Citations 27
Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women
Grant, Delores J. , Alberg, Anthony J. , Barnholtz‐Sloan, Jill S. , Bondy, Melissa L. , Funkhouser, Ellen, Moorman, Patricia G. , Peres, Lauren C. , Peters, Edward , Schwartz, Ann G. , Terry, Paul , Wang, Xin‐Qun, Hoyo, Cathrine , Sandler, Dale P. , Taylor, Jack A. , Edwards, Todd L., Beeghly‐Fadiel, Alicia, Wentzensen, Nicolas , Pearce, Celeste Leigh , Wu, Anna H. , Whittemore, Alice S. , McGuire, Valerie , Sieh, Weiva , Rothstein, Joseph H. , Ness, Roberta B., Moysich, Kirsten B. , Rossing, Mary Anne, Sellers, Thomas A. , Monteiro, Álvaro N.A. , Levine, Douglas A. , Haiman, Christopher A. , Menon, Usha , Ramus, Susan J. , Gayther, Simon A. , Terry, Kathryn L. , Goode, Ellen L. , Cannioto, Rikki , Odunsi, Kunle , Etter, John Lewis , Huang, Ruea‐Yea , Bernardini, Marcus Q. , Tone, Alicia , May, Taymaa, Goodman, Marc T. , Thompson, Pamela J., Carney, Michael E. , Tworoger, Shelley S. , Lambrechts, Diether , Vergote, Ignace , Nieuwenhuysen, Els Van , Salvensen, Helga B., Massuger, Leon F.A.G. , Bruegl, Amanda , Moffitt, Melissa , Le, Nhu D. , Brooks‐Wilson, Angela , Kelemen, Linda E. , Song, Honglin , Eccles, Diana , DeFazio, Anna , Kennedy, Catherine J. , Schildkraut, Joellen M. , Lambrechts, Diether , Barnholtz-Sloan, Jill S , Moysich, Kirsten , Permuth, Jennifer B , Cramer, Daniel W , Fazio, Anna de , Lambrechts, Diether , Ramus, Susan J , Sandler, Dale P , Tworoger, Shelley S , Eccles, Diana , Menon, Usha , Monteiro, Alvaro N , Brooks-Wilson, Angela R , Kennedy, Catherine J , Lambrechts, Diether , Sieh, Weiva , Taylor, Jack A , Goodman, Marc T , Manichaikul, Ani , Bandera, Elisa V. , Coté, Michele L. , Keku, Temitope O , Berchuck, Andrew , O’Brien, Katie M. , Edwards, Digna R. Velez , Beeghly‐Fadiel, Alicia , Modugno, Francesmary , Doherty, Jennifer A. , Permuth, Jennifer B. , Setiawan, Veronica Wendy , Marchand, Loı̈c Le , Wilkens, Lynne R. , Karlan, Beth Y. , Gentry‐Maharaj, Aleksandra , Cramer, Daniel W. , Larson, Melissa C. , Kaufmann, Scott H. , Poole, Elizabeth M. , Vanderstichele, Adriaan , Anton‐Culver, Hoda , Ziogas, Argyrios , Brenton, James D. , Bjørge, Line , Kiemeney, Lambertus A. , Pejovic, Tanja B. , Cook, Linda S. , Pharoah, Paul D.P. , Campbell, Ian
Cancer Medicine | April 19, 2019 | Volume: 8 | Issue: 5 | Pages: 2503-2513
AbstractAn association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom‐designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high‐grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2‐1.7, P = 1.2 × 10−6, BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6‐3.4, P = 1.6 × 10−5, BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2‐1.7, P = 2.3 × 10−5, BFDP = 0.23). Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women. Future studies to validate these findings are warranted. Alterations in EGFR and UGT2A1/2 could perturb enzyme efficacy, proliferation in ovaries, impact and mark susceptibility to EOC.
