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Bedard, Nicholas A.

https://orcid.org/0000-0003-3151-877X

Mayo Clinic

Mayo Clinic

Citations 45

Intermediate to Long-Term Follow-up of Cementing Liners into Well-Fixed Acetabular Components
Bedard, Nicholas A. , Tetreault, Matthew W. , Hanssen, Arlen D. , Lewallen, David G. , Trousdale, Robert T. , Berry, Daniel J. , Abdel, Matthew P. , Abdel, Matthew P , Berry, Daniel J , Bedard, Nicholas A

Journal of Bone and Joint Surgery | September 8, 2020 | Volume: 102 | Issue: 16 | Pages: 1397-1404

10.2106/jbjs.19.01441 Get It

Background: The cementation of a new liner into a well-fixed acetabular component is common during revision total hip arthroplasty (THA) for many indications, but most commonly for lack of a modern, compatible, highly cross-linked polyethylene (HXLPE) liner. However, little is known about the intermediate-term to long-term durability of this strategy. The purpose of this study was to evaluate the implant survivorship, risk of complications, clinical outcomes, and radiographic results of cementing a new HXLPE liner into a well-fixed acetabular component. Methods: We retrospectively identified 323 revision THAs in which a nonconstrained HXLPE liner was cemented into a well-fixed acetabular component. The mean age at the time of the revision THA was 63 years, and 50% of patients were female. The most common indications for revision THA were polyethylene wear and osteolysis (48%), aseptic femoral loosening (35%), and hip instability (8%). The mean follow-up was 9 years. Results: Polyethylene liner failure occurred in 11 cases (3%). In all cases, the cemented liner dissociated from the acetabular component. At 10 years, the survivorship free from any revision was 80% (95% confidence interval [CI], 75% to 84%) and the survivorship free from any reoperation was 77% (95% CI, 72% to 82%). The most common reason for re-revision was dislocation (45% of reoperations). A dislocation occurred in 17% of cases. Hips that underwent revision for instability were significantly more likely to dislocate compared with hips that underwent revision for liner wear (hazard ratio [HR], 2.3 [95% CI, 1.2 to 4.5]; p = 0.02). Elevated rim or face-changing liners were significantly more likely to dissociate than flat liners (HR, 9.0 [95% CI, 1.2 to 70.6]; p = 0.04). Conclusions: Cementation of a nonconstrained HXLPE liner into a well-fixed acetabular component during revision THA provided durable fixation with only a small number of failures at the cement interface (3%). Instability after this procedure remains a concern, but this is multifactorial in nature. These data support the continued use of this technique, when necessary, during revision THA. Level of Evidence: Therapeutic Level IV . See Instructions for Authors for a complete description of levels of evidence.
Outcomes of a technique combining diaphyseal impaction grafting and metaphyseal cones for severe bone loss in revision total knee arthroplasty
Bedard, Nicholas A. , Cates, Robert A. , Lewallen, David G. , Hanssen, Arlen D. , Berry, Daniel J. , Berry, Daniel J , Bedard, Nicholas A , Sierra, Rafael J. , Abdel, Matthew P.

The Bone & Joint Journal | May 31, 2020 | Volume: 102-B | Issue: 6_Supple_A | Pages: 116-122

10.1302/0301-620x.102b6.bjj-2019-1511.r1 Get It

Aims Metaphyseal cones with cemented stems are frequently used in revision total knee arthroplasty (TKA). However, if the diaphysis has been previously violated, the resultant sclerotic canal can impair cemented stem fixation, which is vital for bone ingrowth into the cone, and long-term fixation. We report the outcomes of our solution to this problem, in which impaction grafting and a cemented stem in the diaphysis is combined with an uncemented metaphyseal cone, for revision TKA in patients with severely compromised bone. Methods A metaphyseal cone was combined with diaphyseal impaction grafting and cemented stems for 35 revision TKAs. There were two patients with follow-up of less than two years who were excluded, leaving 33 procedures in 32 patients in the study. The mean age of the patients at the time of revision TKA was 67 years (32 to 87); 20 (60%) were male. Patients had undergone a mean of four (1 to 13) previous knee arthroplasty procedures. The indications for revision were aseptic loosening (80%) and two-stage reimplantation for prosthetic joint infection (PJI; 20%). The mean follow-up was four years (2 to 11). Results Survival free from revision of the cone/impaction grafting construct due to aseptic loosening was 100% at five years. Survival free from any revision of the construct and free from any reoperation were 92% and 73% at five years, respectively. A total of six patients (six TKAs, 17%) required a further revision, four for infection or wound issues, and two for periprosthetic fracture. Radiologically, one unrevised TKA had evidence of loosening which was asymptomatic. In all unrevised TKAs the impacted diaphyseal bone graft appeared to be incorporated radiologically. Conclusion When presented with a sclerotic diaphysis and substantial metaphyseal bone loss, this technique combining diaphyseal impaction grafting with a metaphyseal cone provided near universal success in relation to implant fixation. Moreover, radiographs revealed incorporation of the bone graft and biological fixation of the cone. While long-term follow-up will be important, this technique provides an excellent option for the management of complex revision TKAs. Cite this article: Bone Joint J 2020;102-B(6 Supple A):116–122.
Constrained Liners Implanted Simultaneously at the Time of Acetabular Shell Revision with a Highly Porous Implant
Bedard, Nicholas A. , Brown, Timothy S. , Lewallen, David G. , Trousdale, Robert T. , Berry, Daniel J. , Abdel, Matthew P. , Abdel, Matthew P , Berry, Daniel J , Bedard, Nicholas A

