Citations
Mayo Clinic
1682 citation(s) found for "Rt, Jones".
Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain
Brinkmann, Benjamin H. , Stead, Matt, Kazemi, Noojan , O’Brien, Terence J. , So, Elson L., Blumenfeld, Hal , Mullan, Brian P., Jones, David T. , Worrell, Gregory A. , Brinkmann, Benjamin H
Journal of Cerebral Blood Flow & Metabolism | September 21, 2011 | Volume: 32 | Issue: 1 | Pages: 190-198
10.1038/jcbfm.2011.123
| PMID 21934696
Tc-99m ethyl cysteinate diethylester (ECD) and Tc-99m hexamethyl propylene amine oxime (HMPAO) are commonly used for single-photon emission computed tomography (SPECT) studies of a variety of neurologic disorders. Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal resting brain are limited. Advances in quantitative functional imaging have demonstrated the value of using resting studies from control populations as a baseline to account for physiologic fluctuations in cerebral perfusion. Here, we report results from 30 resting Tc-99m ECD SPECT scans and 14 resting Tc-99m HMPAO scans of normal volunteers with no history of neurologic disease. Scans were analyzed with regions of interest and with statistical parametric mapping, with comparisons performed laterally (left vs. right), as well as for age, gender, and handedness. The results show regions of significant asymmetry in the normal controls affecting widespread areas in the cerebral hemispheres, but most marked in superior parietotemporal region and frontal lobes. The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease.
Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers
Cox, David G. , Simard, Jacques , Sinnett, Daniel , Hamdi, Yosr , Soucy, Penny, Ouimet, Manon , Barjhoux, Laure, Verny-Pierre, Carole, McGuffog, Lesley , Healey, Sue, Greene, Mark H. , Mai, Phuong L., Andrulis, Irene L. , Network, Ontario Cancer Genetics, Thomassen, Mads , Gerdes, Anne‐Marie , Caligo, Maria A. , Friedman, Eitan , Laitman, Yael , Paluch, Shani Shimon, Borg, Åke , Karlsson, Per , Askmalm, Marie Stenmark, Bustinza, Gisela Barbany, Collaborators, SWE-BRCA, Nathanson, Katherine L. , Rebbeck, Timothy R., Hamann, Ute, Rookus, Matti A. , Ouweland, Ans M.W. van den, Ausems, Margreet G.E.M. , Aalfs, Cora M. , Gille, Hans J. J. P., HEBON, EMBRACE, Peock, Susan, Frost, Debra, Evans, D. Gareth , Eeles, Rosalind A. , Izatt, Louise , Adlard, Julian, Paterson, Joan, Eason, Jacqueline, Remon, Marie-Alice, Moncoutier, Virginie, Gauthier‐Villars, Marion , Lasset, Christine, Giraud, Sophie , Hardouin, Agnès, Berthet, Pascaline, Sobol, Hagay , Eisinger, François , Paillerets, Brigitte Bressac–de , Delnatte, Capucine, Collaborators, GEMO Study, Goldgar, David E., Miron, Alex, Özçelik, Hilmi, Southey, Melissa C. , Terry, Mary Beth , Registry, The Breast Cancer Family, Dressler, Anne-Catharina, Tea, Muy‐Kheng M., Hansen, Thomas van Overeem , Jóhannsson, Óskar Þór, Piedmonte, Marion, Rodriguez, Gustavo C. , Basil, Jack, Blank, Stephanie V. , Montagna, Marco , Blanco, Ignacio , Gayther, Simon A. , Moysich, Kirsten B., Schmutzler, Rita