Citations 3
Clinical neurocardiology: defining the value of neuroscience‐based cardiovascular therapeutics – 2024 update
Aksu, Tolga , Arora, Rishi , Chen, Peng‐Sheng , Fudim, Marat , Herring, Neil , Po, Sunny S. , Stavrakis, Stavros , Somers, Virend K. , Tan, Alex Y. , Valderrábano, Miguel , Shivkumar, Kalyanam , Shivkumar, Kalyanam , Ajijola, Olujimi A. , Biaggioni, Italo , Ferrari, Gaetano Maria De , Dusi, Veronica , Goldberger, Jeffrey J , Green, Alexander L. , Khalsa, Sahib S. , Kumar, Rajesh , Lakatta, Edward G. , Mehra, Reena , Meyer, Christian , Somers, Virend K.
The Journal of Physiology | March 12, 2025 | Volume: 603 | Issue: 7 | Pages: 1781-1839
AbstractThe intricate role of the autonomic nervous system (ANS) in regulating cardiac physiology has long been recognized. Aberrant function of the ANS is central to the pathophysiology of cardiovascular diseases. It stands to reason, therefore, that neuroscience‐based cardiovascular therapeutics hold great promise in the treatment of cardiovascular diseases in humans. A decade after the inaugural edition, this White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology and pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases. image
Cardioneuroablation for the treatment of reflex syncope and functional bradyarrhythmias: A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS) and th
Aksu, Tolga , Brignole, Michele , Biase, Luigi Di , Deharo, Jean‐Claude , Fanciulli, Alessandra , Fedorowski, Artur , Morillo, Carlos A. , Moya, Angel , Piotrowski, Roman , Sutton, Richard , Sheldon, Robert S. , Vaseghi, Marmar , Pachon, Jose C, Amin, Reshma , Gupta, Dhiraj, Magnano, M , Malik, Varun , Schauerte, Patrick, Shen, Win-Kuang, Acosta, Juan , Calo, Leonardo , Debruyne, Philippe , Di Biase, Luigi , Deharo, Jean Claude , Fanciulli, Alessandra , Fedorowski, Artur , Kulakowski, Piotr , Morillo, Carlos , Moya, Angel , Piotrowski, Roman , Stec, Sebastian , Sutton, Richard , van Dijk, J Gert , Wichterle, Dan , Tse, Hung-Fat , Yao, Yan , Sheldon, Robert , Vaseghi, Marmar , Pachon, Jose C , Scanavacca, Maurício , Tse, Hung‐Fat , Pachón-M, José Carlos , Scanavacca, Maurício , Meyer, Christian , Gupta, Dhiraj
Europace | July 30, 2024 | Volume: 26 | Issue: 8 | Pages: No page available
Abstract Cardioneuroablation has emerged as a potential alternative to cardiac pacing in selected cases with vasovagal reflex syncope, extrinsic vagally induced sinus bradycardia-arrest or atrioventricular block. The technique was first introduced decades ago, and its use has risen over the past decade. However, as with any intervention, proper patient selection and technique are a prerequisite for a safe and effective use of cardioneuroablation therapy. This document aims to review and interpret available scientific evidence and provide a summary position on the topic.
Abstract 13351: Impact of a Second Incident Arrhythmia on Outcomes in Hospitalized COVID-19 Patients: Insights From the COVID-RHYTHM Registry
Ahmed, Adnan , Charate, Rishi , Trivedi, Jaimin R. , Kabra, Rajesh , Stavrakis, Stavros , Aksu, Tolga , Saha, Sandeep , Liu, Zhenguo , Padmanabhan, Deepak , Al‐Ahmad, Amin , Lakkireddy, Dhanunjaya, Bawa, Danish , Russo, Andrea M, Wan, Elaine Y. , Mar, Philip L. , Gautam, Sandeep , Dominic, Paari , Asad, Zain Ul Abideen , Shenthar, Jayaprakash , Natale, Andrea , Lakkireddy, Dhanunjaya, Gopinathannair, Rakesh
Circulation | December 19, 2023 | Volume: 148 | Issue: Suppl_1 | Pages: No page available
10.1161/circ.148.suppl_1.13351
Introduction: Incident cardiac arrhythmias are common in hospitalized COVID-19 patients, but the impact of a second incident cardiac arrhythmia during hospitalization on clinical outcomes remain unclear. Hypothesis: The aim of this study was to assess the frequency and prognostic implications of a second incident arrhythmia in hospitalized COVID-19 patients over the pandemic course till vaccine availability. Methods: The multicenter COVID-RHYTHM Registry enrolled hospitalized COVID-19 patients from 3/8/2020 to 1/24/2021. Cardiac arrhythmia included documented atrial fibrillation (AF), atrial flutter (AFL), ventricular tachycardia (VT), severe sinus bradycardia (<40 bpm) or AV block. Outcomes were compared between patients with single vs. more than one incident arrhythmias adjusting for baseline variables. Results: Of 6299 hospitalized COVID-19 patients, 4398 had an had an incident cardiac arrhythmia during hospitalization, of which 822 (19%) had a second incident arrhythmia. Those with >1 incident arrhythmia had a higher baseline prevalence of heart failure, chronic kidney disease, coronary artery disease and sleep apnea (Table). Those with >1 incident arrhythmia had higher in-hospital mortality, need for ICU admission and need for rehab upon discharge. Length of stay was similar between the groups. Conclusions: In hospitalized COVID-19 patients with incident cardiac arrhythmias, a second incident arrhythmia during hospitalization was seen in 19%. Having >1 incident arrhythmia was associated with increased need for ICU admission and reduced survival.