Mayo Clinic - AuthorCitation

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease

Vöglein, Jonathan , Paumier, Katrina L. , Preische, Oliver, Hassenstab, Jason , Benzinger, Tammie L.S. , Noble, James M. , Berman, Sarah , Graff‐Radford, Neill R. , Farlow, Martin R. , Chhatwal, Jasmeer P. , Salloway, Stephen , Xiong, Chengjie , Cairns, Nigel J., Mori, Hiroshi , Masters, Colin L. , Goate, Alison , Buckles, Virginia, Fox, Nick C. , Chrem, Patricio, Allegri, Ricardo , Ringman, John M. , Höglinger, Günter U. , Steiner, Harald , Dieterich, Marianne , Haass, Christian , Laske, Christoph , Morris, John C. , Bateman, Randall J. , Danek, Adrian , Network, Dominantly Inherited Alzheimer, Höglinger, Günter U , Bateman, Randall J , Masters, Colin L , Vöglein, Jonathan , Xiong, Chengjie , Benzinger, Tammie L S , Fox, Nick C , Hassenstab, Jason , Morris, John C , Jucker, Mathias , McDade, Eric , Ghetti, Bernardino , Xiong, Chengjie , Karch, Celeste M. , Schofield, Peter R. , Rossor, Martin N. , Network, Dominantly Inherited Alzheimer, Goate, Alison M , Allegri, Ricardo , Berman, Sarah , Noble, James M

Brain | February 25, 2019 | Volume: 142 | Issue: 5 | Pages: 1429-1440

Aβ deposition in the basal ganglia is common in autosomal dominant Alzheimer’s disease. Vöglein et al. report an increased severity of motor symptoms in autosomal dominant versus sporadic disease in advanced disease stages. Motor symptoms are more severe in post-codon 200 presenilin 1 mutation carriers and correlate with basal ganglia Aβ.

Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers

Gordon, Brian A. , Blazey, Tyler , Christensen, Jon, Dincer, Aylin , Flores, Shaney , Keefe, Sarah , Wang, Guoqiao , Hassenstab, Jason , Aschenbrenner, Andrew J. , Hornbeck, Russ C. , Jack, Clifford R. , Berman, Sarah , Brosch, Jared R. , Gauthier, Serge , Dyck, Christopher H. van , Mintun, Mark A., Klein, Gregory , Cairns, Nigel J., Marcus, Daniel S. , Raichle, Marcus E. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , Jack, Clifford R , Gordon, Brian A , Bateman, Randall J , Chen, Charles D , Benzinger, Tammie L S , Hassenstab, Jason , Morris, John C , Aschenbrenner, Andrew J , Chen, Charles , Su, Yi , McDade, Eric , Li, Yan , Ances, Beau M. , Galasko, Douglas , Lah, James J. , Masellis, Mario , Ristic, Smiljana, Xiong, Chengjie , Holtzman, David M. , Berman, Sarah

Brain | January 29, 2019 | Volume: 142 | Issue: 4 | Pages: 1063-1076

10.1093/brain/awz019

O1‐02‐03: DIAN‐TU ADAPTIVE PREVENTION TRIAL LAUNCH AND BASELINE DATA

Santacruz, Anna , Farlow, Martin R. , Salloway, Stephen , Fagan, Anne M. , Wang, Guoqiao , Koeppe, Bob, Martényi, Ferenc, Yaari, R. , Siemers, Eric , Clifford, David B. , Bateman, Randall J. , Mills, Susan, Morris, John C. , Benzinger, Tammie L.S. , Goate, Alison , Hassenstab, Jason , Xiong, Chengjie , Jack, Clifford R. , Searle, Alison, McDade, Eric

Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2018.06.2338

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease

Caballero, Miguel Ángel Araque, Suárez‐Calvet, Marc , Duering, Marco , Franzmeier, Nicolai , Benzinger, Tammie L.S. , Fagan, Anne M. , Bateman, Randall J. , Jack, Clifford R. , Xiong, Chengjie , Dichgans, Martin , Karch, Celeste M. , Masters, Colin L. , Morris, John C. , Weiner, Michael W. , Rossor, Martin N. , Fox, Nick C. , Salloway, Stephen , Danek, Adrian , Goate, Alison , Yakushev, Igor , Hassenstab, Jason , Haass, Christian , Ewers, Michael , Dichgans, Martin , Jack, Clifford R , Franzmeier, Nicolai , Bateman, Randall J , Masters, Colin L , Xiong, Chengjie , Benzinger, Tammie L S , Fox, Nick C , Hassenstab, Jason , Karch, Celeste M , Morris, John C , Jucker, Mathias , Lee, Jae‐Hong , Schofield, Peter R. , Goate, Alison M , Duering, Marco

Brain | August 12, 2018 | Volume: 141 | Issue: 10 | Pages: 3065-3080

10.1093/brain/awy229

Effect ofBDNFVal66Met on disease markers in dominantly inherited Alzheimer's disease

Lim, Yen Ying , Hassenstab, Jason , Goate, Alison , Fagan, Anne M. , Benzinger, Tammie L.S. , Cruchaga, Carlos , Chhatwal, Jasmeer P. , Xiong, Chengjie , Farlow, Martin R. , Graff‐Radford, Neill R. , Laske, Christoph , Masters, Colin L. , Salloway, Stephen , Morris, John C. , Maruff, Paul , Bateman, Randall J. , Network, on behalf of the Dominantly Inherited Alzheimer, Cruchaga, Carlos , Bateman, Randall J , Masters, Colin L , Xiong, Chengjie , Benzinger, Tammie L S , Hassenstab, Jason , Morris, John C , McDade, Eric , Schofield, Peter R. , Network, on behalf of the Dominantly Inherited Alzheimer, Goate, Alison M , Maruff, Paul

Annals of Neurology | July 17, 2018 | Volume: 84 | Issue: 3 | Pages: 424-435

10.1002/ana.25299

ObjectivePrevious studies suggest that the brain‐derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism may influence symptom onset in Alzheimer's disease (AD). Our recent cross‐sectional findings suggest that Met66 may influence clinical expression in dominantly inherited AD (DIAD) through its effects on tau. However, it remains unclear whether carriage of Met66 in DIAD results in faster increases in cerebrospinal fluid (CSF) tau and ptau181, and whether these increases are associated with accelerated brain volume loss and memory decline.MethodsA total of 211 subjects (101 mutation noncarriers, 110 mutation carriers), who were cognitively normal, as defined by a Clinical Dementia Rating global score of 0, completed assessments of cognitive function, neuroimaging, and CSF sampling over 3.5 years as part of the Dominantly Inherited Alzheimer's Network.ResultsIn mutation carriers, Met66 carriers showed faster memory decline (4×), hippocampal volume loss (16×), and CSF tau and ptau181increases (6×) than Val66 homozygotes.BDNFdid not influence rates of cortical β‐amyloid accumulation or change in CSF Aβ42levels in mutation carriers. In mutation noncarriers,BDNFgenotype had no effect on change in cognition, brain volume, cortical β‐amyloid accumulation, or change in any CSF measures of tau, ptau181, and CSF Aβ42.InterpretationAs in sporadic AD, the deleterious effects of β‐amyloid on cognitive function, brain volume loss, and CSF tau in DIAD mutation carriers are less in Val66 homozygotes. TheBDNFVal66Met polymorphism should be considered as a potential moderator of clinical trial outcomes in current treatment and prevention trials in DIAD and sporadic AD. Ann Neurol 2018;84:424–435

[O1–02–03]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: FINDINGS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK

