Citations 88
The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease
Gerrish, Amy , Russo, Giancarlo , Richards, Alexander , Moskvina, Valentina, Ivanov, Dobril , Harold, Denise , Sims, Rebecca , Abraham, Richard, Hollingworth, Paul, Chapman, Jade , Hamshere, Marian L. , Pahwa, Jaspreet Singh, Dowzell, Kimberley, Jones, Nicola, Thomas, Charlene , Stretton, Alexandra, Morgan, Angharad R., Lovestone, Simon , Powell, John , Proitsi, Petroula , Brayne, Carol , Gill, Michael , Lynch, Aoibhinn, Morgan, Kevin , Brown, Kristelle, Passmore, Peter , Craig, David W. , McGuinness, Bernadette , Todd, Stephen , Johnston, Janet, Smith, A. David , Love, Seth , Kehoe, Patrick G. , Hardy, John , Mead, Simon , Fox, Nick C. , Rossor, Martin N. , Collinge, John, Maier, Wolfgang, Jessen, Frank , Kölsch, Heike, Schürmann, Britta, Bussche, Hendrik van den, Heuser, Isabella , Kornhuber, Johannes , Wiltfang, Jens , Dichgans, Martin , Frölich, Lutz, Hampel, Harald , Hüll, Michael, Goate, Alison , Kauwe, John, Cruchaga, Carlos , Nowotny, Petra, Morris, John C. , Mayo, Kevin H. , Livingston, Gill , Gurling, Hugh, McQuillin, Andrew , Gwilliam, Rhian, Deloukas, Panagiotis, Davies, Gail , Starr, John M. , Deary, Ian J. , Al‐Chalabi, Ammar , Shaw, Christopher E. , Tsolaki, Magda , Singleton, Andrew B., Guerreiro, Rita , Mühleisen, Thomas W. , Nöthen, Markus M. , Moebus, Susanne , Jöckel, Karl‐Heinz , Klopp, Norman, Wichmann, H‐Erich, Carrasquillo, Minerva M., Younkin, Steven G., Jones, Lesley , Holmans, Peter , O‘Donovan, Michael , Williams, Julie , Deloukas, Panos , Escott‐Price, Valentina , Denning, Nicola , Dichgans, Martin , Cruchaga, Carlos , Kornhuber, Johannes , Nöthen, Markus M , Hardy, John , Moebus, Susanne , Williams, Amy L. , Lupton, Michelle K. , Rubinsztein, David Chaim , LAWLOR, BRIAN A. , Holmes, Clive , Mann, David , Heun, Reinhard , Rujescu, Dan , Bass, Nicholas , Harris, Sarah , Carrasquillo, Minerva M. , Pankratz, V. Shane , Owen, Michael J. , Fox, Nick C , Morris, John C , Wiltfang, Jens , Al-Chalabi, Ammar , Tsolaki, Magda , Goate, Alison M , McQuillin, Andrew , Escott-Price, Valentina
Journal of Alzheimer's Disease | May 16, 2018 | Volume: 28 | Issue: 2 | Pages: 377-387
[IC‐P‐166]: UTILITY OF PERFUSION PET MODELS AS MEASURE OF NEURODEGENERATION IN AN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE POPULATION: REPORT FROM THE DIAN STUDY
Su, Yi , Jasielec, Mateusz S., Vlassenko, Andrei G. , Hornbeck, Russ C. , Cash, Lisa, Raichle, Marcus E. , Buckles, Virginia, Cairns, Nigel J. , Fagan, Anne M. , Klunk, Bill E., Marcus, Daniel S. , Mayeux, Richard , Paumier, Katrina L. , Ringman, John M. , Xiong, Chengjie , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Ances, Beau M. , Brickman, Adam M. , Cruchaga, Carlos , Goate, Alison , Jack, Clifford R. , Klunk, Bill E., Koeppe, Robert A. , McDade, Eric , Saykin, Andrew J. , Thompson, Paul M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_2 | Pages: No page available
[P3–094]: RESOURCE OF MULTIPLEX AFRICAN AMERICAN FAMILIES FOR WHOLE‐GENOME SEQUENCING
Reitz, Christiane , Beecham, Gary W. , Celis, Katrina, Adams, Larry D., Starks, Takiyah D. , Joseph, N. Paulson, Whitehead, Patrice L., Hamilton‐Nelson, Kara L. , Reyes‐Dumeyer, Dolly , Byfield, Grace , Rosenberg, Roger N., Haines, Jonathan L. , Byrd, Goldie S. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Cuccaro, Michael L. , Cukier, Holly N. , Bennett, David A. , Boeve, Bradley F. , Sweet, Robert A. , Cruchaga, Carlos , Vance, Jeffery M.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_20 | Pages: No page available
