Citations 465
Alzheimer CSF biomarkers may be misleading in normal-pressure hydrocephalus
Graff‐Radford, Neill R.
Neurology | October 20, 2014 | Volume: 83 | Issue: 17 | Pages: 1573-1575
Guidelines for the standardization of preanalytic variables for blood‐based biomarker studies in Alzheimer's disease research
O’Bryant, Sid E. , Gupta, Veer Bala , Henriksen, Kim , Jeromin, Andreas, Lista, Simone , Bazenet, Chantal, Soares, Holly , Lovestone, Simon , Hampel, Harald , Montine, Thomas J. , Blennow, Kaj , Foroud, Tatiana, Carrillo, María C. , Graff‐Radford, Neill R. , Laske, Christoph , Breteler, Monique M.B. , Shaw, Leslie M. , Trojanowski, John Q. , Schupf, Nicole , Fagan, Anne M. , Oberoi, Pankaj, Umek, Robert M., Weiner, Michael W. , Grammas, Paula , Posner, Holly, Martins, Ralph N. , groups, STAR-B and BBBIG working, Edwards, Melissa , Rissman, Robert A. , groups, STAR-B and BBBIG working, O'Bryant, Sid
Alzheimer's & Dementia | October 1, 2014 | Volume: 11 | Issue: 5 | Pages: 549-560
Abstract The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood‐based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field to foster cross‐validation across cohorts and laboratories.
Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease
Jun, Gyungah , Reitz, Christiane, Kunkle, Brian W. , Park, Yo Son, Beecham, Gary W. , Rajbhandary, Ruchita, Hamilton‐Nelson, Kara L., Wang, Li-San, Kauwe, John, Huentelman, Matthew J. , Bird, Thomas D., Baldwin, Clinton T., Jarvik, Gail P. , Crane, Paul K. , Barmada, M. Michael , Demirci, F. Yesim , Cruchaga, Carlos , Kramer, Patricia L., Ertekin‐Taner, Nilüfer , Hardy, John , Graff‐Radford, Neill R. , Larson, Eric B., George‐Hyslop, Peter St , Buxbaum, Joseph D. , Evans, Denis A., Lunetta, Kathryn L. , Kamboh, M. Ilyas , Saykin, Andrew J. , Reiman, Eric M. , Jager, Philip L. De , Morris, John C. , Montine, Thomas J. , Goate, Alison , Blacker, Deborah , Tsuang, Debby W. , Håkonarson, Håkon , Kukull, Walter A. , Foroud, Tatiana, Martin, Eden R. , Haines, Jonathan L. , Mayeux, Richard , Farrer, Lindsay A. , Schellenberg, Gerard D., Pericak‐Vance, Margaret A. , Albert, Marilyn S. , Albin, Roger L. , Apostolova, Liana G. , Arnold, Steven E. , Barber, Robert W., Beach, Thomas G. , Beekly, Duane, Bigio, Eileen H. , Bowen, James D. , Boxer, Adam, Cairns, Nigel J. , Cantwell, Laura B., Cao, Chuanhai , Carlson, Chris , Carney, Regina M., Carrasquillo, Minerva M., Carroll, Steven L. , Chui, Helena C., Clark, David G., Corneveaux, Jason J., Cribbs, David H. , DeCarli, Charles , DeKosky, Steven T. , Dick, Malcolm, Duara, Ranjan , Faber, Kelley M., Fallon, Kenneth B., Farlow, Martin R. , Ferris, Steven H. , Frosch, Matthew P. , Gearing, Marla , Geschwind, Daniel H. , Gilbert, John R., Glass, Jonathan D. , Growdon, John H., Hamilton, Ronald L. , Harrell, Lindy E., Hulette, Christine M., Jicha, Gregory A. , Jin, Lee‐Way, Karydas, Anna, Koo, Edward H. , Kowall, Neil W. , Kramer, Joel H. , LaFerla, Frank M. , Leverenz, James B. , Li, Ge , Lieberman, Andrew P. , Lin, Chiao‐Feng , Lyketsos, Constantine G. , Mack, Wendy J. , Martiniuk, Frank , Mash, Deborah C. , Masliah, Eliezer , McCormick, Wayne C., McKee, Ann C. , Miller, Carol A., Miller, Joshua W., Murrell, Jill R. , Olichney, John , Parisi, Joseph