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Chloe, Gui

Mayo Clinic

University of Toronto

Citations 7

Assessment of Molecular Tools in Pediatric, Adolescent and Young Adult Meningioma Highlights the Need for Lifespan Precision in Neuro-Oncology
Yefet, Leo S., Landry, Alex, Wang, Justin Z, Patil, Vikas, Chloe, Gui, Ajisebutu, Andrew, Yakubov, Rebecca, Kaloti, Ramneet, Persaud, Phooja, Wei, Qingxia , Singh, Olivia, Bunda, Severa, Cohen-Gadol, Aaron A., Tatagiba, Marcos, Behling, Felix, Barnholtz-Sloan, J., Sloan, Andrew E. , Chotai, Silky , Chambless, Lola B. , Makarenko, Serge , Yip, Stephen , Tsang, Derek S, Aldape, Kenneth, Gao, Andrew, Nassiri, Farshad, Zadeh, Gelareh, Landry, Alexander , Liu, Jeff , Patil, Vikas , Gui, Chloe , Ellenbogen, Yosef , Mamatjan, Yasin , Singh, Olivia , Mansouri, Sheila , Cohen-Gadol, Aaron A, Tabatabai, Ghazaleh , Behling, Felix, Mansouri, Alireza , Agnihotri, Sameer , Tsang, Derek S. , Nassiri, Farshad

Journal of Neurological Surgery Part B: Skull Base | February 27, 2026 | Volume: 87 | Issue: No issue available | Pages: No page available

10.1055/s-0046-1818906 Get It

Methylation Profiling Reveals Subgroups of Intracranial Schwannoma with Distinct Biological and Clinical Features
Landry, Alex, Yefet, Leeor S. , Behling, Felix, Ajisebutu, Andrew, Chloe, Gui, Schittenhelm, Jens , Nassiri, Farshad, Tatagiba, Marcos, Zadeh, Gelareh, Landry, Alexander , Behling, Felix, Ellenbogen, Yosef , Gui, Chloe , Nassiri, Farshad

Journal of Neurological Surgery Part B: Skull Base | February 27, 2026 | Volume: 87 | Issue: No issue available | Pages: No page available

10.1055/s-0046-1818837 Get It

Methylation and Proteomic Signatures of Radiosensitivity in Chordoma
Ajisebutu, Andrew, Chloe, Gui, Zuccato, Jeff, Zadeh, Gelareh, Gui, Chloe , Zuccato, Jeffrey

Journal of Neurological Surgery Part B: Skull Base | February 27, 2026 | Volume: 87 | Issue: No issue available | Pages: No page available

10.1055/s-0046-1818754 Get It

Modern Molecular Profiling Recontextualizes the NRG/RTOG 0539 Trial and Reveals Hidden High-Risk and Radiotherapy Resistant Meningiomas
Yefet, Leo S., Landry, Alex, Wang, Justin Z, Patil, Vikas, Chloe, Gui, Ajisebutu, Andrew, Pugh, Stephanie E., Nassiri, Farshad, Aldape, Kenneth, Zadeh, Gelareh, Landry, Alexander , Liu, Jeff , Patil, Vikas , Gui, Chloe , Ellenbogen, Yosef , Pugh, Stephanie, Nassiri, Farshad

Journal of Neurological Surgery Part B: Skull Base | February 27, 2026 | Volume: 87 | Issue: No issue available | Pages: No page available

10.1055/s-0046-1818692 Get It

Establishing the Utility of Deep Learning for H&E-Based Meningioma Molecular Classification and Outcome Prediction
Landry, Alex, Nassiri, Farshad, Yefet, Leeor S. , Lalchungnunga, H., Wang, Justin Z, Chloe, Gui, Ajisebutu, Andrew, Patil, Vikas, Wei, Qingxia , Singh, Olivia, Sosa, Julio , Ma, Shihao , Wang, B. Q., Raghunathan, Aditya, Gao, Andrew, Ruppin, Eytan, Aldape, Kenneth, Zadeh, Gelareh, Gao, Andrew , Landry, Alexander , Nassiri, Farshad , Lalchungnunga, H. , Shulman, Eldad David , Ellenbogen, Yosef , Gui, Chloe , Patil, Vikas, Liu, Jeff , Singh, Olivia , Mansouri, Sheila , Raghunathan, Aditya , Ruppin, Eytan

Journal of Neurological Surgery Part B: Skull Base | February 27, 2026 | Volume: 87 | Issue: No issue available | Pages: No page available

10.1055/s-0046-1818691 Get It

Molecular classification of radiation-induced meningiomas
Ellenbogen, Yosef , Patil, Vikas, Landry, Alexander , Yefet, Leeor S. , Wang, Justin, Ajisebutu, Andrew, Chloe, Gui, Persaud, Phooja, Aldape, K., Nassiri, Farshad, Zadeh, Gelareh, Aldape, Kenneth D, Ellenbogen, Yosef , Patil, Vikas , Gui, Chloe , Liu, Jeff , Nassiri, Farshad , Zadeh, Gelareh

International Journal of Radiation Biology | February 2, 2026 | Volume: No volume available | Issue: No issue available | Pages: 1-7

10.1080/09553002.2026.2618533 Get It

Single-cell transcriptomic profiling of malignant peripheral nerve sheath tumors
Chloe, Gui, Bunda, Severa, Li, Mira , Singh, Olivia, Zadeh, Gelareh, Suppiah, Suganth , Gui, Chloe , Gui, Chloe , Singh, Olivia , Zadeh, Gelareh

Neuro-Oncology Advances | November 27, 2025 | Volume: 8 | Issue: Supplement_1 | Pages: i43-i50

10.1093/noajnl/vdaf243 Get It

Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas arising from Schwann cells and characterized by marked cellular and molecular heterogeneity. Although bulk multi-omic studies have provided valuable insights into MPNST biology, recent advances in single-cell profiling have deepened our understanding of the tumor microenvironment and molecular mechanisms underlying malignant transformation. Single cell analyses have revealed distinct Schwann cell-like, malignant neural crest-like, immune, and stromal cellular subpopulations within MPNSTs and their precursor lesions. Comparative profiling of MPNSTs, neurofibromas, and atypical neurofibromatous neoplasms of uncertain biologic potential, suggest that MPNST progression involves Schwann cell dedifferentiation into a more primitive, stem-like state. In this review, we summarize key discoveries from single-cell characterization studies, and discuss how these findings illuminate MPNST tumorigenesis, cellular plasticity, and potential therapeutic vulnerabilities.