Mayo Clinic - AuthorCitation

Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease

Thomas, Jewell B., Bateman, Randall J. , Benzinger, Tammie L.S. , Raichle, Marcus E. , Mayeux, Richard , Ringman, John M. , Salloway, Stephen , Rossor, Martin N. , Ourselin, Sébastien , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Weiner, Michael W. , Thompson, Paul M. , Fox, Nick C. , Mathis, Chester A. , Oliver, Angela , Blazey, Tyler , Moulder, Krista L., Buckles, Virginia, Hornbeck, Russ C. , Chhatwal, Jasmeer P. , Schultz, Aaron P. , Goate, Alison , Fagan, Anne M. , Cairns, Nigel J. , Marcus, Daniel S. , Morris, John C. , Ances, Beau M. , Thomas, Jewell, Brier, Matthew R. , Snyder, Abraham Z. , Xiong, Chengjie , Holtzman, David M. , Sperling, Reisa Anne , Ghetti, Bernardino , McDade, Eric , Koeppe, Robert A. , Jack, Clifford R. , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Ances, Beau M , Fox, Nick C , Morris, John C , Goate, Alison M

JAMA Neurology | July 28, 2014 | Volume: 71 | Issue: 9 | Pages: 1111

10.1001/jamaneurol.2014.1654

Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease

Benzinger, Tammie L.S. , Blazey, Tyler , Xiong, Chengjie , Raichle, Marcus E. , Ances, Beau M. , Bateman, Randall J. , Cairns, Nigel J., Fagan, Anne M. , Goate, Alison , Marcus, Daniel S. , Aisen, Paul, Christensen, Jon, Ercole, Lindsay, Hornbeck, Russ C. , Farrar, Angela, Aldea, Patricia, Jasielec, Mateusz S., Owen, Christopher J. , Xie, Xianyun, Mayeux, Richard , Klunk, William E. , Mathis, Chester A. , Ringman, John M. , Thompson, Paul M. , Saykin, Andrew J. , Johnson, Keith A. , Salloway, Stephen , Correia, Stephen , Schofield, Peter R. , Masters, Colin L. , Villemagne, Victor L. , Martins, Ralph N. , Ourselin, Sébastien , Rossor, Martin N. , Fox, Nick C. , Cash, David M. , Weiner, Michael W. , Buckles, Virginia, Moulder, Krista L., Morris, John C. , Jack, Clifford R. , Koeppe, Robert A. , Su, Yi , Xiong, Chengjie , Snyder, Abraham Z. , Brickman, Adam M. , McDade, Eric , Ghetti, Bernardino , Sperling, Reisa Anne , Rowe, Christopher Cleon , Holtzman, David M. , Saykin, Andrew J , Schofield, Peter R , Thompson, Paul M , Bateman, Randall J , Masters, Colin L , Benzinger, Tammie L S , Ances, Beau M , Fox, Nick C , Morris, John C , Cash, David M , Goate, Alison M

Proceedings of the National Academy of Sciences | November 5, 2013 | Volume: 110 | Issue: 47 | Pages: No page available

Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering of these biomarkers prior to dementia remains untested. In a cohort with Alzheimer’s disease mutations, we performed an integrated whole-brain analysis of three major imaging techniques: amyloid PET, [ 18 F]fluro-deoxyglucose PET, and structural MRI. We found that most gray-matter structures with amyloid plaques later have hypometabolism followed by atrophy. Critically, however, not all regions lose metabolic function, and not all regions atrophy, even when there is significant amyloid deposition. These regional disparities have important implications for clinical trials of disease-modifying therapies.

IC‐P‐184: Resting state functional connectivity in autosomal dominant and sporadic Alzheimer's disease

Thomas, Jewell, Xiong, Chengjie , Raichle, Marcus E. , Mayeux, Richard , Ringman, John M. , Salloway, Stephen , Oliver, Angela , Moulder, Krista L., Buckles, Virginia, Hornbeck, Russ C. , Chhatwal, Jasmeer P. , Fagan, Anne M. , Cairns, Nigel J. , Marcus, Daniel S. , Brier, Matthew R. , Bateman, Randall J. , Snyder, Abraham Z. , Benzinger, Tammie L.S. , Xiong, Chengjie , Sperling, Reisa Anne , Ghetti, Bernardino , McDade, Eric , Rossor, Martin N. , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Jack, Clifford R. , Blazey, Tyler , Schultz, Aaron P. , Goate, Alison , Morris, John C. , Ances, Beau M.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_2 | Pages: No page available

10.1016/j.jalz.2013.05.181

P1–271: Resting state functional connectivity in autosomal dominant and sporadic Alzheimer's disease