Abstract 1308: Transcriptome-wide association study among 66,450 women to identify candidate susceptible genes for ovarian cancer risk
Lu, Yingchang , Schildkraut, Joellen M. , Sellers, Thomas A. , Wu, Lang , Li, Bingshan , Chen, Y. Ann , Doherty, Jennifer B., Gayther, Simon A. , Goode, Ellen L. , Im, Hae Kyung , Lawrenson, Kate , Reid, Brett M. , Teer, Jamie K. , Osório, Ana , Guo, Xingyi , Kar, Siddhartha , Manichaikul, Ani , Permuth, Jennifer B. , Pharoah, Paul D.P. , Zheng, Wei , Long, Jirong , Lawrenson, Kate , Im, H K
Cancer Research | July 31, 2017 | Volume: 77 | Issue: 13_Supplement | Pages: 1308-1308
Abstract Background: Large-scale genome-wide association studies (GWAS) have identified ~35 loci associated with epithelial ovarian cancer risk. However, these genetic loci together explain only a small portion of the heritability of this malignancy. The large majority of the GWAS-identified variants are located in non-coding regions, thus possible causal genes in these loci remain largely unknown. We performed a transcriptome-wide association study (TWAS) to search for novel genetic loci for ovarian cancer risk and plausible causal genes at GWAS-identified loci. Method: Transcriptome data from normal ovarian tissue samples (n=68) and all tissue samples (n = 369), along with their high-density genotyping data, obtained from only European descendants included in the Genotype-Tissue Expression Project (GTEx), were used to build ovarian linear prediction models and cross-tissue models (to increase statistical power) using the elastic net method. Based on model performance, we evaluated 17,121 genes for their cis-predicted gene expressions in relation to ovarian cancer risk using summary statistics data generated in GWAS of ovarian cancer from 25,509 cases and 40,941 controls. MetaXcan was used to integrate gene expression prediction model with summary statistics. Results: We identified 35 genes with predicted expression levels associated with ovarian cancer risk at P value < 2.2 × 10-6, the Bonferroni corrected significance level for multiple comparisons. Of these, 12 genes at 4 genetic loci are located ≥500kb away from risk SNPs previously reported in GWAS, representing potential novel genetic loci for ovarian cancer risk. The remaining 23 genes at 12 loci are located within known ovarian cancer risk loci. Fifteen of these genes at the 12 loci have not been reported in previous studies. Analyses by ovarian cancer histological subtypes showed that the majority of these 35 genes are associated with serous invasive carcinoma. Several new associations were identified in histological subtype analyses. Conclusion: In this TWAS we identified multiple genes with predicted expressions related to ovarian cancer risk and provide substantial new information to enhance the understanding of ovarian cancer biology and genetics. Citation Format: Yingchang Lu, Joellen M. Schildkraut, Thomas A. Sellers, Lang Wu, Xingyi Guo, Bingshan Li, Y. Ann Chen, Jennifer B. Doherty, Simon Gayther, Ellen L. Goode, Hae Kyung Im, Siddhartha Kar, Kate Lawrenson, Ani W. Manichaikul, Jennifer B. Permuth, Brett M. Reid, Jamie K. Teer, Paul Pharoah, Wei Zheng, Jirong Long. Transcriptome-wide association study among 66,450 women to identify candidate susceptible genes for ovarian cancer risk [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1308. doi:10.1158/1538-7445.AM2017-1308