K., Wappenschmidt, Barbara , Engel, Christoph , Meindl, Alfons , Ditsch, Nina , Arnold, Norbert , Niederacher, Dieter , Sutter, Christian , Gadzicki, Dorothea, Fiebig, Britta, Caldes, Trinidad, Laframboise, Rachel , Nevanlinna, Heli , Chen, Xiaoqing, Spurdle, Amanda B. , Ding, Yuan Chun , Peterlongo, Paolo , Manoukian, Siranoush , Bernard, Loris, Radice, Paolo , Easton, Douglas F. , Chenevix‐Trench, Georgia , Antoniou, Antonis C. , Mazoyer, Sylvie, Sinilnikova, Olga M., Sinilnikova, Olga M., Dumont, Martine, Mai, Phuong , Greene, MH, Glendon, Gord, Selander, Teresa, Weerasooriya, Nayana , Karlsson, Per, Nordling, Margareta , Bergman, Annika, Einbeigi, Zakaria , Stenmark-Askmalm, Marie, Liedgren, S, Borg, Åke, Loman, Niklas, Olsson, Håkan , Kristoffersson, Ulf , Harbst, Katja , Henriksson, Karin, Lindblom, Annika , Arver, Brita, Wachenfeldt, Anna von , Liljegren, Annelie, Rantala, Johanna, Melin, Beatrice , Grönberg, Henrik , Stattin, Eva‐Lena , Emanuelsson, Monica, Ehrencrona, Hans , Seidel‐Renkert, Antje, Hogervorst, Frans B.L., Verhoef, S., Verheus, Martijn, Veer, Laura J. van’t , Leeuwen, Flora E. van , Rookus, M.A., Collée, Margriet , Ouweland, A.M.W. van den, Jager, Agnes , Hooning, Maartje J. , Tilanus‐Linthorst, Madeleine M.A., Seynaeve, Caroline, Asperen, C.J. van, Tollenaar, R.A., Devilee, P., Ligtenberg, M.J., Hoogerbrugge, Nicoline , Ausems, M.G., Aalfs, C.M., Os, T.A. van, Gille, J.J.P., Waisfisz, Quinten , Meijers‐Heijboer, Hanne , Gómez, E. , Roozendaal, Cees E. Van, Blok, Marinus J. , Caanen, BA, Oosterwijk, Jan C., Hout, Annemarie H. van der, Mourits, M J E , Vasen, Hans F. A. , Easton, Douglas F., Peock, Susan, Cook, Margaret, Frost, Debra, Platte, Radka, Miedzybrodzka, Zosia , Gregory, Helen , Jeffers, Lisa, Cole, T, Ong, Kai-Ren, Hoffman, Jonathan , Donaldson, Alan, James, Margaret, Paterson, Joan, Downing, Sarah, Murray, Alexandra, Rogers, Mark T., McCann, Emma, Kennedy, M. John, Barton, David , Porteous, Mary, Drummond, Sarah, Brewer, Carole, Kivuva, Emma , Searle, Anne, Goodman, Selina , Hill, Kathryn , Davidson, Rosemarie, Murday, Victoria, Bradshaw, Nicola, Snadden, Lesley, Longmuir, Mark, Watt, Catherine, Gibson, Sarah , Haque, Eshika, Tobias, Edward S. , Duncan, Alexis E. , Izatt, Louise, Jacobs, Chris , Langman, Caroline, Whaite, Anna , Barwell, Julian, Adlard, Julian, Chu, Carol , Miller, Julie, Ellis, Ian O. , Evans, D. Gareth, Lalloo, Fiona, Side, Lucy, Male, Alison , Berlin, Cheryl, Eason, Jacqueline , Collier, Rebecca, Douglas, Fiona, Claber, Oonagh, Jobson, Irene, Walker, Lisa, McLeod, Diane M., Halliday, Dorothy , Durell, Sarah, Stayner, Barbara, Eeles, Ros, Shanley, Susan, Rahman, Nazneen , Bancroft, Elizabeth, D'Mello, Lucia, Page, Elizabeth, Ardern‐Jones, Audrey, Castro, Elena , Robertson, Lisa , Bardsley, Cathryn, Hodgson, Shirley, Goff, Sheila, Brice, Glen , Winchester, Lizzie, Eddy, Charlotte, Tripathi, Vishakha , Attard, Virginia, Eccles, Diana , Lucassen, Anneke , Crawford, Gillian, McBride, Donna, Smalley, Sarah, Evans, D. Gareth, Lalloo, Fiona, Eeles, Ros, Bancroft, Elizabeth, D'Mello, Lucia, Sinilnikova, Olga, Sinilnikova, Olga, Giraud, Sophie, Léone, Mélanie, Mazoyer, Sylvie , Stoppa-Lyonnet, Dominique, Gauthier-Villars, Marion, Buecher, Bruno, Houdayer, Claude , Moncoutier, Virginie, Belotti, Muriel, Tirapo, Carole, Pauw, Antoine de, Bressac-de-Paillerets, Brigitte, Remenieras, Audrey, Byrde, Véronique, Lenoir, Gilbert, Bignon, Yves‐Jean , Uhrhammer, Nancy , Lasset, Christine, Bonadona, Valérie, Berthet, Pascaline, Bourdon, Violaine , Noguchi, Tetsuro, Eisinger, François, Coulet, Florence , Colas, Chrystelle , Soubrier, Florent , Coupier, Isabelle, Peyrat, Jean‐Philippe, Révillion, Françoise, Vennin, Philippe, Adenis, Claude, Rouleau, Étienne , Lidereau, Rosette, Demange, Liliane, Noguès, Catherine , Muller, Danièle, Fricker, Jean‐Pierre , Longy, Michel , Sevenet, Nicolas, Toulas, Christine , Guimbaud, Rosine, Gladieff, Laurence , Feillel, Viviane, Leroux, Dominique, Dreyfus, Hélène, Rebischung, Christine , Coron, Fanny, Faivre, Laurence, Prieur, Fabienne, Lebrun, Marine, Ferrer, Sandra Fert, Frénay, Marc, Venat‐Bouvet, Laurence , Delnatte, Capucine, Mortemousque, Isabelle, Lynch, Henry T., Snyder, Carrie, Ejlertsen, Bent, Andersen, Mette Klarskov , Kjaergaard, Susanne, Sweet, Kevin , O’Connor, Michelle , Ramus, Susan, Pye, Carole, Wozniak, Eva , Varon-Mateeva, Raymonda, Kast, Karin, Preisler‐Adams, Sabine, Deißler, Helmut , Schönbuchner, Ines, Heinritz, Wolfram, Schäfer, Dieter, Aittomäki, Kristiina , Erkkilä, R.N. Irja, Thorne, Heather , Niedermayr, Eveline, Perez-Segura, Pedro, Durocher, Francine , John, Esther M. , Adlard, Julian , Stenmark‐Askmalm, Marie , Faivre, Laurence , Szabo, Csilla I. , Mai, Phuong L., Network, Ontario Cancer Genetics, Kaufman, Bella , Collaborators, SWE-BRCA, Domchek, Susan M. , Benı́tez, Javier , Asperen, Christi J. van , Devilee, Peter , HEBON, EMBRACE, Peock, Susan, Frost, Debra, Adlard, Julian, Paterson, Joan, Eason, Jacqueline, Godwin, Andrew K. , Lasset, Christine , Berthet, Pascaline, Caron, Olivier , Collaborators, GEMO Study, Buys, Saundra S. , Registry, The Breast Cancer Family, Singer, Christian F. , Dressler, Anne Catharina, Toland, Amanda Ewart , Isaacs, Claudine , Meindl, Alfons , Caldes, Trinidad, Chen, Xiaoqing, Beesley, Jonathan , Neuhausen, Susan L. , Couch, Fergus J. , Wang, Xianshu , Stoppa‐Lyonnet, Dominique , Mazoyer, Sylvie, Sinilnikova, Olga M., Dumont, Martine , Karlsson, Per, Borg, Åke, Soller, Maria , Jernström, Helena , Barbany, Gisela , Torres, Diana , Rashid, Muhammad Usman , Rookus, M.A., Asperen, C.J. van, Wijnen, Juul , Vreeswijk, Maaike P.G. , Devilee, P., Ligtenberg, M.J., Ausems, M.G., Luijt, Rob B. van der , Aalfs, C.M., Os, T.A. van, Gille, J.J.P., Easton, Douglas F., Cook, Margaret, Morrison, Patrick J. , Cole, Trevor, James, Margaret, Taylor, Amy , McCann, Emma, Kennedy, M. John, Snadden, Lesley, Izatt, Louise, Dorkins, Huw , Barwell, Julian, Adlard, Julian, Houghton, Catherine E. , Evans, D. Gareth, Lalloo, Fiona, Taylor, Jane Elizabeth , Berlin, Cheryl, Eeles, Ros, Houlston, Richard S. , Bancroft, Elizabeth, D'Mello, Lucia, Kohut, Kelly , Wiggins, Jennifer M. , Mitra, Anita , Cook, Jackie A , Quarrell, Oliver , Crawford, Gillian, Evans, D. Gareth, Lalloo, Fiona, Eeles, Ros, Bancroft, Elizabeth, D'Mello, Lucia, Sinilnikova, Olga, Sinilnikova, Olga, Giraud, Sophie, Stoppa-Lyonnet, Dominique, Moncoutier, Virginie, Pauw, Antoine de, Bressac-de-Paillerets, Brigitte, Remenieras, Audrey, Lasset, Christine, Bonadona, Valérie, Eisinger, François, Pujol, Pascal , Fournier, Joëlle , Vennin, Philippe, Delnatte, Capucine, Ejlertsen, Bent , Kjærgaard, Susanne, Senter, Leigha , Craven, Caroline M. , Pharoah, Paul D.P. , Harrington, Patricia , Blomqvist, Carl , Heikkinen, Tuomas , Hoya, Miguel de la , Nevanlinna, H , Caligo, Maria A , Peterlongo, Paolo , Spurdle, Amanda B , Eccles, Diana , Moysich, Kirsten , Radice, Paolo , Adlard, Julian , Arnold, Norbert , Eeles, Rosalind A , Ehrencrona, Hans , Evans, D Gareth , John, Esther M , Southey, Melissa C , Nathanson, Katherine L , Engel, Christoph , Montagna, Marco , Simard, Jacques , Chenevix-Trench, Georgia , Faivre, Laurence , Gómez-García, Encarna B , Hansen, Thomas van Overeem , Manoukian, Siranoush , Terry, Mary Beth , Lindblom, Annika , Ellis, Ian
Human Molecular Genetics | September 3, 2011 | Volume: 20 | Issue: 23 | Pages: 4732-4747
Altered functional connectivity in asymptomatic MAPT subjects
Whitwell, Jennifer L. , Josephs, Keith A. , Avula, Ramesh, Tosakulwong, Nirubol , Weigand, Stephen D. , Senjem, Matthew L. , Vemuri, Prashanthi , Gunter, Jeffrey L. , Baker, Matt , Rademakers, Rosa , Petersen, R. C., Boeve, B. F., Jack, Clifford R. , Jones, David T. , Wszołek, Zbigniew K. , Knopman, David S. , Jack, Clifford R , Vemuri, Prashanthi , Senjem, Matthew L
Neurology | August 22, 2011 | Volume: 77 | Issue: 9 | Pages: 866-874
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium†
García‐Closas, Montserrat , Humphreys, Manjeet K., Platte, Radka, Hopper, John L. , Southey, Melissa C. , Apicella, Carmel, Hammet, Fleur, Schmidt, Marjanka K. , Tollenaar, Rob A.�E.�M. , Veer, Laura J. van’t , Fasching, Peter A. , Beckmann, Matthias W. , Ekici, Arif B. , Strick, Reiner , Peto, Julian , dos‐Santos‐Silva, Isabel , Fletcher, Olivia , Johnson, Nichola , Sawyer, Elinor J. , Tomlinson, Ian , Kerin, Michael J. , Burwinkel, Barbara , Marmé, F., Schneeweiß, Andreas , Sohn, Christof , Bojesen, Stig E. , Flyger, Henrik, Nordestgaard, Børge G. , Zamora, M. Pilar , Brenner, Hermann , Rahman, Nazneen , Turnbull, Clare , Seal, Sheila, Renwick, Anthony, Brauch, Hiltrud , Justenhoven, Christina , Brüning, Thomas , Network, The GENICA, Chang‐Claude, Jenny , Hein, Rebecca, Wang‐Gohrke, Shan , Dörk, Thilo , Schürmann, Peter , Bremer, Michael , Hillemanns, Peter , Nevanlinna, Heli , Heikkinen, Tuomas , Aittomäki, Kristiina, Blomqvist, Carl , Bogdanova, Natalia , Antonenkova, Natalia, Rogov, Yuriy , Karstens, Johann H., Bermisheva, Marina , Prokofieva, Darya, Gantcev, Shamil Hanafievich, Хуснутдинова, Э. К. , Lindblom, Annika , Margolin, Sara , Chenevix‐Trench, Georgia , Chen, Xiaoqing, Group, for the kConFab AOCS Management, Mannermaa, Arto, Kosma, Veli‐Matti , Soini, Ylermi, Kataja, Vesa , Lambrechts, Diether , Yesilyurt, Betül T., Chrisiaens, Marie-Rose, Peeters, Stéphanie , Radice, Paolo , Peterlongo, Paolo , Manoukian, Siranoush , Barile, Monica, Couch, Fergus, Diasio, Robert B. , Giles, Graham G. , Severi, Gianluca , Baglietto, Laura , Maclean, Catriona, Offit, Ken, Robson, Mark E. , Vijai, Joseph , Gaudet, Mia M., John, Esther M. , Winqvist, Robert , Pylkäs, Katri , Jukkola‐Vuorinen, Arja , Grip, Mervi, Andrulis, Irene L. , Knight, Julia A. , Mulligan, Anna Marie , O’Malley, Frances P., Brinton, Louise A. , Sherman, Mark E., Lissowska, Jolanta , Hooning, Maartje J. , Ouweland, Ans M.W. van den, Collée, J. Margriet, Czene, Kamila , Cox, Angela , Brock, Ian W., Reed, Malcolm , Cross, Simon S. , Dunning, Alison M. , Kang, Daehee , Yoo, Keun-Young, Noh, Dong‐Young , Ahn, Sei Hyun , Jakubowska, Anna , Lubiński, Jan , Jaworska, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn , Gaborieau, Valérie , Brennan, Paul , McKay, James , Shen, Chen‐Yang , Ding, Shian-ling, Hsu, Huan-Ming, Yu, Jyh-Cherng, Ashworth, Alan , Swerdlow, Anthony J. , Jones, Michael E. , Orr, Nick , Egan, Kathleen M. , Titus‐Ernstoff, Linda, Easton, Doug , Spurdle, Amanda B. , Webb, Penelope M. , DeFazio, Anna , Thorne, Heather , Lambrechts, Diether , Figueroa, Jonine D. , Broeks, Annegien , Benı́tez, Javier , Milne, Roger L. , Arias, José Ignacio , Müller, Heiko , Arndt, Volker , Network, The GENICA, Beesley, Jonathan , Chen, Xiaoqing, Group, for the kConFab AOCS Management, Mannermaa, Arto, Lee, Adam M. , Wang, Xianshu , Chanock, Stephen Jacob , Martens, John W.M. , Hall, Per N , Pharoah, Paul D.P. , Anton‐Culver, Hoda , Ziogas, Argyrios , Trentham‐Dietz, Amy , Newcomb, Polly A. , Fazio, Anna de , Nevanlinna, H , Dörk, Thilo , Lambrechts, Diether , Giles, Graham G , Peterlongo, Paolo , Spurdle, Amanda B , Webb, Penelope M , Hillemanns, Peter , Swerdlow, Anthony J , Radice, Paolo , Lissowska, Jolanta , John, Esther M , Joseph, Vijai , Southey, Melissa C , Dunning, Alison M , Jakubowska, Anna , Jones, Michael E , Lambrechts, Diether , Brenner, Hermann , Cox, Angela , García-Closas, Montserrat , Schmidt, Marjanka K , Severi, Gianluca , Ekici, Arif B , Bogdanova, Natalia V , Robson, Mark , Chenevix-Trench, Georgia , Czene, Kamila , Pylkäs, Katri , Manoukian, Siranoush , Lubinski, Jan , Baglietto, Laura , Fletcher, Olivia , Bojesen, Stig E , Brauch, Hiltrud , Lindblom, Annika , Sawyer, Elinor J , Orr, Nick , Kang, Daehee
Human Molecular Genetics | August 18, 2011 | Volume: 20 | Issue: 23 | Pages: 4693-4706
P4‐102: Age related changes in the default mode network are more advanced in Alzheimer's disease
Gunter, Jeffrey L. , Przybelski, Scott A. , Avula, Ramesh, Petersen, Ronald C. , Jones, David T. , Machulda, Mary M. , Vemuri, Prashanthi , McDade, Eric , Zeng, Guang‐Zhi , Senjem, Matthew L. , Knopman, David S. , Boeve, Bradley F. , Jack, Clifford R.