[IC‐P‐057]: CLINICAL RISK RELATED TO CEREBRAL MICROHEMORRHAGES IN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE: LONGITUDINAL RESULTS FROM THE DIAN STUDY
Ringman, John M. , Salloway, Stephen , Su, Yi , Hornbeck, Russ C. , Raichle, Marcus E. , Marcus, Daniel S. , Cairns, Nigel J. , Xiong, Chengjie , Buckles, Virginia, Paumier, Katrina L. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Kantarci, Kejal , Jack, Clifford R. , McDade, Eric , Clifford, David J , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Mills, Susan , Ances, Beau M. , Cruchaga, Carlos , Goate, Alison , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_1 | Pages: No page available
[O1–02–04]: CLINICAL RISK RELATED TO CEREBRAL MICROHEMORRHAGES IN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE: LONGITUDINAL RESULTS FROM THE DIAN STUDY
Ringman, John M. , Salloway, Stephen , Clifford, David B. , Su, Yi , Hornbeck, Russ C. , Raichle, Marcus E. , Marcus, Daniel S. , Cairns, Nigel J. , Buckles, Virginia, Paumier, Katrina L. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Kantarci, Kejal , Jack, Clifford R. , McDade, Eric , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Mills, Susan , Ances, Beau M. , Xiong, Chengjie , Cruchaga, Carlos , Goate, Alison , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_3 | Pages: No page available
[P2–372]: UTILITY OF PERFUSION PET MODELS AS MEASURES OF NEURODEGENERATION IN AN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE POPULATION: REPORT FROM THE DIAN STUDY
Jasielec, Mateusz S., Vlassenko, Andrei G. , Hornbeck, Russ C. , Cash, Lisa, Raichle, Marcus E. , Buckles, Virginia, Cairns, Nigel J. , Fagan, Anne M. , Klunk, Bill E., Marcus, Daniel S., Mayeux, Richard , Paumier, Katrina L. , Ringman, John M. , Network, Dominantly Inherited Alzheimer, Joseph‐Mathurin, Nelly , Su, Yi , Blazey, Tyler , Friedrichsen, Karl A. , Gordon, Brian A. , Ances, Beau M. , Brickman, Adam M. , Cruchaga, Carlos , Goate, Alison , Jack, Clifford R. , Klunk, Bill E., Koeppe, Robert A. , McDade, Eric , Saykin, Andrew J. , Thompson, Paul M. , Xiong, Chengjie , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Network, Dominantly Inherited Alzheimer
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_15 | Pages: No page available
Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
Jun, Gyungah , Chung, Jaeyoon , Beecham, Gary W. , Bennett, David A. , Buxbaum, Joseph D. , Byrd, Goldie S. , Carrasquillo, Minerva M., Crane, Paul K. , Cruchaga, Carlos , Jager, Philip L. De , Ertekin‐Taner, Nilüfer , Evans, Denis A., Fallin, M. Danielle, Friedland, Robert P. , Goate, Alison , Graff‐Radford, Neill R. , Hendrie, Hugh C. , Hall, Kathleen, Hamilton‐Nelson, Kara L., Kukull, Walter A. , Kunkle, Brian W. , Kuwano, Ryozo, Larson, Eric B., Martin, Eden R. , Montine, Thomas J. , Reiman, Eric M. , Reitz, Christiane, Sherva, Richard , George‐Hyslop, Peter St , Thornton, Timothy, Younkin, Steven G., Wang, Li‐San , Wendlund, Jens R., Winslow, Ashley R. , Adams, Perrie M. , Albert, Marilyn S. , Albin, Roger L. , Apostolova, Liana G. , Arnold, Steven E. , Asthana, Sanjay , Atwood, Craig , Barmada, Michjael M, Beach, Thomas G. , Bigio, Eileen H. , Bird, Thomas D., Blacker, Deborah , Bowen, James D. , Boxer, Adam, Cairns, Nigel J. , Cao, Chuanhai , Carlson, Chris , Carlsson, Cynthia M., Carney, Regina M., Carroll, Steven L. , Chui, Helena C., Clark, David G., Corneveaux, Jason J., Cribbs, David H. , DeKosky, Steven T. , Demirci, F. Yesim , Dick, Malcolm, Doody, Rachelle S., Duara, Ranjan , Faber, Kelley , Fairchild, Thomas, Fallon, Kenneth B., Farlow, Martin R. , Frosch, Matthew P. , Gearing, Marla , Geschwind, Daniel H. , Gilbert, John