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Xiong, Chengjie

0000-0003-0044-4499

Mayo Clinic

Washington University in St. Louis

Citations 71

Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease
Benzinger, Tammie L.S. , Blazey, Tyler , Xiong, Chengjie , Raichle, Marcus E. , Ances, Beau M. , Bateman, Randall J. , Cairns, Nigel J., Fagan, Anne M. , Goate, Alison , Marcus, Daniel S. , Aisen, Paul, Christensen, Jon, Ercole, Lindsay, Hornbeck, Russ C. , Farrar, Angela, Aldea, Patricia, Jasielec, Mateusz S., Owen, Christopher J. , Xie, Xianyun, Mayeux, Richard , Klunk, William E. , Mathis, Chester A. , Ringman, John M. , Thompson, Paul M. , Saykin, Andrew J. , Johnson, Keith A. , Salloway, Stephen , Correia, Stephen , Schofield, Peter R. , Masters, Colin L. , Villemagne, Victor L. , Martins, Ralph N. , Ourselin, Sébastien , Rossor, Martin N. , Fox, Nick C. , Cash, David M. , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Morris, John C. , Jack, Clifford R. , Koeppe, Robert A. , Su, Yi , Xiong, Chengjie , Snyder, Abraham Z. , Brickman, Adam M. , McDade, Eric , Ghetti, Bernardino , Sperling, Reisa Anne , Rowe, Christopher Cleon , Holtzman, David M. , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Ances, Beau M , Fox, Nick C , Morris, John C , Cash, David M , Goate, Alison M

Proceedings of the National Academy of Sciences | November 5, 2013 | Volume: 110 | Issue: 47 | Pages: No page available

10.1073/pnas.1317918110 Get It

Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering of these biomarkers prior to dementia remains untested. In a cohort with Alzheimer’s disease mutations, we performed an integrated whole-brain analysis of three major imaging techniques: amyloid PET, [ 18 F]fluro-deoxyglucose PET, and structural MRI. We found that most gray-matter structures with amyloid plaques later have hypometabolism followed by atrophy. Critically, however, not all regions lose metabolic function, and not all regions atrophy, even when there is significant amyloid deposition. These regional disparities have important implications for clinical trials of disease-modifying therapies.
IC‐P‐184: Resting state functional connectivity in autosomal dominant and sporadic Alzheimer's disease
Thomas, Jewell, Xiong, Chengjie , Raichle, Marcus E. , Mayeux, Richard , Ringman, John M. , Salloway, Stephen , Oliver, Angela , Moulder, Krista L., Buckles, Virginia, Hornbeck, Russ C. , Chhatwal, Jasmeer P. , Fagan, Anne M. , Cairns, Nigel J. , Marcus, Daniel S. , Brier, Matthew R. , Bateman, Randall J. , Snyder, Abraham Z. , Benzinger, Tammie L.S. , Xiong, Chengjie , Sperling, Reisa Anne , Ghetti, Bernardino , McDade, Eric , Rossor, Martin N. , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Jack, Clifford R. , Blazey, Tyler , Schultz, Aaron P. , Goate, Alison , Morris, John C. , Ances, Beau M.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_2 | Pages: No page available

10.1016/j.jalz.2013.05.181 Get It

P1–271: Resting state functional connectivity in autosomal dominant and sporadic Alzheimer's disease
Thomas, Jewell, Xiong, Chengjie , Raichle, Marcus E. , Sperling, Reisa, Mayeux, Richard , Ringman, John M. , Salloway, Stephen , Oliver, Angela , Moulder, Krista L., Buckles, Virginia, Hornbeck, Russ C. , Chhatwal, Jasmeer P. , Fagan, Anne M. , Cairns, Nigel J. , Marcus, Daniel, Brier, Matthew R. , Bateman, Randall J. , Snyder, Abraham Z. , Benzinger, Tammie L.S. , Xiong, Chengjie , Ghetti, Bernardino , McDade, Eric , Rossor, Martin N. , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Jack, Clifford R. , Blazey, Tyler , Schultz, Aaron P. , Goate, Alison , Morris, John C. , Ances, Beau M.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_6 | Pages: No page available

10.1016/j.jalz.2013.05.496 Get It

O4–03–03: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from the Dominantly Inherited Alzheimer Network
Chhatwal, Jasmeer P. , Johnson, Keith A. , Sullivan, Caroline, Salloway, Stephen , Ringman, John M. , Marcus, Daniel S. , Correia, Stephen , Rowe, Christopher C., Mayeux, Richard , Xiong, Chengjie , Buckles, Virginia, Schultz, Aaron P. , Benzinger, Tammie L.S. , Jack, Clifford R. , Ances, Beau M. , Koeppe, Robert A. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Fox, Nick C. , Brickman, Adam M. , McDade, Eric , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Sperling, Reisa Anne