Dincer, Aylin , Christensen, Jon, Cairns, Nigel J., Fagan, Anne M. , Marcus, Daniel S. , Hornbeck, Russ C. , Paumier, Katrina L. , Raichle, Marcus E. , Gordon, Brian A. , Blazey, Tyler , Su, Yi , Hari‐Raj, Amrita , Flores, Shaney , McDade, Eric , Wang, Guoqiao , Xiong, Chengjie , Hassenstab, Jason , Jack, Clifford R. , Koeppe, Robert A. , Ances, Beau M. , Holtzman, David M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_3 | Pages: No page available

10.1016/j.jalz.2017.07.041

[IC‐P‐054]: EXAMINING LONGITUDINAL NEUROIMAGING PATTERNS IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE: RESULTS FROM THE DOMINANTLY INHERITED ALZHEIMER NETWORK

Hari‐Raj, Amrita , Dincer, Aylin , Christensen, Jon, Wang, Guoqiao , Cairns, Nigel J. , Fagan, Anne M. , Marcus, Daniel S., Hornbeck, Russ C. , Paumier, Katrina L. , Raichle, Marcus E. , Gordon, Brian A. , Blazey, Tyler , Su, Yi , Flores, Shaney , McDade, Eric , Xiong, Chengjie , Hassenstab, Jason , Jack, Clifford R. , Koeppe, Robert A. , Ances, Beau M. , Holtzman, David M. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S.

Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2017.06.2327

O5‐02‐01: Longitudinal Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease: The Dominantly Inherited Alzheimer Network

Weng, Hua , Wang, Guoqiao , Xiong, Chengjie , Fagan, Anne M. , Marcus, Daniel S., Cairns, Nigel J. , Buckles, Virginia, Farlow, Martin R. , Mayeux, Richard , Ringman, John M. , Chhatwal, Jasmeer P. , Graff‐Radford, Neill R. , Salloway, Stephen , McDade, Eric , Hassenstab, Jason , Morris, John C. , Benzinger, Tammie L.S. , Goate, Alison , Holtzman, David M. , Berman, Sarah , Ghetti, Bernardino , Schofield, Peter R. , Masters, Colin L. , Martins, Ralph N. , Rossor, Martin N. , Fox, Nick C. , Xiong, Chengjie , Danek, Adrian , Jucker, Mathias , Bateman, Randall J.

Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_7 | Pages: No page available

10.1016/j.jalz.2016.06.710

O3‐09‐05: The Dian‐Nacc UDS Comparison Study: Rates of Cognitive Decline

Buckles, Virginia, Weng, Hua , Chhatwal, Jasmeer P. , Graff‐Radford, Neill R. , Mayeux, Richard , Moulder, Krista L., Paumier, Katrina L. , Ringman, John M. , Salloway, Stephen , Network, the Dominantly Inherited Alzheimer, Xiong, Chengjie , Bateman, Randall J. , Ghetti, Bernardino , Goate, Alison , Hassenstab, Jason , Masters, Colin L. , McDade, Eric , Schofield, Peter William , Morris, John C. , Network, the Dominantly Inherited Alzheimer

Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_6 | Pages: No page available

10.1016/j.jalz.2016.06.559

F5‐02‐03: BDNF VAL66MET Moderates Cognitive Impairment, Neuronal Dysfunction and TAU in Preclinical Autosomal Dominant Alzheimer's Disease

Fagan, Anne M. , Benzinger, Tammie Lee Smith, Ricardo, Allegri, Chhatwal, Jasmeer P. , Farlow, Martin R. , Graff‐Radford, Neill R. , Laske, Christoph , Ringman, John M. , Salloway, Stephen , Lim, Yen Ying , Hassenstab, Jason , Cruchaga, Carlos , Goate, Alison , Benzinger, Tammie L.S. , Maruff, Paul , Snyder, Peter J. , Masters, Colin L. , Allegri, Ricardo , Xiong, Chengjie , McDade, Eric , Rossor, Martin N. , Schofield, Peter William , Holtzman, David M. , Morris, John C. , Bateman, Randall J.