Alzheimer's & Dementia | August 1, 2011 | Volume: 7 | Issue: 4S_Part_21 | Pages: No page available
IC‐P‐165: Age‐related changes in the default mode network are more advanced in Alzheimer's disease
Jones, David, Gunter, Jeffrey L. , Przybelski, Scott A. , Avula, Ramesh, Petersen, Ronald, Jones, David, Machulda, Mary M. , Vemuri, Prashanthi , McDade, Eric , Zeng, Guang‐Zhi , Senjem, Matthew L. , Knopman, David S. , Boeve, Bradley F. , Jack, Clifford R.
Alzheimer's & Dementia | August 1, 2011 | Volume: 7 | Issue: 4S_Part_2 | Pages: No page available
P2‐098: Seed‐based characterization of intrinsic connectivity networks for distinguishing dementia
Jones, David, Przybelski, Scott A. , Gunter, Jeffrey L. , Whitwell, Jennifer , Josephs, Keith A. , Petersen, Ronald, Vemuri, Prashanthi , Machulda, Mary M. , Knopman, David S. , Boeve, Bradley F. , Jack, Clifford R.
Alzheimer's & Dementia | August 1, 2011 | Volume: 7 | Issue: 4S_Part_10 | Pages: No page available
IC‐P‐014: Seed‐based characterization of intrinsic connectivity networks for distinguishing dementia
Jones, David , Przybelski, Scott A. , Gunter, Jeffrey L. , Whitwell, Jennifer , Josephs, Keith A. , Petersen, Ronald C. , Vemuri, Prashanthi , Machulda, Mary M. , Knopman, David S. , Boeve, Bradley F. , Jack, Clifford R.
Alzheimer's & Dementia | August 1, 2011 | Volume: 7 | Issue: 4S_Part_1 | Pages: No page available
Low Testosterone Associated With Obesity and the Metabolic Syndrome Contributes to Sexual Dysfunction and Cardiovascular Disease Risk in Men With Type 2 Diabetes
Jackson, Graham, Jones, T. Hugh , Matsumoto, Alvin M. , Nehra, Ajay, Perelman, Michael A. , Traish, A., Zitzmann, Michael , Cunningham, Glenn R. , Wang, Christina , Swerdloff, Ronald S.
Diabetes Care | June 28, 2011 | Volume: 34 | Issue: 7 | Pages: 1669-1675
Gastroesophageal Reflux Therapy Is Associated with Longer Survival in Patients with Idiopathic Pulmonary Fibrosis
Lee, Joyce , Ryu, Jay H. , Elicker, Brett M. , Lydell, Carmen, Jones, Kirk D. , Wolters, Paul J. , King, Talmadge E. , Collard, Harold R. , Ryu, Jay H , Lee, Joyce S
American Journal of Respiratory and Critical Care Medicine | June 25, 2011 | Volume: 184 | Issue: 12 | Pages: 1390-1394
10.1164/rccm.201101-0138oc
| PMID 21700909
Abstract Rationale Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF. Objectives To investigate the relationship between GER-related variables and survival time in patients with IPF. Methods Regression analysis was used to investigate the relationship between GER-related variables and survival time in a retrospectively identified cohort of patients with well-characterized IPF from two academic medical centers. Measurements and Main Results Two hundred four patients were identified for inclusion. GER-related variables were common in this cohort: reported symptoms of GER (34%), a history of GER disease (45%), reported use of GER medications (47%), and Nissen fundoplication (5%). These GER-related variables were significantly associated with longer survival time on unadjusted analysis. After adjustment, the use of GER medications was an independent predictor of longer survival time. In addition, the use of gastroesophageal reflux medications was associated with a lower radiologic fibrosis score. These findings were present regardless of center. Conclusions The reported use of GER medications is associated with decreased radiologic fibrosis and is an independent predictor of longer survival time in patients with IPF. These findings further support the hypothesis that GER and chronic microaspiration may play important roles in the pathobiology of IPF.