Citations 4
Clinical criteria for limbic‐predominant age‐related TDP‐43 encephalopathy
Nelson, Peter T. , Apostolova, Liana G. , Arfanakis, Konstantinos , Boyle, Patricia A. , Carlsson, Cynthia M. , Dacks, Penny A. , Domoto‐Reilly, Kimiko , Dugger, Brittany N. , Edelmayer, Rebecca M. , Grothe, Michel J. , Kawas, Claudia H. , Lee, Edward B., Lincoln, Karen D. , Maestre, Gladys E. , Mormino, Elizabeth C. , Onyike, Chiadi U. , Petersen, Ronald C. , Rabinovici, Gil D. , Rademakers, Rosa , Raman, Rema , Rascovsky, Katya, Rogalskı, Emily , Sperling, Reisa A., Yang, Hyun‐Sik , Corriveau-Lecavalier, Nick , Dugger, Brittany N , Domoto-Reilly, Kimiko , Rabinovici, Gil D , Grothe, Michel J , Dacks, Penny , Wolk, David A. , Corriveau‐Lecavalier, Nick , Dickerson, Bradford Clark , Fardo, David W. , Hohman, Timothy J. , Irwin, David J. , Jicha, Gregory A. , Jones, David T. , Rissman, Robert A. , Scheltens, Philip , Sperling, Reisa Anne , Yu, Lei , Zetterberg, Henrik , Schneider, Julie A.
Alzheimer's & Dementia | January 14, 2025 | Volume: 21 | Issue: 1 | Pages: No page available
Abstract Limbic predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC) is highly prevalent in late life and a common co‐pathology with Alzheimer's disease neuropathologic change (ADNC). LATE‐NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE‐NC is associated with a more rapid course. With the emergence of anti‐amyloid therapeutics, discrimination of LATE‐NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co‐pathology with LATE‐NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE‐NC. We propose criteria for clinical diagnosis of LATE as an initial framework for further validation. In the context of progressive memory loss and substantial hippocampal atrophy, criteria are laid out for probable (amyloid negative) or possible LATE (amyloid biomarkers are unavailable or when amyloid is present, but hippocampal neurodegeneration is out of proportion to expected pure ADNC). Highlights Limbic‐predominant age‐related TDP‐43 encephalopathy (LATE) is a highly prevalent driver of neuropathologic memory loss in late life. LATE neuropathologic change (LATE‐NC) is a common co‐pathology with Alzheimer's disease neuropathologic change (ADNC) and may influence outcomes with emerging disease‐modifying medicines. We provide initial clinical criteria for diagnosing LATE during life either when LATE‐NC is the likely primary driver of symptoms or when observed in conjunction with AD. Definitions of possible and probable LATE are provided.
Reply: LATE to the PART-y
Nelson, Peter T. , Trojanowski, John Q. , Jack, Clifford R. , Boyle, Patricia A. , Arfanakis, Konstantinos , Rademakers, Rosa , Alafuzoff, Irina , Attems, Johannes , Brayne, Carol , Fardo, David W. , Flanagan, Margaret E. , Halliday, Glenda M. , Jicha, Gregory A. , Kawas, Claudia H. , Keene, C. Dirk , Kovács, Gábor G. , Kukull, Walter A. , Levey, Allan I. , Makkinejad, Nazanin , Montine, Thomas J. , Murray, Melissa E. , Nag, Sukriti , White, Charles L. , Halliday, Glenda , Jack, Clifford R , White, Charles L , Kovacs, Gabor G , Murray, Melissa E , Dickson, Dennis W. , Coyle-Gilchrist, Ian T S , Hunter, Sally , Katsumata, Yuriko , Seeley, William W. , Sperling, Reisa Anne , Schneider, Julie A. , Jicha, Gregory A , Levey, Allan I