E., Paulson, Henry L. , Peskind, Elaine R. , Petersen, Ronald , Pierce, Aimee, Poon, Wayne W. , Raj, Ashok , Raskind, Murray A. , Reisberg, Barry , Ringman, John M. , Rosen, Howard J., Rosenberg, Roger N., Sano, Mary , Schneider, Lon S. , Smith, Amanda , Sonnen, Joshua A. , Stern, Robert A. , Tanzi, Rudolph E. , Thornton‐Wells, Tricia A., Trojanowski, John Q. , Troncoso, Juan C. , Vinters, Harry V. , Vonsattel, Jean Paul, Weıntraub, Sandra , Wishnek, Sarah, Woltjer, Randall L. , Wright, Clinton B., Younkin, Steven G., Yu, Chang‐En , Yu, Lei, Bennett, David A. , DeCarli, Charles , Pankratz, Vernon S, Naj, Adam Christian , Perry, William , Hamilton‐Nelson, Kara L. , Wang, Li-San, Myers, Amanda , Boeve, Bradley F. , Rogaeva, Ekaterina A. , Cruchaga, Carlos , Kramer, P. L., Green, Robert C. , Schneider, Julie A. , Bennett, David , Barnes, Lisa L. , Becker, James T. , Burke, James R. , Carrasquillo, Minerva M. , Chui, Helena C. , Crocco, Elizabeth , Dickson, Dennis W. , Duara, Ranjan , Galasko, Douglas , Ganguli, Mary , Ghetti, Bernardino , Head, Elizabeth , Honig, Lawrence S. , Hyman, Bradley T. , Kaye, Jeffrey , Kim, Ronald , Lah, James J. , Levey, Allan I. , López, Oscar L. , McCurry, Susan M. , McDavid, Andrew , Mesulam, Marsel M. , Miller, Bruce L. , Pankratz, V. Shane , Potter, Huntington , Quinn, Joseph F. , Roberson, Erik D. , Seeley, William W. , Spina, Salvatore , Valladares, Otto , Deerlin, Vivianna M. Van , Eldik, Linda J. Van , Vardarajan, Badri Narayan , Welsh-Bohmer, Kathleen Anne , Williamson, Jennifer , Bennett, David A. , Hakonarson, Hakon , Saykin, Andrew J , Leverenz, James B , Jarvik, Gail P , Paulson, Henry L , Stern, Robert A , Hardy, John , Morris, John C , Goate, Alison M , Jicha, Gregory A , Sonnen, Joshua
JAMA Neurology | September 8, 2014 | Volume: 71 | Issue: 11 | Pages: 1394
IC‐02‐06: LONGITUDINAL CHANGES IN BRAIN MRI AND NEUROPSYCHOLOGICAL MEASURES IN ASYMPTOMATIC AND SYMPTOMATIC FAMILIAL FRONTOTEMPORAL LOBAR DEGENERATION WITH MUTATIONS IN MAPT
Weigand, Stephen D. , Przybelski, Scott A. , Graff‐Radford, Jonathan , Mathew, Senjem, Gunter, Jeffrey L. , Whitwell, Jennifer , Graff‐Radford, Neill R. , Josephs, Kieth, Fields, Julie A. , Lucas, John A. , Lowe, Val J. , Gavrilova, Ralitza, Kuntz, Karen M. , Hernandez, Mariely DeJesus, Rademakers, Rosa , Petersen, Ronald C. , Jones, David T. , Knopman, David S. , Wszołek, Zbigniew K. , Vemuri, Prashanthi , Machulda, Mary M. , Ferman, Tanis J. , Baker, Matthew , Kantarci, Kejal , Jack, Clifford R. , Boeve, Bradley F.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_1 | Pages: No page available
O1‐12‐03: THAL AMYLOID PHASE: CLINICOPATHOLOGIC AND PIB‐PET IMPLICATIONS OF AD PATHOPHYSIOLOGY
Murray, Melissa E. , Graff‐Radford, Neill R. , Liesinger, Amanda M., Rawal, Bhupendra, Petersen, Ronald C. , Duara, Ranjan , Lowe, Val J. , Cannon, Ashley , Jack, Clifford R. , Kantarci, Kejal , Ross, Owen A. , Duara, Ranjan , Dickson, Dennis W. , Murray, Melissa E
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_2 | Pages: No page available
P1‐202: HISTORY OF HEAD INJURY AND ALZHEIMER'S DISEASE (AD) NEUROPATHOLOGY
Camsari, Gamze Balci, Murray, Melissa E. , Khan, Qurat ul Ain , Graff‐Radford, Neill R. , Dickson, Dennis W. , Murray, Melissa E
