Harvey, Nicholas C.
https://orcid.org/0000-0002-8194-2512
Mayo Clinic
University Hospital Southampton NHS Foundation Trust
Citations 2
Body mass index and subsequent fracture risk: a meta-analysis to update FRAX
Harvey, Nicholas C. , Johansson, Helena, McCloskey, Eugène , Liu, Enwu , Åkesson, Kristina , Anderson, Fred, Bager, Cecilie L. , Christiansen, Claus, Cooper, Cyrus , Crandall, Carolyn , Cummings, Steven R. , Dawson‐Hughes, Bess , Eisman, John A. , Fujita, Yuki , Fujiwara, Saeko , Glüer, Claus‐Christian , Guðnason, Vilmundur , Hall, Jill, Huisman, Martijn , Iki, Masayuki , Ish‐Shalom, Sophia, Koromani, Fjorda , Kröger, Heikki , Esfahani, Zahra , McGuigan, Fiona E. , Mellström, Dan, Merlijn, Thomas , Nguyen, Tuan V., Ohlsson, Claes , Pasco, Julie A. , Rivadeneira, Fernando, Schei, Berit , Shiroma, Eric J. , Siggeirsdóttir, Kristín , Swart, Karin M. A. , Tamaki, Junko , Staa, Tjeerd van , Wareham, Nicholas J, Yoshimura, Noriko , Zwart, Marta , Kanis, John A, McCloskey, Eugene V , Åkesson, Kristina E , Biver, Emmanuel , Center, Jacqueline R , Cooper, Cyrus , Crandall, Carolyn J , Dawson-Hughes, Bess , Dufour, Alyssa B , Eisman, John A , Ferrari, Serge , Hans, Didier B. , Iki, Masayuki , Karlsson, Magnus K , Khosla, Sundeep , Kiel, Douglas P , Koromani, Fjorda , Kwok, Timothy , Lamy, Olivier , Larijani, Bagher , McGuigan, Fiona E A , Merlijn, Thomas , Ohlsson, Claes , Orwoll, Eric S , Simonsick, Eleanor Marie , Sund, Reijo , Szulc, Pawel , Tamaki, Junko , Wright, Nicole C , Zillikens, M. Carola , Lorentzon, Mattias , Leslie, William D , Azagra, Rafael , Beaudart, Charlotte , Bischoff‐Ferrari, Heike A. , Biver, Emmanuel , Bruyère, Olivier , Cauley, Jane A. , Chapurlat, Roland D , Silva, José António Pereira da , Díez‐Pérez, Adolfo , Elders, Petra J. M. , Ferrari, Serge , Goldshtein, Inbal , Goltzman, David , Hall, Jill, Hoff, Mari , Hollick, Rosemary J , Jones, Graeme , Khosla, Sundeep , Kiel, Douglas P. , Koh, Woon‐Puay , Kotowicz, Mark A. , Langhammer, Arnulf , Lippuner, Kurt , Nordström, Anna , Nordström, Peter , O’Neill, Terence W , Obermayer-Pietsch, Barbara Maria , Orwoll, Eric , Rivadeneira, Fernando , Schott, Anne‐Marie , Sornay‐Rendu, Elisabeth , Szulc, Paweł , Torgerson, David John , Schoor, Natasja M. van , Vila, Joan , Vandenput, Liesbeth , Lorentzon, Mattias , Leslie, William D. , Kanis, John A.