R., Glass, Jonathan D. , Growdon, John H., Håkonarson, Håkon , Hamilton, Ronald L. , Hardy, John , Harrell, Lindy E., Huentelman, Matthew J. , Hulette, Christine M., Jarvik, Gail P. , Jicha, Gregory A. , Jin, Lee‐Way, Karydas, Anna, Koo, Edward H. , Kowall, Neil W. , Kramer, Joel H. , LaFerla, Frank M. , Leverenz, James B. , Ge, Li , Lieberman, Andrew P. , Lin, Chiao‐Feng , Lyketsos, Constantine G. , Mack, Wendy J. , Marson, Daniel , Martiniuk, Frank , Mash, Deborah C. , Masliah, Eliezer , McCormick, Wayne C., McKee, Ann C. , Mesulam, Marsel, Miller, Carol A., Miller, Joshua W., Morris, John C. , Murrell, Jill R. , Olichney, John , Parisi, Joseph E., Partch, Amanda, Paulson, Henry L. , Peskind, Elaine R. , Petersen, Ronald , Pierce, Aimee, Poon, Wayne W. , Raj, Ashok , Raskind, Murray A. , Reisch, Joan, Ringman, John M. , Rosen, Howard J., Rosenberg, Roger N., Royall, Donald R., Sager, Mark A., Sano, Mary , Saykin, Andrew J. , Schneider, Lon S. , Smith, Amanda , Sonnen, Joshua A. , Tanzi, Rudolph E. , Thornton‐Wells, Tricia A., Trojanowski, John Q. , Troncoso, Juan C. , Vinters, Harry V. , Vonsattel, Jean Paul, Weıntraub, Sandra , Wishnek, Sarah, Woltjer, Randall L. , Wright, Clinton B., Wu, Chuang‐Kuo, Yu, Chang‐En , Yu, Lei , Haines, Jonathan L. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Schellenberg, Gerard, Lunetta, Kathryn L. , Farrer, Lindsay A. , Bennett, David A. , Mez, Jesse , Barber, Robert C. , Carrasquillo, Minerva M. , Cruchaga, Carlos , Foroud, Tatiana , Hamilton‐Nelson, Kara L. , Inzelberg, Rivka , Kamboh, M. Ilyas , Kauwe, John S. K. , Logue, Mark W. , Manly, Jennifer J. , Mukherjee, Shubhabrata , Naj, Adam Christian , Sherva, Richard , Vardarajan, Badri Narayan , Barnes, Lisa L. , Becker, James T. , Boeve, Bradley F. , Burke, James R. , Carlsson, Cynthia M. , Chui, Helena C. , Crocco, Elizabeth , DeCarli, Charles , Dickson, Dennis W. , Duara, Ranjan , Ferris, Steven H. , Galasko, Douglas , Ghetti, Bernardino , Green, Robert C. , Head, Elizabeth , Honig, Lawrence S. , Huebinger, Ryan , Hyman, Bradley T. , Kaye, Jeffrey , Kim, Ronald , Lah, James J. , Levey, Allan I. , Li, Ge, López, Oscar L. , McCurry, Susan M. , McDavid, Andrew , Mesulam, Marsel M. , Miller, Bruce L. , Myers, Amanda , O’Bryant, Sid E. , Pankratz, V. Shane , Perry, William , Potter, Huntington , Quinn, Joseph F. , Reisberg, Barry , Roberson, Erik D. , Rogaeva, Ekaterina A. , Schneider, Julie A. , Seeley, William W. , Spina, Salvatore , Stern, Robert A. , Tsuang, Debby W. , Deerlin, Vivianna M. Van , Eldik, Linda J. Van , Welsh-Bohmer, Kathleen Anne , Williamson, Jennifer , Zhang, Xiaoling , Hakonarson, Hakon , Saykin, Andrew J , Leverenz, James B , Jarvik, Gail P , Paulson, Henry L , Hardy, John , Morris, John C , Goate, Alison M , Jicha, Gregory A , Sonnen, Joshua
Alzheimer's & Dementia | February 6, 2017 | Volume: 13 | Issue: 7 | Pages: 727-738
Abstract Introduction Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. Methods We conducted a transethnic genome‐wide association study (GWAS) for late‐onset AD in Stage 1 sample including whites of European Ancestry, African‐Americans, Japanese, and Israeli‐Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Results Genome‐wide significant (GWS) associations in single‐nucleotide polymorphism (SNP)–based tests ( P < 5 × 10 −8 ) were identified for SNPs in PFDN1/HBEGF , USP6NL/ECHDC3 , and BZRAP1‐AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence ( P < 2.7 × 10 −6 ) for gene‐based association in the total sample with a novel locus, TPBG ( P = 1.8 × 10 −6 ). Discussion Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.
