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Kortüm, K. Martin

https://orcid.org/0000-0002-7011-0286

Mayo Clinic

University of Würzburg

Citations 24

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes
Mai, Elias K., Hanafiah, Nur Hafzan Md , Shi, Chang-Xi, Zhu, Yuan-Xiao, Bruins, Laura A., Barrio, Santiago , Jedlowski, Patrick , Merz, Maximilian , Xu, Jing , Andrulis, Mindaugas , Jauch, Anna , Hillengaß, Jens , Goldschmidt, Hartmut , Bergsagel, P. Leif , Braggio, Esteban , Stewart, A. Keith, Bergsagel, P. Leif , Bruins, Laura, Stewart, Robert A, Raab, Marc S , Kortüm, K. Martin , Mai, Elias K., Stewart, Robert A., Raab, Marc S. , Braggio, Esteban , Merz, Maximilian

Blood | July 25, 2016 | Volume: 128 | Issue: 9 | Pages: 1226-1233

10.1182/blood-2016-02-698092 Get It

Key Points The incidence of mutations within the MAPK pathway, the CRBN pathway, and TP53 is significantly increased in drug-refractory MM. Mutations in CRBN might contribute to IMiD resistance in drug-refractory MM.
Bioinformatics Strategies for Identifying Regions of Epigenetic Deregulation Associated with Aberrant Transcript Splicing and RNA-editing
Champion, Mia D., Hlady, Ryan A. , Yan, Huihuang , Evans, Jared M., Nie, Jeff, Nandakumar, Kannabiran, Davila, Jaime , Moore, Raymond M. , Nair, Asha, Zhu, Yuanxiao, Ördög, Tamás , Kocher, Jean-Pierre A., Jonasch, Eric, Tibes, Raoul , Lee, Jeong‐Heon , Bogenberger, James M. , O’Brien, Daniel J. , Kortüm, K. Martin , Zhang, Zhiguo , Joseph, Richard W. , Jonasch, Eric W. , Robertson, Keith D. , Ho, Thai H. , Davila, Jaime I

Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms | February 2, 2015 | Volume: No volume available | Issue: No issue available | Pages: 163-170

10.5220/0005248001630170 Get It

Identification of recurrent truncated DDX3X mutations in chronic lymphocytic leukaemia
Ojha, Juhi, Secreto, Charla, Rabe, Kari G. , Dyke, Daniel L. Van , Braggio, Esteban , Kortüm, K. Martin , Slager, Susan L. , Shanafelt, Tait D. , Fonseca, Rafaël , Kay, Neil E. , Chaffee, Kari G. , Braggio, Esteban

British Journal of Haematology | November 10, 2014 | Volume: 169 | Issue: 3 | Pages: 445-448

10.1111/bjh.13211 Get It

Targeted sequencing using a 47 gene multiple myeloma mutation panel (M3P) in ‐17p high risk disease
Langer, Christian , Monge, Jorge , Bruins, Laura A., Egan, Jan B. , Zhu, Yuan Xiao , Jedlowski, Patrick , Schmidt, Jessica, Ojha, Juhi, Bullinger, Lars , Liebisch, Peter, Kull, Miriam, Champion, Mia D., Wier, Scott Van, Ahmann, Gregory , Rasche, Leo , Knop, Stefan , Stewart, A. Keith, Braggio, Esteban , Kortüm, Klaus M, Kortüm, K. Martin , Chang, Shi , Fonseca, Rafaël , Einsele, Hermann , Braggio, Esteban

British Journal of Haematology | October 10, 2014 | Volume: 168 | Issue: 4 | Pages: 507-510

10.1111/bjh.13171 Get It

SummaryWe constructed a multiple myeloma (MM)‐specific gene panel for targeted sequencing and investigated 72 untreated high‐risk (del17p) MM patients. Mutations were identified in 78% of the patients. While the majority of studied genes were mutated at similar frequency to published literature, the prevalence of TP53 mutation was increased (28%) and no mutations were found in FAM46C. This study provides a comprehensive insight into the mutational landscape of del17p high‐risk MM. Additionally, our work demonstrates the practical use of a customized sequencing panel, as an easy, cheap and fast approach to characterize the mutational profile of MM.