Citations 4
Longitudinal Evaluation of Cognitive Functioning in Pediatric Multiple Sclerosis (MS): Report from the U.S. Pediatric Multiple Sclerosis Network (S33.004)
Cleary, Rebecca A., Serafin, Dana, Julián, Laura , Baruch, Natalie F, Belman, Anita , Ness, Jayne , Krupp, Lauren , Charvet, Leigh , O’Donnell, Ellen , Parrish, Joy , Benedict, Ralph H. B. , Chitnis, Tanuja , Rodriguez, Moses , Waubant, Emmanuelle L. , Weinstock‐Guttman, Bianca
Neurology | December 7, 2023 | Volume: 82 | Issue: 10_supplement | Pages: No page available
Impaired Cognition without Behavioral Problems in Pediatric Clinically Isolated Syndrome (CIS) (P02.113)
Serafin, Dana, Julián, Laura , Ackerson, Joseph, Braaten, Ellen B. , Brown, Tanya M. , Preston, Thomas J. , Zaccariello, Michael J. , Belman, Anita , Gorman, Mark , Kaufman, Emma , Ness, Jayne , Yeh, E. Ann , Krupp, Lauren , Charvet, Leigh , Benedict, Ralph H. B. , O’Donnell, Ellen , Parrish, Joy , Chitnis, Tanuja , Kaufman, Emma, Patterson, Marc C. , Rodriguez, Moses , Waubant, Emmanuelle L. , Weinstock‐Guttman, Bianca
Neurology | December 7, 2023 | Volume: 80 | Issue: 7_supplement | Pages: No page available
Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: report from the US Pediatric Multiple Sclerosis Network
Charvet, Leigh , O’Donnell, Elisabeth K., Belman, AL, Ness, J., Parrish, Joy , Patterson, Marc C. , Rodriguez, Moses , Krupp, Lauren , O’Donnell, Ellen , Chitnis, Tanuja , Waubant, Emmanuelle L. , Weinstock‐Guttman, Bianca , Krupp, Lauren , Rodriguez, Moses , Charvet, Leigh E , Patterson, Marc
Multiple Sclerosis Journal | March 31, 2014 | Volume: 20 | Issue: 11 | Pages: 1502-1510
Background: Approximately one-third of those with pediatric-onset multiple sclerosis (MS) experience cognitive impairment. Less is known concerning their change in cognitive functioning over time. Objective: Changes in cognitive function over time were measured in the largest pediatric cohort to date through the US Network of Pediatric MS Centers. Methods: A total of 67 individuals with pediatric MS ( n=62) or clinically isolated syndrome (CIS, n=5), ranging from 8–17 years of age (mean age±standard deviation (SD)=14.37±2.02) completed initial and follow-up neuropsychological testing after an average of 1.64±0.63 years apart. The nine tests administered measure general intellect, attention and working memory, verbal memory, visuomotor integration, language, and executive functioning. Results: Rate of impairment (having one-third or more scores in the impaired range) was 37% at baseline and 33% at follow-up. Tests commonly impaired were measures of visuomotor integration, speeded processing, and attention. Most tested did not decline over two years. There was no clear pattern of change on any specific measure. Conclusion: Findings suggest that, over short timeframes, stable or even improved performances on measures of cognitive ability can occur. Pediatric MS may instead prevent expected age-related cognitive gains.
Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis
Julián, Laura , Serafin, Dana, Charvet, Leigh , Ackerson, Joseph, Braaten, Ellen B. , Brown, Tanya M. , O’Donnell, Ellen , Parrish, Joy , Preston, Thomas, Zaccariello, Michael J. , Belman, Anita , Gorman, Mark , Ness, Jayne , Patterson, Marc C. , Rodriguez, Moses , Yeh, E. Ann , Krupp, Lauren , Benedict, Ralph H. B. , Chitnis, Tanuja , Waubant, Emmanuelle L. , Weinstock‐Guttman, Bianca , Krupp, Lauren , Rodriguez, Moses , Charvet, Leigh E , Patterson, Marc
Journal of Child Neurology | November 15, 2012 | Volume: 28 | Issue: 1 | Pages: 102-107
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.