Citations 2
Impact of Anemia on Clinical Outcomes in Atrial Fibrillation Patients on Oral Anticoagulants: A Prognostic Meta‐Analysis
Amin, Ahmed Mazen , Elbenawi, Hossam , Odat, Ramez M. , Elgebaly, Mohamed , Al‐Shammari, Ali Saad , Manasrah, AlMothana , Nakhla, Michael , Ayman, Dina , Ali, Mohamed Ahmed , Helmi, Ahmed , Ternes, Caique M. P. , Zeb, Irfan , Deshmukh, Abhishek , Abuelazm, Mohamed , Ternes, Caique M P , Abdelazeem, Basel , Zeb, Irfan , Deshmukh, Abhishek J , DeSimone, Christopher V , d'Avila, Andre , Odat, Ramez M , Al-Shammari, Ali Saad , Ali, Mohamed Ahmed , Abuelazm, Mohamed , Abdelazeem, Basel , DeSimone, Christopher V.
Journal of Cardiovascular Electrophysiology | December 24, 2024 | Volume: 36 | Issue: 2 | Pages: 430-448
ABSTRACTBackgroundAnemia is frequently observed as a comorbidity in atrial fibrillation (AF), especially in elderly patients and in those on anticoagulation. This has been associated with poor clinical outcomes. We aim to investigate the impact of anemia on clinical outcomes in patients with AF on oral anticoagulation.MethodsWe comprehensively searched PubMed, WOS, SCOPUS, EMBASE, and CENTRAL through March 2024 and conducted a prognostic systematic review and meta‐analysis. All analyses were performed using R V. 4.3.1. This meta‐analysis was registered at PROSPERO (CRD42024556023).ResultsWe included 23 studies comprising 286,781 patients for analysis. Anemia had a significant association with an 84% increase in risk of major bleeding (HR: 1.84 with 95% CI [1.59, 2.13], p < 0.01), a 32% increase in the risk of intracranial hemorrhage (HR: 1.32 with 95% CI [1.10, 1.58], p < 0.01), a 98% increase in the risk of gastrointestinal bleeding (HR: 1.98 with 95% CI [1.67, 2.35], p < 0.01), and a 91% increase in the risk of all‐cause mortality (HR: 1.91 with 95% CI [1.46, 2.51], p < 0.01). However, the impact of anemia did not significantly affect the risk of stroke, transient ischemic stroke (TIA), or systemic embolism (HR: 1.07 with 95% CI [0.93, 1.22], p = 0.36).ConclusionAnemia was significantly associated with an increased risk of major bleeding, intracranial hemorrhage, gastrointestinal bleeding, and all‐cause mortality. However, anemia did not significantly impact stroke, TIA, or systemic embolism.
Ectopic fat and adipokines in metabolically benign overweight/obese women: The kronos early estrogen prevention study
Ogorodnikova, Alexandra D., McGinn, Aileen P., Zeb, Irfan , Budoff, Matthew J. , Harman, S. Mitchell , Miller, Virginia M. , Hodis, Howard N., Merriam, George R., Cedars, Marcelle I. , Taylor, Hugh S. , Løbo, Rogerio A. , Wildman, Rachel P., Khan, Unab Inayat , Brinton, Eliot A. , Manson, JoAnn E. , Naftolin, Frederick , Santoro, Nanette F. , Budoff, Matthew
Obesity | May 13, 2013 | Volume: 21 | Issue: 8 | Pages: 1726-1733
ObjectiveIt is unclear why despite a comparable cardiometabolic risk profile, “metabolically benign” overweight/obese individuals show an elevated risk of cardiovascular disease compared to normal weight individuals.Design and MethodsIn cross‐sectional analyses, we compared levels of ectopic fat (epicardial, pericardial, and hepatic fat) and adipokines (leptin, soluble leptin receptor, and high molecular weight [HMW] adiponectin) among metabolically benign (MBO) and at‐risk overweight/obese (ARO), and metabolically benign normal weight (MBNW) women, screened for the Kronos Early Estrogen Prevention Study. We defined “metabolically benign” with ≤ 1, and “at‐risk” with ≥2 components of the metabolic syndrome.ResultsCompared to MBO women, ARO women had significantly elevated odds of being in the top tertile of epicardial fat (OR: 1.76, 95% CI: 1.04‐2.99), hepatic fat (OR: 1.90, 95% CI:1.12‐3.24) and leptin (OR: 2.15, 95% CI: 1.23‐3.76), and the bottom tertile of HMW‐adiponectin (OR: 2.90, 95% CI: 1.62‐5.19). Compared to MBNW women, MBO women had significantly higher odds of being in the top tertile of epicardial fat (OR: 5.17, 95% CI: 3.22‐8.29), pericardial fat (OR: 9.27, 95% CI: 5.52‐15.56) and hepatic fat (OR: 2.72, 95% CI: 1.77‐4.19) and the bottom tertile of HMW adiponectin levels (OR: 2.51, 95% CI: 1.60‐3.94).ConclusionsLevels of ectopic fat and the adverse adipokine profile increase on a continuum of BMI, suggesting that the metabolically benign phenotype may be a transient state.