Abstract 1307: Identification of novel epithelial ovarian cancer loci in women of African ancestry from the Ovarian Cancer Association Consortium
Peres, Lauren C. , Wang, Xin-Qun , Lawrenson, Kate , Abbott, Sarah, Schwartz, Ann G. , Wu, Anna H. , Peters, Edward , Moorman, Patricia G. , Kelemen, Linda E., Goode, Ellen L. , Gather, Simon A., Schildkraut, Joellen, Manichaikul, Ani , Abbott, Sarah, Coté, Michele L. , Bondy, Melissa L. , Barnholtz‐Sloan, Jill S. , Berchuck, Andrew , Doherty, Jennifer A. , Pharoah, Paul D.P. , Lawrenson, Kate
Cancer Research | July 31, 2017 | Volume: 77 | Issue: 13_Supplement | Pages: 1307-1307
Abstract Epithelial ovarian cancer (EOC) is a rare but deadly disease for which there is notably poorer survival in women of African Ancestry (AA) compared to women of European Ancestry (EA). Previous EA-based genome-wide association studies (GWAS) have identified 30 common, low penetrant EOC susceptibility alleles. Using the custom-designed 533,631 SNP Illumina OncoArray and imputation to ~12 million genetic variants in the 1000 Genomes Phase 3, we conducted a GWAS in 755 AA EOC cases, including 537 high-grade serous ovarian cancer (HGSOC) cases, and 1,235 AA controls from the Ovarian Cancer Association Consortium (OCAC). We identified novel susceptibility loci with suggestive evidence of association with EOC, based on a threshold of P<1x10-6, at three distinct loci including 10p15.1 (lead SNP rs4525119, intronic to AKR1C3, P=4.9 x 10-7, minor allele frequency [MAF]=0.33), 3p25.3 (lead SNP rs7643459, intronic to LOC101927394, P=8.4 x 10-7, MAF=0.36), and 4q13.3 (lead SNP rs4286604, 15 kb 3’ of UGT2A1, P=8.5x10-7, MAF=0.27). In analysis of HGSOC, we identified suggestive evidence of association at six distinct loci including 5q11.2 (lead SNP rs37792, 132 kb 5’ of FST, P=6.0x10-8, MAF=0.34), Xq27.2 (lead SNP rs57403204, 81 kb 3' of MAGEC1, P=1.7x10-7, MAF=0.06), 10p15.1 (lead SNP rs79079890, LOC105376360 intronic, P=3.0x10-7, MAF=0.03), 17p25.1 (lead SNP rs66459581, 5 kb 5’ of PRPSAP1, P=5.1x10-7, MAF=0.23), 15p12 (lead SNP rs116046250, GABRG3 intronic, P=8.7x10-7, MAF=0.05), and 4q21.21 (lead SNP rs192876988, 30 kb 3’ of GK2, P=9.2x10-7, MAF=0.05). These SNPs showed no evidence of association with risk in the OCAC EA GWAS including up to 23,543 EOC cases and 29,444 controls. Of the SNPs identified with suggestive evidence of association in our GWAS, two are located near genes known to regulate hormones and previously reported in relation to diseases of the ovary (AKR1C3 and FST), two have been linked to cancer (AKR1C3 and MAGEC1) and one represents testis-specific expression (GK2). Of the 30 SNPs identified previously in a EA EOC GWAS, we observed nominally significant associations (P<0.05) with consistent direction of effect for eight SNPs in AA women. Our investigation presents evidence of (1) variants for EOC shared among EA and AA women and (2) novel EOC risk loci of importance for AA women. Citation Format: Ani Manichaikul, Lauren C. Peres, Xin-Qun Wang, Kate Lawrenson, Sarah Abbott, Ann G. Schwartz, Anna H. Wu, Edward Peters, Patricia G. Moorman, Michele L. Cote, Melissa Bondy, Linda Kelemen, Ellen L. Goode, Jill Barnholtz-Sloan, Simon A. Gather, Andrew Berchuck, Jennifer A. Doherty, Paul Pharoah, Joellen Schildkraut. Identification of novel epithelial ovarian cancer loci in women of African ancestry from the Ovarian Cancer Association Consortium [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1307. doi:10.1158/1538-7445.AM2017-1307