Journal of Bone and Mineral Research | August 12, 2025 | Volume: 40 | Issue: 10 | Pages: 1144-1155
Abstract The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1 667 922 men and women from 32 countries (63 cohorts), followed for a total of 16.0 million person-years were studied. 293 325 had FN BMD measured (2.2 million person-years follow-up). An extended Poisson model in each cohort was used to investigate relationships between WHO-defined BMI categories (Underweight: <18.5 kg/m2; Normal: 18.5-24.9 kg/m2; Overweight: 25.0-29.9 kg/m2; Obese I: 30.0-34.9 kg/m2; Obese II: ≥35.0 kg/m2) and risk of incident osteoporotic, major osteoporotic and hip fracture (HF). Inverse-variance weighted β-coefficients were used to merge the cohort-specific results. For the subset with BMD available, in models adjusted for age and follow-up time, the hazard ratio (95% CI) for HF comparing underweight with normal weight was 2.35 (2.10-2.60) in women and for men was 2.45 (1.90-3.17). Hip fracture risk was lower in overweight and obese categories compared to normal weight [obese II vs normal: women 0.66 (0.55-0.80); men 0.91 (0.66-1.26)]. Further adjustment for FN BMD T-score attenuated the increased risk associated with underweight [underweight vs normal: women 1.69 (1.47-1.96); men 1.46 (1.00-2.13)]. In these models, the protective effects of overweight and obesity were attenuated, and in both sexes, the direction of association reversed to higher fracture risk in Obese II category [Obese II vs Normal: women 1.24 (0.97-1.58); men 1.70 (1.06-2.75)]. Results were similar for other fracture outcomes. Underweight is a risk factor for fracture in both men and women regardless of adjustment for BMD. However, while overweight/obesity appeared protective in base models, they became risk factors after additional adjustment for FN BMD, particularly in the Obese II category. This effect in the highest BMI categories was of greater magnitude in men than women. These results will inform the second iteration of FRAX®.
Bone Research Society Abstracts
Team, the ERC ADREEM, Roelofs, Anke J. , Cummings, Steven R. , Bhimjiyani, A. , Neuburger, Jenny , Gregson, Celia L, Sparkes, Penny C. , Swiatkowska, Agnes, Lelliott, Christopher J. , Williams, Graham R. , Bassett, J. H. Duncan , Paton‐Hough, Julia, Tazzyman, Simon , Evans, Holly , Lath, Darren , Down, Jenny , Green, Alanna, Snowden, John A. , Chantry, Andrew, Na, Harvey, Shepstone, Lee , Kanis, John А. , Lenaghan, Elizabeth, Clarke, Shane, Harvey, I., Heawood, Ali, Howe, Amanda , Marshall, Tarnya, McCloskey, Eugène , Group, the SCOOP Trial, Hardy, Rebecca , Adams, Judith E., Aspden, Richard, Js, Gregory , Vlachopoulo, Dimitris, Maslin, Kate , Gossiel, Fatma , Bishop, Nicholas , Fraser, Robert, Gandhi, Saurabh , Prentice, Ann , Schoenmakers, Inez , Eastell, Richard , Cooper, Cyrus, Group, the MAVIDOS