Citations 42
P2‐025: Genetic and epigenetic influences on brain gene expression in psp
Allen, Mariet , Wang, Xue , Younkin, Curtis, Ballard, Travis, Serie, Daniel, Baheti, Saurabh , Carrasquillo, Minerva M. , Nguyen, Thuy , Malphrus, Kimberly G., Lincoln, Sarah, Zou, Fanggeng, Chai, High-Seng, Schellenberg, Gerard D. , Younkin, Steven G., Ördög, Tamás , Asmann, Yan W. , Taner, Nilüfer, Burgess, Jeremy D. , Wang, Chen , Sun, Zhifu , Carrasquillo, Minerva M. , Crook, Julia E. , Dickson, Dennis W.
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_10 | Pages: No page available
Late-onset Alzheimer disease risk variants mark brain regulatory loci
Allen, Mariet , Kachadoorian, Michaela, Carrasquillo, Minerva M. , Manly, Lester S. , Burgess, Jeremy D. , Serie, Daniel, Siuda, Joanna , Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Medway, Christopher, Nguyen, Thuy , Malphrus, Kimberly G., Lincoln, Sarah, Petersen, Ronald C. , Graff‐Radford, Neill R. , Asmann, Yan W. , Younkin, Steven G. , Ertekin‐Taner, Nilüfer , Karhade, Aditya, Manly, Lester, Crook, Julia, Carrasquillo, Minerva M. , Karhade, Aditya V. , Wang, Chen , Wang, Xue , Siuda, Joanna S. , Crook, Julia E. , Ma, Li , Dickson, Dennis W.
Neurology Genetics | August 27, 2015 | Volume: 1 | Issue: 2 | Pages: No page available
Convergent genetic and expression data implicate immunity in Alzheimer's disease
Jones, Lesley , Lambert, Jean‐Charles , Choi, Seung‐Hoan, Harold, Denise , Vedernikov, Alexey , Escott‐Price, Valentina , Stone, Timothy, Richards, Alexander , Bellenguez, Céline , Sims, Rebecca , DeStefano, Anita L. , Bis, Joshua C. , Beecham, Gary W. , Grenier‐Boley, Benjamin , Russo, Giancarlo , Thornton‐Wells, Tricia A., Jones, Nicola, Smith, Albert V. , Thomas, Charlene , Zélénika, Diana, Kamatani, Yoichiro, Lin, Chiao‐Feng , Schmidt, Helena , Kunkle, Brian W. , Dunstan, Melanie , Ruiz, Agustı́n , Bihoreau, Marie‐Thérèse, Reitz, Christiane, Hollingworth, Paul, Hanon, Olivier , Fitzpatrick, Annette L., Buxbaum, Joseph D. , Campion, Dominique , Crane, Paul K. , Guðnason, Vilmundur , Cruchaga, Carlos , Craig, David W. , Amin, Najaf , Jager, Philip L. De , Deramecourt, Vincent , Johnston, Janet, Evans, Denis A., Lovestone, Simon , Letteneur, Luc, Kornhuber, Johanes, Tárraga, Lluís , Eiriksdottir, Gudny, Goate, Alison , Fiévet, Nathalie, Huentelman, Matthew J. , Gill, Michael , Emilsson, Valur , Brown, Kristelle, Kamboh, M. Ilyas , Keller, Lina, Barberger‐Gateau, Pascale, McGuinness, Bernadette , Larson, Eric B., Dufouil, Carole , Todd, Stephen , Wallon, David , Kehoe, Patrick G. , George‐Hyslop, Peter St , Lleὀ, Alberti, Bayer, Anthony, Tsuang, Debby W. , Yu, Lei, Tsolaki, Magda , Bossù, Paola , Spalletta, Gianfranco , Proitsi, Petra, Collinge, John, Sorbi, Sandro , Hardy, John , Naranjo, María Cándida Déniz, Razquín, Cristina , Bosco, Paola , Clarke, Robert , Brayne, Carol , Galimberti, Daniela , CFAS, MRC, Moebus, Susanne , Mecocci, Patrizia , Zompo, Maria Del, Maier, Wolfgang, Hampel, Harald , Pilotto, Alberto, Bullido, María J. , Panza, Francesco , Caffarra, Paolo , Nacmias, Benedetta , Gilbert, John R., Mayhaus, Manuel, Jessen, Frank , Dichgans, Martin , Lannfelt, Lars , Håkonarson, Håkon , Pichler, Sabrina, Carrasquillo, Minerva M., Beekly, Duane, Alavarez, Victoria, Zou, Fanggeng, Younkin, Steven G., Hamilton‐Nelson, Kara L., Mateo, Ignacio, Faber, Kelley M., Jónsson, Pálmi V. , Combarros, Onofre, O‘Donovan, Michael , Cantwell, Laura B., Blacker, Deborah , Mead, Simon , Harris, Tamara B., Fratiglioni, Laura , Bruijn, Renée F.A.G. de, Passmore, Peter , Montine, Thomas J. , Bettens, Karolien, Rotter, Jerome I. , Brice, Alexis , Morgan, Kevin , Foroud, Tatiana, Kukull, Walter A. , Hannequin, Didier , Powell, John , Nalls, Michael A., Ritchie, Karen , Lunetta, Kathryn L. , Kauwe, John S.K., Boerwinkle, Eric , Riemenschneider, Matthias, Boada, Merçé , Hiltunen, Mikko , Martin, Eden R. , Pástor, Pau , Schmidt, Reinhold, Dartigues, Jean‐François, Mayeux, Richard , Tzourio, Christophe , Hofman, Albert , Nöthen, Markus M. , Graff, Caroline , Haines, Jonathan L. , Lathrop, Mark, Pericak‐Vance, Margaret A. , Launer, Lenore J. , Farrer, Lindsay A. , Duijn, Cornelia M. van , Broeckhoven, Christine Van , Ramı́rez, Alfredo , Schellenberg, Gerard D., Seshadri, Sudha , Amouyel, Philippe , Williams, Julie , Holmans, Peter , Bennett, David A. , Proitsi, Petroula , Ballantyne, Christie M. , Denning, Nicola , Wang, Weixin , Ibrahim‐Verbaas, Carla A. , Naj, Adam Christian , Gerrish, Amy , Jun, Gyungah , Chouraki, Vincent Antoine , Ikram, M. Arfan , Vardarajan, Badri Narayan , Kamatani, Yoichiro, Pasquier, Florence , Becker, Tim , Cruchaga, Carlos , Berr, Claudine , López, Oscar L. , Rubinsztein, David Chaim , Sleegers, Kristel , Myers, Amanda , Love, Seth , Rogaeva, Ekaterina A. , Gallacher, John , Clarimón, Jordi , Bayer, Anthony, Proitsi, Petra, Sánchez-García, Florentino , Fox, Nick C. , Mancuso, Michelangelo , CFAS, MRC, Carrasquillo, Minerva M. , Ingelsson, Martin , Valladares, Otto , Coto, Eliécer , Hamilton‐Nelson, Kara L. , Owen, Michael J. , Soininen, Hilkka S. , Mosley, Thomas H. , Bennett, David , Holmes, Clive , Riemenschneider, Matthias, Rujescu, Dan , Psaty, Bruce M. , Bennett, David A. , Dichgans, Martin , Ramirez, Alfredo , Hakonarson, Hakon , Nöthen, Markus M , Seshadri, Sudha , Hardy, John , Amouyel, Philippe , Tzourio, Christophe , van Duijn, Cornelia M , Smith, Albert V , Ballantyne, Christie M , Rotter, Jerome I , Moebus, Susanne , Ruiz, Agustín , Pastor, Pau , Boada, Merce , Tsolaki, Magda , Brice, Alexis , Goate, Alison M , Galimberti, Daniela , Escott-Price, Valentina , Mecocci, Patrizia , Nacmias, Benedetta , Graff, Caroline , Riemenschneider, Markus J.
Alzheimer's & Dementia | December 20, 2014 | Volume: 11 | Issue: 6 | Pages: 658-671
AbstractBackgroundLate‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis.MethodsThe ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain.ResultsALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 × 10−12 after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 × 10−11), cholesterol transport (P = 2.96 × 10−9), and proteasome‐ubiquitin activity (P = 1.34 × 10−6). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002–.05).ConclusionsThe immune response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.