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases
Haycock, Philip , Burgess, Stephen , Nounu, Aayah , Zheng, Jie , Okoli, George N. , Wade, Kaitlin H. , Timpson, Nicholas J. , Evans, David M. , Willeit, Peter , Aviv, Abraham , Gaunt, Tom R. , Hemani, Gibran , Mangino, Massimo , Ellis, Hayley, Kurian, Kathreena M. , Pooley, Karen A. , Eeles, Rosalind A. , Lee, Jeffrey E. , Fang, Shenying , Chen, Wei V., Law, Matthew H. , Bowdler, Lisa, Iles, Mark M. , Worrall, Bradford B. , Markus, Hugh S. , Hung, Rayjean J., Amos, Chris, Thompson, Deborah J. , O’Mara, Tracy A. , Wolpin, Brian M. , Ámundadóttir, Laufey T. , Trichopoulou, Antonia , Onland‐Moret, N. Charlotte , Lund, Eiliv , Canzian, Federico , Severi, Gianluca , Overvad, Kim , Gunter, Marc J. , Tumino, Rosario , Svenson, Ulrika, Rij, André van, Baas, Annette F., Bown, Matthew J. , Samani, Nilesh J. , t’Hof, Femke N.G. van, Tromp, Gerard , Jones, Gregory T. , Kuivaniemi, Helena , Elmore, James R. , Johansson, Mattias , McKay, James , Scélo, Ghislaine , Carreras‐Torres, Robert , Gaborieau, Valérie , Brennan, Paul , Bracci, Paige M. , Olson, Sara H. , Gallinger, Steven , Li, Donghui , Petersen, Gloria M. , Han, Jiali , Abnet, Christian C. , Freedman, Neal D. , Aben, Katja K.H. , Kiemeney, Lambertus A. , Vermeulen, Sita H. , Walsh, Kyle M. , Wrensch, Margaret , Rice, Terri, Turnbull, Clare , Litchfield, Kevin , Paternoster, Lavinia , Standl, Marie , Mijatovic, Vladan, Sapkota, Yadav , Zondervan, Krina T. , Nyholt, Dale R. , Heel, David A. van , Arking, Dan E. , Ashar, Foram N., Sotoodehnia, Nona, Woo, Daniel , Comeau, Mary E. , Brown, W. Mark , Silverman, Edwin K. , Hokanson, John E. , Hui, Jennie , Thompson, Philip J. , Morrison, Alanna C. , Smith, Nicholas L. , Christiano, Angela M. , Petukhova, Lynn , Betz, Regina C. , Zhang, Xuejun, Zhu, Caihong, Langefeld, Carl D. , Thompson, Susan D. , Wang, Feijie , Fingerlin, Tasha E. , Rotter, Jerome I. , Cotch, Mary Frances , Jensen, Richard A., Munz, Matthias , Dommisch, Henrik , Schäefer, Arne S. , Ollila, Hanna M. , Hillary, Ryan P. , Zeng, Chenjie , Zheng, Wei , Shu, Xiao-Ou , Reis, André , Uebe, Steffen , Hüffmeier, Ulrike , Kawamura, Yoshiya, Otowa, Takeshi , Sasaki, Tsukasa, Dávila, Sonia , Siminovitch, Katherine A. , Bei, Jin‐Xin , Zeng, Yi‐Xin , Chen, Bowang , Franke, Andre, Fischer, Annegret, Ellinghaus, David , Flores, Carlos , Noth, Imre , Ma, Shwu‐Fan , Foo, Jia Nee , Liu, Jianjun , Cox, David G. , Delattre, Olivier , Mirabeau, Olivier , Skibola, Christine F., Tang, Clara Sze-Man , Garcia-Barceló, Mercè, Su, Wen-Hui , Chang, Yu‐Sun , Wade, Tracey , Lee, Chaeyoung , Kubo, Michiaki , Cha, Pei-Chieng , Nakamura, Yusuke, Levy, Daniel , Hunt, S. E., Spector, Tim D. , Soranzo, Nicole , Barr, R. Graham, Kahali, Bratati , Speliotes, Elizabeth K. , Yerges-Armstrong, Laura M. , Cheng, Ching‐Yu , Wong, Tien Yin , Fogh, Isabella , Powell, John , Rice, Kenneth , Relton, Caroline L. , Martin, Richard M. , Smith, George Davey , Hung, Rayjean J. , Bowden, Jack , Yang, Qiong , Spurdle, Amanda B. , Stolzenberg‐Solomon, Rachael Z. , Duell, Eric J. , Neale, Rachel Ε. , Risch, Harvey A. , Klein, Alison P. , Taylor, Philip R. , Maris, John M. , Wiencke, John K. , Abecasis, Gonçalo R. , SanGiovanni, John Paul , Li, Yong , Low, Siew‐Kee , Montgomery, Grant W. , Hunt, Karen A. , Rosand, Jonathan M. , Cho, Michael H. , Ferreira, Manuel A. R. , Felix, Janine F. , Fan, Xing Hua , Xu, Lin , Schwartz, David A. , Han, Fang , Albagha, Omar , Ralston, Stuart H. , Sasaki, Tsukasa, Hibberd, Martin Lloyd , Xie, Gang , Försti, Asta , Landi, Stefano , Ellinghaus, David , Kim, Jong‐Won , Chang, Kai‐Ping , Martin, Nicholas G. , Gordon, Scott D. , Kimura, Masayuki , Hwang, Shih‐Jen , Manichaikul, Ani , Barr, R. Graham, Jonas, Jost B , Lin, Kuang , Amundadottir, Laufey , Kiemeney, Lambertus A , Eeles, Rosalind A , van Heel, David A , Gunter, Marc J , Canzian, Federico , Hung, Rayjean J , O'Mara, Tracy A , Abnet, Christian C , Haycock, Philip , Tumino, Rosario , Han, Jiali , Martin, Richard M , Severi, Gianluca , Reis, André , Zheng, Wei , Rotter, Jerome I , Carreras-Torres, Robert , Law, Matthew H , Davey Smith, George , Johansson, Mattias , Iles, Mark M , Morrison, Alanna C , Rice, Ken , Freedman, Neal D , Foo, Jia Nee , Levy, Daniel , Rice, Kenneth , Sapkota, Yadav , Wong, Tien Y , Liu, Jing
JAMA Oncology | February 27, 2017 | Volume: 3 | Issue: 5 | Pages: 636
Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci
Zubair, Niha, Graff, Mariaelisa , Ambite, José Luis , Bush, William S. , Kichaev, Gleb , Lu, Yingchang , Absher, Devin , Assimes, Themistocles L. , Bielinski, Suzette J. , Böttinger, Erwin P. , Bůžková, Petra , Chuang, Lee‐Ming , Chung, Ren‐Hua , Cochran, Barbara, Dumitrescu, Logan , Gottesman, Omri, Haessler, Jeffrey, Haiman, Christopher A. , Heiss, Gerardo , Hsiung, Chao A., Hung, Yi‐Jen , Juang, Jyh‐Ming Jimmy , Lee, I‐Te , Lee, Wen‐Jane , Lin, Li‐An , Lin, D. Y. , Lin, Shih-Yi, Mackey, Rachel H. , Paşaniuc, Bogdan , Peters, Ulrike , Predazzi, Irene M., Quertermous, Thomas , Reiner, Alex P. , Robinson, Jennifer G., Rotter, Jerome I. , Ryckman, Kelli K. , Schreiner, Pamela J. , Stahl, Eli A. , Tao, Ran , Tsai, Michael Y. , Waite, Lindsay L. , Wang, Tzung‐Dau , Buyske, Steven , Chen, Yii‐Der Ida , Crawford, Dana C. , Loos, Ruth J. F. , Rich, Stephen S. , Fornage, Myriam , Carty, Cara L. , Manichaikul, Ani , Sheu, Wayne Huey‐Herng , Hwu, Chii-Min , Marchand, Loı̈c Le , Martin, Lisa W. , Cheng, Iona C. , North, Kari E. , Kooperberg, Charles , Rich, Stephen S , Bielinski, Suzette , Assimes, Themistocles L , Loos, Ruth J F , Rotter, Jerome I , Dumitrescu, Logan , Bush, William S
Human Molecular Genetics | October 26, 2016 | Volume: 25 | Issue: 24 | Pages: 5500-5512
Lymphocyte activation gene 3 and coronary artery disease
Golden, D.A. , Kolmakova, Antonina, Sura, Sunitha R. , Vella, Anthony T. , Wang, Xin‐Qun, Chen, Yii-Der Ida , Rodríguez, Annabelle , Bielinski, Suzette J. , Manichaikul, Ani , Taylor, Kent D. , Rich, Stephen S.
