Mayo Clinic - AuthorCitation

[O1–02–03]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: FINDINGS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK

Dincer, Aylin , Christensen, Jon, Cairns, Nigel J., Fagan, Anne M. , Marcus, Daniel S. , Hornbeck, Russ C. , Paumier, Katrina L. , Raichle, Marcus E. , Gordon, Brian A. , Blazey, Tyler , Su, Yi , Hari‐Raj, Amrita , Flores, Shaney , McDade, Eric , Wang, Guoqiao , Xiong, Chengjie , Hassenstab, Jason , Jack, Clifford R. , Koeppe, Robert A. , Ances, Beau M. , Holtzman, David M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2017.07.041

[IC‐P‐166]: UTILITY OF PERFUSION PET MODELS AS MEASURE OF NEURODEGENERATION IN AN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE POPULATION: REPORT FROM THE DIAN STUDY

Su, Yi , Jasielec, Mateusz S., Vlassenko, Andrei G. , Hornbeck, Russ C. , Cash, Lisa, Raichle, Marcus E. , Buckles, Virginia, Cairns, Nigel J. , Fagan, Anne M. , Klunk, Bill E., Marcus, Daniel S. , Mayeux, Richard , Paumier, Katrina L. , Ringman, John M. , Xiong, Chengjie , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Ances, Beau M. , Brickman, Adam M. , Cruchaga, Carlos , Goate, Alison , Jack, Clifford R. , Klunk, Bill E., Koeppe, Robert A. , McDade, Eric , Saykin, Andrew J. , Thompson, Paul M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_2 | Pages: No page available

10.1016/j.jalz.2017.06.2541

[IC‐P‐054]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: RESULTS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK

Hari‐Raj, Amrita , Dincer, Aylin , Christensen, Jon, Wang, Guoqiao , Cairns, Nigel J. , Fagan, Anne M. , Marcus, Daniel S., Hornbeck, Russ C. , Paumier, Katrina L. , Raichle, Marcus E. , Gordon, Brian A. , Blazey, Tyler , Su, Yi , Flores, Shaney , McDade, Eric , Xiong, Chengjie , Hassenstab, Jason , Jack, Clifford R. , Koeppe, Robert A. , Ances, Beau M. , Holtzman, David M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2017.06.2327

[IC‐P‐057]: CLINICAL RISK RELATED TO CEREBRAL MICROHEMORRHAGES IN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE: LONGITUDINAL RESULTS FROM THE DIAN STUDY

Ringman, John M. , Salloway, Stephen , Su, Yi , Hornbeck, Russ C. , Raichle, Marcus E. , Marcus, Daniel S. , Cairns, Nigel J. , Xiong, Chengjie , Buckles, Virginia, Paumier, Katrina L. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Kantarci, Kejal , Jack, Clifford R. , McDade, Eric , Clifford, David J , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Mills, Susan , Ances, Beau M. , Cruchaga, Carlos , Goate, Alison , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2017.06.2330

[O1–02–04]: CLINICAL RISK RELATED TO CEREBRAL MICROHEMORRHAGES IN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE: LONGITUDINAL RESULTS FROM THE DIAN STUDY

Ringman, John M. , Salloway, Stephen , Clifford, David B. , Su, Yi , Hornbeck, Russ C. , Raichle, Marcus E. , Marcus, Daniel S. , Cairns, Nigel J. , Buckles, Virginia, Paumier, Katrina L. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Kantarci, Kejal , Jack, Clifford R. , McDade, Eric , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Mills, Susan , Ances, Beau M. , Xiong, Chengjie , Cruchaga, Carlos , Goate, Alison , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2017.07.042

[P2–372]: UTILITY OF PERFUSION PET MODELS AS MEASURES OF NEURODEGENERATION IN AN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE POPULATION: REPORT FROM THE DIAN STUDY

Jasielec, Mateusz S., Vlassenko, Andrei G. , Hornbeck, Russ C. , Cash, Lisa, Raichle, Marcus E. , Buckles, Virginia, Cairns, Nigel J. , Fagan, Anne M. , Klunk, Bill E., Marcus, Daniel S., Mayeux, Richard , Paumier, Katrina L. , Ringman, John M. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Su, Yi , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Ances, Beau M. , Brickman, Adam M. , Cruchaga, Carlos , Goate, Alison , Jack, Clifford R. , Klunk, Bill E., Koeppe, Robert A. , McDade, Eric , Saykin, Andrew J. , Thompson, Paul M. , Xiong, Chengjie , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_15 | Pages: No page available

10.1016/j.jalz.2017.06.1027

O2‐01‐03: Amyloid load increase and cerebral microbleed prevalence differ as a function of the position of the mutation within the PSEN1 coding sequence

