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Abraham, Richard

Mayo Clinic

Cardiff University

Citations 6

The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease
Gerrish, Amy , Russo, Giancarlo , Richards, Alexander , Moskvina, Valentina, Ivanov, Dobril , Harold, Denise , Sims, Rebecca , Abraham, Richard, Hollingworth, Paul, Chapman, Jade , Hamshere, Marian L. , Pahwa, Jaspreet Singh, Dowzell, Kimberley, Jones, Nicola, Thomas, Charlene , Stretton, Alexandra, Morgan, Angharad R., Lovestone, Simon , Powell, John , Proitsi, Petroula , Brayne, Carol , Gill, Michael , Lynch, Aoibhinn, Morgan, Kevin , Brown, Kristelle, Passmore, Peter , Craig, David W. , McGuinness, Bernadette , Todd, Stephen , Johnston, Janet, Smith, A. David , Love, Seth , Kehoe, Patrick G. , Hardy, John , Mead, Simon , Fox, Nick C. , Rossor, Martin N. , Collinge, John, Maier, Wolfgang, Jessen, Frank , Kölsch, Heike, Schürmann, Britta, Bussche, Hendrik van den, Heuser, Isabella , Kornhuber, Johannes , Wiltfang, Jens , Dichgans, Martin , Frölich, Lutz, Hampel, Harald , Hüll, Michael, Goate, Alison , Kauwe, John, Cruchaga, Carlos , Nowotny, Petra, Morris, John C. , Mayo, Kevin H. , Livingston, Gill , Gurling, Hugh, McQuillin, Andrew , Gwilliam, Rhian, Deloukas, Panagiotis, Davies, Gail , Starr, John M. , Deary, Ian J. , Al‐Chalabi, Ammar , Shaw, Christopher E. , Tsolaki, Magda , Singleton, Andrew B., Guerreiro, Rita , Mühleisen, Thomas W. , Nöthen, Markus M. , Moebus, Susanne , Jöckel, Karl‐Heinz , Klopp, Norman, Wichmann, H‐Erich, Carrasquillo, Minerva M., Younkin, Steven G., Jones, Lesley , Holmans, Peter , O‘Donovan, Michael , Williams, Julie , Deloukas, Panos , Escott‐Price, Valentina , Denning, Nicola , Dichgans, Martin , Cruchaga, Carlos , Kornhuber, Johannes , Nöthen, Markus M , Hardy, John , Moebus, Susanne , Williams, Amy L. , Lupton, Michelle K. , Rubinsztein, David Chaim , LAWLOR, BRIAN A. , Holmes, Clive , Mann, David , Heun, Reinhard , Rujescu, Dan , Bass, Nicholas , Harris, Sarah , Carrasquillo, Minerva M. , Pankratz, V. Shane , Owen, Michael J. , Fox, Nick C , Morris, John C , Wiltfang, Jens , Al-Chalabi, Ammar , Tsolaki, Magda , Goate, Alison M , McQuillin, Andrew , Escott-Price, Valentina

Journal of Alzheimer's Disease | May 16, 2018 | Volume: 28 | Issue: 2 | Pages: 377-387

10.3233/jad-2011-110824 Get It

A Multi-Center Study of ACE and the Risk of Late-Onset Alzheimer's Disease
Belbin, Olivia , Brown, Kristelle, Shi, Hui , Medway, Christopher, Abraham, Richard, Passmore, Peter , Mann, David, Smith, A. David , McGuinness, Bernadette , Craig, David , Warden, Donald, Kölsch, Heike, Love, Seth , Kalsheker, Noor , Williams, Julie , Carrasquillo, Minerva M., Younkin, Steven G., Morgan, Kevin , Kehoe, Patrick G. , Belbin, Olivia , Mann, David, Holmes, Clive , Heun, Reinhard , Owen, Michael J. , Carrasquillo, Minerva M.

Journal of Alzheimer's Disease | May 16, 2018 | Volume: 24 | Issue: 3 | Pages: 587-597

10.3233/jad-2011-101914 Get It

P4‐133: Genome‐wide association study of age at onset of Alzheimer's disease
Hollingworth, Paul, Hamshere, Marian L. , Abraham, Richard, Passmore, Peter , Maier, Wolfgang, Livingston, Gill , Bass, Nicola, Younkin, Steven G., Gwilliam, Rhian, Owen, Michael , Harold, Denise , Holmans, Peter , Sims, Rebecca , Gerrish, Amy , Lovestone, Simon , Brayne, Carol , Gill, Michael , LAWLOR, BRIAN A. , Nöthen, Markus M. , Goate, Alison , Al‐Chalabi, Ammar , Morgan, Kevin , Deloukas, Panos , O‘Donovan, Michael , Williams, Julie

Alzheimer's & Dementia | June 25, 2009 | Volume: 5 | Issue: 4S_Part_15 | Pages: No page available

10.1016/j.jalz.2009.04.801 Get It

P4‐124: An examination of previously reported Alzheimer candidate genes within a large genome‐wide association dataset
Abraham, Richard, Hollingworth, Paul, Hamshere, Marian L. , Passmore, Peter , Livingston, Gill , Bass, Nicolas, Younkin, Steve, Gwilliam, Rhian, Gerrish, Amy , Harold, Denise , Sims, Rebecca , Lovestone, Simon , Brayne, Carol , Gill, Michael , LAWLOR, BRIAN A. , Nöthen, Markus M. , Mayer, Wolfgang , Goate, Alison , Al‐Chalabi, Ammar , Morgan, Kevin , Deloukas, Panos , Holmans, Peter , O‘Donovan, Michael , Owen, Michael J. , Williams, Julie

Alzheimer's & Dementia | June 25, 2009 | Volume: 5 | Issue: 4S_Part_15 | Pages: No page available

10.1016/j.jalz.2009.04.792 Get It

P4‐121: Genome‐wide association study of Alzheimer's with psychotic symptoms
Hollingworth, Paul, Abraham, Richard, Hamshere, Marian L. , Passmore, Peter , Livingston, Gill , Bass, Nicolas, Younkin, Steve, Gwilliam, Rhian, Sims, Rebecca , Harold, Denise , Gerrish, Amy , Lovestone, Simon , Brayne, Carol , Gill, Michael , LAWLOR, BRIAN A. , Nöthen, Markus M. , Mayer, Wolfgang , Goate, Alison , Al‐Chalabi, Ammar , Morgan, Kevin , Deloukas, Panos , Holmans, Peter , O‘Donovan, Michael , Owen, Michael J. , Williams, Julie

Alzheimer's & Dementia | June 25, 2009 | Volume: 5 | Issue: 4S_Part_15 | Pages: No page available

10.1016/j.jalz.2009.04.789 Get It

Susceptibility Locus for Alzheimer's Disease on Chromosome 10
Holmans, Peter , Marshall, Helen, Kwon, Jennifer M. , Meyer, David , Ramic, Dzanan, Shears, Shantia, DeVriéze, Fabienne Wavrant, Hamshere, Marian L. , Abraham, Richard, Tunstall, Nigel, Rice, Frances , Carty, Stephanie, Lillystone, Sara, Kehoe, Patrick G. , Rudrasingham, Varuni, Jones, Lesley , Lovestone, Simon , Pérez‐Tur, Jordi , Williams, Julie , Hardy, John , Goate, Alison , Myers, Amanda , Booth, Jeremy , Crook, Richard , Owen, Michael J. , Hardy, John , Goate, Alison M

Science | July 27, 2002 | Volume: 290 | Issue: 5500 | Pages: 2304-2305

10.1126/science.290.5500.2304 Get It

The apolipoprotein E ( APOE ) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.