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Custo, María T. Greig

Mayo Clinic

Mount Sinai Medical Center

Citations 4

P1‐160: ABI3 AND PLCG2 AS RISK FACTORS FOR ALZHEIMER'S DISEASE IN CAUCASIANS AND AFRICAN AMERICANS
Conway, Olivia J., Carrasquillo, Minerva M. , Bredenberg, Jenny M., Reddy, Joseph S. , Younkin, Curtis, Allen, Mariet , Nguyen, Thuy , Lincoln, Sarah, Malphrus, Kimberly G., Duara, Ranjan , Custo, María T. Greig, Petersen, Ronald C. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Duara, Ranjan , Dickson, Dennis W. , Graff, Caroline

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_6 | Pages: No page available

10.1016/j.jalz.2018.06.164 Get It

[P3–096]: NOVEL CANDIDATE AD‐RISK LOCI IDENTIFIED THROUGH WHOLE EXOME SEQUENCING IN AFRICAN‐AMERICANS
Carrasquillo, Minerva M. , Ho, Charlotte C.G. , N’Songo, Aurelie, Wang, Xue , Nguyen, Thuy , Bisceglio, Gina, Lincoln, Sarah, Malphrus, Kimberly G., Asmann, Yan W. , Younkin, Steven G., Duara, Ranjan , Custo, María T. Greig, Graff‐Radford, Neill R. , Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Burgess, Jeremy D. , Ma, Li , Duara, Ranjan

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_20 | Pages: No page available

10.1016/j.jalz.2017.06.1306 Get It

African American exome sequencing identifies potential risk variants at Alzheimer disease loci
N’Songo, Aurelie, Carrasquillo, Minerva M. , Wang, Xue , Burgess, Jeremy D. , Nguyen, Thuy , Asmann, Yan W. , Serie, Daniel, Younkin, Steven G., Allen, Mariet , Pedraza, Otto , Duara, Ranjan , Custo, María T. Greig, Ertekin‐Taner, Nilüfer , Serie, Daniel J, Greig Custo, Maria T, Carrasquillo, Minerva M. , Duara, Ranjan , Graff, Caroline

Neurology Genetics | April 8, 2017 | Volume: 3 | Issue: 2 | Pages: No page available

10.1212/nxg.0000000000000141 Get It

Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer’s Disease Genes in African Americans Identifies Novel PSEN Variants
N’Songo, Aurelie, Carrasquillo, Minerva M. , Wang, Xue , Nguyen, Thuy , Asmann, Yan W. , Younkin, Steven G., Allen, Mariet , Duara, Ranjan , Custo, María T. Greig, Graff‐Radford, Neill R. , Ertekin‐Taner, Nilüfer , Asmann, Yan, Carrasquillo, Minerva M. , Duara, Ranjan

Journal of Alzheimer’s Disease | January 20, 2017 | Volume: 56 | Issue: 4 | Pages: 1215-1222

10.3233/jad-161185 Get It

We conducted a comprehensive screening of rare coding variants in an African American cohort to identify novel pathogenic mutations within the early-onset Alzheimer’s disease (EOAD) genes ( APP, PSEN1 , and PSEN2) in this understudied population. Whole-exome sequencing of 238 African American subjects identified 6 rare missense variants within the EOAD genes, which were observed in AD cases but never among controls. These variants were analyzed in an independent cohort of 300 African American subjects in which PSEN2 :NM_000447:exon5:c.T331C:p.Phe111Leu and PSEN1-minilin rs777923890 variants were again not observed, indicating that these novel rare variants, may contribute to AD risk in this population.