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Lee, Jeong‐Heon

https://orcid.org/0000-0003-4007-9166

Mayo Clinic

Mayo Clinic

Citations 44

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
Fang, Dong, Gan, Haiyun , Lee, Jeong‐Heon , Han, Jing, Wang, Zhiquan , Riester, Scott M. , Jin, Long , Chen, Jianji , Zhou, Hui , Wang, Jinglong , Zhang, Honglian , Bradley, Elizabeth W. , Ho, Thai H. , Bridge, Julia A. , Thibodeau, Stephen N. , Ördög, Tamás , Chen, Yue , Wijnen, André J. van , Oliveira, André M. , Xu, Rui-Ming , Zhang, Zhiguo , van Wijnen, Andre J, Fang, Dong, Yang, Na , Rubin, Brian P. , Westendorf, Jennifer J. , van Wijnen, Andre J , Ho, Thai , Bradley, Elizabeth W , Zhang, Zhiguo , Lee, Jeong-Heon , Wang, Zhiquan

Science | May 27, 2016 | Volume: 352 | Issue: 6291 | Pages: 1344-1348

10.1126/science.aae0065 Get It

A cancer-promoting histone protein Mutations in the chromatin protein histone H3 are found in a number of pediatric cancers. The lysine-36–to–methionine (K36M) “oncohistone” mutation is seen in almost all chondroblastomas. Fang et al. show that the K36M mutant histones inhibit the normal methylation of this same residue in wild-type H3 histones. They do so by interfering with the enzymes that normally methylate this residue. The altered chromatin methylation patterns alter the expression of known cancer-related genes and impart cancer-related characteristics to the chondrocyte cells. Science , this issue p. 1344
Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma
Tiedemann, Rochelle L. , Hlady, Ryan A. , Hanavan, Paul D., Lake, Douglas F. , Tibes, Raoul , Lee, Jeong‐Heon , Choi, Jeong‐Hyeon , Ho, Thai H. , Robertson, Keith D. , Ho, Thai , Robertson, Keith D , Lee, Jeong-Heon

Oncotarget | December 6, 2015 | Volume: 7 | Issue: 2 | Pages: 1927-1946

10.18632/oncotarget.6481 Get It

The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma
Boddicker, Rebecca L., Kip, N. Sertac, Xing, Xiaoming , Zeng, Yu , Yang, Zhi‐Zhang, Lee, Jeong‐Heon , Almada, Luciana L. , Elsawa, Sherine F. , Knudson, Ryan A., Ketterling, Rhett P. , Cunningham, Julie M. , Wu, Yanhong , O’Byrne, Megan M., Link, Brian K. , Porcher, Julie C., Grote, Deanna M., Jelinek, Diane F., Ansell, Stephen M. , Fernández-Zapico, Martín E. , Feldman, Andrew L. , Luchtel, Rebecca A. , Law, Mark E. , O'Byrne, Megan M, Doǧan, Ahmet , Law, Mark E., Maurer, Matthew J. , Cerhan, James R. , Slager, Susan L. , Feldman, Andrew L , Elsawa, Sherine F , Link, Brian K , Lee, Jeong-Heon , Ketterling, Rhett P

Blood | April 2, 2015 | Volume: 125 | Issue: 20 | Pages: 3118-3127

10.1182/blood-2014-05-578575 Get It

Key PointsThe NF-κB subunits p52 and RelB increase IRF4 promoter activity and expression in PTCL cells. A positive feedback loop involving CD30, NF-κB, and IRF4 drives PTCL cell proliferation and can be blocked by NF-κB inhibitors.
Bioinformatics Strategies for Identifying Regions of Epigenetic Deregulation Associated with Aberrant Transcript Splicing and RNA-editing
Champion, Mia D., Hlady, Ryan A. , Yan, Huihuang , Evans, Jared M., Nie, Jeff, Nandakumar, Kannabiran, Davila, Jaime , Moore, Raymond M. , Nair, Asha, Zhu, Yuanxiao, Ördög, Tamás , Kocher, Jean-Pierre A., Jonasch, Eric, Tibes, Raoul , Lee, Jeong‐Heon , Bogenberger, James M. , O’Brien, Daniel J. , Kortüm, K. Martin , Zhang, Zhiguo , Joseph, Richard W. , Jonasch, Eric W. , Robertson, Keith D. , Ho, Thai H. , Davila, Jaime I

Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms | February 2, 2015 | Volume: No volume available | Issue: No issue available | Pages: 163-170

10.5220/0005248001630170 Get It