Mayo Clinic - AuthorCitation

Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia

Nedelská, Zuzana , Lesnick, Timothy G. , Przybelski, Scott A. , Lowe, Val J. , Kremers, Walter K. , Gunter, Jeffrey L. , Senjem, Matthew L. , Graff‐Radford, Jonathan , Ferman, Tanis J. , Fields, Julie A. , Petersen, Ronald C. , Jack, Clifford R. , Kantarci, Kejal , Jack, Clifford R , Nedelska, Zuzana , Senjem, Matthew L , Kantarci, Kejal , Ferman, Tanis J , Kremers, Walter K , Schwarz, Christopher G. , Boeve, Bradley F. , Knopman, David S.

JAMA Network Open | December 2, 2019 | Volume: 2 | Issue: 12 | Pages: e1916439

10.1001/jamanetworkopen.2019.16439

Tau‐positron emission tomography correlates with neuropathology findings

Lowe, Val J. , Lundt, Emily S. , Albertson, Sabrina M., Min, Hoon‐Ki , Fang, Ping , Przybelski, Scott A. , Senjem, Matthew L. , Kantarci, Kejal , Reichard, R. Ross , Tranovich, Jessica F., Al‐Shaikh, Fadi S. Hanna , Petersen, Ronald C. , Murray, Melissa E. , Hanna Al-Shaikh, Fadi S, Min, Hoon-Ki Paul , Senjem, Matthew L , Kantarci, Kejal , Murray, Melissa E , Schwarz, Christopher G. , Boeve, Bradley F. , Jones, David T. , Knopman, David S. , Jack, Clifford R. , Dickson, Dennis W. , Lundt, Emily S

Alzheimer's & Dementia | November 26, 2019 | Volume: 16 | Issue: 3 | Pages: 561-571

10.1016/j.jalz.2019.09.079

AbstractIntroductionComparison of tau (flortaucipir) positron emission tomography (FTP‐PET) to autopsy is important to demonstrate the relationship of FTP‐PET to neuropathologic findings.MethodsAutopsies were performed on 26 participants who had antemortem FTP‐PET. FTP‐PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP‐PET signal.ResultsParticipants with Braak stages of IV or greater had elevated FTP‐PET signal. FTP‐PET was elevated in participants with Alzheimer's disease. An FTP‐PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP‐PET signal (rho's from 0.61 to 0.70, P ≤ .02).DiscussionElevated FTP‐PET reflects Braak IV or greater neuropathology. Participants with primary age‐related tauopathy and hippocampal sclerosis did not show elevated FTP‐PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP‐PET signal.

Cerebrospinal fluid dynamics disorders

Graff‐Radford, Jonathan , Gunter, Jeffrey L. , Przybelski, Scott A. , Lowe, Val J. , Elder, Benjamin D. , Gunter, Nathaniel B. , Petersen, Ronald C. , Kantarci, Kejal , Vemuri, Prashanthi , Graff‐Radford, Neill R. , Jack, Clifford R. , Jack, Clifford R , Vemuri, Prashanthi , Kantarci, Kejal , Jones, David T. , Schwarz, Christopher G. , Huston, John , Machulda, Mary M. , Mielke, Michelle M. , Knopman, David S.

Neurology | November 13, 2019 | Volume: 93 | Issue: 24 | Pages: No page available

10.1212/wnl.0000000000008616

Identification of Anonymous MRI Research Participants with Face-Recognition Software

Schwarz, Christopher G. , Kremers, Walter K. , Therneau, Terry M. , Sharp, Richard R. , Gunter, Jeffrey L. , Vemuri, Prashanthi , Arani, Arvin , Spychalla, Anthony J., Kantarci, Kejal , Petersen, Ronald C. , Jack, Clifford R. , Jack, Clifford R , Schwarz, Christopher G , Arani, Arvin , Sharp, Richard R , Vemuri, Prashanthi , Kantarci, Kejal , Kremers, Walter K , Knopman, David S.