JCI Insight | October 19, 2016 | Volume: 1 | Issue: 17 | Pages: No page available
BACKGROUND: The lipoprotein scavenger receptor BI ( SCARB1 ) rs10846744 noncoding variant is significantly associated with atherosclerotic disease independently of traditional cardiovascular risk factors. We identified a potentially novel connection between rs10846744, the immune checkpoint inhibitor lymphocyte activation gene 3 ( LAG3 ), and atherosclerosis. METHODS: In vitro approaches included flow cytometry, lipid raft isolation, phosphosignaling, cytokine measurements, and overexpressing and silencing LAG3 protein. Fasting plasma LAG3 protein was measured in hyperalphalipoproteinemic (HALP) and Multi-Ethnic Study of Atherosclerosis (MESA) participants. RESULTS: In comparison with rs10846744 reference (GG homozygous) cells, LAG3 protein levels by flow cytometry ( P < 0.001), in lipid rafts stimulated and unstimulated ( P = 0.03), and phosphosignaling downstream of B cell receptor engagement of CD79A ( P = 0.04), CD19 ( P = 0.04), and LYN ( P = 0.001) were lower in rs10846744 risk (CC homozygous) cells. Overexpressing LAG3 protein in risk cells and silencing LAG3 in reference cells confirmed its importance in phosphosignaling. Secretion of TNF-α was higher ( P = 0.04) and IL-10 was lower ( P = 0.04) in risk cells. Plasma LAG3 levels were lower in HALP carriers of the CC allele ( P < 0.0001) and by race ( P = 0.004). In MESA, race ( P = 0.0005), age ( P = 0.003), lipid medications ( P = 0.03), smoking history ( P < 0.0001), and rs10846744 genotype ( P = 0.002) were independent predictors of plasma LAG3. In multivariable regression models, plasma LAG3 was significantly associated with HDL-cholesterol (HDL-C) ( P = 0.007), plasma IL-10 ( P < 0.0001), and provided additional predictive value above the Framingham risk score ( P = 0.04). In MESA, when stratified by high HDL-C, plasma LAG3 was associated with coronary heart disease (CHD) (odds ratio 1.45, P = 0.004). CONCLUSION: Plasma LAG3 is a potentially novel independent predictor of HDL-C levels and CHD risk. FUNDING: This work was supported by an NIH RO1 grant (HL075646), the endowed Linda and David Roth Chair for Cardiovascular Research, and the Harold S. Geneen Charitable Trust Coronary Heart Disease Research award to Annabelle Rodriguez. MESA is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with MESA investigators. Support for MESA is provided by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, UL1-TR-001079, UL1-TR-000040, and DK063491. Cardiometabochip genotyping data for the MESA samples was supported in part by grants and contracts R01HL98077, N02-HL-64278, HL071205, UL1TR000124, DK063491, RD831697, and P50 ES015915.
Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke
Auer, Paul L. , Nalls, Mike A., Worrall, Bradford B. , Longstreth, W.T. , Seshadri, Sudha , Burger, Kathleen, Carlson, Christopher S. , Carty, Cara L. , Chen, Wei‐Min , Cupples, L. Adrienne , DeStefano, Anita L. , Fornage, Myriam , Hardy, John , Jackson, Rebecca D. , Jarvik, Gail P. , Kim, Daniel Seung , Lakshminarayan, Kamakshi , Lange, Leslie A., Manichaikul, Ani , Quinlan, Aaron R. , Singleton, Andrew , Thornton, Timothy, Nickerson, Deborah A. , Peters, Ulrike , Rich, Stephen S. , Franceschini, Nora , Padmanabhan, Sandosh , Caan, Bette J. , Akey, Joshua M. , Liu, Dajiang J. , Ballantyne, Christie M. , Bustamante, Carlos D. , Lin, Honghuang , Meschia, James F. , Kooperberg, Charles , Hsu, Li , Rich, Stephen S , Seshadri, Sudha , Jarvik, Gail P , Hardy, John , Ballantyne, Christie M , Manichaikul, Ani W , Padmanabhan, Sandosh , Caan, Bette J , Lin, Honghuang
JAMA Neurology | May 11, 2015 | Volume: 72 | Issue: 7 | Pages: 781