Citations 1
The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
Fang, Dong, Gan, Haiyun , Lee, Jeong‐Heon , Han, Jing, Wang, Zhiquan , Riester, Scott M. , Jin, Long , Chen, Jianji , Zhou, Hui , Wang, Jinglong , Zhang, Honglian , Bradley, Elizabeth W. , Ho, Thai H. , Bridge, Julia A. , Thibodeau, Stephen N. , Ördög, Tamás , Chen, Yue , Wijnen, André J. van , Oliveira, André M. , Xu, Rui-Ming , Zhang, Zhiguo , van Wijnen, Andre J, Fang, Dong, Yang, Na , Rubin, Brian P. , Westendorf, Jennifer J. , van Wijnen, Andre J , Ho, Thai , Bradley, Elizabeth W , Zhang, Zhiguo , Lee, Jeong-Heon , Wang, Zhiquan
Science | May 27, 2016 | Volume: 352 | Issue: 6291 | Pages: 1344-1348
A cancer-promoting histone protein Mutations in the chromatin protein histone H3 are found in a number of pediatric cancers. The lysine-36–to–methionine (K36M) “oncohistone” mutation is seen in almost all chondroblastomas. Fang et al. show that the K36M mutant histones inhibit the normal methylation of this same residue in wild-type H3 histones. They do so by interfering with the enzymes that normally methylate this residue. The altered chromatin methylation patterns alter the expression of known cancer-related genes and impart cancer-related characteristics to the chondrocyte cells. Science , this issue p. 1344