Trial, Ward, Kate, Cooper, Cyrus, Dennison, Elaine, Bonnet, Cleo, Eccles, Emily, Norman, K. Duane, Ko, Jeong‐Hun, Williams, G. Rhys, Madhusudan, Namrata, Bountra, C. , Oppermann, Udo , Oreffo, Richard OC , McEwan, Josephine, White, Kate L. , Oreffo, Richard, Dunlop, D. , Cornish, Jillian , Goring, Alice, Boyde, A. , Hesse, Eric , Olsen, Björn, Pitsilides, Andrew, Oreffo, Richard, Hartley, A M, Fraser, William, Tobias, JS, Harvey, Nicolas, Johansson, Helena , Cooper, Cyrus, Team, SCOOP Study, Roberts, Fiona , Rashdan, Nabil A. , Staines, Katherine, Milne, Elspeth , Morton, Nicholas M. , McCulloch, Kendal, Dunning, Lynette, Lockhart, John C. , Thomas, Neil Peter, Ranganath, L. , Gallagher, James A., Ward, Kate, Stewart, Angela, Garratt, Liz, Bastin, Sonja , Gamble, Gregory D., Shaw, Nick , Prieto-Alhambra, D, Cooper, Cyrus, Hughes, Juliette H. , Liu, Ke , Hughes, Andrew, Nijjar, Jagtar Singh , Padley, Jessica, Poole, Ken, Litwic, Anna, Dennison, Elaine, Edwards, Mark H. , Cooper, Cyrus, Dennison, Elaine, Ishimoto, Yuyu , Cooper, Cyrus, Ntani, Georgia , Yamada, H. , Muraki, Shigeyuki , Yoshida, Munehito , Yoshimura, Tan, Juan, Poole, Kenneth, Larrouture, Quitterie C. , Athanasou, Nick, Al-Sari, Usama , Felder, Alessandro , Chua, Melissa Y, Lodhia, Kalyani, Kłosowski, Michał M. , Farquharson, Colin, Inglis, Stefanie , Redl, Heinz , Oreffo, Richard, Gogakos, Apostolos , Ebri, Davide Komla, Pipelines, Sanger Mouse, Cidonio, Gianluca , Lanham, Stuart , Dawson, Jonathan, Oreffo, Richard, McEwan, Josephine, Wells, Julia, Oka, Hiroyuki , Iidaka, Toshiko , Kodama, Rie , Horii, Chiaki , Nakamura, Kozo, Akune, Toru, Hudson, Katie, Fisher, Matt , Chantry, Andrew, Adoum, Anne‐Tounsia, Bassett, Duncan, Mannan, Naila S., Dewhurst, Hannah F. , Ghirardello, Elena J. , Pipelines, Sangar Mouse, Komla‐Ebri, David, Curry, Katharine F., 𠀉, JH, Ganguly, Payal , Sparkes, Penny, Curry, Katherine F., Sim, Alisia, Kaczynski, Jakub , Novak, Amanda , Mills, David , Bonnet, Cleo, Ihenacho, Menna, Cronin, Rose‐Marie, Mason, Debbie , Rodriguez, Alexander, Xu, Cecilia, Scott, David , Dennison, Elaine, Stephenson, Sonya, Cosulich, Carlotta, Cooper, Cyrus, Sano, Hiroshige, Kondo, Naoki , Shimakura, Taketoshi, Fujisawa, Junichi, Kijima, Yasufumi, Skingle, Linda , Yamamoto, Noriaki , Takahashi, Hideaki E. , Endo, Naoto , Beamish, Rebecca, Evans, Sam, Morgan, Stephanie , Hooper, Kirsty M. , Halewood, Katherine , Stevens, Craig , Staines, Katherine, Steenhuis, Pieter, Ignelzi, Michael A., Morris, Michael D., Karabetsos, Matthew, VanRenterghem, Gloria, Ayyalusamy, Ramamoorthy, Kadamban, Premila, Vaughan‐Lane, Timothy, Wright, Maria da Glória Miotto , Poole, Kenneth , Cooper, Cyrus, Neven, Ellen, Wheeler‐Jones, Caroline , Rukuni, Ruramayi , Crabtree, Nicola , Mukwasi, Cynthia, McHugh, Grace , Gregson, Celia L, Luo, Jin , Dodhia, Vikash , Czekanska, Ewa M., Oreffo, Richard, Arnold, Emily