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1458 citation(s) found for "Wu, Sean M".

‘July effect’ in management and outcomes of patients admitted with pulmonary embolism in the United States, 2016 to 2021
Bansal, Mridul , Mehta, Aryan , Morris, D. Lynn, Mehta, Chirag, Abbott, J. Dawn, Vallabhajosyula, Saraschandra , Vallabhajosyula, Saraschandra , Jentzer, Jacob C. , Diepen, Sean van

Baylor University Medical Center Proceedings | July 8, 2025 | Volume: 38 | Issue: 5 | Pages: 675-682

10.1080/08998280.2025.2520125 | PMID 40821483 Get It

Epidemiology of Elbow Medial Ulnar Collateral Ligament Surgeries in Major and Minor League Baseball Pitchers: A Descriptive Study of 2281 Cases
Meta, Fabien , Meister, Keith, Griffith, Timothy B. , Conte, Stan, Chalmers, Peter N., Mavrommatis, Sophia , Hebert, Elizabeth, Clark, Sean C. , Griffith, Timothy Bryan , Chalmers, Peter N. , Hebert, Elizabeth, Camp, Christopher L.

Orthopaedic Journal of Sports Medicine | July 7, 2025 | Volume: 13 | Issue: 7 | Pages: No page available

10.1177/23259671251352199 | PMID 40630505 Get It

Background: Injuries of the medial ulnar collateral ligament (MUCL) among baseball pitchers are increasing. Surgical treatment is evolving to optimize outcomes. Purpose/Hypothesis: This study’s purpose was to highlight trends in MUCL repair and reconstruction in professional pitchers, describe outcomes such as return to any level of play (RTP), and identify factors impacting these outcomes. It was hypothesized that primary and revision MUCL surgery is increasing, with revision surgery requiring greater RTP time. Study Design: Case series; Level of evidence, 4. Methods: The Major League Baseball (MLB) Health and Injury Tracking System database was used to procure data during the study period (2010-2023). All professional pitchers who underwent MUCL surgery during this period were included. RTP was defined as a pitcher returning to at least 1 professional game after index surgery. Return to the same level of play (RTSL) was defined as return to at least 1 game in the same league of play as before surgery. Because of the coronavirus pandemic, the year 2020 was considered an outlier and omitted from time-trend analysis. Results: A total of 2281 pitchers who underwent MUCL surgery during the study period were included for analysis. The number of MUCL surgeries for pitchers increased yearly ( R 2 = 0.821; P < .001), as did the number of reconstructions with internal brace augmentation ( R 2 = 0.896; P < .001). The RTP rate for MLB pitchers was significantly higher than the RTSL rate (93% vs 71%; P < .001). This difference was not observed in Minor League Baseball (MiLB) pitchers (RTP 76% vs RTSL 74%; P = .142). RTP rates after revision surgery were lower than those after primary surgery (71% vs 80%; P = .020). The mean time to RTP was shorter (470 ± 135 days) than the mean time to RTSL (499 ± 153 days; P < .001). Conclusion: The incidence of MUCL surgery and revision surgery is increasing among professional pitchers. Overall, 79% of pitchers returned to any level of play at a mean of 470 days, while 74% returned to the same level of play at a mean of 499 days, but this varied based on level of play. This study will guide athlete expectations and surgeon decision-making.
Interobserver reproducibility of hilar soft tissue invasion in testicular germ cell tumours among genitourinary pathologists
Wu, Douglas, Williamson, Sean R. , Pacheco, Richard R. , Acosta, Andrés , Al‐Obaidy, Khaleel I. , Amin, Mahul B. , Berney, Daniel M. , Brimo, Fadi , Cheng, Liang , Cornejo, Kristine M. , Downes, Michelle R. , Epstein, Jonathan I. , Hirsch, Michelle S. , Jiménez, Rafael E. , Kaushal, Seema , Lobo, Anandi , Mehra, Rohit , Mohanty, Sambit K. , Paner, Gladell P. , Reuter, Victor E. , Smith, Steven C. , Tretiakova, Maria , Trpkov, Kiril , Wobker, Sara E. , Tamboli, Pheroze, Zynger, Debra L. , Sangoi, Ankur R , Cheng, Liang , Sangoi, Ankur R. , Williamson, Sean R , Acosta, Andrés M , Al-Obaidy, Khaleel , Berney, Daniel M , Comperat, Eva , Downes, Michelle , Hirsch, Michelle S , Jimenez, Raphael E , Mehra, Rohit , Mohanty, Sambit K , Smith, Steven , Tretiakova, Maria S , Trpkov, Kiril , Zynger, Debra , Sangoi, Ankur R , Cheng, Liang , Sangoi, Ankur R , Akgül, Mahmut , Colecchia, Maurizio , Compérat, Éva , Dhillon, Jasreman , López-Beltrán, Antonio , Rao, Priya , Shah, Rajal B. , Shen, Steven S. , Tamboli, Pheroze

