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Reddy, Joseph S.

https://orcid.org/0000-0002-1783-4453

Mayo Clinic

Mayo Clinic in Florida

Citations 70

O5‐02‐04: INTEGRATIVE GENOMIC PROFILING TO IDENTIFY GENES AND PATHWAYS ASSOCIATED WITH VASCULAR RISK IN AD
Allen, Mariet , Reddy, Joseph S. , Carrasquillo, Minerva M. , Wang, Xue , Lincoln, Sarah, Nguyen, Thuy , Malphrus, Kimberly G., Asmann, Yan W. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Murray, Melissa E. , Bu, Guojun , Dickson, Dennis W.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_31 | Pages: No page available

10.1016/j.jalz.2019.06.4843 Get It

O2‐10‐01: STOP‐GAIN AND NON‐SYNONYMOUS VARIANTS IN NOVEL GENES OF AN IMMUNE CO‐REGULATORY NETWORK SHOW STRONG ASSOCIATION WITH ALZHEIMER'S DISEASE
Reddy, Joseph S. , Allen, Mariet , Wang, Xue , Gregory, Jenkins D., Carrasquillo, Minerva M. , Ertekin‐Taner, Nilüfer , Younkin, Steven G. , Biernacka, Joanna M. , Carrasquillo, Minerva M.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_11 | Pages: No page available

10.1016/j.jalz.2019.06.4505 Get It

O3‐06‐02: POLYGENIC SCORE ANALYSIS OF EXONIC VARIANTS IN AN IMMUNE CO‐REGULATORY NETWORK IDENTIFIES NOVEL PROTEIN‐ALTERING VARIANTS THAT ASSOCIATE WITH ALZHEIMER'S DISEASE
Reddy, Joseph S. , Allen, Mariet , Wang, Xue , Gregory, Jenkins D., Toral, Shastri M., Sarangi, Vivekananda , Asmann, Yan W. , Carrasquillo, Minerva M. , Ren, Yingxue , Younkin, Curtis, Rademakers, Rosa , Ertekin‐Taner, Nilüfer , Younkin, Steven G. , Biernacka, Joanna M. , McDonnell, Shannon K. , Sinnwell, Jason P. , Carrasquillo, Minerva M. , Pottier, Cyril , Ross, Owen A.

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_19 | Pages: No page available

10.1016/j.jalz.2018.06.2801 Get It

P3‐132: GENOME‐WIDE ASSOCIATION STUDY OF CEREBRAL MICROBLEEDS AND INFARCTION IDENTIFIES CANDIDATE GENES FOR VASCULAR RISK IN DEMENTIA
Carrasquillo, Minerva M. , Reddy, Joseph S. , Allen, Mariet , Reyes, Denise A., Graff‐Radford, Jonathan , Kosel, Matthew , Gregory, Jenkins D., Nguyen, Thuy , Lincoln, Sarah, Malphrus, Kimberly G., Lowe, Val J. , Petersen, Ronald C. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , McDonnell, Shannon K. , Crook, Julia E. , Jack, Clifford R. , Knopman, David S. , Kantarci, Kejal , Bu, Guojun

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_21 | Pages: No page available

10.1016/j.jalz.2018.06.1489 Get It

P3‐129: MAPPING FUNCTIONAL REGULATORY VARIANTS AT ALZHEIMER'S DISEASE RISK LOCI
Allen, Mariet , Bredenberg, Jenny M., Reddy, Joseph S. , Sarangi, Vivekananda , Carrasquillo, Minerva M. , Lincoln, Sarah, Nguyen, Thuy , Malphrus, Kimberly G., Asmann, Yan W. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Wang, Xue, Dickson, Dennis W.

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_21 | Pages: No page available

10.1016/j.jalz.2018.06.1486 Get It

P2‐141: CHR17Q21 H2 HAPLOTYPE STRATIFIED GWAS REVEALS DIFFERENTIAL ASSOCIATION FOR AD RISK VARIANTS
Strickland, Samantha L. , Reddy, Joseph S. , Allen, Mariet , N’Songo, Aurelie, Corda, M, Ballard, Travis, Boehme, Kevin L. , Kauwe, John, Ertekin‐Taner, Nilüfer , ADGC, Burgess, Jeremy D. , Corda, Morgane M., Mukherjee, Shubhabrata , Crane, Paul K. , ADGC

