Mayo Clinic - AuthorCitation

Tau‐positron emission tomography correlates with neuropathology findings

Lowe, Val J. , Lundt, Emily S. , Albertson, Sabrina M., Min, Hoon‐Ki , Fang, Ping , Przybelski, Scott A. , Senjem, Matthew L. , Kantarci, Kejal , Reichard, R. Ross , Tranovich, Jessica F., Al‐Shaikh, Fadi S. Hanna , Petersen, Ronald C. , Murray, Melissa E. , Hanna Al-Shaikh, Fadi S, Min, Hoon-Ki Paul , Senjem, Matthew L , Kantarci, Kejal , Murray, Melissa E , Schwarz, Christopher G. , Boeve, Bradley F. , Jones, David T. , Knopman, David S. , Jack, Clifford R. , Dickson, Dennis W. , Lundt, Emily S

Alzheimer's & Dementia | November 26, 2019 | Volume: 16 | Issue: 3 | Pages: 561-571

10.1016/j.jalz.2019.09.079

AbstractIntroductionComparison of tau (flortaucipir) positron emission tomography (FTP‐PET) to autopsy is important to demonstrate the relationship of FTP‐PET to neuropathologic findings.MethodsAutopsies were performed on 26 participants who had antemortem FTP‐PET. FTP‐PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP‐PET signal.ResultsParticipants with Braak stages of IV or greater had elevated FTP‐PET signal. FTP‐PET was elevated in participants with Alzheimer's disease. An FTP‐PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP‐PET signal (rho's from 0.61 to 0.70, P ≤ .02).DiscussionElevated FTP‐PET reflects Braak IV or greater neuropathology. Participants with primary age‐related tauopathy and hippocampal sclerosis did not show elevated FTP‐PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP‐PET signal.

Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease

Al‐Shaikh, Fadi S. Hanna , Duara, Ranjan , Lesser, Elizabeth R. , Schaeverbeke, Jolien , Hinkle, Kelly M., Ross, Owen A. , Ertekin‐Taner, Nilüfer , Pedraza, Otto , Graff‐Radford, Neill R. , Murray, Melissa E. , Hanna Al-Shaikh, Fadi S, Crook, Julia E. , Ross, Owen A , Murray, Melissa E , Duara, Ranjan , Dickson, Dennis W.

JAMA Neurology | October 28, 2019 | Volume: 77 | Issue: 2 | Pages: 225

10.1001/jamaneurol.2019.3606

DT‐02‐01: REPURPOSING FDG‐PET AS A DIAGNOSTIC TOOL FOR ALZHEIMER'S‐RELATED TDP‐43‐PROTEINOPATHY

Petersen, Ronald C. , Petrucelli, Leonard , Lowe, Val J. , Whitwell, Jennifer L. , Josephs, Keith A. , Buciuc, Marina , Botha, Hugo , Murray, Melissa E. , Jones, David T. , Knopman, David S. , Boeve, Bradley F. , Jack, Clifford R. , Dickson, Dennis W.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_28 | Pages: No page available

10.1016/j.jalz.2019.08.010

O5‐02‐04: INTEGRATIVE GENOMIC PROFILING TO IDENTIFY GENES AND PATHWAYS ASSOCIATED WITH VASCULAR RISK IN AD

Allen, Mariet , Reddy, Joseph S. , Carrasquillo, Minerva M. , Wang, Xue , Lincoln, Sarah, Nguyen, Thuy , Malphrus, Kimberly G., Asmann, Yan W. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Murray, Melissa E. , Bu, Guojun , Dickson, Dennis W.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_31 | Pages: No page available

10.1016/j.jalz.2019.06.4843

O4‐12‐01: TAU PET IMAGING CORRELATES WITH NEUROPATHOLOGY

Lowe, Val J. , Albertson, Sabrina M., Nancy, Scott, Fang, Ping , Parisi, Joseph E., Petersen, Ronald C. , Lundt, Emily S. , Min, Hoon-Ki Paul , Senjem, Matthew L. , Schwarz, Christopher G. , Kantarci, Kejal , Boeve, Bradley F. , Jones, David T. , Knopman, David S. , Jack, Clifford R. , Dickson, Dennis W. , Murray, Melissa E.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_24 | Pages: No page available

10.1016/j.jalz.2019.06.4806

O4‐03‐03: CLINICAL CHARACTERIZATION OF MILD COGNITIVE IMPAIRMENT ASSOCIATED WITH EVENTUAL LEWY BODY DISEASE PATHOLOGY

Graff‐Radford, Neill R. , Graff‐Radford, Jonathan , Savica, Rodolfo , Drubach, Daniel A., Fields, Julie A. , Lucas, John A. , Forsberg, Leah K. , Miyagawa, Toji , Allen, Laura A., Parisi, Joseph E., Petersen, Ronald C. , Boeve, Bradley F. , Ferman, Tanis J. , Knopman, David S. , Jones, David T. , Machulda, Mary M. , Kantarci, Kejal , Murray, Melissa E. , Dickson, Dennis W.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_23 | Pages: No page available