Histopathology | July 4, 2025 | Volume: 87 | Issue: 5 | Pages: 677-686

10.1111/his.15504 | PMID 40611804 Get It

AimsCompared to lymphovascular invasion (LVI), hilar soft tissue invasion (HSTI) is a relatively novel pT2 staging parameter in testicular germ cell tumours (GCT), associated with metastasis at the time of diagnosis and a risk factor for disease relapse. Given diagnostic variability in how pathologists interpret HSTI, herein we explore interobserver reproducibility among genitourinary (GU) pathologists.MethodsTwenty haematoxylin and eosin‐stained digitized slides from testicular GCTs were distributed to 30 GU pathologists to classify each as HSTI or not HSTI based on their respective clinical practices; slides with concomitant LVI were excluded. Slides were then evaluated for the following morphologic features: tumour invasion beyond prominent hilar vessels, tumour invasion beyond the rete, tumour invasion beyond the level parallel to hilar adipose tissue and tumour within (directly touching) hilar adipose tissue. Interobserver reproducibility was assessed, and the morphological features were correlated with HSTI. Relationships between pathologists' interpretations, morphological features and HSTI were evaluated using hierarchical clustering.ResultsAlthough the diagnosis of HSTI was relatively uniform with a majority agreement (>67%) reached in 17/20 slides, overall interobserver reproducibility was only moderate (kappa = 0.50). Morphological features such as invasion beyond the level parallel to hilar adipose tissue and invasion into fat were more sensitive and specific for HSTI, while features such as invasion beyond hilar vessels and invasion beyond rete were less useful.ConclusionsThese findings suggest that more specific defined diagnostic criteria for testicular GCT HSTI are needed.
CHIC: A machine learning framework for inferring the presence of high‐risk clonal hematopoiesis using complete blood count data from 431,531 UK Biobank participants
Dunn, William G. , Withnell, Isabella, Gu, Muxin , Quirós, Pedro M. , Kovilakam, Sruthi Cheloor, Marando, Ludovica , Wen, Sean, Quiros, Pedro , Dunn, William G , Fabre, Margarete A. , Mohorianu, Irina I , Vuckovic, Dragana , Vassiliou, George S.

