Citations 6
P2‐158: LINKAGE AND WHOLE GENOME SEQUENCE ANALYSIS OF ALZHEIMER'S DISEASE RESILIENCE AND RISK
Kauwe, Keoni, Arano, Ivan, Murcia, Josue D. Gonzalez , Hardy, John , Munger, Ronald G. , Norton, Maria C. , Ridge, Perry G. , Sassi, Celeste , Singleton, Andrew , Tschanz, JoAnn T. , Younkin, Steven G., Corcoran, Christopher, Group), AESG (Alzheimer’s Exome Sequencing, Brás, José , Cannon‐Albright, Lisa , Cruchaga, Carlos , Goate, Alison , Guerreiro, Rita , Hsu, Simon , Karch, Celeste M. , Teerlink, Craig C. , Group), AESG (Alzheimer’s Exome Sequencing, Hardy, John
Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_14 | Pages: No page available
Rarity of the Alzheimer Disease–ProtectiveAPPA673T Variant in the United States
Wang, Li-San, Graham, Robert , Crane, Paul K. , Kunkle, Brian W. , Cruchaga, Carlos , Murcia, Josue D. Gonzalez , Cannon‐Albright, Lisa , Baldwin, Clinton T., Blennow, Kaj , Kukull, Walter A. , Faber, Kelley M., Schupf, Nicole , Norton, Maria C. , Tschanz, JoAnn T. , Munger, Ronald G. , Corcoran, Christopher, Lin, Chiao‐Feng , Dombroski, Beth A. , Cantwell, Laura B., Partch, Amanda, Håkonarson, Håkon , George‐Hyslop, Peter St , Goate, Alison , Foroud, Tatiana, Carney, Regina M., Larson, Eric B., Behrens, Timothy W. , Kauwe, John, Haines, Jonathan L. , Farrer, Lindsay A. , Pericak‐Vance, Margaret A. , Mayeux, Richard , Schellenberg, Gerard D., Albert, Marilyn S. , Albin, Roger L. , Apostolova, Liana G. , Arnold, Steven E. , Barber, Robert W., Barmada, M. Michael , Beach, Thomas G. , Beecham, Gary W. , Beekly, Duane, Bennett, David A. , Bigio, Eileen H. , Bird, Thomas D., Blacker, Deborah , Bowen, James D. , Boxer, Adam, Buxbaum, Joseph D. , Cairns, Nigel J. , Cao, Chuanhai , Carlson, Chris , Carroll, Steven L. , Chui, Helena C., Clark, David G., Cribbs, David H. , DeCarli, Charles , DeKosky, Steven T. , Demirci, F. Yesim , Dick, Malcolm, Duara, Ranjan , Ertekin‐Taner, Nilüfer , Fallon, Kenneth B., Farlow, Martin R. , Ferris, Steven H. , Frosch, Matthew P. , Gearing, Marla , Geschwind, Daniel H. , Gilbert, John R., Glass, Jonathan D. , Graff‐Radford, Neill R. , Growdon, John H., Hamilton, Ronald L. , Hamilton‐Nelson, Kara L., Harrell, Lindy E., Hulette, Christine M., Jicha, Gregory A. , Jin, Lee‐Way, Jun, Gyungah , Kamboh, M. Ilyas , Karydas, Anna, Koo, Edward H. , Kowall, Neil W. , Kramer, Joel H. , Kramer, Patricia, LaFerla, Frank M. , Leverenz, James B. , Lieberman, Andrew P. , Lunetta, Kathryn L. , Lyketsos, Constantine G. , Mack, Wendy J. , Marson, Daniel , Martin, Eden R. , Martiniuk, Frank , Mash, Deborah C. , Masliah, Eliezer , McCormick, Wayne C., McKee, Ann C. , Miller, Carol A., Miller, Joshua W., Montine, Thomas J. , Morris, John C. , Murrell, Jill R. , Olichney, John , Parisi, Joseph E., Peskind, Elaine R. , Petersen, Ronald , Pierce, Aimee, Poon, Wayne W. , Raj, Ashok , Raskind, Murray A. , Reiman, Eric M. , Reisberg, Barry , Reitz, Christiane , Ringman, John M. , Rosen, Howard J., Rosenberg, Roger N., Sano, Mary , Saykin, Andrew J. , Schneider, Lon S. , Smith, Amanda , Sonnen, Joshua A. , Stern, Robert A. , Tanzi, Rudolph E. , Thornton‐Wells, Tricia A., Trojanowski, John Q. , Troncoso, Juan C. , Tsuang, Debby W. , Vinters, Harry V. , Vonsattel, Jean Paul, Weıntraub, Sandra , Wishnek, Sarah, Woltjer, Randall L. , Wright, Clinton B., Younkin, Steven G., Yu, Chang‐En , Yu, Lei , DeCarli, Charles , Wang, Li-San, Naj, Adam Christian , Cruchaga, Carlos , Zetterberg, Henrik , Rogaeva, Ekaterina A. , Valladares, Otto , Green, Robert C. , Barnes, Lisa L. , Becker, James T. , Boeve, Bradley F. , Burke, James R. , Chui, Helena C. , Crocco, Elizabeth , Dickson, Dennis W. , Duara, Ranjan , Galasko, Douglas , Ganguli, Mary , Ghetti, Bernardino , Hamilton‐Nelson, Kara L. , Head, Elizabeth , Honig, Lawrence S. , Hyman, Bradley T. , Jarvik, Gail P. , Kaye, Jeffrey , Kim, Ronald , Lah, James J. , Levey, Allan I. , Li, Ge , López, Oscar L. , McCurry, Susan M. , McDavid, Andrew , Mesulam, Marsel M. , Miller, Bruce L. , Perry, William , Potter, Huntington , Quinn, Joseph F. , Roberson, Erik D. , Schneider, Julie A. , Seeley, William W. , Spina, Salvatore , Deerlin, Vivianna M. Van , Eldik, Linda J. Van , Vardarajan, Badri Narayan , Welsh-Bohmer, Kathleen Anne , Williamson, Jennifer , Bennett, David A. , Hakonarson, Hakon , Saykin, Andrew J , Leverenz, James B , Cannon-Albright, Lisa A , Stern, Robert A , Morris, John C , Goate, Alison M , Jicha, Gregory A , Sonnen, Joshua
JAMA Neurology | December 22, 2014 | Volume: 72 | Issue: 2 | Pages: 209
P4–095: Vascular factors as predictors of severe dementia and mortality in Alzheimer's disease: The Cache County dementia progression study
Tschanz, JoAnn T. , Schwartz, Sarah , Gilbert, Mac, Wanzek, Joseph, Sanders, Chelsea , Corcoran, Chris , Norton, Maria C. , Mielke, Michelle M. , Lyketsos, Constantine G.
Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_18 | Pages: No page available
Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study
Hess, Kyle, Corcoran, Chris , Mielke, Michelle M. , Norton, Maria C. , Breitner, John C.S. , Leoutsakos, Jeannie‐Marie , Welsh‐Bohmer, Kathleen A., Lyketsos, Constantine G. , Tschanz, JoAnn T. , Steinberg, Martin H. , Green, Robert C. , Mielke, Michelle M
International Journal of Geriatric Psychiatry | May 17, 2013 | Volume: 29 | Issue: 2 | Pages: 153-159
Objective Knowledge of potentially modifiable risk factors for neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) is important. This study longitudinally explores modifiable vascular risk factors for NPS in AD. Methods Participants enrolled in the Cache County Study on Memory in Aging with no dementia at baseline were subsequently assessed over three additional waves, and those with incident (new onset) dementia were invited to join the Dementia Progression Study for longitudinal follow‐up. A total of 327 participants with incident AD were identified and assessed for the following vascular factors: atrial fibrillation, hypertension, diabetes mellitus, angina, coronary artery bypass surgery, myocardial infarction, cerebrovascular accident, and use of antihypertensive or diabetes medicines. A vascular index (VI) was also calculated. NPS were assessed over time using the Neuropsychiatric Inventory (NPI). Affective and Psychotic symptom clusters were assessed separately. The association between vascular factors and change in NPI total score was analyzed using linear mixed model and in symptom clusters using a random effects model. Results No individual vascular risk factors or the VI significantly predicted change in any individual NPS. The use of antihypertensive medications more than four times per week was associated with higher total NPI and Affective cluster scores. Conclusions Use of antihypertensive medication was associated with higher total NPI and Affective cluster scores. The results of this study do not otherwise support vascular risk factors as modifiers of longitudinal change in NPS in AD. Copyright © 2013 John Wiley & Sons, Ltd.