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_13 | Pages: No page available

10.1016/j.jalz.2018.06.827 Get It

P1‐160: ABI3 AND PLCG2 AS RISK FACTORS FOR ALZHEIMER'S DISEASE IN CAUCASIANS AND AFRICAN AMERICANS
Conway, Olivia J., Carrasquillo, Minerva M. , Bredenberg, Jenny M., Reddy, Joseph S. , Younkin, Curtis, Allen, Mariet , Nguyen, Thuy , Lincoln, Sarah, Malphrus, Kimberly G., Duara, Ranjan , Custo, María T. Greig, Petersen, Ronald C. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Duara, Ranjan , Dickson, Dennis W. , Graff, Caroline

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_6 | Pages: No page available

10.1016/j.jalz.2018.06.164 Get It

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease
Chakrabarty, Paramita , Li, Andrew, Ladd, Thomas B., Strickland, Michael R. , Koller, Emily J., Burgess, Jeremy D. , Funk, Cory C. , Allen, Mariet , Yaroshenko, Mariya, Wang, Xue , Younkin, Curtis, Reddy, Joseph S. , Lohrer, Benjamin , Mehrke, Leonie S. , Moore, Brenda D. , Ceballos‐Diaz, Carolina, Rosario, Awilda M., Medway, Christopher, Janus, Christopher, Li, Hongdong , Giasson, Benoit I. , Price, Nathan D. , Younkin, Steven G. , Ertekin‐Taner, Nilüfer , Golde, Todd E. , Reddy, Joseph , Mehrke, Leonie, Price, Nathan D , Golde, Todd E , Cruz, Pedro E. , Wang, Xue, Liu, Xuefei , Li, Hong-Dong, Dickson, Dennis W.

Journal of Experimental Medicine | August 29, 2018 | Volume: 215 | Issue: 9 | Pages: 2247-2264

10.1084/jem.20180484 Get It

There is considerable interest in harnessing innate immunity to treat Alzheimer’s disease (AD). Here, we explore whether a decoy receptor strategy using the ectodomain of select TLRs has therapeutic potential in AD. AAV-mediated expression of human TLR5 ectodomain (sTLR5) alone or fused to human IgG4 Fc (sTLR5Fc) results in robust attenuation of amyloid β (Aβ) accumulation in a mouse model of Alzheimer-type Aβ pathology. sTLR5Fc binds to oligomeric and fibrillar Aβ with high affinity, forms complexes with Aβ, and blocks Aβ toxicity. Oligomeric and fibrillar Aβ modulates flagellin-mediated activation of human TLR5 but does not, by itself, activate TLR5 signaling. Genetic analysis shows that rare protein coding variants in human TLR5 may be associated with a reduced risk of AD. Further, transcriptome analysis shows altered TLR gene expression in human AD. Collectively, our data suggest that TLR5 decoy receptor–based biologics represent a novel and safe Aβ-selective class of biotherapy in AD.
[O2–13–03]: USING TISSUE‐BASED TRANSCRIPTOMICS TO PROFILE CELL TYPE VARIABILITY IN THE BRAIN
Allen, Mariet , Wang, Xue , Reddy, Joseph S. , Carrasquillo, Minerva M. , Younkin, Curtis, Funk, Cory C. , Nguyen, Thuy , Lincoln, Sarah, Malphrus, Kimberly G., Asmann, Yan W. , Younkin, Steven G. , Golde, Todd E. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Burgess, Jeremy D. , Price, Nathan D. , Dickson, Dennis W.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_11 | Pages: No page available

10.1016/j.jalz.2017.07.218 Get It

ABCA7 loss-of-function variants, expression, and neurologic disease risk
Allen, Mariet , Lincoln, Sarah, Corda, M, Carrasquillo, Minerva M. , Reddy, Joseph S. , Burgess, Jeremy D. , Nguyen, Thuy , Malphrus, Kimberly G., Petersen, Ronald C. , Graff‐Radford, Neill R. , Ertekin‐Taner, Nilüfer , Lincoln, Sarah J, Corda, Morgane, Watzlawik, Jens O. , Carrasquillo, Minerva M. , Dickson, Dennis W.

Neurology Genetics | January 6, 2017 | Volume: 3 | Issue: 1 | Pages: No page available

10.1212/nxg.0000000000000126 Get It