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_9 | Pages: No page available
O3‐03‐05: LONGITUDINAL MRI AND NEUROPSYCHOLOGICAL CHANGES IN SYMPTOMATIC FRONTOTEMPORAL LOBAR DEGENERATION SUBJECTS WITH MUTATIONS IN MAPT, PGRN, AND C9ORF72
Graff‐Radford, Jonathan, Weigand, Stephen D. , Przybelski, Scott A. , Whitwell, Jennifer , Graff‐Radford, Neill R. , Josephs, Keith A. , Fields, Julie A. , Lucas, John A. , Lowe, Val J. , Gavrilova, Ralitza H. , Kuntz, Karen M. , Hernandez, Mariely DeJesus, Rademakers, Rosa , Petersen, Ronald C. , Graff‐Radford, Jonathan , Jones, David T. , Senjem, Matthew L. , Knopman, David S. , Wszołek, Zbigniew K. , Vemuri, Prashanthi , Ferman, Tanis J. , Baker, Matthew , Kantarci, Kejal , Jack, Clifford R. , Boeve, Bradley F.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_3 | Pages: No page available
P2‐388: ELIGIBILITY FOR AN EXERCISE STUDY IN ASYMPTOMATIC PRE‐ALZHEIMER'S DISEASE
Haley, Dana , Parfitt, Francine, Fletcher, Barbara J., Fletcher, Gerald F., Jain, Manoj , Lowe, Val J. , Vemuri, Prashanthi R., Diehl, Nancy N. , Graff‐Radford, Neill R. , Jack, Clifford R. , Vemuri, Prashanthi , Crook, Julia E.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available
ARE PLASMA Aβ MEASURES ASSOCIATED WITH LONGITUDINAL CHANGE IN HIPPOCAMPAL VOLUME?
Graff‐Radford, Neill R. , Thomas, Colleen S. , Younkin, Linda H., Petersen, Ronald C. , Younkin, Steven G. , Crook, Julia E. , Knopman, David S. , Boeve, Bradley F. , Jack, Clifford R.
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_5 | Pages: No page available
Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans
Schu, Matthew , Farrell, John J. , Bennett, David A. , Buxbaum, Joseph D. , Byrd, Goldie S. , Ertekin‐Taner, Nilüfer , Evans, Denis A., Goate, Alison , Graff‐Radford, Neill R. , Kamboh, M. Ilyas , Kukull, Walter A. , Haines, Jonathan L. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Schellenberg, Gerard D. , Baldwin, Clinton T., Fallin, M. Daniele , Farrer, Lindsay A. , Tsuang, Debby W. , Carroll, Steven L. , Logue, Mark W. , Vardarajan, Badri Narayan , Foroud, Tatiana , Manly, Jennifer J. , Lunetta, Kathryn L. , Bennett, David A. , Goate, Alison M
Alzheimer's & Dementia | August 26, 2014 | Volume: 10 | Issue: 6 | Pages: 609
AbstractBackgroundLess is known about the genetic basis of Alzheimer's disease (AD) in African Americans (AAs) than in non‐Hispanic whites.MethodsWhole exome sequencing (WES) was performed on seven AA AD cases. Disease association with potentially AD‐related variants from WES was assessed in an AA discovery cohort of 422 cases and 394 controls. Replication was sought in an AA sample of 1037 cases and 1869 controls from the Alzheimer Disease Genetics Consortium (ADGC).ResultsForty‐four single nucleotide polymorphisms (SNPs) from WES passed filtering criteria and were successfully genotyped. Nominally significant (P < .05) association to AD was observed with two African‐descent specific AKAP9 SNPs in tight linkage disequilibrium: rs144662445 (P = .014) and rs149979685 (P = .037). These associations were replicated in the ADGC sample (rs144662445: P = .0022, odds ratio [OR] = 2.75; rs149979685: P = .0022, OR = 3.61).ConclusionsBecause AKAP9 was not previously linked to AD risk, this study indicates a potential new disease mechanism.