O'Byrne, Megan M
Mayo Clinic
Department of Health Sciences Research, Mayo Clinic, Rochester, MN;
Citations 1
The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma
Boddicker, Rebecca L., Kip, N. Sertac, Xing, Xiaoming , Zeng, Yu , Yang, Zhi‐Zhang, Lee, Jeong‐Heon , Almada, Luciana L. , Elsawa, Sherine F. , Knudson, Ryan A., Ketterling, Rhett P. , Cunningham, Julie M. , Wu, Yanhong , O’Byrne, Megan M., Link, Brian K. , Porcher, Julie C., Grote, Deanna M., Jelinek, Diane F., Ansell, Stephen M. , Fernández-Zapico, Martín E. , Feldman, Andrew L. , Luchtel, Rebecca A. , Law, Mark E. , O'Byrne, Megan M, Doǧan, Ahmet , Law, Mark E., Maurer, Matthew J. , Cerhan, James R. , Slager, Susan L. , Feldman, Andrew L , Elsawa, Sherine F , Link, Brian K , Lee, Jeong-Heon , Ketterling, Rhett P
Blood | April 2, 2015 | Volume: 125 | Issue: 20 | Pages: 3118-3127
Key PointsThe NF-κB subunits p52 and RelB increase IRF4 promoter activity and expression in PTCL cells. A positive feedback loop involving CD30, NF-κB, and IRF4 drives PTCL cell proliferation and can be blocked by NF-κB inhibitors.