New England Journal of Medicine | October 23, 2019 | Volume: 381 | Issue: 17 | Pages: 1684-1686

10.1056/nejmc1908881

O4‐12‐01: TAU PET IMAGING CORRELATES WITH NEUROPATHOLOGY

Lowe, Val J. , Albertson, Sabrina M., Nancy, Scott, Fang, Ping , Parisi, Joseph E., Petersen, Ronald C. , Lundt, Emily S. , Min, Hoon-Ki Paul , Senjem, Matthew L. , Schwarz, Christopher G. , Kantarci, Kejal , Boeve, Bradley F. , Jones, David T. , Knopman, David S. , Jack, Clifford R. , Dickson, Dennis W. , Murray, Melissa E.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_24 | Pages: No page available

10.1016/j.jalz.2019.06.4806

O3‐09‐03: RELATIONSHIP BETWEEN MIDLIFE FACTORS AND MULTIMODAL IMAGING MEASURES OF NEUROBIOLOGICAL CAPITAL: MAYO CLINIC STUDY OF AGING

Graff‐Radford, Jonathan , Przybelski, Scott A. , Lesnick, Timothy G. , Petersen, Ronald C. , Neth, Bryan J. , Schwarz, Christopher G. , Reid, Robert I. , Senjem, Matthew L. , Mielke, Michelle M. , Jack, Clifford R. , Knopman, David S. , Vemuri, Prashanthi

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_17 | Pages: No page available

10.1016/j.jalz.2019.06.4674

O2‐08‐01: ANTE‐MORTEM VOLUME LOSS MIRRORS TDP43 STAGING IN NON‐FTLD OLDER ADULTS

Martin, Peter R. , Tosakulwong, Nirubol , Petersen, Ronald C. , Parisi, Joseph E., Whitwell, Jennifer L. , Josephs, Keith A. , Bejanin, Alexandre , Murray, Melissa E. , Botha, Hugo , Schwarz, Christopher G. , Senjem, Matthew L. , Chételat, Gaël , Jack, Clifford R. , Boeve, Bradley F. , Knopman, David S. , Giannini, Caterina , Dickson, Dennis W. , Whitwell, Jennifer L.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_10 | Pages: No page available

10.1016/j.jalz.2019.06.4493

O2‐03‐05: PREVALENCE OF CLINICALLY VERSUS BIOLOGICALLY DEFINED ALZHEIMER'S SPECTRUM ENTITIES USING THE NATIONAL INSTITUTE ON AGING – ALZHEIMER'S ASSOCIATION RESEARCH FRAMEWORK

Therneau, Terry M. , Weigand, Stephen D. , Wiste, Heather J. , Lowe, Val J. , Roberts, Rosebud O., Graff‐Radford, Jonathan , Gunter, Jeffrey L. , Rocca, Walter A. , Petersen, Ronald C. , Jack, Clifford R. , Knopman, David S. , Vemuri, Prashanthi , Mielke, Michelle M. , Machulda, Mary M. , Jones, David T. , Schwarz, Christopher G. , Senjem, Matthew L.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_10 | Pages: No page available

10.1016/j.jalz.2019.06.4467

IC‐P‐171: MENTAL AND PHYSICAL ACTIVITY DURING THE 80‐MINUTE UPTAKE TIME AFFECTS OFF‐TARGET BINDING IN TAU PET SCANS (18F‐FTP)

Apgar, Christopher, Nancy, Scott, Albertson, Sabrina M., Gunter, Jeffrey L. , Petersen, Ronald C. , Lowe, Val J. , Min, Hoon-Ki Paul , Lundt, Emily S. , Schwarz, Christopher G. , Botha, Hugo , Vemuri, Prashanthi , Jack, Clifford R.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_2 | Pages: No page available

10.1016/j.jalz.2019.06.4286

IC‐P‐127: VARIABILITY IN MRI AND PET MEASUREMENTS INTRODUCED BY CHANGE IN MRI VENDOR

Wiste, Heather J. , Gunter, Jeffrey L. , Lowe, Val J. , Petersen, Ronald C. , Schwarz, Christopher G. , Senjem, Matthew L. , Knopman, David S. , Jack, Clifford R.