Citations 2
Impact of Anemia on Clinical Outcomes in Atrial Fibrillation Patients on Oral Anticoagulants: A Prognostic Meta‐Analysis
Amin, Ahmed Mazen , Elbenawi, Hossam , Odat, Ramez M. , Elgebaly, Mohamed , Al‐Shammari, Ali Saad , Manasrah, AlMothana , Nakhla, Michael , Ayman, Dina , Ali, Mohamed Ahmed , Helmi, Ahmed , Ternes, Caique M. P. , Zeb, Irfan , Deshmukh, Abhishek , Abuelazm, Mohamed , Ternes, Caique M P , Abdelazeem, Basel , Zeb, Irfan , Deshmukh, Abhishek J , DeSimone, Christopher V , d'Avila, Andre , Odat, Ramez M , Al-Shammari, Ali Saad , Ali, Mohamed Ahmed , Abuelazm, Mohamed , Abdelazeem, Basel , DeSimone, Christopher V.
Journal of Cardiovascular Electrophysiology | December 24, 2024 | Volume: 36 | Issue: 2 | Pages: 430-448
ABSTRACTBackgroundAnemia is frequently observed as a comorbidity in atrial fibrillation (AF), especially in elderly patients and in those on anticoagulation. This has been associated with poor clinical outcomes. We aim to investigate the impact of anemia on clinical outcomes in patients with AF on oral anticoagulation.MethodsWe comprehensively searched PubMed, WOS, SCOPUS, EMBASE, and CENTRAL through March 2024 and conducted a prognostic systematic review and meta‐analysis. All analyses were performed using R V. 4.3.1. This meta‐analysis was registered at PROSPERO (CRD42024556023).ResultsWe included 23 studies comprising 286,781 patients for analysis. Anemia had a significant association with an 84% increase in risk of major bleeding (HR: 1.84 with 95% CI [1.59, 2.13], p < 0.01), a 32% increase in the risk of intracranial hemorrhage (HR: 1.32 with 95% CI [1.10, 1.58], p < 0.01), a 98% increase in the risk of gastrointestinal bleeding (HR: 1.98 with 95% CI [1.67, 2.35], p < 0.01), and a 91% increase in the risk of all‐cause mortality (HR: 1.91 with 95% CI [1.46, 2.51], p < 0.01). However, the impact of anemia did not significantly affect the risk of stroke, transient ischemic stroke (TIA), or systemic embolism (HR: 1.07 with 95% CI [0.93, 1.22], p = 0.36).ConclusionAnemia was significantly associated with an increased risk of major bleeding, intracranial hemorrhage, gastrointestinal bleeding, and all‐cause mortality. However, anemia did not significantly impact stroke, TIA, or systemic embolism.
Abstract 4138558: The effect of pulsatile vs. non-pulsatile perfusion on hospital stay, ICU stay, and intubation time in patients undergoing cardiopulmonary bypass: A meta-analysis randomized controlled trials.
Ramadan, Mohamed , Amin, Ahmed Mazen , Ahmed, Ali Ashraf Salah , Saeed, Abdallah , Elshenawy, Salem , Ayman, Dina , Alshaker, Hassan , Hassan, Abdul Rhman , AlBarakat, Majd M. , Alsaed, Mohamad , Mahmoud, Abdelrahman , Salamah, Hazem Mohamed , Ali, Mohamed A. M. , Katamesh, Basant E. , Abdelazeem, Basel
Circulation | November 14, 2024 | Volume: 150 | Issue: Suppl_1 | Pages: No page available
10.1161/circ.150.suppl_1.4138558
Background: Pulsatile perfusion is a developing technique that attempts to mimic the natural pulsatile flow of blood during cardiopulmonary bypass (CBP). Purpose: Our meta-analysis was done to evaluate the effects of pulsatile perfusion in CPB compared to non-pulsatile on hospital stay, ICU stay, and intubation time. Methods: Randomized control trials that evaluated the implementation of pulsatile perfusion during CPB were identified by a literature search of the following databases (PubMed, Web of Science, Scopus, Central, and Embase) up to February 2024. Results: Our search yielded 33 trials with 3174 patients, the analysis showed that pulsatile perfusion led to a significant decrease in hospital stay [MD = -1.38, 95% CI (-2.51, -0.25), P = 0.016], ICU stay [MD = -0.47, 95% CI (-0.82, -0.13), P = 0.007], intubation time [MD = -3.73, 95% CI (-5.42, -2.04), P < 0.001]. However, no significant difference between the two regimens was detected in the adult subgroup when we performed sungroup analysis based on the age for hospital stay and ICU stay outcomes [MD = -0.31, 95% CI (-0.95, 0.33), P = 0.334] and [MD = -3.73, 95% CI (-5.42, -2.04), P < 0.001] respectively. Conclusion: Pulsatile perfusion showed positive effects on hospital stay, ICU stay, and intubation time. However, there was no difference between the two methods on hospital and ICU stay in the adult’s subgroup. Also, the outcomes showed significant heterogeneity, which requires more robust RCTs to be conducted to increase the quality and the certainty of evidence.