O3‐04‐06: GENE EXPRESSION PROFILING AND DNA METHYLATION IN ALZHEIMER'S DISEASE BRAINS
Allen, Mariet , Serie, Daniel, Baheti, Saurabh , Walsh, Mike C., Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Pancratz, V. Shane, Carrasquillo, Minerva M. , Nair, Asha, Maharjan, Sooraj, Nguyen, Thuy , Malphrus, Kimberly G., Lincoln, Sarah, Bisceglio, Gina, Ördög, Tamás , Petersen, Ronald C. , Graff‐Radford, Neill R., Younkin, Steven G., Asmann, Yan W. , Ertekin‐Taner, Nilüfer , Sun, Zhifu , Siuda, Joanna S. , Burgess, Jeremy D. , Crook, Julia E. , Carrasquillo, Minerva M. , Middha, Sumit , Ma, Li , Dickson, Dennis W. , Graff‐Radford, Neill R.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_3 | Pages: No page available
O4‐04‐06: TRANSCRIPTIONAL REGULATION OF GENES AT THE ALZHEIMER'S DISEASE RISK LOCI
Kachadoorian, Michaela, Allen, Mariet , Lincoln, Sarah, Manly, Lester S. , Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Pancratz, V. Shane, Carrasquillo, Minerva M. , Nair, Asha, Maharjan, Sooraj, Nguyen, Thuy , Malphrus, Kimberly G., Bisceglio, Gina, Petersen, Ronald C. , Graff‐Radford, Neill R., Younkin, Steven G., Ertekin‐Taner, Nilüfer , Karhade, Aditya V. , Crook, Julia E. , Carrasquillo, Minerva M. , Middha, Sumit , Ma, Li , Graff‐Radford, Neill R., Dickson, Dennis W.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_4 | Pages: No page available
P3‐022: TRANSCRIPTIONAL REGULATION AT THE TREM GENE CLUSTER IN AD BRAINS
Carrasquillo, Minerva M. , Allen, Mariet , Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Pancratz, V. Shane, Nair, Asha, Maharjan, Sooraj, Nguyen, Thuy , Ma, Li , Lincoln, Sarah, Malphrus, Kimberly G., Bisceglio, Gina, Petersen, Ronald C. , Graff‐Radford, Neill R., Younkin, Steven G., Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Crook, Julia E. , Middha, Sumit , Graff‐Radford, Neill R., Dickson, Dennis W.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available
P1‐055: MULTIPLE ABCA7 MISSENSE VARIANTS MINED FROM THE EXOME VARIANT SERVER SHOW INDEPENDENT ASSOCIATION WITH INCREASED OR DECREASED RISK OF LATE‐ONSET ALZHEIMER'S DISEASE (LOAD)
Medway, Christopher W, Abdul‐Hay, Samer O., Mims, Tynickwa, Zou, Fanggeng, Bisceglio, Gina, Pankratz, Shane, Sando, Sigrid Botne , Aasly, Jan , Carrasquillo, Minerva M. , Graff‐Radford, Neill R., Petersen, Ronald C. , Ertekin‐Taner, Nilüfer , Younkin, Steven G., Ma, Li , Barcikowska, Maria , Siuda, Joanna S. , Wszołek, Zbigniew K. , Ross, Owen A. , Carrasquillo, Minerva M. , Dickson, Dennis W. , Graff‐Radford, Neill R., Morgan, Kevin
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_8 | Pages: No page available
O5–01–05: Haplotypes at the MAPT locus associate with risk for LOAD and brain gene expression
Allen, Mariet , Kachadoorian, Michaela, Quicksall, Zachary , Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Carrasquillo, Minerva M. , Krishnan, Siddarth, Nguyen, Thuy , Malphrus, Kimberly G., Lincoln, Sarah, Bisceglio, Gina, Kolbert, Christopher P., Jen, Jin , Petersen, Ronald C. , Graff‐Radford, Neill R. , Younkin, Steven G. , Ertekin‐Taner, Nilüfer , Crook, Julia E. , Pankratz, V. Shane , Carrasquillo, Minerva M. , Ma, Li , Dickson, Dennis W.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_21 | Pages: No page available
O3‐11‐03: Genetic association of variants with late‐onset Alzheimer's disease risk and brain gene expression
Allen, Mariet , Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Carrasquillo, Minerva M. , Rowley, Christopher , Nair, Asha, Maharjan, Sooraj, Nguyen, Thuy , Malphrus, Kimberly G., Palusak, Ryan, Lincoln, Sarah, Bisceglio, Gina, Georgescu, Constantin , Kolbert, Christopher P., Jen, Jin , Haines, Jonathan L. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Schellenberg, Gerard, Petersen, Ronald , Graff‐Radford, Neill R. , Younkin, Steven G., Ertekin‐Taner, Nilüfer , Crook, Julia E. , Pankratz, V. Shane , Carrasquillo, Minerva M. , Middha, Sumit , Ma, Li , Farrer, Lindsay A. , Dickson, Dennis W.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_12 | Pages: No page available
O5‐03‐03: Genetic association of progressive supranuclear palsy (PSP) risk loci variants with brain gene expression and neuropathology endophenotypes
Ertekin‐Taner, Nilüfer , Allen, Mariet , Murray, Melissa E. , Serie, Daniel, Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Carrasquillo, Minerva M. , Rowley, Christopher , Nair, Asha, Maharjan, Sooraj, Nguyen, Thuy , Malphrus, Kimberly G., Palusak, Ryan, Lincoln, Sarah, Bisceglio, Gina, Georgescu, Constantin , Kolbert, Christopher P., Jen, Jin , Schellenberg, Gerard D. , Petersen, Ronald C. , Graff‐Radford, Neill R. , Younkin, Steven G. , Crook, Julia E. , Pankratz, V. Shane , Carrasquillo, Minerva M. , Middha, Sumit , Ma, Li , Kouri, Naomi , Dickson, Dennis W. , Murray, Melissa E
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_20 | Pages: No page available