10.1016/j.jalz.2019.06.4754

O1‐04‐05: PATHOLOGIC ASSOCIATIONS OF FDG PET IN LEWY BODY DISEASE

Graff‐Radford, Jonathan , Chen, Qin , Przybelski, Scott A. , Savica, Rodolfo , Lowe, Val J. , Lesnick, Timothy G. , Knopman, David S. , Petersen, Ronald C. , Murray, Melissa E. , Jones, David T. , Boeve, Bradley F. , Ferman, Tanis J. , Knopman, David S. , Jack, Clifford R. , Dickson, Dennis W. , Kantarci, Kejal

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_4 | Pages: No page available

10.1016/j.jalz.2019.06.4539

O2‐08‐01: ANTE‐MORTEM VOLUME LOSS MIRRORS TDP43 STAGING IN NON‐FTLD OLDER ADULTS

Martin, Peter R. , Tosakulwong, Nirubol , Petersen, Ronald C. , Parisi, Joseph E., Whitwell, Jennifer L. , Josephs, Keith A. , Bejanin, Alexandre , Murray, Melissa E. , Botha, Hugo , Schwarz, Christopher G. , Senjem, Matthew L. , Chételat, Gaël , Jack, Clifford R. , Boeve, Bradley F. , Knopman, David S. , Giannini, Caterina , Dickson, Dennis W. , Whitwell, Jennifer L.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_10 | Pages: No page available

10.1016/j.jalz.2019.06.4493

F2‐01‐04: PARADOXICAL AGING IN ALZHEIMER'S DISEASE

Murray, Melissa E.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_10 | Pages: No page available

10.1016/j.jalz.2019.06.4419

IC‐P‐048: COMPARISON OF 123I‐FP‐CIT SPECT THREE QUANTIFICATION METHODS: A CLINICOPATHOLOGIC ANALYSIS IN 23 PATIENTS

Maltais, Daniela D., Lowe, Val J. , Miyagawa, Toji , Jordan, Lennon, Przybelski, Scott A. , Boeve, Bradley F. , Kantarci, Kejal , Min, Hoon-Ki Paul , Murray, Melissa E. , Dickson, Dennis W.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2019.06.4210

Murray, Melissa E.

Citations 308

Tau‐positron emission tomography correlates with neuropathology findings

Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease

DT‐02‐01: REPURPOSING FDG‐PET AS A DIAGNOSTIC TOOL FOR ALZHEIMER'S‐RELATED TDP‐43‐PROTEINOPATHY

Petersen, Ronald C. , Petrucelli, Leonard , Lowe, Val J. , Whitwell, Jennifer L. , Josephs, Keith A. , Buciuc, Marina , Botha, Hugo , Murray, Melissa E. , Jones, David T. , Knopman, David S. , Boeve, Bradley F. , Jack, Clifford R. , Dickson, Dennis W.

O5‐02‐04: INTEGRATIVE GENOMIC PROFILING TO IDENTIFY GENES AND PATHWAYS ASSOCIATED WITH VASCULAR RISK IN AD

Allen, Mariet , Reddy, Joseph S. , Carrasquillo, Minerva M. , Wang, Xue , Lincoln, Sarah, Nguyen, Thuy , Malphrus, Kimberly G., Asmann, Yan W. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Murray, Melissa E. , Bu, Guojun , Dickson, Dennis W.

O4‐12‐01: TAU PET IMAGING CORRELATES WITH NEUROPATHOLOGY

O4‐03‐03: CLINICAL CHARACTERIZATION OF MILD COGNITIVE IMPAIRMENT ASSOCIATED WITH EVENTUAL LEWY BODY DISEASE PATHOLOGY

O1‐04‐05: PATHOLOGIC ASSOCIATIONS OF FDG PET IN LEWY BODY DISEASE

O2‐08‐01: ANTE‐MORTEM VOLUME LOSS MIRRORS TDP43 STAGING IN NON‐FTLD OLDER ADULTS

F2‐01‐04: PARADOXICAL AGING IN ALZHEIMER'S DISEASE

Murray, Melissa E.

IC‐P‐048: COMPARISON OF 123I‐FP‐CIT SPECT THREE QUANTIFICATION METHODS: A CLINICOPATHOLOGIC ANALYSIS IN 23 PATIENTS

Maltais, Daniela D., Lowe, Val J. , Miyagawa, Toji , Jordan, Lennon, Przybelski, Scott A. , Boeve, Bradley F. , Kantarci, Kejal , Min, Hoon-Ki Paul , Murray, Melissa E. , Dickson, Dennis W.