during childhood, pediatric MS offer a unique opportunity to investigate more closely their influence on susceptibility. Our aim was to determine if MS patients who were positive for these viruses had higher levels of antibodies to these viruses. We also assessed whether human leukocyte antigen (HLA)-DRB1*1501 genotype influenced viral antibody levels. Methods: Antibody response levels toward Epstein Barr virus (EBV), cytomegalovirus (CMV), and herpes simplex virus (HSV)-1, and HLA-DRB1*1501 status were determined in pediatric MS patients ( n=189) and controls ( n=38). Multivariate analyses were used, adjusted for age, gender, race, ethnicity and use of disease-modifying therapies. Results: The antibody concentrations against EBV (Epstein-Barr nuclear antigen 1 (EBNA-1), viral capsid antigen (VCA) and early antigen (EA)), CMV and HSV-1 were similar between pediatric MS patients and controls positive for seroconversion against the virus of interest. EBNA-1 humoral responses were higher in HLA-DRB1 positive individuals ( p=0.005) whereas other viral humoral responses were similar in HLA-DRB1 positive and negative individuals. Conclusion: Among those positive for EBNA-1, MS patients did not have higher levels of antibody response to EBNA-1: however, titers for EBNA-1 were higher in those who were HLA-DRB1 positive. This suggests that genotype might influence the humoral response to EBV. Whether other genotypes influence antibody response to other viruses remains to be determined.
Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis
Julián, Laura , Serafin, Dana, Charvet, Leigh , Ackerson, Joseph, Braaten, Ellen B. , Brown, Tanya M. , O’Donnell, Ellen , Parrish, Joy , Preston, Thomas, Zaccariello, Michael J. , Belman, Anita , Gorman, Mark , Ness, Jayne , Patterson, Marc C. , Rodriguez, Moses , Yeh, E. Ann , Krupp, Lauren , Benedict, Ralph H. B. , Chitnis, Tanuja , Waubant, Emmanuelle L. , Weinstock‐Guttman, Bianca , Krupp, Lauren , Rodriguez, Moses , Charvet, Leigh E , Patterson, Marc
Journal of Child Neurology | November 15, 2012 | Volume: 28 | Issue: 1 | Pages: 102-107
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.
Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases
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Neurology | July 27, 2012 | Volume: 79 | Issue: 9 | Pages: 878-882
Common viruses associated with lower pediatric multiple sclerosis risk
Mowry, Ellen M. , Krupp, Lauren , Yeh, E. Ann , Kuntz, Nancy L. , Ness, Jayne , Chabas, Dorothée , Strober, Jonathan B., McDonald, Jamie, Belman, Anita , Milazzo, Maria , Gorman, Mark , Weinstock‐Guttman, B., Rodriguez, Moses , Oksenberg, Jorge R. , Network, For the US Pediatric MS, Waubant, Emmanuelle L. , Krupp, Lauren , Chitnis, Tanuja , James, Judith A. , Network, For the US Pediatric MS, Rodriguez, Moses
Neurology | June 6, 2011 | Volume: 76 | Issue: 23 | Pages: 1989-1995
Younger children with MS have a distinct CSF inflammatory profile at disease onset
Chabas, Dorothée , Ness, Jayne , Belman, Anita , Yeh, E. Ann , Kuntz, Nancy L. , Gorman, Mark , Strober, Jonathan B., Rodriguez, Moses , Krupp, Lauren , Kouchkovsky, Ivan de , McCulloch, Charles E. , Chitnis, Tanuja , Weinstock‐Guttman, Bianca , Krupp, Lauren , Waubant, Emmanuelle L. , Rodriguez, Moses
Neurology | February 1, 2010 | Volume: 74 | Issue: 5 | Pages: 399-405