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2013.04.348 Get It

IC‐P‐082: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from DIAN
Chhatwal, Jasmeer P. , Johnson, Keith A. , Sullivan, Caroline, Salloway, Stephen , Ringman, John M. , Marcus, Daniel S. , Correia, Stephen , Rowe, Christopher C., Mayeux, Richard , Xiong, Chengjie , Buckles, Virginia, Schultz, Aaron P. , Benzinger, Tammie L.S. , Jack, Clifford R. , Ances, Beau M. , Koeppe, Robert A. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Fox, Nick C. , Brickman, Adam M. , McDade, Eric , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Sperling, Reisa Anne

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_2 | Pages: No page available

10.1016/j.jalz.2013.05.079 Get It

IC‐P‐103: Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease
Preboske, Gregory M., Ringman, John M. , Raichle, Marc, Hornbeck, Russ C. , Salloway, Stephen , Correia, Stephen , Weiner, Michael W. , Mayeux, Richard , Cairns, Nigel J. , Marcus, Daniel C. , Fagan, Anne M. , Xiong, Chengjie , Buckles, Virginia, Moulder, Krista L., Blazey, Tyler , Jack, Clifford R. , Kantarci, Kejal , Brickman, Adam M. , Saykin, Andrew J. , McDade, Eric , Rossor, Martin N. , Fox, Nick C. , Thompson, Paul M. , Rowe, Christopher Cleon , Ghetti, Bernardino , Sperling, Reisa Anne , Schofield, Peter R. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_2 | Pages: No page available

10.1016/j.jalz.2013.05.100 Get It

O1–03–05: Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease
Preboske, Gregory M., Ringman, John M. , Raichle, Marc, Hornbeck, Russ C. , Salloway, Stephen , Correia, Stephen , Mayeux, Richard , Sperling, Reisa, Cairns, Nigel J. , Marcus, Daniel, Fagan, Anne M. , Xiong, Chengjie , Buckles, Virginia, Moulder, Krista L., Blazey, Tyler , Jack, Clifford R. , Kantarci, Kejal , Brickman, Adam M. , Saykin, Andrew J. , McDade, Eric , Rossor, Martin N. , Fox, Nick C. , Thompson, Paul M. , Rowe, Christopher Cleon , Weiner, Michael W. , Ghetti, Bernardino , Schofield, Peter R. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_3 | Pages: No page available

10.1016/j.jalz.2013.04.065 Get It

The pattern of atrophy in familial Alzheimer disease
Cash, David M. , Ridgway, Gerard R. , Ryan, Natalie S. , Kinnunen, Kirsi M. , Yeatman, Thomas, Malone, Ian B. , Benzinger, Tammie L.S. , Thompson, Paul M. , Saykin, Andrew J. , Masters, Colin L. , Ringman, John M. , Salloway, Stephen , Schofield, Peter R. , Cairns, Nigel J., Marcus, Daniel S. , Bateman, Randall J. , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C. , Liang, Yuying , Jack, Clifford R. , Ghetti, Bernardino , Sperling, Reisa Anne , Xiong, Chengjie , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Fox, Nick C , Morris, John C , Cash, David M

Neurology | September 19, 2013 | Volume: 81 | Issue: 16 | Pages: 1425-1433

10.1212/wnl.0b013e3182a841c6 Get It

O2‐06‐05: A voxel‐based morphometry study of volumetric MRI in familial Alzheimer's disease
Cash, David, Ryan, Natalie S. , Kinnunen, Kirsi M. , Yeatman, Tom, Malone, Ian B. , Raichle, Marc, Marcus, Daniel S., Ringman, John M. , Thompson, Paul , Salloway, Steven, Correia, Stephen , Villemagne, Victor L. , Mayeux, Richard , Fagan, Anne M. , Cairns, Nigel J., Buckles, Virginia, Moulder, Krista L., Ridgway, Gerard R. , Benzinger, Tammie L.S. , Koeppe, Robert A. , Jack, Clifford R. , Saykin, Andrew J. , Salloway, Steve , Johnson, Keith J. , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Martins, Ralph N. , Brickman, Adam M. , Weiner, Michael W. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.

Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available

10.1016/j.jalz.2012.05.658 Get It

O2‐06‐02: FDG metabolism in the DIAN study of autosomal dominant Alzheimer's disease
Marcus, Daniel S. , Raichle, Marc, Correia, Stephen , Weiner, Michael W. , Fagan, Anne M. , Buckles, Virginia, Moulder, Krista L., Mayeux, Richard , Cairns, Nigel J. , Ringman, John M. , Salloway, Stephen , Johnson, Keith A. , Becker, John Alex , Koeppe, Robert A. , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Schofield, Peter R. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Ghetti, Bernardino , Masters, Colin L. , Mathis, Chester A. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Martins, Ralph N. , Morris, John C. , Sperling, Reisa Anne

Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_7 | Pages: No page available

10.1016/j.jalz.2012.05.655 Get It