Journal of Bone and Joint Surgery | May 26, 2020 | Volume: 102 | Issue: 17 | Pages: 1521-1529

10.2106/jbjs.19.01332 Get It

Background: Many surgeons are reluctant to use a constrained liner at the time of acetabular component revision because of concerns that doing so might result in early acetabular component loosening related to high bone-implant interface stresses transmitted from the constrained liner. We hypothesized that, with appropriate initial implant stabilization using highly porous acetabular components with robust supplemental screw fixation, constrained liners could be safely used at the time of acetabular revision. Methods: We retrospectively identified 148 revision total hip arthroplasties (THAs) in which a constrained liner of 1 design was cemented into a newly placed highly porous acetabular component fixed with supplemental screws (mean, 5 screws). The mean age at the time of revision THA was 69 years, and 68% of the patients were female. The most common indications for revision were 2-stage reimplantation (33%), recurrent dislocation (30%), and aseptic loosening of the acetabular component (22%) or both the acetabular and femoral components (9%). The mean duration of follow-up was 7 years. Results: There were no failures at the bone-implant interface. No cases of acetabular metal shell loosening were identified on radiographic analysis. The 10-year survival rates with acetabular revision and any reoperation as the end points were 75% and 67%, respectively. Overall, 33 hips (22%) required revision or reoperation because of infection or wound complications (n = 12), dislocation or mechanical failure of the constrained liner (n = 11), periprosthetic femoral fracture (n = 4), femoral loosening (n = 3), or other reasons (n = 3). The 10-year survival rate with re-revision for instability as the end point was 88% overall, which was similar to the 85% 10-year survival rate with re-revision for instability as the end point among hips that were specifically revised because of instability during index revision THA (p = 0.9). Conclusions: Implanting a constrained liner at the time of acetabular revision in high-risk patients resulted in no cases of aseptic metal acetabular component loosening in this large series. This finding is likely related to the fact that a highly porous acetabular component was utilized with robust supplemental screw fixation in each case. Such information is valuable as these data favor a paradigm shift when compared with some traditionally held tenets. Level of Evidence: Therapeutic Level IV . See Instructions for Authors for a complete description of levels of evidence.
Preoperative Opioid Usage, Male Sex, and Preexisting Knee Osteoarthritis Impacts Opioid Refills After Isolated Arthroscopic Meniscectomy: A Population‐Based Study
Khazi, Zain , Baron, Jacqueline , Shamrock, Alan G. , Gulbrandsen, Trevor R. , Bedard, Nicholas A. , Wolf, Brian R. , Duchman, Kyle R. , Westermann, Robert W. , Bedard, Nicolas, Bedard, Nicholas A

Arthroscopy | May 10, 2020 | Volume: 36 | Issue: 9 | Pages: 2478-2485

10.1016/j.arthro.2020.04.039 Get It

Purpose To identify risk factors for opioid consumption after arthroscopic meniscectomy using a large national database. Methods Patients undergoing primary arthroscopic meniscectomy from 2007 to 2016 were retrospectively accessed from the Humana database. Patients were categorized as those who filled opioid prescriptions within 3 months (OU), within 1 month (A‐OU), between 1 and 3 months (C‐OU), and never filled opioid prescriptions (N‐OU) before surgery. Rates of opioid use were evaluated preoperatively and longitudinally tracked for each cohort. Prolonged opioid use was defined as continued opioid prescription filling at ≥3 months after surgery. Multiple logistic regression analysis was used to identify factors associated with opioid refills at 12 months after surgery. Results There were 88,120 patients (53.7% female) who underwent arthroscopic meniscectomy, of whom 46.1% (n = 39,078) were N‐OU. About a quarter (25.3%) of patients continued filling opioid prescriptions at 1 year postoperatively. In addition, opioid fill rate at 1 year was significantly greater in the OU group compared with the N‐OU group with a relative risk of 2.89 (40.7% vs 14.1%; 95% confidence interval 2.81‐2.98; P < .0001). Multiple logistic regression model identified C‐OU (odds ratio 3.67; 95% confidence interval 3.53‐3.82; P < .0001) as the strongest predictor of opioid use at 12 months postoperatively. Furthermore, male sex, A‐OU, knee osteoarthritis, diabetes mellitus, hypertension, chronic obstructive pulmonary disease, fibromyalgia, anxiety or depression, alcohol use disorder, and tobacco use ( P < .02 for all) had significantly increased odds of opioid use at 12 months postoperatively. However, patients <40 years ( P < .0001) had significantly decreased odds of opioid use 12 months postoperatively. Conclusions Preoperative opioid filling is a significant risk factor for opioid use at 12 months postoperatively. Male sex, preexisting knee osteoarthritis, and diagnosis of anxiety or depression were independent risk factors for opioid use 12 months following arthroscopic meniscectomy. Level of Evidence Level‐III, Retrospective Cohort Study.
Opioids After Orthopaedic Surgery: There Is a Need for Universal Prescribing Recommendations
Bedard, Nicholas A. , Sierra, Rafael J. , Mabry, Tad M. , Sierra, Rafael J , Bedard, Nicholas A

Journal of Bone and Joint Surgery | February 7, 2018 | Volume: 100 | Issue: 3 | Pages: e17

10.2106/jbjs.17.01480 Get It