Citations 2
Abstract 11505: Predicting In-Hospital All-Cause Mortality in Chronic Total Occlusion Percutaneous Coronary Intervention: PROGRESS-CTO Mortality Score
Karácsonyi, Judit , Göktekín, Ömer , Guindy, Ahmed El, Chandwaney, Raj, Patel, Mitul , Karmpaliotis, Dimitrios, Rangan, Bavana V. , Sandoval, Yader , Choi, James W. , Nicholson, William , Jaber, Wissam , Rinfret, Stéphane , KUTUZIS, MICHAEL, Yeh, Robert W. , Mastrodemos, Olga , Simsek, Bahadir , Kostantinis, Spyridon , Alaswad, Khaldoon , Krestyaninov, Oleg V. , Khelimskii, Dmitrii A. , Davies, Rhian E. , Görgülü, Şevket , Khatri, Jaikirshan J , Jaffer, Farouc A , KUTUZIS, MICHAEL, Tsiafoutis, Ioannis N. , Burke, M. Nicholas , Allana, Salman , Brilakis, Emmanouil S.
Circulation | June 15, 2023 | Volume: 146 | Issue: Suppl_1 | Pages: No page available
10.1161/circ.146.suppl_1.11505
Introduction: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is associated with increased risk of periprocedural complications. Estimating the risk of complications facilitates risk-benefit assessment and procedural planning. Methods: We analyzed the Prospective Global Registry for the Study of Chronic Total Occlusion Intervention (PROGRESS-CTO, NCT02061436) and created a risk score for in-hospital all-cause mortality. Logistic regression prediction modeling was used to identify independently associated variables and the model was internally validated with bootstrapping. Results: Of the 10,480 CTO PCI cases performed between 2012-2022 at 40 US and non-US centers, in-hospital mortality occurred in 47 (0.45%). The final prediction model identified 4 independent predictors of mortality: Age ≥65 years, Odds Ratio [OR]: 2.83 (95% confidence interval [CI], 1.30-6.16), 1-point; Left ventricular ejection fraction ≤45%, OR: 2.13 (95% CI, 1.14-3.98), 1-point; Moderate-severe calcification, OR: 2.45 (95% CI, 1.18-5.08), 1-point; and Antegrade dissection re-entry, OR: 2.81 (95% CI, 1.06-7.43), 1-point; or Retrograde strategy, OR: 3.51 (95% CI, 1.67-7.37), 1-point; with a bootstrap corrected c-statistics of 0.71 (95% confidence interval: 0.63-0.81). The calculated risk percentages for mortality based on the PROGRESS-CTO mortality score ranged from 0.05-2.42% for mortality, and 63% of patients in the PROGRESS-CTO cohort had PROGRESS-CTO mortality score of 1 or 2, corresponding to a mortality risk of 0.1-0.5% (Figure 1). Conclusions: The PROGRESS-CTO in-hospital mortality risk score can facilitate risk-benefit assessment and procedural planning in patients undergoing CTO PCI.
Intravascular lithotripsy in chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS‐CTO registry
Kostantinis, Spyridon , Karácsonyi, Judit , Benton, Stewart M., Nicholson, William , Rinfret, Stéphane , Jaber, Wissam , Raj, Leah, Sandesara, Pratik B. , Basir, Mir B. , Young, Laura , Rafeh, Nidal Abi, Patel, Mitul , Kerrigan, Jimmy , Haddad, Elias V., Sandoval, Yader , Sheikh, Abdul Malik, ElGuindy, Ahmed , Göktekín, Ömer , Mastrodemos, Olga , Rangan, Bavana V. , Simsek, Bahadir , Sandesara, Pratik B , Basir, Mir B , Khatri, Jaikirshan J , Young, Laura D , Jaffer, Farouc A , Kerrigan, Jimmy L , Dattilo, Phil , Sandoval, Yader , Brilakis, Emmanouil S , Kostantinis, Spyridon , Megaly, Michael S. , Davies, Rhian E. , Alaswad, Khaldoon , Schimmel, Daniel R. , Burke, M. Nicholas , Brilakis, Emmanouil S.
Catheterization and Cardiovascular Interventions | August 2, 2022 | Volume: 100 | Issue: 4 | Pages: 512-519
AbstractBackgroundThe use of intravascular lithotripsy (IVL) in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study.MethodsWe analyzed the baseline clinical and angiographic characteristics and procedural outcomes of 82 CTO PCIs that required IVL at 14 centers between 2020 and 2022.ResultsDuring the study period, IVL was used in 82 of 3301 (2.5%) CTO PCI procedures (0.4% in 2020 and 7% in 2022; p for trend < 0.001). Mean patient age was 69 ± 11 years and 79% were men. The prevalence of hypertension (95%), diabetes mellitus (62%), and prior PCI (61%) was high. The most common target vessel was the right coronary artery (54%), followed by the left circumflex (23%). The mean J‐CTO and PROGRESS‐CTO scores were 2.8 ± 1.1 and 1.3 ± 1.0, respectively. Antegrade wiring was the final successful crossing strategy in 65% and the retrograde approach was used in 22%. IVL was used in 10% of all heavily calcified lesions and 11% of all balloon undilatable lesions. The 3.5 mm lithotripsy balloon was the most commonly used balloon (28%). The mean number of pulses per lithotripsy run was 33 ± 32 and the median duration of lithotripsy was 80 (interquartile range: 40−103) seconds. Technical and procedural success was achieved in 77 (94%) and 74 (90%) cases, respectively. Two (2.4%) Ellis Class 2 perforations occurred after IVL use and were managed conservatively.ConclusionIVL is increasingly being used in CTO PCI with encouraging outcomes.