P2‐158: LINKAGE AND WHOLE GENOME SEQUENCE ANALYSIS OF ALZHEIMER'S DISEASE RESILIENCE AND RISK
Kauwe, Keoni, Arano, Ivan, Murcia, Josue D. Gonzalez , Hardy, John , Munger, Ronald G. , Norton, Maria C. , Ridge, Perry G. , Sassi, Celeste , Singleton, Andrew , Tschanz, JoAnn T. , Younkin, Steven G., Corcoran, Christopher, Group), AESG (Alzheimer’s Exome Sequencing, Brás, José , Cannon‐Albright, Lisa , Cruchaga, Carlos , Goate, Alison , Guerreiro, Rita , Hsu, Simon , Karch, Celeste M. , Teerlink, Craig C. , Group), AESG (Alzheimer’s Exome Sequencing, Hardy, John
Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_14 | Pages: No page available
O2‐10‐05: Cerebrospinal Fluid Levels of Amyloid Beta and Tau as Endophenotypes Reveal Novel Variants Potentially Informative for Alzheimer's Disease
Deming, Yuetiva, Harari, Oscar , Black, Kathleen, Cai, Yefei, Ma, Sheng‐mei , Saef, Ben, Bertelsen, Sarah , Kauwe, John, Fagan, Anne M. , Kim, Sungeun , Saykin, Andy J., Jager, Philip L. De , Albert, Marilyn S. , O’Brien, Richard , Riemenschneider, Matthias, Petersen, Ronald , Blennow, Kaj , Minthon, Lennart, Shaw, Leslie M. , Trojanowski, John Q. , Peskind, Elaine R. , Li, Gail, Carrell, David , Del‐Aguila, Jorge L. , Fernández, María Victoria , Budde, John , Holtzman, David M. , Morris, John C. , Saykin, Andy J., Goate, Alison , Cruchaga, Carlos , Moghekar, Abhay , Riemenschneider, Matthias, Zetterberg, Henrik , Deerlin, Vivianna M. Van , Lee, Virginia M.‐Y.
Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_5 | Pages: No page available
F5‐02‐03: BDNF VAL66MET Moderates Cognitive Impairment, Neuronal Dysfunction and TAU in Preclinical Autosomal Dominant Alzheimer's Disease
Fagan, Anne M. , Benzinger, Tammie Lee Smith, Ricardo, Allegri, Chhatwal, Jasmeer P. , Farlow, Martin R. , Graff‐Radford, Neill R. , Laske, Christoph , Ringman, John M. , Salloway, Stephen , Lim, Yen Ying , Hassenstab, Jason , Cruchaga, Carlos , Goate, Alison , Benzinger, Tammie L.S. , Maruff, Paul , Snyder, Peter J. , Masters, Colin L. , Allegri, Ricardo , Xiong, Chengjie , McDade, Eric , Rossor, Martin N. , Schofield, Peter William , Holtzman, David M. , Morris, John C. , Bateman, Randall J.
Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_7 | Pages: No page available