Thomas, Jewell, Xiong, Chengjie , Raichle, Marcus E. , Sperling, Reisa, Mayeux, Richard , Ringman, John M. , Salloway, Stephen , Oliver, Angela , Moulder, Krista L., Buckles, Virginia, Hornbeck, Russ C. , Chhatwal, Jasmeer P. , Fagan, Anne M. , Cairns, Nigel J. , Marcus, Daniel, Brier, Matthew R. , Bateman, Randall J. , Snyder, Abraham Z. , Benzinger, Tammie L.S. , Xiong, Chengjie , Ghetti, Bernardino , McDade, Eric , Rossor, Martin N. , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Jack, Clifford R. , Blazey, Tyler , Schultz, Aaron P. , Goate, Alison , Morris, John C. , Ances, Beau M.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_6 | Pages: No page available

10.1016/j.jalz.2013.05.496

IC‐P‐103: Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease

Preboske, Gregory M., Ringman, John M. , Raichle, Marc, Hornbeck, Russ C. , Salloway, Stephen , Correia, Stephen , Weiner, Michael W. , Mayeux, Richard , Cairns, Nigel J. , Marcus, Daniel C. , Fagan, Anne M. , Xiong, Chengjie , Buckles, Virginia, Moulder, Krista L., Blazey, Tyler , Jack, Clifford R. , Kantarci, Kejal , Brickman, Adam M. , Saykin, Andrew J. , McDade, Eric , Rossor, Martin N. , Fox, Nick C. , Thompson, Paul M. , Rowe, Christopher Cleon , Ghetti, Bernardino , Sperling, Reisa Anne , Schofield, Peter R. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_2 | Pages: No page available

10.1016/j.jalz.2013.05.100

O1–03–05: Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease

Preboske, Gregory M., Ringman, John M. , Raichle, Marc, Hornbeck, Russ C. , Salloway, Stephen , Correia, Stephen , Mayeux, Richard , Sperling, Reisa, Cairns, Nigel J. , Marcus, Daniel, Fagan, Anne M. , Xiong, Chengjie , Buckles, Virginia, Moulder, Krista L., Blazey, Tyler , Jack, Clifford R. , Kantarci, Kejal , Brickman, Adam M. , Saykin, Andrew J. , McDade, Eric , Rossor, Martin N. , Fox, Nick C. , Thompson, Paul M. , Rowe, Christopher Cleon , Weiner, Michael W. , Ghetti, Bernardino , Schofield, Peter R. , Bateman, Randall J. , Goate, Alison , Xiong, Chengjie , Morris, John C. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_3 | Pages: No page available

10.1016/j.jalz.2013.04.065

IC‐P‐099: Elevated PiB precedes dementia in autosomal dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort

Raichle, Marcus E. , Marcus, Daniel C. , Ringman, John M. , Salloway, Stephen , Correia, Steve, Johnson, Keith A. , Villemagne, Victor L. , Mayeux, Richard , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Moulder, Krista L., Benzinger, Tammie L.S. , Blazey, Tyler , Koeppe, Robert A. , Jack, Clifford R. , Su, Yi , Snyder, Abraham Z. , Thompson, Paul M. , Ghetti, Bernardino , Saykin, Andrew J. , Sperling, Reisa Anne , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Martins, Ralph N. , Mathis, Chester A. , Klunk, William E. , Weiner, Michael D. , Bateman, Randall J. , Goate, Alison , Morris, John C.

Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_2 | Pages: No page available

10.1016/j.jalz.2012.05.132

P4‐154: Progressive white matter abnormalities in autosomal‐dominant Alzheimer's disease: Results of the DIAN study

Koeppe, Robert, Raichle, Marc, Marcus, Daniel, Ringman, John M. , Thompson, Paul , Su, Yi , Salloway, Stephen , Johnson, Keith A. , Correia, Steve, Schofield, Peter , Moulder, Krista L., Buckles, Virginia, Mayeux, Richard , Villemagne, Victor L. , John, Morris, Benzinger, Tammie L.S. , Blazey, Tyler , Jack, Clifford R. , Ances, Beau M. , Snyder, Abraham Z. , Ghetti, Bernardino , Saykin, Andrew J. , Sperling, Reisa Anne , Fox, Nick C. , Rowe, Christopher Cleon , Bateman, Randall J. , Mathis, Chester A. , McDade, Eric , Weiner, Michael W. , Goate, Alison , Masters, Colin L.

Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_19 | Pages: No page available

10.1016/j.jalz.2012.05.1858

P4‐153: Elevated PiB precedes dementia in autosomal‐dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort

Raichle, Marc, Su, Yi , Marcus, Daniel S. , Ringman, John M. , Mayeux, Richard , Weiner, Michael W. , Fagan, Anne M. , Cairns, Nigel J. , Buckles, Virginia, Moulder, Krista L., Villemagne, Victor L. , Benzinger, Tammie L.S. , Blazey, Tyler , Koeppe, Robert A. , Jack, Clifford R. , Snyder, Abraham Z. , Johnson, Keith J. , Sperling, Reisa Anne , Thompson, Paul M. , Ghetti, Bernardino , Saykin, Andrew J. , Schofield, Peter R. , Masters, Colin L. , Rowe, Christopher Cleon , Fox, Nick C. , Brickman, Adam M. , Martins, Ralph N. , Mathis, Chester A. , Klunk, William E. , Bateman, Randall J. , Goate, Alison , Morris, John C.