Brain | July 19, 2019 | Volume: 142 | Issue: 9 | Pages: e48-e48
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson, Peter T. , Dickson, Dennis W. , Trojanowski, John Q. , Jack, Clifford R. , Boyle, Patricia A. , Arfanakis, Konstantinos , Rademakers, Rosa , Alafuzoff, Irina , Attems, Johannes , Brayne, Carol , Chui, Helena C., Fardo, David W. , Flanagan, Margaret E. , Halliday, Glenda M. , Hokkanen, Suvi R. K. , Jicha, Gregory A. , Kawas, Claudia H. , Keene, C. Dirk , Kovács, Gábor G. , Kukull, Walter A. , Levey, Allan I. , Makkinejad, Nazanin , Montine, Thomas J. , Murayama, Shigeo , Murray, Melissa E. , Nag, Sukriti , White, Charles L. , Yu, Lei , Halliday, Glenda , Dickson, Dennis W , Jack, Clifford R , White, Charles L , Kovacs, Gabor G , Murray, Melissa E , Coyle-Gilchrist, Ian T S , Chui, Helena C. , Hunter, Sally , Katsumata, Yuriko , Rissman, Robert A. , Seeley, William W. , Sperling, Reisa Anne , Schneider, Julie A. , Jicha, Gregory A , Levey, Allan I
Brain | March 22, 2019 | Volume: 142 | Issue: 6 | Pages: 1503-1527
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Rietveld, Cornelius A. , Medland, Sarah E. , Derringer, Jaime , Esko, Tõnu , Martín, Nicolás W., Westra, Harm-Jan , Shakhbazov, Konstantin, Abdellaoui, Abdel , Albrecht, Eva, Alizadeh, Behrooz Z. , Amin, Najaf , Baumeister, Sebastian E. , Benke, Kelly S. , Bielak, Lawrence F. , Boatman, Jeffrey A. , Boyle, Patricia A. , Davies, Gail , Leeuw, Christiaan de , Eklund, Niina, Evans, Daniel S. , Ferhmann, Rudolf, Fischer, Krista , Gieger, Christian , Gjessing, Håkon K. , Hägg, Sara , Harris, Jennifer R. , Hayward, Caroline , Jacobsson, Bo , Joshi, Peter K. , Jugessur, Astanand , Kaakinen, Marika , Kanoni, Stavroula , Karjalainen, Juha, Kolčić, Ivana , Kristiansson, Kati , Kutalik, Zoltán , Lahti, Jari , Lee, Sang , Lin, Peng, Lind, Penelope A. , Lohman, Kurt, Loitfelder, Marisa, McMahon, George, Marques‐Vidal, Pedro , Meirelles, Osorio , Milani, Lili , Myhre, Ronny , Nuotio, Marja-Liisa , Oldmeadow, Christopher , Petrovic, Katja, Peyrot, Wouter J. , Polašek, Ozren , Quaye, Lydia, Reinmaa, Eva, Rice, John P. , Rizzi, Thais S., Schmidt, Helena , Schmidt, Reinhold, Smith, Albert V. , Smith, Jennifer A. , Terracciano, Antonio , Loos, Matthijs J. H. M. van der, Vitart, Véronique , Völzke, Henry , Wellmann, Jürgen , Yu, Lei , Zhao, Wei , Allïk, Jüri , Bandinelli, Stefania , Bastardot, François , Beauchamp, Jonathan , Bennett, David A. , Berger, Klaus, Bültmann, Ute , Campbell, Harry, Chabris, Christopher F., Cherkas, Lynn, Chung, Mina K. , Cucca, Francesco , Jager, Philip L. De , Neve, Jan-Emmanuel De, Deary, Ian J. , Dedoussis, George , Deloukas, Panos , Dimitriou, Maria , Eiríksdóttir, Guðný , Elderson, Martin F., Eriksson, Johan G. , Evans, David M. , Faul, Jessica D. , Ferrucci, Luigi , Garcia, Melissa E., Grönberg, Henrik , Guðnason, Vilmundur , Harris, Tamara B., Hastie, Nicholas D. , Hernández, Dena , Hoffmann, Wolfgang , Hofman, Adriaan, Holle, Rolf , Holliday, Elizabeth G., Hottenga, Jouke‐Jan , Illig, Thomas, Järvelin, Marjo‐Riitta , Kähönen, Mika , Kaprio, Jaakko , Kirkpatrick, Robert M. , Kowgier, Matthew , Latvala, Antti , Lawlor, Debbie A. , Lehtimäki, Terho , Li, Jingmei , Lichtenstein, Paul , Lichtner, Peter , Liewald, David C. , Madden, Pamela A. F., Magnusson, Patrik K. E. , Mäkinen, Tomi E., Masala, Marco , McGue, Matt , Mielck, Andreas, Miller, Michael B., Montgomery, Grant W. , Mukherjee, Sutapa , Nyholt, Dale R. , Oostra, Ben A., Palmer, Lyle J. , Palotie, Aarno , Perola, Markus, Peyser, Patricia A. , Preisig, Martin , Räikkönen, Katri , Rivadeneira, Fernando , Rudan, Igor , Rustichini, Aldo , Sarin, Antti-Pekka, Schlessinger, David, Scott, Rodney J. , Snieder, Harold , Pourcain, Beaté St , Starr, John M. , Sul, Jae Hoon , Surakka, Ida , Svento, Rauli , Teumer, Alexander , Study, The LifeLines Cohort, Tiemeier, Henning , Rooij, Frank J.A. van , Wagoner, David R. Van , Vartiainen, Erkki , Viikari, Jorma , Vollenweider, Péter , Vonk, Judith M. , Waeber, Gérard , Weir, David R. , Wichmann, H.‐Erich , Widén, Elisabeth , Willemsen, Gonneke , Wright, Alan F., Davey-Smith, George, Franke, Lude , Groenen, Patrick J. F. , Hofman, Albert , Johannesson, Magnus , Kardia, Sharon L. R., Krueger, Robert F., Laibson, David, Martin, Nicholas G. , Meyer, Michelle N., Posthuma, Daniëlle , Thurik, Roy , Timpson, Nicholas J. , Uitterlinden, André G. , Duijn, Cornelia M. van , Visscher, Peter M. , Benjamin, Daniel J. , Cesarini, David , Koellinger, Philipp , Bennett, David A. , Smith, George Davey , Meyer, Michelle N. , Westra, Harm-Jan , Yang, Jian , Agrawal, Arpana , Barnard, John , Holzapfel, Christina M. , Ibrahim‐Verbaas, Carla A. , Ingelsson, Erik , Lin, Peng, Liu, Ching‐Ti , Tanaka, Toshiko , Attia, John , Berger, Klaus, Bierut, Laura Jean , Boomsma, Dorret I , Andrade, Mariza de , Hall, Per N , Harris, Juliette , Heath, Andrew C. , Hofman, Adriaan, Holliday, Elizabeth G., Iacono, William G. , Launer, Lenore J. , Mäkinen, Tomi E., Metspalu, Andres , Palotie, Aarno V. , Penninx, Brenda W.J.H. , Raitakari, Olli Tuomas , Realo, Anu , Ring, Susan M. , Ripatti, Samuli , Salomaa, Veikko , Study, The LifeLines Cohort, Wilson, James Fox , Conley, Dalton , Davey-Smith, George, Smith, Jennifer A , Hottenga, Jouke-Jan , Martin, Nicholas G , Posthuma, Danielle , St Pourcain, Beate , Medland, Sarah E , Li, Jingmei , Teumer, Alexander , van Duijn, Cornelia M , Smith, Albert V , Ferrucci, Luigi , Davey Smith, George , Vonk, Judith M , Kanoni, Stavroula , Surakka, Ida
Science | May 31, 2013 | Volume: 340 | Issue: 6139 | Pages: 1467-1471
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.