HemaSphere | July 4, 2025 | Volume: 9 | Issue: 7 | Pages: No page available

10.1002/hem3.70169 | PMID 40620734 Get It

Outcomes of Patients With Embolic Stroke of Undetermined Source Treated With Antiplatelet Agents or Anticoagulation
Siegler, James E. , Badillo‐Goicoechea, Elena , Penckofer, Mary , Eklund, Kelsey , Yaghi, Shadi , Stretz, Christoph , Lineback, Christina , Stamm, Brian , Peter, Shani , D’Souza, Marissa , Conyers, Frank, Khasiyev, Farid , Kerrigan, Deborah , Lewis, Skylar, Ali, Hamid , Nour, Hassan Aboul , Sharma, Richa, Glover, Patrick , Thompson, Sean, Alshaer, Qasem , Thottempudi, Neeharika, Melkumova, Emiliya , Chionatos, Rafail , Daniel, Jean-Philippe Auguste, Frankel, Michael , Dumitrașcu, Oana , Parikh, Parth , Doolittle, Charles, Yahnke, Ian, Sathya, Anvitha , Kang, Jieun , Kirchhoffer, Kaitlyn, Bowman, Anna, Smith, M. J., Asabere, Aaron, Shahrivari, Mahan, Sheibani, Nazanin , Krishnaiah, Balaji , Gaudio, Elizabeth, Rothstein, Aaron , Alvi, Muhammad M. , Annam, Saketh , Amankwah, Curtis , Kam, Wayneho , Abburi, Nandini , Rojas-Soto, Diana , Molaie, Amir , Khezri, Nicole, Zubair, Adeel , Abbasi, Mehdi , Coevering, Russell J. Van , Nedelcu, Simona , Herpich, Franziska , Chahien, Dalia, Sehgal, Siddharth, Liebeskind, David S. , Linares, Guillermo , Zha, Alicia , Sarkar, Monica , Xi, Romi, Nelson, Ashley, Qdais, Ahmad Abu, Kasab, Sami Al , Singh, Eesha , Patel, Vivek , Mehndiratta, Prachi , DeMarco, Alexis, Cucchiara, Brett , Omran, Setareh Salehi , Dubinski, Michael , Ackerman, Jiyoun, Thon, Jesse , Brown, Samantha , Siegler, James E , Goicoechea, Elena Badillo , Lineback, Christina M , Conyers, F Garrett , Aboul-Nour, Hassan , Sharma, Richa , Nahab, Fadi B , Glover, Patrick , Alshaer, Qasem N , de Havenon, Adam H , Melkumova, Emiliya , Chionatos, Rafail A , Jillella, Dinesh V , Frankel, Michael R , Dumitrascu, Oana M , Sathya, Anvitha , Smith, Matthew M , Brorson, James R , Elangovan, Cheran , Krishnaiah, Balaji , Sloane, Kelly L , Rothstein, Aaron , Alvi, Muhammad M , Kam, Wayneho , Abburi, Nandini , Farooqui, Mudassir , Molaie, Amir , Zubair, Adeel , Abbasi, Mehdi , Van Coevering, Russell J , Nedelcu, Simona , Liebeskind, David S. , Linares, Guillermo , Zha, Alicia , Abu Qdais, Ahmad , Al Kasab, Sami , Aziz, Yasmin , Mehndiratta, Prachi , Sharrief, Anjail , Cucchiara, Brett L , Salehi Omran, Setareh , Nguyen, Thanh N , Thon, Jesse , Yaghi, Shadi , Stretz, Christoph , Penckofer, Mary , Khasiyev, Farid , Brown, Samantha J , Eklund, Kelsey , Stamm, Brian , Daniel, Jean-Philippe Auguste , D'Souza, Marissa , Sharma, Richa , Thottempudi, Neeharika , Havenon, Adam de , Culbertson, Collin J , Jillella, Dinesh , Daniel, Jean-Philippe Auguste, Ro, Jennifer , Brown, Samantha, Doolittle, Charles, Brorson, James R. , Asabere, Aaron, Elangovan, Cheran , Chen, Lucia , Aziz, Yasmin , Nguyen, Thanh N. , Ackerman, Jiyoun

Neurology | July 3, 2025 | Volume: 105 | Issue: 3 | Pages: No page available

10.1212/wnl.0000000000213876 | PMID 40609061 Get It

Simulating the Overall Hospital Quality Star Ratings With Random Measure Weights
Ubl, Daniel S. , Devkaran, Subashnie, Dowdy, Sean C. , Pollock, Benjamin D.

