Citations 1
Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis
Julián, Laura , Serafin, Dana, Charvet, Leigh , Ackerson, Joseph, Braaten, Ellen B. , Brown, Tanya M. , O’Donnell, Ellen , Parrish, Joy , Preston, Thomas, Zaccariello, Michael J. , Belman, Anita , Gorman, Mark , Ness, Jayne , Patterson, Marc C. , Rodriguez, Moses , Yeh, E. Ann , Krupp, Lauren , Benedict, Ralph H. B. , Chitnis, Tanuja , Waubant, Emmanuelle L. , Weinstock‐Guttman, Bianca , Krupp, Lauren , Rodriguez, Moses , Charvet, Leigh E , Patterson, Marc
Journal of Child Neurology | November 15, 2012 | Volume: 28 | Issue: 1 | Pages: 102-107
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.