Hormone therapy and Alzheimer disease dementia
Shao, Huibo, Breitner, John C.S. , Whitmer, Rachel A. , Wang, Junmin , Hayden, Kathleen M. , Wengreen, Heidi J. , Corcoran, Chris , Tschanz, JoAnn T., Norton, Maria C. , Munger, Ron, Zandi, Peter P. , Anthony, James C. , Bigler, Erin D. , Burke, James , Christopher, Eric J. , Helms, Michael J., Hulette, Christine, Khachaturian, Ara , Klein, Liz, Leslie, Carol, Onyike, Chiadi U. , Petersen, Ron, Piercy, Kathy, Plassman, Brenda L. , Rabins, Peter V., Raj, Pritham, Toohill, Marty, Toone, Leslie, Townsend, Jeannette J., Wyse, Bonita W., Welsh-Bohmer, Kathleen Anne , Brookmeyer, Ron , Gagliardi, Jane P. , Green, Robert C. , Lyketsos, Constantine G. , Morris, John C. , Østbye, Truls , Pieper, Carl F. , Skoog, Ingmar , Steffens, David C. , Steinberg, Martin H. , Toohill, Margaret, Williams, Michael Andrew
Neurology | October 25, 2012 | Volume: 79 | Issue: 18 | Pages: 1846-1852
The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease
Rosenberg, Paul B. , Leoutsakos, Jeannie‐Marie , Lyketsos, Constantine G. , Rabins, Peter V., Zandi, Peter P. , Breitner, John C.S. , Norton, Maria C. , Zuckerman, Ilene H., Rattinger, Gail B. , Green, R. C., Tschanz, JoAnn T. , Mielke, Michelle M. , Han, Dan , Welsh-Bohmer, Kathleen Anne , Corcoran, Cheryl Mary
International Journal of Geriatric Psychiatry | February 29, 2012 | Volume: 27 | Issue: 12 | Pages: 1248-1257
ObjectiveThe use of psychotropic medications in Alzheimer's disease (AD) has been associated with both deleterious and potentially beneficial outcomes. We examined the longitudinal association of psychotropic medication use with cognitive, functional, and neuropsychiatric symptom (NPS) trajectories among community‐ascertained incident AD cases from the Cache County Dementia Progression Study.MethodsA total of 230 participants were followed for a mean of 3.7 years. Persistency index (PI) was calculated for all antidepressants, selective serotonin reuptake inhibitors (SSRIs), antipsychotics (atypical and typical), and benzodiazepines as the proportion of observed time of medication exposure. Mixed‐effects models were used to examine the association between PI for each medication class and Mini‐Mental State Exam (MMSE), Clinical Dementia Rating Sum of Boxes (CDR‐Sum), and Neuropsychiatric Inventory – Total (NPI‐Total) trajectories, controlling for appropriate demographic and clinical covariates.ResultsAt baseline, psychotropic medication use was associated with greater severity of dementia and poorer medical status. Higher PI for all medication classes was associated with a more rapid decline in MMSE. For antidepressant, SSRI, benzodiazepine, and typical antipsychotic use, a higher PI was associated with a more rapid increase in CDR‐Sum. For SSRIs, antipsychotics, and typical antipsychotics, a higher PI was associated with more rapid increase in NPI‐Total.ConclusionsPsychotropic medication use was associated with more rapid cognitive and functional decline in AD, and not with improved NPS. Clinicians may tend to prescribe psychotropic medications to AD patients at risk of poorer outcomes, but one cannot rule out the possibility of poorer outcomes being caused by psychotropic medications. Copyright © 2012 John Wiley & Sons, Ltd.