JAMA Network Open | July 3, 2025 | Volume: 8 | Issue: 7 | Pages: e2519029

10.1001/jamanetworkopen.2025.19029 | PMID 40608337 Get It

ImportanceHospital ratings including the US News &amp;amp; World Report’s Best Hospitals rankings and the Centers for Medicare &amp;amp; Medicaid Services’ (CMS’) Overall Hospital Quality Star Rating (Overall Star Rating) measure different outcomes and are weakly correlated. Therefore, methods for defining and measuring reliable excellence, defined as consistently great performance across all quality measures, are needed.ObjectiveTo assess a measure of reliable excellence using the 45 quality measures reported in the Overall Star Ratings.Design, Setting, and ParticipantsThis cross-sectional study used hospital-level data from the 2023 and 2024 CMS Overall Star Ratings at all US hospitals with a 2023 and 2024 CMS Overall Star Rating.ExposuresThe exposure was the CMS Overall Star Rating summary score, a continuous variable calculated from the weighted z scores of 45 quality measures used in the Overall Star Rating. A total of 100 000 simulations were run in which all US hospitals’ CMS Overall Star Rating summary scores were calculated through summation of z scores from randomly generated measure weights, as opposed to the existing weights used in the Overall Star Rating method.Main Outcomes and MeasuresReliable excellence, defined as achieving a 90th percentile (or better) CMS Overall Star Rating summary score on at least 50 000 of 100 000 simulations. The percentage of hospitals achieving reliable excellence was calculated both overall and stratified by CMS Ovearll Star Ratings.ResultsThere were 2700 hospitals in the analysis, with 335 5-star hospitals (12.4%), 727 4-star hospitals (26.9%), 799 3-star hospitals (29.6%), 572 2-star hospitals (21.2%), and 267 1-star hospitals (9.9%) in the 2024 CMS Overall Star Rating. A total of 244 of 2700 hospitals (9.0%) met the study definition of reliable excellence, whereas 1287 of 2700 hospitals (47.7%) achieved excellence in at least 1 simulation.Conclusions and RelevanceThis cross-sectional study of 2700 US hospitals found that only 244 hospitals (9.0%), including less than two-thirds of the CMS 5-star rated hospitals, were reliably excellent across 100 000 CMS Overall Star Rating scoring simulations using random measure weightings. These findings lend credence to the ubiquity of inconsistent greatness in health care quality and illuminate the need for methods to distinguish hospitals that provide reliably excellent care.
Transforming Health Care — Shared Commitments for a Learning Health System
Madara, James, Miyamoto, Suzanne, Dowdy, Sean C. , Greene, Sarah M. , Tarrant, Julie, Margolis, Peter A. , Tarrant, Julie

New England Journal of Medicine | June 25, 2025 | Volume: 393 | Issue: 2 | Pages: 192-197

10.1056/nejmsb2507600 | PMID 40561191 Get It

Personalizing Mechanical Circulatory Support for Cardiogenic Shock: A Review and Comparison of Current Devices
Fujiuchi, Bradley, Benavente, Kevin , Virk, Hafeez Ul Hassan , Alam, Mahboob , Tedford, Ryan J. , Krittanawong, Chayakrit , Tedford, Ryan J , Krittanawong, Chayakrit , Hassan Virk, Hafeez Ul , Jentzer, Jacob C. , Diepen, Sean van

Catheterization and Cardiovascular Interventions | June 23, 2025 | Volume: 106 | Issue: 2 | Pages: 1446-1458

10.1002/ccd.31698 | PMID 40545708 Get It

ABSTRACT Cardiogenic shock (CS) remains a high morbidity and mortality condition worldwide frequently complicating acute myocardial infarction (AMI) and decompensated heart failure (HF). Within the management of CS, mechanical circulatory support (MCS) devices play a critical role in maintaining hemodynamic stability, preserving end‐organ perfusion and bridging patients through to recovery, implantation of durable support or transplantation. Despite their use, optimal timing of initiation, as well as patient and device selection remain unclear. This review explores the current landscape of MCS devices, surrounding evidence and key distinctions between devices. With increasing acknowledgment for the heterogeneity of CS, understanding the strengths and limitations of each device remains crucial to improving outcomes in this high‐risk population.