Tang, Mengxuan , Owen, Christopher J. , Su, Yi , Hornbeck, Russ C. , Stevenson, Trish A., Cash, Lisa, Raichle, Marcus E., Preboske, Gregory M., Xiong, Chengjie , Moulder, Krista L., Buckles, Virginia, Joseph‐Mathurin, Nelly , Friedrichsen, Karl A. , Raichle, Marcus E. , Gordon, Brian A. , Koeppe, Robert A. , Jack, Clifford R. , Goate, Alison , Cruchaga, Carlos , Bateman, Randall J. , Morris, John C. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_4 | Pages: No page available

10.1016/j.jalz.2015.07.132

IC‐P‐051: Amyloid load increase and cerebral microbleed prevalence differ as a function of the position of the mutation within the PSEN1 coding sequence

Tang, Mengxuan , Owen, Christopher J. , Hornbeck, Russ C. , Stevenson, Trish A., Cash, Lisa, Raichle, Marcus E. , Preboske, Gregory M., Xiong, Chengjie , Moulder, Krista L., Buckles, Virginia, Joseph‐Mathurin, Nelly , Friedrichsen, Karl A. , Su, Yi , Gordon, Brian A. , Koeppe, Robert A. , Jack, Clifford R. , Goate, Alison , Cruchaga, Carlos , Bateman, Randall J. , Morris, John C. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2015.06.072

Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease

Thomas, Jewell B., Bateman, Randall J. , Benzinger, Tammie L.S. , Raichle, Marcus E. , Mayeux, Richard , Ringman, John M. , Salloway, Stephen , Rossor, Martin N. , Ourselin, Sébastien , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Weiner, Michael W. , Thompson, Paul M. , Fox, Nick C. , Mathis, Chester A. , Oliver, Angela , Blazey, Tyler , Moulder, Krista L., Buckles, Virginia, Hornbeck, Russ C. , Chhatwal, Jasmeer P. , Schultz, Aaron P. , Goate, Alison , Fagan, Anne M. , Cairns, Nigel J. , Marcus, Daniel S. , Morris, John C. , Ances, Beau M. , Thomas, Jewell, Brier, Matthew R. , Snyder, Abraham Z. , Xiong, Chengjie , Holtzman, David M. , Sperling, Reisa Anne , Ghetti, Bernardino , McDade, Eric , Koeppe, Robert A. , Jack, Clifford R. , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Ances, Beau M , Fox, Nick C , Morris, John C , Goate, Alison M

JAMA Neurology | July 28, 2014 | Volume: 71 | Issue: 9 | Pages: 1111

10.1001/jamaneurol.2014.1654

Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease

Benzinger, Tammie L.S. , Blazey, Tyler , Xiong, Chengjie , Raichle, Marcus E. , Ances, Beau M. , Bateman, Randall J. , Cairns, Nigel J., Fagan, Anne M. , Goate, Alison , Marcus, Daniel S. , Aisen, Paul, Christensen, Jon, Ercole, Lindsay, Hornbeck, Russ C. , Farrar, Angela, Aldea, Patricia, Jasielec, Mateusz S., Owen, Christopher J. , Xie, Xianyun, Mayeux, Richard , Klunk, William E. , Mathis, Chester A. , Ringman, John M. , Thompson, Paul M. , Saykin, Andrew J. , Johnson, Keith A. , Salloway, Stephen , Correia, Stephen , Schofield, Peter R. , Masters, Colin L. , Villemagne, Victor L. , Martins, Ralph N. , Ourselin, Sébastien , Rossor, Martin N. , Fox, Nick C. , Cash, David M. , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Morris, John C. , Jack, Clifford R. , Koeppe, Robert A. , Su, Yi , Xiong, Chengjie , Snyder, Abraham Z. , Brickman, Adam M. , McDade, Eric , Ghetti, Bernardino , Sperling, Reisa Anne , Rowe, Christopher Cleon , Holtzman, David M. , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Ances, Beau M , Fox, Nick C , Morris, John C , Cash, David M , Goate, Alison M

Proceedings of the National Academy of Sciences | November 5, 2013 | Volume: 110 | Issue: 47 | Pages: No page available

10.1073/pnas.1317918110

Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering of these biomarkers prior to dementia remains untested. In a cohort with Alzheimer’s disease mutations, we performed an integrated whole-brain analysis of three major imaging techniques: amyloid PET, [ 18 F]fluro-deoxyglucose PET, and structural MRI. We found that most gray-matter structures with amyloid plaques later have hypometabolism followed by atrophy. Critically, however, not all regions lose metabolic function, and not all regions atrophy, even when there is significant amyloid deposition. These regional disparities have important implications for clinical trials of disease-modifying therapies.

Hornbeck, Russ C.

Citations 34