L. , Gohin, Stéphanie , Soper, Robin, Ytrebø, Lars Marius , Meeson, Richard , Howat, D. , Hodges, Stephen , Evelyn‐Wright, Stephanie , Mavrogordato, Mark , Rankin, Kathryn , Stocks, Oliver, Hartley, Chris , Kerslake, R. W. , Thomson, Seamus , Muderis, Munjed Al, Ward, Kevin R. , Sowman, Aneka, Hart, Deborah , Spector, Tim D. , Coxon, Joshua, Townsend, Paul , Jones, Rebecca , Lawrence, Kevin M., Egan, B. T., Tattersall, Luke , Holm, Stefan H. , Martin, Jenny, Saunders, Fiona, Martin, J F, Saunders, Fiona, Davies, Amanda, Hugtenburg, R.P. , Wintsch, Emma, Anderson, Susan, Alshamrani, Hassan A. , Paggiosi, Margaret , Bishop, Nick , Offiah, Amaka C , Pretorius, Sarah, Roberts, Scott, Logan, Malcolm , Allaire, Brett , Bouxsein, Mary , Olatokun, Olamide, Nash, Thomas H., Abdul-Jabar, Hani B., Tran, Anh Nhi, Segeletz, Sandra, McDermott, Emma, Wileman, Tom, Helfrich, Miep , Redman, Amelia, Elford, Carole, Evans, Bronwen, Bradley, Mark , Martín, Iván , Khosla, Sundeep , Mahajan, Sumeet , Heller, Markus O.W. , Schneider, Philipp , Bonewald, Lynda F. , Lillycrop, Karen A. , Hanson, Mark, Lord, Janet M. , Maes, Christa , Ben‐Shlomo, Yoav , Leitch, Victoria D. , Logan, John G. , Croucher, Peter Ian , Lawson, Michelle Anne , Chantry, Andrew , Parsons, Camille M. , Fordham, Richard J , Gittoes, Neil , Holland, Richard , Redmond, Niamh Maria , Peters, T. J. , Torgerson, David John , O’Neill, Terence W , Cooper, Cyrus , Ireland, Alex , Muthuri, Stella G. , Saunders, Fiona R. , Pavlova, Anastasia Vladimirovna , Martin, Kathryn Remmes , Barr, Rebecca J. , Kuh, Diana J. , Cooper, Rachel , BARKER, ALAN ROBERT , Ubago‐Guisado, Esther , Williams, Craig Anthony , Gracia‐Marco, Luis , Curtis, Elizabeth Mary , D’Angelo, Stefania , Moon, Rebecca Jane , Crozier, Sarah , Kennedy, Stephen , Papageorghiou, Aris T. , Fraser, Robert, Inskip, Hazel M. , Godfrey, Keith M. , Javaid, M K , Cooper, Cyrus, Harvey, Nicholas C. , Group, the MAVIDOS Trial, Fuggle, Nicholas R. , Westbury, Leo D. , Syddall, Holly Emma , Ward, Kate, Duggal, Niharika Arora , Bonnet, Cleo Selina , Gilbert, Sophie J. , Norman, Kingsley, Mason, Deborah J. , Pereira, Marie , Petretto, Enrico , Williams, Graham R, Behmoaras, Jacques V. , Andrés, María C. de , Goriainov, Vitali , McEwan, Josephine K, White, Kate, Ferrara, Napoleone, Olsen, Bjorn, Clarkin, Claire E. , Paternoster, Lavinia , Kemp, John P. , Evans, David, TANG, JONATHAN C. Y. , Tobias, Jon H, Gregson, Celia Louise , Harvey, Nicolas, Orriss, Isabel R. , Ahmed, Faisal, Farquharson, Colin , MacRae, Vicky E. , Huesa, Carmen , Hof, Rob vanʼt , Goodyear, Carl S. , Thomas, Neil P. , Jeffery, Nathan S. , Breasail, Mícheál Ó , Reid, Ian R. , Horne, Anne M. , Mihov, Borislav , Bolland, Mark J , Delmestri, Antonella , Pinedo‐Villanueva, Rafael , Wilson, Peter, Hughes, Andrew, Bou–Gharios, George , Ward, Kate, Yamada, Hiroshi, Hashizume, Hiroshi , Tanaka, Sakae , Walker-Bone, Karen E , Knowles, Helen J. , Snelling, Sarah , Tobias, Jon H, Clark, Emma , Doube, Michael , Hutchinson, John R. , Shefelbine, Sandra J. , Dillon, Scott , Nudelman, Fabio , Kanczler, Janos M. , Schneider, Karl H. , Pollard, Andrea S. , Butterfield, Natalie C. , Williams, Graham R, Ahlfeld, Tilman , Glinka, Michael , Kim, Yang‐Hee , Yang, Shoufeng , Gelinsky, Michael , Wells, Julia A. , Kawaguchi, Hiroshi , Fisher, Matt, Miszkiewicz, Justyna Jolanta , Yoshimura, Takashi , Allen, Rebecca S. , El‐Jawhari, Jehan J. , Burska, Agata N. , Ponchel, Frédérique , Giannoudis, Peter Vasilios , Jones, Elena , Komla-Ebri, Davide S. K. , Hohenstein, Peter , Hung, John , Newby, David E. , Baker, Andrew, Karsenty, Gérard , Hsu, Shun‐Neng , Staines, Katherine Ann , Blain, Emma J. , Mason, Debbie, Rodriguez, Alexander, McMillan, Lachlan B. , Srikanth, Velandai , Ebeling, Peter R. , Javaheri, Behzâd , Ferrara, Napoleone, Olsen, Bjorn, Pitsillides, Andrew A. , Jones, Tim J , Clynes, Michael A. , James, Anthony , Harvey, Nicolas, Ersek, Adel , Cosulich, Carlotta Cecilia, Udalova, Irina A. , Horwood, Nicole J. , Jameson, Karen, Dennison, Elaine Margaret , Ayre, Wayne Nishio , Evans, Sam, Morgan, Stephanie, Mandair, Gurjit S. , Kohn, David H. , Kadamban, Premila, Galloway, James Benjamin , Vaughan-Lane, Tim, Wright, Maria, Brassett, Cecilia , Poole, Kenneth, Judge, Andrew , Leyland, Kirsten M. , Bourne, Lucie E. , Patel, Jessal J. , D’Haese, Patrick C. , Majonga, Edith D. , Mujuru, Hilda Angela , Ferrand, Rashida A. , Chen, Jiye , Dawson, Jonathan I. , Geng, Jin , Lim, Khoon S. , Woodfield, Tim B. F. , Greenwood, Charlene , Rogers, Keith D. , McGivern, Hannah , Márquez‐Grant, Nicholas , Zioupos, Peter , Hopkinson, Mark , Howat, David, Williams, Katherine A. , Gostling, Neil J. , Dyke, Gareth J. , Browne, Martin , Woods, Christopher, Dickinson, Alex , Zakrzewski, Sonia , Hartley, Chris, Folland, Jonathan P. , Brooke-Wavell, Katherine S. F. , Ossipov, Dmitri A. , Lu, William W. , Arden, Nigel , Edwards, James R., Kluzek, Stefan , Sanchez-Santos, Maria Teresa , Ismail, Omar Mohammad , Egan, Ben, Birchall, James C. , Heard, Charles, Marchi, Elena De , Virgilio, Francesco Di , Adinolfi, Elena , Gartland, Alison , Moura, Catarina Costa , Tare, Rahul S. , Xavier, Miguel , Beech, Jason Paul , Spencer, Daniel C. , Tegenfeldt, Jonas Olof , Morgan, Hywel , Murphy, Caitlin C. , Gregory, J.S. , Riemen, Anna H.K. , Davies, Amanda, Ahmad, Faizan , Theobald, Peter S. , Johnston, Richard, Piercy, Richard J. , Millar, Sophie , Anderson, Susan, O’Sullivan, Saoirse Elizabeth , Roberts, Scott, Jóhannesdóttir, Fjóla , Anderson, Dennis , Samelson, Elizabeth J , Kiel, Douglas P. , Nash, Thomas, Rochford, Justin J. , Al‐Sabah, Ayesha , Hardy, Rebecca
JBMR Plus | October 2, 2018 | Volume: 2 | Issue: S1 | Pages: No page available